AU542611B2 - Indole and isoquinoline derivatives - Google Patents

Indole and isoquinoline derivatives

Info

Publication number: AU542611B2
Authority: AU; Australia
Prior art keywords: indole; isoquinoline derivatives; isoquinoline; derivatives
Prior art date: 1980-10-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired, expires 2006-10-01

Application number

AU75949/81A

Other versions

AU7594981A (en

Inventor

Michel Laubie

Georges Remond

Michel Vincent

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

ADIR SARL

Original Assignee

ADIR SARL

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-10-02

Filing date

1981-10-01

Publication date

1985-02-28

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26222007&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU542611(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1980-10-02 Priority claimed from FR8021095A external-priority patent/FR2491469A1/en

1981-10-01 Application filed by ADIR SARL filed Critical ADIR SARL

1982-04-08 Publication of AU7594981A publication Critical patent/AU7594981A/en

1985-02-28 Application granted granted Critical

1985-02-28 Publication of AU542611B2 publication Critical patent/AU542611B2/en

2006-10-01 Adjusted expiration legal-status Critical

Status Expired legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/08—Six-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

AU75949/81A 1980-10-02 1981-10-01 Indole and isoquinoline derivatives Expired AU542611B2 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
FR8021095A FR2491469A1 (en)	1980-10-02	1980-10-02	2-Carboxy-per:hydro-indole(s) and per or tetra:hydro-isoquinoline(s) - having a carboxy-substd. amino-acyl N-gp., inhibit carboxy:poly:peptidase(s), and kininase II and control hypertension
FR8021095		1980-10-02
FR8106916		1981-04-07
FR8106916A FR2503155A2 (en)	1980-10-02	1981-04-07	NOVEL SUBSTITUTED IMINO DIACIDES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS AN ENZYME INHIBITOR

Publications (2)

Publication Number	Publication Date
AU7594981A AU7594981A (en)	1982-04-08
AU542611B2 true AU542611B2 (en)	1985-02-28

Family

ID=26222007

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU75949/81A Expired AU542611B2 (en)	1980-10-02	1981-10-01	Indole and isoquinoline derivatives

Country Status (29)

Country	Link
EP (1)	EP0049658B1 (en)
JP (1)	JPS5791974A (en)
KR (1)	KR860001875B1 (en)
AR (1)	AR242949A1 (en)
AT (1)	ATE7910T1 (en)
AU (1)	AU542611B2 (en)
CA (1)	CA1341196C (en)
DD (1)	DD201783A5 (en)
DE (1)	DE3164201D1 (en)
DK (1)	DK157011C (en)
EG (1)	EG15361A (en)
ES (1)	ES8305723A1 (en)
FI (1)	FI77230C (en)
FR (1)	FR2503155A2 (en)
GE (1)	GEP19970943B (en)
GR (1)	GR75016B (en)
HU (1)	HU185147B (en)
IE (1)	IE51821B1 (en)
IL (1)	IL63940A (en)
LU (1)	LU88262I2 (en)
MD (1)	MD381C2 (en)
NL (1)	NL930046I2 (en)
NO (1)	NO160780C (en)
NZ (1)	NZ198535A (en)
OA (1)	OA06914A (en)
PH (1)	PH17516A (en)
PT (1)	PT73755B (en)
SU (1)	SU1153827A3 (en)
UA (1)	UA6308A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU581455B2 (en) *	1984-09-01	1989-02-23	Wellcome Foundation Limited, The	New peptides with angiotensin converting enzyme inhibitory activity
AU599151B2 (en) *	1980-08-30	1990-07-12	Aventis Pharma Deutschland Gmbh	Aminoacid derivatives, a process for their preparation, agents containing these compounds, and the use thereof

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4344949A (en) *	1980-10-03	1982-08-17	Warner-Lambert Company	Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
ZA817261B (en) *	1980-10-23	1982-09-29	Schering Corp	Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
EP0050800B2 (en) *	1980-10-23	1995-06-07	Schering Corporation	Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
US4479963A (en) *	1981-02-17	1984-10-30	Ciba-Geigy Corporation	1-Carboxyalkanoylindoline-2-carboxylic acids
US4532342A (en) *	1981-02-20	1985-07-30	Warner-Lambert Company	N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
IN156096B (en) *	1981-03-19	1985-05-11	Usv Pharma Corp
EP0065301A1 (en) *	1981-05-18	1982-11-24	Merck & Co. Inc.	Isoquinoline carboxylic acid derivates, process for preparing and pharmaceutical composition containing the same
DE3226768A1 (en) *	1981-11-05	1983-05-26	Hoechst Ag, 6230 Frankfurt	DERIVATIVES OF CIS, ENDO-2-AZABICYCLO- (3.3.0) -OCTAN-3-CARBONIC ACID, METHOD FOR THE PRODUCTION THEREOF, THE MEANS CONTAINING THEM AND THE USE THEREOF
SU1327787A3 (en) *	1981-11-05	1987-07-30	Хехст Аг (Фирма)	Method of producing cis,endo-2-azabicyclo-(3,3,0)-octane-3-carboxylic acids or acid-additive salts thereof
IE55867B1 (en) *	1981-12-29	1991-02-14	Hoechst Ag	New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation
ATE25244T1 (en) *	1981-12-29	1987-02-15	Hoechst Ag	NEW DERIVATIVES OF BICYCLIC AMINO ACIDS, PROCESS FOR THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AND THEIR USE, AS WELL AS NEW BICYCLIC AMINO ACIDS AS INTERMEDIATE STAGES AND PROCESS FOR THEIR PREPARATION.
DE3210496A1 (en) *	1982-03-23	1983-10-06	Hoechst Ag	NEW DERIVATIVES OF BICYCLIC AMINO ACIDS, METHOD FOR THE PRODUCTION THEREOF, THE MEANS CONTAINING THEM AND THE USE THEREOF, AND NEW BICYCLIC AMINO ACIDS AS INTERMEDIATE STAGES AND METHOD FOR THE PRODUCTION THEREOF
DE3302125A1 (en) *	1983-01-22	1984-07-26	Boehringer Ingelheim KG, 6507 Ingelheim	AMINO ACID DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF
US5175306A (en) *	1983-01-31	1992-12-29	Hoechst Aktiengesellschaft	Process for the resolution of racemates of optically active bicyclic imino-α-carboxylic esters
HU191120B (en) *	1983-01-31	1987-01-28	Hoechts Ag,De	Process for raceme separation of optically active byciclic imino-alpha-carbonic acid esthers
DE3303344A1 (en)	1983-02-02	1984-08-02	Hoechst Ag, 6230 Frankfurt	METHOD FOR PRODUCING N-ALKYLATED AMINO ACIDS AND THEIR ESTERS
DE3333455A1 (en) *	1983-09-16	1985-04-11	Hoechst Ag, 6230 Frankfurt	METHOD FOR PRODUCING N-ALKYLATED DIPEPTIDES AND THEIR ESTERS
DE3333454A1 (en) *	1983-09-16	1985-04-11	Hoechst Ag, 6230 Frankfurt	METHOD FOR PRODUCING N-ALKYLATED DIPEPTIDES AND THEIR ESTERS
DE3408923A1 (en) *	1984-03-12	1985-09-26	Hoechst Ag, 6230 Frankfurt	CARBOXYALKYLDIPEPTIDE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THE AGENTS CONTAINING THEM AND THE USE THEREOF
US5684016A (en) *	1984-04-12	1997-11-04	Hoechst Aktiengesellschaft	Method of treating cardiac insufficiency
DE3413710A1 (en) *	1984-04-12	1985-10-24	Hoechst Ag, 6230 Frankfurt	METHOD FOR TREATING HEART INSUFFICIENCY
DE3431541A1 (en) *	1984-08-28	1986-03-06	Hoechst Ag, 6230 Frankfurt	CIS, ENDO-2-AZABICYCLOALKAN-3-CARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AND INTERMEDIATE PRODUCTS IN THEIR PRODUCTION
US5231080A (en) *	1985-10-15	1993-07-27	Hoechst Aktiengesellschaft	Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease
US4693996A (en) *	1985-12-23	1987-09-15	Warner-Lambert Company	Method of treating heart failure and medicaments therefor
US5231084A (en) *	1986-03-27	1993-07-27	Hoechst Aktiengesellschaft	Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons
DE3633496A1 (en) *	1986-10-02	1988-04-14	Hoechst Ag	COMBINATION OF ANGIOTENSIN CONVERTING ENZYME INHIBITORS WITH CALCIUMANTAGONISTS AND THEIR USE IN MEDICINAL PRODUCTS
DE3639879A1 (en) *	1986-11-21	1988-06-01	Hoechst Ag	METHOD FOR PRODUCING MONO, BI AND TRICYCLIC AMINO ACIDS, INTERMEDIATE PRODUCTS OF THIS METHOD, AND A METHOD FOR PRODUCING THE SAME
DE3722007A1 (en) *	1987-07-03	1989-01-12	Hoechst Ag	METHOD FOR PRODUCING BICYCLIC AMINOCARBONIC ACIDS, INTERMEDIATE PRODUCTS OF THIS METHOD AND THE USE THEREOF
FR2620700B1 (en) *	1987-09-17	1990-06-01	Adir	PROCESS FOR THE SYNTHESIS OF ALPHA AMINO ACIDS N ALKYLS AND THEIR ESTERS. APPLICATION TO THE SYNTHESIS OF CARBOXYALKYL DIPEPTIDES
FR2620703B1 (en) *	1987-09-17	1991-10-04	Adir	PROCESS FOR THE INDUSTRIAL SYNTHESIS OF PERHYDROINDOLE CARBOXYLIC ACID - 2 (2S, 3AS, 7AS). APPLICATION TO THE SYNTHESIS OF CARBOXYALKYL DIPEPTIDES
FR2620699B1 (en) *	1987-09-17	1990-06-01	Adir	PROCESS FOR THE SYNTHESIS OF ALPHA AMINO N ALKYL ACIDS AND THEIR ESTERS. APPLICATION TO THE SYNTHESIS OF CARBOXYALKYL DIPEPTIDES
FR2620709B1 (en) *	1987-09-17	1990-09-07	Adir	PROCESS FOR THE INDUSTRIAL SYNTHESIS OF PERINDOPRIL AND ITS MAIN INTERMEDIATE SYNTHESIS
US4902695A (en) *	1989-02-13	1990-02-20	Eli Lilly And Company	Excitatory amino acid receptor antagonists
TW197945B (en) *	1990-11-27	1993-01-11	Hoechst Ag
US5246943A (en) *	1992-05-19	1993-09-21	Warner-Lambert Company	Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties
LT3872B (en)	1993-12-06	1996-04-25	Hoechst Ag	Novel peptides and pharmaceutical compositions containing them
EP0796855B1 (en)	1996-03-20	2002-02-06	Hoechst Aktiengesellschaft	Inhibitors of bone resorption and vitronectin receptor antagonists
FR2746394B1 (en)	1996-03-20	1998-05-29	Roussel Uclaf	NOVEL TRICYCLIC COMPOUNDS, THEIR PREPARATION PROCESS, AND INTERMEDIATES THEREOF, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
DE19653647A1 (en)	1996-12-20	1998-06-25	Hoechst Ag	Vitronectin receptor antagonists, their preparation and their use
DE19741873A1 (en) *	1997-09-23	1999-03-25	Hoechst Marion Roussel De Gmbh	New 5-ring heterocycles, their preparation, their use and pharmaceutical preparations containing them
DE19751251A1 (en)	1997-11-19	1999-05-20	Hoechst Marion Roussel De Gmbh	Substituted imidazolidine derivatives, their manufacture, their use and pharmaceutical preparations containing them
DE19821483A1 (en)	1998-05-14	1999-11-18	Hoechst Marion Roussel De Gmbh	New imidazolidine derivatives useful as leukocyte adhesion and migration inhibitors and/or VLA-4 receptor antagonists for treating E.G. inflammatory and allergic disorders
FR2807431B1 (en) *	2000-04-06	2002-07-19	Adir	NOVEL PROCESS FOR THE SYNTHESIS OF PERINDOPRIL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS
FR2807430B1 (en) *	2000-04-11	2002-05-17	Adir	NOVEL PROCESS FOR THE SYNTHESIS OF N - [(S) -1- CARBOXYBUTYL] - (S) -ALANINE ESTERS AND APPLICATION TO THE SYNTHESIS OF PERINDOPRIL
AU2007203451B2 (en) *	2000-07-06	2010-09-02	Les Laboratoires Servier	Pharmaceutical composition containing a crystalline form of perindopril tert-butylamine salt
FR2811320B1 (en) *	2000-07-06	2002-08-23	Adir	NOVEL ALPHA CRYSTALLINE FORM OF TERT-BUTYLAMINE SALT OF PERINDOPRIL, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2811318B1 (en) *	2000-07-06	2002-08-23	Adir	NOVEL GAMMA CRYSTALLINE FORM OF TERT-BUTYLAMINE SALT OF PERINDOPRIL, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2827860B1 (en)	2001-07-24	2004-12-10	Servier Lab	NOVEL PROCESS FOR SYNTHESIS OF ACID DERIVATIVES (2S, 3AS, 7AS) -1 - [(S) -ALANYL] -OCTAHYDRO-1H-INDOLE-2-CARBOXYLINE AND APPLICATION TO THE SYNTHESIS OF PERINDOPRIL
DK1333026T3 (en) *	2002-01-30	2007-10-22	Servier Lab	Process for the preparation of high purity perindopril and useful intermediates for the synthesis
FR2838648B1 (en) *	2002-04-18	2004-05-21	Servier Lab	NEW PERINDOPRIL SALT AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING IT
GB2395195A (en) *	2002-11-18	2004-05-19	Cipla Ltd	Preparation of perindopril from carboxy-protected precursor, & perindopril monohydrates for use as angiotensin converting enzyme (ACE) inhibitors
BRPI0411966A (en)	2003-06-24	2006-08-29	Servier Lab	crystalline forms of perindopril erbumin
DK1367061T3 (en) *	2003-06-30	2006-05-15	Servier Lab	Process for the synthesis of perindopril and pharmaceutically acceptable salts thereof
SI1380590T1 (en) *	2003-08-29	2006-12-31	Servier Lab	Method for synthesis of perindopril and its pharmaceutically acceptable salts
SI1362845T1 (en) *	2003-09-01	2010-01-29	Servier Lab	New process for the synthesis of N-((S)-1-carboxybutyl)-(S)-alanine esters and their use in the synthesis of perindopril
SI21703A (en)	2004-01-14	2005-08-31	Lek Farmacevtska Druzba Dd	Inclusion complexes of perindopril, procedure of their preparation, pharmaceutical compositions containing these complexes and their application in treatment of hypertensia
GB2413128A (en) *	2004-04-13	2005-10-19	Neopharma Ltd	Process for the preparation of perindopril
SI21800A (en)	2004-05-14	2005-12-31	Krka, Tovarna Zdravil, D.D., Novo Mesto	New procedure of synthesis of perindopril
SI21881A (en)	2004-10-15	2006-04-30	Diagen, Smartno Pri Ljubljani, D.O.O.	New crystal forms of perindopril erbumine hydrates, procedure of their preparation and pharmaceutical forms containing these compounds
ES2314583T4 (en)	2005-01-06	2009-05-18	Ipca Laboratories Limited	PROCESS FOR SYNTHESIS OF ACID DERIVATIVES (2S, 3AS, 7AS) -1- (S) -ALANIL-OCTAHIDRO-1H-INDOL-2-CARBOXILICO AND ITS USE IN PERINDROPIL SYNTHESIS.
EP1815857A1 (en)	2006-02-02	2007-08-08	LEK Pharmaceuticals D.D.	A pharmaceutical composition comprising perindopril
FR2897866B1 (en)	2006-02-28	2008-04-18	Servier Lab	ALPHA CRYSTALLINE FORM OF PERINOPRIL ARGININE SALT, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
SI22543A (en)	2007-06-27	2008-12-31	Krka, Tovarna Zdravil, D.D., Novo Mesto	New salts of perindopril
GB0910692D0 (en)	2009-06-20	2009-08-05	Teva Pharma	Compound
PT105315B (en)	2010-09-29	2013-01-16	Inst Superior Tecnico	A NEW CRYSTALIN HYDRATE FORM OF PERINDOPRIL ERBUMINE, METHODS FOR PREPARATION AND USE IN PHARMACEUTICAL PREPARATIONS
FR2985511B1 (en)	2012-01-05	2014-01-03	Servier Lab	CRYSTALLINE DELTA FORM OF PERINOPRIL ARGININE SALT, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2985512B1 (en)	2012-01-05	2014-06-20	Servier Lab	PROCESS FOR THE PREPARATION OF L-ARGININE SALT OF PERINDOPRIL
WO2016178591A2 (en)	2015-05-05	2016-11-10	Gene Predit, Sa	Genetic markers and treatment of male obesity
PH12018502155B1 (en)	2016-04-20	2024-03-27	Servier Lab	Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid
EP3842035A1 (en)	2019-12-23	2021-06-30	KRKA, d.d., Novo mesto	Composition for the preparation of perindopril arginine granules, a method for their preparation and pharmaceutical composition comprising the granules

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5572169A (en) *	1978-11-27	1980-05-30	Tanabe Seiyaku Co Ltd	Isoquinoline derivative and its preparation
IL58849A (en) *	1978-12-11	1983-03-31	Merck & Co Inc	Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4461896A (en) *	1979-02-07	1984-07-24	Norwich Eaton Pharmaceuticals, Inc.	1-[Acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acids
EP0018104B1 (en) *	1979-03-26	1983-05-25	Takeda Chemical Industries, Ltd.	Tetrahydroisoquinolines, their production and the compounds and pharmaceutical compositions containing them for use in the prevention or treatment of hypertension
US4294832A (en) *	1979-04-28	1981-10-13	Tanabe Seiyaku Co., Ltd.	Tetrahydroisoquinoline compounds and a pharmaceutical composition thereof
GB2048863B (en) *	1979-05-16	1983-06-15	Morton Norwich Products Inc	Tetrahydroisoquinoline-3-carboxylic acids
US4303583A (en) *	1979-08-13	1981-12-01	American Home Products Corporation	1H,5H-[1,4]Thiazepino[4,3-a]indole-1,5-diones
FR2487829A2 (en) *	1979-12-07	1982-02-05	Science Union & Cie	NOVEL SUBSTITUTED IMINO ACIDS, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS AN ENZYME INHIBITOR
FR2470767A1 (en) *	1979-12-07	1981-06-12	Science Union & Cie	N-Acyl-2-carboxy fused ring heterocyclic cpds. - useful for inhibiting angiotensin converting enzyme and enkephalin(s)
ZA811493B (en) *	1980-04-02	1982-03-31	Warner Lambert Co	Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
US4251444A (en) *	1980-04-07	1981-02-17	American Home Products Corporation	Thiazepino-[4,3-b]-isoquinoline-1,5-dione derivatives and precursors
DE3177311D1 (en) *	1980-08-30	1994-06-09	Hoechst Ag	Amino acid derivatives, processes for their preparation, compositions containing them and their use.
US4344949A (en) *	1980-10-03	1982-08-17	Warner-Lambert Company	Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids

1981
- 1981-04-07 FR FR8106916A patent/FR2503155A2/en active Granted
- 1981-09-25 IL IL63940A patent/IL63940A/en not_active IP Right Cessation
- 1981-09-29 EP EP81401501A patent/EP0049658B1/en not_active Expired
- 1981-09-29 DE DE8181401501T patent/DE3164201D1/en not_active Expired
- 1981-09-29 AT AT81401501T patent/ATE7910T1/en active
- 1981-09-29 IE IE2257/81A patent/IE51821B1/en active Protection Beyond IP Right Term
- 1981-09-29 LU LU88262C patent/LU88262I2/xx unknown
- 1981-09-30 FI FI813034A patent/FI77230C/en not_active IP Right Cessation
- 1981-09-30 EG EG556/81A patent/EG15361A/en active
- 1981-09-30 AR AR81286934A patent/AR242949A1/en active
- 1981-10-01 NO NO813339A patent/NO160780C/en not_active IP Right Cessation
- 1981-10-01 UA UA3344196A patent/UA6308A1/en unknown
- 1981-10-01 PH PH26297A patent/PH17516A/en unknown
- 1981-10-01 DK DK434381A patent/DK157011C/en not_active IP Right Cessation
- 1981-10-01 AU AU75949/81A patent/AU542611B2/en not_active Expired
- 1981-10-01 PT PT73755A patent/PT73755B/en unknown
- 1981-10-01 OA OA57509A patent/OA06914A/en unknown
- 1981-10-01 HU HU812838A patent/HU185147B/en not_active IP Right Cessation
- 1981-10-01 CA CA000387093A patent/CA1341196C/en not_active Expired - Lifetime
- 1981-10-01 SU SU813344196A patent/SU1153827A3/en active
- 1981-10-01 DD DD81233794A patent/DD201783A5/en unknown
- 1981-10-01 GR GR66179A patent/GR75016B/el unknown
- 1981-10-02 JP JP56157367A patent/JPS5791974A/en active Granted
- 1981-10-02 ES ES505999A patent/ES8305723A1/en not_active Expired
- 1981-10-02 NZ NZ198535A patent/NZ198535A/en unknown
- 1981-10-02 KR KR1019810003709A patent/KR860001875B1/en not_active Expired
1993
- 1993-06-01 NL NL930046C patent/NL930046I2/en unknown
1994
- 1994-05-16 GE GEAP19941926A patent/GEP19970943B/en unknown
- 1994-12-29 MD MD95-0107A patent/MD381C2/en unknown

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU599151B2 (en) *	1980-08-30	1990-07-12	Aventis Pharma Deutschland Gmbh	Aminoacid derivatives, a process for their preparation, agents containing these compounds, and the use thereof
AU627741B2 (en) *	1980-08-30	1992-09-03	Aventis Pharma Deutschland Gmbh	Aminoacid derivatives, a process for their preparation, agents containing these compounds, and the use thereof
AU581455B2 (en) *	1984-09-01	1989-02-23	Wellcome Foundation Limited, The	New peptides with angiotensin converting enzyme inhibitory activity

Also Published As

Publication number	Publication date
UA6308A1 (en)	1994-12-29
PT73755B (en)	1983-10-11
IE51821B1 (en)	1987-04-01
KR860001875B1 (en)	1986-10-24
DK157011B (en)	1989-10-30
JPH0132239B2 (en)	1989-06-29
KR830007564A (en)	1983-10-21
JPS5791974A (en)	1982-06-08
AR242949A1 (en)	1993-06-30
GEP19970943B (en)	1997-04-18
GR75016B (en)	1984-07-12
IL63940A0 (en)	1981-12-31
IE812257L (en)	1983-03-29
DE3164201D1 (en)	1984-07-19
FI77230C (en)	1989-02-10
ES505999A0 (en)	1983-04-16
OA06914A (en)	1983-05-31
SU1153827A3 (en)	1985-04-30
AU7594981A (en)	1982-04-08
ES8305723A1 (en)	1983-04-16
DK434381A (en)	1982-04-03
NO160780C (en)	1989-05-31
DK157011C (en)	1990-03-26
DD201783A5 (en)	1983-08-10
MD381C2 (en)	1996-05-31
PH17516A (en)	1984-09-13
FI813034L (en)	1982-04-03
PT73755A (en)	1981-11-01
EP0049658B1 (en)	1984-06-13
ATE7910T1 (en)	1984-06-15
FR2503155A2 (en)	1982-10-08
NZ198535A (en)	1984-09-28
NO160780B (en)	1989-02-20
LU88262I2 (en)	1994-02-03
FR2503155B2 (en)	1983-07-01
FI77230B (en)	1988-10-31
EP0049658A1 (en)	1982-04-14
NL930046I1 (en)	1993-09-01
CA1341196C (en)	2001-03-06
NO813339L (en)	1982-04-05
NL930046I2 (en)	1994-01-03
EG15361A (en)	1987-04-30
HU185147B (en)	1984-12-28
IL63940A (en)	1985-06-30

Publication	Publication Date	Title
AU542611B2 (en)	1985-02-28	Indole and isoquinoline derivatives
AU8167382A (en)	1982-11-04	Benzo-furan,-thiophen,-pyran-2-one and indole derivatives
AU566149B2 (en)	1987-10-08	Indole derivatives
AU575365B2 (en)	1988-07-28	Indole derivatives
AU542544B2 (en)	1985-02-28	Tetrahydrophthalimide derivatives
PH22850A (en)	1989-01-19	Indole derivatives
AU548467B2 (en)	1985-12-12	Tryptamines and their isoindolylethyl derivatives
AU6151380A (en)	1981-03-05	Phthalimidine derivatives
AU574744B2 (en)	1988-07-14	Indole derivatives
IL75122A0 (en)	1985-09-29	Indoline and 2-indoline derivatives
AU584142B2 (en)	1989-05-18	Indole derivatives
AU554791B2 (en)	1986-09-04	Quinoline and isoquinoline derivatives
ZA854355B (en)	1986-02-26	Indole derivatives
AU6810881A (en)	1981-09-10	Quinoline derivatives
AU566347B2 (en)	1987-10-15	Isoquinoline derivatives
AU540284B2 (en)	1984-11-08	"isoquinoline derivatives"
AU538526B2 (en)	1984-08-16	Isoquinoline derivatives
AU545825B2 (en)	1985-08-01	Biphenylmethanols and derivatives thereof
AU8165582A (en)	1982-10-07	Quinolin derivatives
AU538065B2 (en)	1984-07-26	Isoquinoline derivatives
GB2090829B (en)	1984-06-27	16-amino-pgf2 and derivatives
AU7993382A (en)	1982-08-05	I-spiro isobenzofuranic and i-spiro isobenzothiophenic derivatives
AU536127B2 (en)	1984-04-19	Isoquinoline derivatives
GB2076810B (en)	1984-02-01	Indole derivatives
ZA859244B (en)	1986-09-24	Indole derivatives