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AU541278B2 - A 6-substituted 4-hydroxy pyran-2-one - Google Patents

A 6-substituted 4-hydroxy pyran-2-one

Info

Publication number
AU541278B2
AU541278B2 AU72467/81A AU7246781A AU541278B2 AU 541278 B2 AU541278 B2 AU 541278B2 AU 72467/81 A AU72467/81 A AU 72467/81A AU 7246781 A AU7246781 A AU 7246781A AU 541278 B2 AU541278 B2 AU 541278B2
Authority
AU
Australia
Prior art keywords
substituted
hydroxy pyran
pyran
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU72467/81A
Other versions
AU7246781A (en
Inventor
Edward J. Cragoe
William F. Hoffman
Frederick C. Novello
Alvin K. Willard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP19810105013 priority Critical patent/EP0068038B1/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Priority to AU72467/81A priority patent/AU541278B2/en
Publication of AU7246781A publication Critical patent/AU7246781A/en
Application granted granted Critical
Publication of AU541278B2 publication Critical patent/AU541278B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/006—Palladium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/512—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being a free hydroxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/516—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of nitrogen-containing compounds to >C = O groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU72467/81A 1981-06-29 1981-07-01 A 6-substituted 4-hydroxy pyran-2-one Ceased AU541278B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP19810105013 EP0068038B1 (en) 1981-06-29 1981-06-29 (+)-(4r,6s)-(e)-6-(2-(4'-fluoro-3,3',5-trimethyl-(1,1'-biphenyl)-2-yl)ethenyl)-3,4,5,6-tetrahydro-4-hydroxy-2h-pyran-2-one, a process for preparing and a pharmaceutical composition containing the same
AU72467/81A AU541278B2 (en) 1981-06-29 1981-07-01 A 6-substituted 4-hydroxy pyran-2-one

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19810105013 EP0068038B1 (en) 1981-06-29 1981-06-29 (+)-(4r,6s)-(e)-6-(2-(4'-fluoro-3,3',5-trimethyl-(1,1'-biphenyl)-2-yl)ethenyl)-3,4,5,6-tetrahydro-4-hydroxy-2h-pyran-2-one, a process for preparing and a pharmaceutical composition containing the same
AU72467/81A AU541278B2 (en) 1981-06-29 1981-07-01 A 6-substituted 4-hydroxy pyran-2-one

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
AU66915/81A Addition AU542045B2 (en) 1981-02-04 1981-02-04 Substituted pyranone inhibitors of cholesterol synthesis

Publications (2)

Publication Number Publication Date
AU7246781A AU7246781A (en) 1983-01-06
AU541278B2 true AU541278B2 (en) 1985-01-03

Family

ID=25637036

Family Applications (1)

Application Number Title Priority Date Filing Date
AU72467/81A Ceased AU541278B2 (en) 1981-06-29 1981-07-01 A 6-substituted 4-hydroxy pyran-2-one

Country Status (2)

Country Link
EP (1) EP0068038B1 (en)
AU (1) AU541278B2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1327360C (en) * 1983-11-14 1994-03-01 William F. Hoffman Oxo-analogs of mevinolin-like antihypercholesterolemic agents
US4588820A (en) * 1984-06-11 1986-05-13 Merck & Co., Inc. Process for epimerization at C6 of 3,4,5,6-tetrahydro-2H-pyran-2-one
US4613610A (en) * 1984-06-22 1986-09-23 Sandoz Pharmaceuticals Corp. Cholesterol biosynthesis inhibiting pyrazole analogs of mevalonolactone and its derivatives
US4804679A (en) * 1984-07-24 1989-02-14 Sandoz Pharm. Corp. Erythro-(E)-7-(3'-C1-3alkyl-1'-(3",5"-dimethylphenyl)naphth-2'-yl)-3,5-dihydroxyhept-6-enoic acids and derivatives thereof
US4647576A (en) * 1984-09-24 1987-03-03 Warner-Lambert Company Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis
US4668794A (en) * 1985-05-22 1987-05-26 Sandoz Pharm. Corp. Intermediate imidazole acrolein analogs
US4678806A (en) * 1986-09-02 1987-07-07 Merck & Co., Inc. Prodrugs of antihypercholesterolemic compounds
US4898949A (en) * 1987-02-25 1990-02-06 Bristol-Myers Company Intermediates for the preparation of antihypercholesterolemic tetrazole compounds
US4897490A (en) * 1987-02-25 1990-01-30 Bristol-Meyers Company Antihypercholesterolemic tetrazole compounds
DE3832570A1 (en) * 1988-09-24 1990-03-29 Hoechst Ag 7-SUBSTITUTED DERIVATIVES OF 3,5-DIHYDROXYHEPT-6-ACID, METHODS FOR THE PRODUCTION THEREOF, THEIR USE AS MEDICINAL PRODUCTS AND INTERMEDIATE PRODUCTS
DE3909378A1 (en) * 1989-03-22 1990-09-27 Bayer Ag SUBSTITUTED BIPHENYLE
EA200400034A1 (en) 2001-06-13 2004-06-24 Ранбакси Лабораторис Лимитед METHYL SIMULASTATIN ANALOGUES AS NEW HMG-CoA REDUCTASE INHIBITORS
CN113749037A (en) * 2021-10-11 2021-12-07 安徽靖淮农业科技有限公司 Construction method of environment-friendly warming land-based fishing ground
CN114933675B (en) * 2022-07-25 2022-10-04 潍坊金石环保科技有限公司 Comprehensive utilization method of 2-acrylamide-2-methyl propanesulfonic acid distillation concentrate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ191762A (en) * 1978-10-19 1982-09-14 Merck & Co Inc Hypocholesteremic composition containing cholesterol synthesis inhibitor and anion exchange resin
JPS5559180A (en) * 1978-10-30 1980-05-02 Sankyo Co Ltd 4-hydroxy-2-pyrone ring compound, its preparation, and remedy for hyperlipemia comprising it as active constituent
NZ194557A (en) * 1979-08-17 1984-09-28 Merck & Co Inc Substituted pyranone derivatives;dihydroxy acids therefrom;pharmaceutical compositions

Also Published As

Publication number Publication date
EP0068038A1 (en) 1983-01-05
AU7246781A (en) 1983-01-06
EP0068038B1 (en) 1985-09-25

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