AU5368699A - Derivatives of triptolide, and preparation and uses thereof - Google Patents
Derivatives of triptolide, and preparation and uses thereofInfo
- Publication number
- AU5368699A AU5368699A AU53686/99A AU5368699A AU5368699A AU 5368699 A AU5368699 A AU 5368699A AU 53686/99 A AU53686/99 A AU 53686/99A AU 5368699 A AU5368699 A AU 5368699A AU 5368699 A AU5368699 A AU 5368699A
- Authority
- AU
- Australia
- Prior art keywords
- triptolide
- derivatives
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- DFBIRQPKNDILPW-CIVMWXNOSA-N Triptolide Chemical class O=C1OCC([C@@H]2C3)=C1CC[C@]2(C)[C@]12O[C@H]1[C@@H]1O[C@]1(C(C)C)[C@@H](O)[C@]21[C@H]3O1 DFBIRQPKNDILPW-CIVMWXNOSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99105796 | 1999-04-16 | ||
| CN99105796 | 1999-04-16 | ||
| PCT/CN1999/000123 WO2000063212A1 (en) | 1999-04-16 | 1999-08-20 | Derivatives of triptolide, and preparation and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU5368699A true AU5368699A (en) | 2000-11-02 |
Family
ID=5272134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU53686/99A Abandoned AU5368699A (en) | 1999-04-16 | 1999-08-20 | Derivatives of triptolide, and preparation and uses thereof |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU5368699A (en) |
| WO (1) | WO2000063212A1 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2448795A1 (en) | 2001-03-15 | 2002-09-26 | Pharmagenesis, Inc. | Amino acid derivatives of triptolide compounds as immune modulators and anticancer agent |
| EP2468277A1 (en) | 2002-05-31 | 2012-06-27 | Pharmagenesis, Inc. | Triptolide derivatives for modulation of apoptosis and immunosuppression |
| CN100398544C (en) * | 2002-09-18 | 2008-07-02 | 成都达远药物有限公司 | Water-soluble triptolide derivatives with high immunosuppressive activity and their application |
| US7820834B2 (en) | 2003-12-24 | 2010-10-26 | Pharmagenesis, Inc. | Triptolide 5,6-derivatives as immunomodulators and anticancer agents |
| US8048914B2 (en) | 2004-02-09 | 2011-11-01 | Pharmagenesis, Inc. | Methods for isolation of triptolide compounds from Tripterygium wilfordii |
| WO2005084365A2 (en) | 2004-03-02 | 2005-09-15 | Pharmagenesis, Inc. | Triptolide lactone ring derivatives as immunomodulators and anticancer agents |
| US8617906B2 (en) | 2004-10-13 | 2013-12-31 | Pharmagenesis, Inc. | Identification and screening of triptolide target molecules |
| US9150600B2 (en) | 2009-05-07 | 2015-10-06 | Regents Of The University Of Minnesota | Triptolide prodrugs |
| MX2011011776A (en) | 2009-05-07 | 2012-08-03 | Univ Minnesota | Triptolide prodrugs. |
| CN116606803B (en) * | 2023-06-26 | 2025-05-06 | 北京原生元生物科技有限公司 | Application of Tripterygium wilfordii monomer in inhibiting the tumor-promoting activity of mesenchymal stem cells |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4005108A (en) * | 1973-04-03 | 1977-01-25 | Research Corporation | Novel anti-leukemic diterpenoid triepoxides |
| CN1052859A (en) * | 1989-12-22 | 1991-07-10 | 中国医学科学院皮肤病研究所 | Structure and preparation method of 17-hydroxytriptolide and its analogs |
| CN1052860A (en) * | 1989-12-22 | 1991-07-10 | 中国医学科学院皮肤病研究所 | The preparation method of tripchlorolide and antifertility purposes |
| CN1052861A (en) * | 1989-12-22 | 1991-07-10 | 中国医学科学院皮肤病研究所 | The preparation method of wilfordii alcoholic lactone and antifertility purposes |
| US5663335A (en) * | 1996-03-01 | 1997-09-02 | Pharmagenesis, Inc. | Immunosuppressive compounds and methods |
-
1999
- 1999-08-20 WO PCT/CN1999/000123 patent/WO2000063212A1/en not_active Ceased
- 1999-08-20 AU AU53686/99A patent/AU5368699A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000063212A1 (en) | 2000-10-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |