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AU4242993A - Cultured (taxus) tissues as a source of taxol, related taxanes and other novel anti-tumor/anti-viral compounds - Google Patents

Cultured (taxus) tissues as a source of taxol, related taxanes and other novel anti-tumor/anti-viral compounds

Info

Publication number
AU4242993A
AU4242993A AU42429/93A AU4242993A AU4242993A AU 4242993 A AU4242993 A AU 4242993A AU 42429/93 A AU42429/93 A AU 42429/93A AU 4242993 A AU4242993 A AU 4242993A AU 4242993 A AU4242993 A AU 4242993A
Authority
AU
Australia
Prior art keywords
taxus
taxol
cultured
tumor
tissues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU42429/93A
Inventor
Richard N Arteca
Enaksha Wickremesinhe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Penn State Research Foundation
Original Assignee
Penn State Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Penn State Research Foundation filed Critical Penn State Research Foundation
Publication of AU4242993A publication Critical patent/AU4242993A/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D305/00Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/04Plant cells or tissues
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02Oxygen as only ring hetero atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Botany (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Epoxy Compounds (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU42429/93A 1992-05-21 1993-05-11 Cultured (taxus) tissues as a source of taxol, related taxanes and other novel anti-tumor/anti-viral compounds Abandoned AU4242993A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US886619 1986-07-18
US88661992A 1992-05-21 1992-05-21

Publications (1)

Publication Number Publication Date
AU4242993A true AU4242993A (en) 1993-12-13

Family

ID=25389395

Family Applications (1)

Application Number Title Priority Date Filing Date
AU42429/93A Abandoned AU4242993A (en) 1992-05-21 1993-05-11 Cultured (taxus) tissues as a source of taxol, related taxanes and other novel anti-tumor/anti-viral compounds

Country Status (5)

Country Link
EP (1) EP0642586A4 (en)
JP (1) JPH08500973A (en)
AU (1) AU4242993A (en)
CA (1) CA2136213A1 (en)
WO (1) WO1993023555A1 (en)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7264951B1 (en) 1992-02-20 2007-09-04 Phyton, Inc. Enhanced production of taxol and taxanes by cell cultures of Taxus species
CA2092849C (en) * 1992-04-07 2003-11-18 Paul M. Cino Callus cell induction and the preparation of taxanes
WO1994020606A1 (en) * 1993-03-05 1994-09-15 Celex Laboratories Inc. Plant tissue culture method for taxol production
KR950005081B1 (en) * 1993-07-06 1995-05-18 산림청임목육종연구소 Method for producing taxol and its derivatives from embryo cultures of taxus species
EP1695698B1 (en) 1993-07-19 2011-03-23 Angiotech Pharmaceuticals, Inc. Anti-angiogene compositions and methods of use
US5637484A (en) * 1993-11-15 1997-06-10 Mitsui Petrochemical Industries, Ltd. Method of producing a taxane-type diterpene and a method of obtaining cultured cells which produce the taxane-type diterpene at a high rate
AU716005B2 (en) 1995-06-07 2000-02-17 Cook Medical Technologies Llc Implantable medical device
EP1538214A1 (en) 1996-05-24 2005-06-08 Phyton, Inc. Enhanced production of taxanes by cell cultures of taxus species
WO1998011135A1 (en) * 1996-09-12 1998-03-19 Hwang Byung Doo A taxol-like protein (talp) and process for preparing the same
IL121320A (en) 1997-02-23 2000-12-06 Ibr Ltd Extracts from cells or tissue of organisms which are capable of entering dormancy for inhibition of proliferation of target cells or tissue
US20040234472A1 (en) 2001-04-20 2004-11-25 Jackson John K. Micellar drug delivery systems for hydrophobic drugs
CA2307393A1 (en) 2000-05-01 2001-11-01 The University Of British Columbia Ginsenoside chemotherapy
EP2014307A3 (en) 2001-03-13 2010-12-08 Angiotech International Ag Micellar drug delivery vehicles and uses thereof
US7351542B2 (en) 2002-05-20 2008-04-01 The Regents Of The University Of California Methods of modulating tubulin deacetylase activity
ATE457716T1 (en) 2002-12-30 2010-03-15 Angiotech Int Ag RELEASE OF ACTIVE INGREDIENTS FROM QUICK-GELLING POLYMER COMPOSITION
EP1633317A4 (en) 2003-05-16 2008-08-20 Intermune Inc LIGANDS OF SYNTHETIC CHEMKINIC RECEPTORS AND METHODS OF USE
US7407973B2 (en) 2003-10-24 2008-08-05 Intermune, Inc. Use of pirfenidone in therapeutic regimens
US8003122B2 (en) 2004-03-31 2011-08-23 Cordis Corporation Device for local and/or regional delivery employing liquid formulations of therapeutic agents
US7989490B2 (en) 2004-06-02 2011-08-02 Cordis Corporation Injectable formulations of taxanes for cad treatment
US7846940B2 (en) 2004-03-31 2010-12-07 Cordis Corporation Solution formulations of sirolimus and its analogs for CAD treatment
US7597884B2 (en) 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
US8691780B2 (en) 2005-02-17 2014-04-08 The Board Of Trustees Of The Leland Stanford Junior University Txr1 and enhanced taxane sensitivity based on the modulation of a pathway mediated thereby
EP1891206B1 (en) 2005-06-03 2013-07-24 Samyang Genexbio Corporation Mass production of secondary metabolites in plant cell culture by use of a saccharide mixture in the culture medium
CN100393879C (en) * 2005-12-26 2008-06-11 合肥宏源生物技术开发有限公司 The method of electroporation transfer Ri plasmid to induce hairy roots of Taxus chinensis
ES2609388T3 (en) 2006-03-22 2017-04-20 Syncore Biotechnology Co., Ltd Treatment of triple receptor-negative breast cancer
WO2008005284A2 (en) 2006-06-30 2008-01-10 Cook Incorporated Methods of manufacturing and modifying taxane coatings for implantable medical devices
US8409601B2 (en) 2008-03-31 2013-04-02 Cordis Corporation Rapamycin coated expandable devices
US8273404B2 (en) 2008-05-19 2012-09-25 Cordis Corporation Extraction of solvents from drug containing polymer reservoirs
WO2009143454A2 (en) 2008-05-22 2009-11-26 Kereos, Inc. Combination antitumor therapy
EP2310507A4 (en) 2008-07-08 2013-03-20 David Gladstone Inst METHODS AND COMPOSITIONS FOR MODULATING ANGIOGENESIS
US8642063B2 (en) 2008-08-22 2014-02-04 Cook Medical Technologies Llc Implantable medical device coatings with biodegradable elastomer and releasable taxane agent
US20120302954A1 (en) 2011-05-25 2012-11-29 Zhao Jonathon Z Expandable devices coated with a paclitaxel composition
US20120303115A1 (en) 2011-05-25 2012-11-29 Dadino Ronald C Expandable devices coated with a rapamycin composition
US9956385B2 (en) 2012-06-28 2018-05-01 The Spectranetics Corporation Post-processing of a medical device to control morphology and mechanical properties
EP3539563A1 (en) 2012-07-19 2019-09-18 Redwood Bioscience, Inc. Antibody specific for cd22 and methods of use thereof
WO2014074218A1 (en) 2012-11-12 2014-05-15 Redwood Bioscience, Inc. Compounds and methods for producing a conjugate
ES2653487T3 (en) 2013-02-15 2018-02-07 The Regents Of The University Of California Chimeric antigen receptor and methods of use thereof
US9670162B2 (en) 2013-03-14 2017-06-06 The Board Of Trustees Of The Leland Stanford Junio Mitochondrial aldehyde dehyrogenase-2 modulators and methods of use thereof
AU2014354643B2 (en) 2013-11-27 2020-03-05 Redwood Bioscience, Inc. Hydrazinyl-pyrrolo compounds and methods for producing a conjugate
WO2015127137A1 (en) 2014-02-19 2015-08-27 Aldea Pharmaceuticals, Inc. Mitochondrial aldehyde dehydrogenase 2 (aldh2) binding polycyclic amides and their use for the treatment of cancer
AU2016326747A1 (en) 2015-09-25 2018-03-01 Zy Therapeutics Inc. Drug formulation based on particulates comprising polysaccharide-vitamin conjugate
EP3373977A4 (en) 2015-11-12 2019-07-17 The Board of Trustees of the Leland Stanford Junior University CELLULAR PENETRATION-RICH GUANIDINIC OLIGOPHOSPHOTRIESTERS FOR THE DELIVERY OF MEDICATION AND PROBE
TWI760319B (en) 2015-12-30 2022-04-11 杏國新藥股份有限公司 Treatment of breast cancer
CN109071634A (en) 2016-04-26 2018-12-21 R.P.谢勒技术有限责任公司 Antibody coupling matter and its preparation and application
JP7109427B2 (en) 2016-06-01 2022-07-29 セルヴィエ アイピー ユーケー リミテッド Formulations of polyalkylene oxide-asparaginase and methods of making and using the same
TWI852903B (en) 2017-01-05 2024-08-21 杏國新藥股份有限公司 Treatment of pancreatic cancer
US12187801B2 (en) 2017-01-18 2025-01-07 Exuma Biotech Corp. Chimeric antigen receptors against AXL or ROR2 and methods of use thereof
EP3388082A1 (en) 2017-04-13 2018-10-17 Galera Labs, LLC Combination cancer immunotherapy with pentaaza macrocyclic ring complex
EP3630189A4 (en) 2017-05-24 2021-06-23 The Board of Regents of The University of Texas System BODIES FOR ANTIBODY-DRUG SPOUSES
EP3746085A4 (en) 2018-01-31 2022-03-09 Galera Labs, LLC ANTI-CANCER POLYTHERAPY BY MEANS OF A PENTAAZA MACROCYCLIC CYCLE-TYPE COMPLEX AND AN ANTI-CANCER AGENT BASED ON PLATINUM
EP3773633A4 (en) 2018-04-06 2022-01-26 The Regents of The University of California GLIOBLASTOMA TREATMENT METHODS
EP3773632A4 (en) 2018-04-06 2022-05-18 The Regents of The University of California METHODS OF TREATMENT OF EGFRVIII-EXPRESSING GLIOBLASTOMAS
AU2019252676A1 (en) 2018-04-11 2020-11-26 Ohio State Innovation Foundation Methods and compositions for sustained release microparticles for ocular drug delivery
US11897928B2 (en) 2018-07-18 2024-02-13 Manzanita Pharmaceuticals, Inc. Conjugates for delivering an anti-cancer agent to nerve cells, methods of use and methods of making thereof
WO2020148612A1 (en) 2019-01-14 2020-07-23 Ignite Immunotherapy, Inc. Recombinant vaccinia virus and methods of use thereof
CA3129883A1 (en) 2019-02-14 2020-08-20 Ignite Immunotherapy, Inc. Recombinant vaccinia virus and methods of use thereof
BR112021019701A2 (en) 2019-04-02 2021-12-14 Kenjockety Biotechnology Inc Multispecific antibodies to efflux pump cancer antigen and compositions, reagents, kits and methods related thereto
JP7266226B2 (en) * 2019-08-22 2023-04-28 北海道三井化学株式会社 Method for producing hairy roots of Taxus
MX2022007237A (en) 2019-12-12 2022-07-13 Ignite Immunotherapy Inc Variant oncolytic vaccinia virus and methods of use thereof.
EP4097134A1 (en) 2020-01-29 2022-12-07 Kenjockety Biotechnology, Inc. Anti-mdr1 antibodies and uses thereof
AU2021284240A1 (en) 2020-06-04 2022-12-08 William Robert ARATHOON Anti-ABCG2 antibodies and uses thereof
AU2021283080A1 (en) 2020-06-04 2022-12-15 William Robert ARATHOON ABCG2 efflux pump-cancer antigen multi-specific antibodies and compositions, reagents, kits and methods related thereto
CN116133671A (en) 2020-07-14 2023-05-16 辉瑞公司 recombinant vaccinia virus
AU2021338286A1 (en) 2020-09-02 2023-03-23 William Robert ARATHOON Anti-ABCC1 antibodies and uses thereof
EP4244257A1 (en) 2020-11-13 2023-09-20 Kenjockety Biotechnology, Inc. Anti-mrp4 (encoded by abcc4 gene) antibodies and uses thereof
MX2023005979A (en) 2020-11-20 2023-08-11 Scherer Technologies Llc R P Glycoside dual-cleavage linkers for antibody-drug conjugates.
US11299700B1 (en) 2021-02-19 2022-04-12 Acequia Biotechnology, Llc Bioreactor containers and methods of growing hairy roots using the same
WO2023114658A1 (en) 2021-12-13 2023-06-22 Kenjockety Biotechnology, Inc. Anti-abcb1 antibodies
WO2023159220A1 (en) 2022-02-18 2023-08-24 Kenjockety Biotechnology, Inc. Anti-cd47 antibodies

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4942184A (en) * 1988-03-07 1990-07-17 The United States Of America As Represented By The Department Of Health And Human Services Water soluble, antineoplastic derivatives of taxol
FR2629819B1 (en) * 1988-04-06 1990-11-16 Rhone Poulenc Sante PROCESS FOR THE PREPARATION OF BACCATIN III AND DESACETYL-10 BACCATIN III DERIVATIVES
US5019504A (en) * 1989-03-23 1991-05-28 The United States Of America As Represented By The Secretary Of Agriculture Production of taxol or taxol-like compounds in cell culture
WO1992013961A1 (en) * 1991-02-12 1992-08-20 Nippon Steel Corporation Process for producing taxol by cell culture of taxus species
US5407816A (en) * 1992-02-20 1995-04-18 Phyton Catalytic, Inc. Enhanced production of taxol and taxanes by cell cultures of taxus species
WO1994020606A1 (en) * 1993-03-05 1994-09-15 Celex Laboratories Inc. Plant tissue culture method for taxol production

Also Published As

Publication number Publication date
CA2136213A1 (en) 1993-11-25
EP0642586A4 (en) 1995-11-29
JPH08500973A (en) 1996-02-06
EP0642586A1 (en) 1995-03-15
WO1993023555A1 (en) 1993-11-25

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