AU5314999A - Modified oligonucleotides - Google Patents

Modified oligonucleotides

Info

Publication number: AU5314999A
Authority: AU; Australia
Prior art keywords: modified oligonucleotides; oligonucleotides; modified
Prior art date: 1998-07-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU53149/99A

Inventor

Phillip Dan Cook

Muthiah Manoharan

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Ionis Pharmaceuticals Inc

Original Assignee

Isis Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-14

Filing date

1999-07-13

Publication date

2000-02-07

1999-07-13 Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc

2000-02-07 Publication of AU5314999A publication Critical patent/AU5314999A/en

Status Abandoned legal-status Critical Current

Links

JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Chemical class Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AU53149/99A 1998-07-14 1999-07-13 Modified oligonucleotides Abandoned AU5314999A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US11504398A	1998-07-14	1998-07-14
US09115043		1998-07-14
PCT/US1999/015886 WO2000004189A1 (en)	1998-07-14	1999-07-13	Modified oligonucleotides

Publications (1)

Publication Number	Publication Date
AU5314999A true AU5314999A (en)	2000-02-07

Family

ID=22358989

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU53149/99A Abandoned AU5314999A (en)	1998-07-14	1999-07-13	Modified oligonucleotides

Country Status (2)

Country	Link
AU (1)	AU5314999A (en)
WO (1)	WO2000004189A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10133915A1 (en) *	2001-07-12	2003-02-06	Aventis Pharma Gmbh	New oligoribonucleotide derivatives for targeted inhibition of gene expression
DE10133858A1 (en) *	2001-07-12	2003-02-06	Aventis Pharma Gmbh	Synthetic double-stranded oligonucleotides for targeted inhibition of gene expression
CN108424432B (en) *	2017-07-13	2021-04-23	上海兆维科技发展有限公司	Preparation method of 3' -O-methoxyethyl nucleoside

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5188897A (en) *	1987-10-22	1993-02-23	Temple University Of The Commonwealth System Of Higher Education	Encapsulated 2',5'-phosphorothioate oligoadenylates
US5434257A (en) *	1992-06-01	1995-07-18	Gilead Sciences, Inc.	Binding compentent oligomers containing unsaturated 3',5' and 2',5' linkages

1999
- 1999-07-13 WO PCT/US1999/015886 patent/WO2000004189A1/en not_active Ceased
- 1999-07-13 AU AU53149/99A patent/AU5314999A/en not_active Abandoned

Also Published As

Publication number	Publication date
WO2000004189A1 (en)	2000-01-27

Publication	Publication Date	Title
AU9392998A (en)	1999-09-20	Pack-a-pillow
AU3340797A (en)	1998-01-21	Modified oligonucleotides
AUPP328398A0 (en)	1998-05-21	Remove-a-line
AU3437799A (en)	1999-11-08	City-car
AU3522399A (en)	1999-11-01	Carvedilol-galenics
AU5407599A (en)	2000-01-17	Sphingolipid-desaturase
AU3253699A (en)	1999-09-06	Myxochelines
AU8363398A (en)	2000-01-24	Capotasto
AU2609599A (en)	2000-07-12	Sensor-coupling
AU3204999A (en)	1999-10-18	Futureball
AU2069199A (en)	1999-08-09	Codelets
AU5314999A (en)	2000-02-07	Modified oligonucleotides
AU5223199A (en)	2000-02-14	Bathtub-bathseat
AU9347498A (en)	2000-03-21	Imidazotriazolopyrimidines
AU3347599A (en)	1999-12-13	Aeromobile
AU2696897A (en)	1997-11-19	Modified oligonucleotides
AU2840799A (en)	1999-10-11	1-phosphanorbornadienes
AU3819799A (en)	1999-11-23	Methoximinomethyloxathiazines
AU4768799A (en)	2000-01-24	Bookcover
AU1779099A (en)	1999-08-09	Heterocyclyl-derivatives
AU9218098A (en)	2000-03-27	Exocyclic-phosphoethanolamines
AUPP184898A0 (en)	1998-03-12	Lifepad
AUPP487598A0 (en)	1998-08-20	Hydro-bio-fit
AU2000211601A1 (en)	2000-05-18	Turscharnier
AUPP345898A0 (en)	1998-06-04	Mouse-mate

Legal Events

Date	Code	Title	Description
2001-04-05	MK6	Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase