AU5311800A - Rhodanine derivatives for use in a method of inhibiting amyloid protein aggregation and imaging amyloid deposits - Google Patents
Rhodanine derivatives for use in a method of inhibiting amyloid protein aggregation and imaging amyloid depositsInfo
- Publication number
- AU5311800A AU5311800A AU53118/00A AU5311800A AU5311800A AU 5311800 A AU5311800 A AU 5311800A AU 53118/00 A AU53118/00 A AU 53118/00A AU 5311800 A AU5311800 A AU 5311800A AU 5311800 A AU5311800 A AU 5311800A
- Authority
- AU
- Australia
- Prior art keywords
- protein aggregation
- imaging
- inhibiting
- rhodanine derivatives
- amyloid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 208000037259 Amyloid Plaque Diseases 0.000 title 1
- 102000009091 Amyloidogenic Proteins Human genes 0.000 title 1
- 108010048112 Amyloidogenic Proteins Proteins 0.000 title 1
- 238000003384 imaging method Methods 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 230000004845 protein aggregation Effects 0.000 title 1
- KIWUVOGUEXMXSV-UHFFFAOYSA-N rhodanine Chemical class O=C1CSC(=S)N1 KIWUVOGUEXMXSV-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13854499P | 1999-06-10 | 1999-06-10 | |
| US60138544 | 1999-06-10 | ||
| PCT/US2000/015069 WO2000076987A1 (en) | 1999-06-10 | 2000-05-31 | Rhodanine derivatives for use in a method of inhibiting amyloid protein aggregation and imaging amyloid deposits |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU5311800A true AU5311800A (en) | 2001-01-02 |
Family
ID=22482512
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU53118/00A Abandoned AU5311800A (en) | 1999-06-10 | 2000-05-31 | Rhodanine derivatives for use in a method of inhibiting amyloid protein aggregation and imaging amyloid deposits |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1192143A1 (en) |
| JP (1) | JP2003502320A (en) |
| AU (1) | AU5311800A (en) |
| BR (1) | BR0011441A (en) |
| CA (1) | CA2374616A1 (en) |
| MX (1) | MXPA01010490A (en) |
| TR (1) | TR200103562T2 (en) |
| WO (1) | WO2000076987A1 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20020394A1 (en) | 2000-08-18 | 2002-06-21 | Agouron Pharma | PIRAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM, MODULATE AND / OR INHIBIT THE ACTIVITY OF ERAB / HADH2 |
| BR0316386A (en) | 2002-12-06 | 2005-09-27 | Warner Lambert Co | Benzoxazin-3-ones and their derivatives as p13k inhibitors |
| US20060106077A1 (en) * | 2003-07-18 | 2006-05-18 | Pintex Pharmaceuticals, Inc. | Pin1-Modulating compounds and methods of use thereof |
| CA2676715A1 (en) | 2007-02-12 | 2008-08-21 | Merck & Co., Inc. | Piperazine derivatives for treatment of ad and related conditions |
| CN103402516B (en) | 2010-06-17 | 2018-01-30 | 富津世生物技术有限公司 | Compound, composition and application method as antiviral drugs |
| CN106045986B (en) * | 2016-05-31 | 2019-12-06 | 广东工业大学 | novel phenothiazine derivative and preparation method and application thereof |
| CN106045987B (en) * | 2016-06-21 | 2019-04-23 | 广东工业大学 | A kind of multifunctional near-infrared fluorescent magnetic nanoparticle and its preparation and application |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5740478A (en) * | 1980-08-22 | 1982-03-06 | Ono Pharmaceut Co Ltd | Rhodanine derivative, its preparation and aldose reductase inhibitor containing rhodanine derivative |
| JPH01147462A (en) * | 1987-12-03 | 1989-06-09 | Mita Ind Co Ltd | Carrier generating material and its production |
| JPH01147476A (en) * | 1987-12-03 | 1989-06-09 | Mita Ind Co Ltd | Photoconductive toner |
| US5143929A (en) * | 1991-05-09 | 1992-09-01 | Warner-Lambert Company | 2-substituted thiazolidinone, oxazolidinone, and imidazolidinone derivatives of fenamates as antiinflammatory agents |
| EP0587377A3 (en) * | 1992-09-10 | 1994-09-21 | Lilly Co Eli | Thiazolidinone derivatives as hypoglycemic agents and for treating alzheimer's disease |
| DE4318550A1 (en) * | 1993-06-04 | 1994-12-08 | Boehringer Mannheim Gmbh | Arylidene-4-oxo-2-thioxo-3-thiazolidinecarboxylic acids, process for their preparation and pharmaceutical compositions containing them |
| US6251928B1 (en) * | 1994-03-16 | 2001-06-26 | Eli Lilly And Company | Treatment of alzheimer's disease employing inhibitors of cathepsin D |
| US6001331A (en) * | 1996-01-24 | 1999-12-14 | Warner-Lambert Company | Method of imaging amyloid deposits |
| KR20010099623A (en) * | 1998-08-21 | 2001-11-09 | 비로파마 인코포레이티드 | Compounds, compositions and methods for treating or preventing viral infections and associated diseases |
| JP2002525362A (en) * | 1998-09-30 | 2002-08-13 | エスヴァイン、アンゲリカ | Rhodanin carboxylic acid derivatives for treatment and prevention of metabolic bone disorders |
-
2000
- 2000-05-31 MX MXPA01010490A patent/MXPA01010490A/en unknown
- 2000-05-31 WO PCT/US2000/015069 patent/WO2000076987A1/en not_active Ceased
- 2000-05-31 JP JP2001503845A patent/JP2003502320A/en active Pending
- 2000-05-31 AU AU53118/00A patent/AU5311800A/en not_active Abandoned
- 2000-05-31 TR TR2001/03562T patent/TR200103562T2/en unknown
- 2000-05-31 EP EP00938021A patent/EP1192143A1/en not_active Withdrawn
- 2000-05-31 BR BR0011441-3A patent/BR0011441A/en not_active IP Right Cessation
- 2000-05-31 CA CA002374616A patent/CA2374616A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1192143A1 (en) | 2002-04-03 |
| BR0011441A (en) | 2002-07-16 |
| TR200103562T2 (en) | 2002-04-22 |
| MXPA01010490A (en) | 2005-05-27 |
| JP2003502320A (en) | 2003-01-21 |
| WO2000076987A1 (en) | 2000-12-21 |
| CA2374616A1 (en) | 2000-12-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |