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AU4090697A - Improved process for preparing the antiviral agent {1s-(1alpha, 3alpha, 4beta)}-2-amino-1,9-dihydro-9-{4-hydroxy-3-(hydroxymethyl)-2 -methylenecyclopentyl}-6h-purin-6-one - Google Patents

Improved process for preparing the antiviral agent {1s-(1alpha, 3alpha, 4beta)}-2-amino-1,9-dihydro-9-{4-hydroxy-3-(hydroxymethyl)-2 -methylenecyclopentyl}-6h-purin-6-one

Info

Publication number
AU4090697A
AU4090697A AU40906/97A AU4090697A AU4090697A AU 4090697 A AU4090697 A AU 4090697A AU 40906/97 A AU40906/97 A AU 40906/97A AU 4090697 A AU4090697 A AU 4090697A AU 4090697 A AU4090697 A AU 4090697A
Authority
AU
Australia
Prior art keywords
4beta
methylenecyclopentyl
3alpha
1alpha
purin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU40906/97A
Other languages
English (en)
Inventor
Gregory S. Bisacchi
Joseph E. Sundeen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AU4090697A publication Critical patent/AU4090697A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU40906/97A 1996-09-03 1997-08-26 Improved process for preparing the antiviral agent {1s-(1alpha, 3alpha, 4beta)}-2-amino-1,9-dihydro-9-{4-hydroxy-3-(hydroxymethyl)-2 -methylenecyclopentyl}-6h-purin-6-one Abandoned AU4090697A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2537896P 1996-09-03 1996-09-03
US60025378 1996-09-03
PCT/US1997/015007 WO1998009964A1 (fr) 1996-09-03 1997-08-26 PROCEDE DE PREPARATION AMELIORE DE L'AGENT ANTIVIRAL [1S-(1α, 3α, 4β)]-2-AMINO-1,9-DIHYDRO-9-[4-HYDROXY-3-(HYDROXYMETHYL)-2-METHYLENE-CYCLOPENTYL]-6-H-PURINE-6-ONE

Publications (1)

Publication Number Publication Date
AU4090697A true AU4090697A (en) 1998-03-26

Family

ID=21825687

Family Applications (1)

Application Number Title Priority Date Filing Date
AU40906/97A Abandoned AU4090697A (en) 1996-09-03 1997-08-26 Improved process for preparing the antiviral agent {1s-(1alpha, 3alpha, 4beta)}-2-amino-1,9-dihydro-9-{4-hydroxy-3-(hydroxymethyl)-2 -methylenecyclopentyl}-6h-purin-6-one

Country Status (2)

Country Link
AU (1) AU4090697A (fr)
WO (1) WO1998009964A1 (fr)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE312613T1 (de) 2000-02-29 2005-12-15 Bristol Myers Squibb Co Niedrig dosierte entecavir formulierung und deren verwendung
US6831102B2 (en) 2001-12-07 2004-12-14 Bristol-Myers Squibb Company Phenyl naphthol ligands for thyroid hormone receptor
CN101130552B (zh) * 2002-12-11 2010-07-28 布里斯托尔-迈尔斯斯奎布公司 制备抗病毒药[1S-(1α,3α,4β)]-2-氨基-1,9-二氢-9-[4-羟基-3-(羟甲基)-2-亚甲环戊基]-6H-嘌呤-6-酮的方法
TW200540175A (en) * 2004-06-04 2005-12-16 Bristol Myers Squibb Co Process for the preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation
US7511139B2 (en) 2004-06-04 2009-03-31 Bristol-Myers Squibb Company Process for the preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation
CN100379736C (zh) * 2005-05-13 2008-04-09 上海仲夏化学有限公司 恩替卡韦的制备方法
US20070060599A1 (en) * 2005-09-09 2007-03-15 Dimarco John D Crystalline forms of [1S-(1alpha, 3alpha, 4beta)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one
CN101130542B (zh) * 2006-08-24 2010-08-04 江苏正大天晴药业股份有限公司 抗病毒核苷类似物的合成方法
CN101371841A (zh) * 2007-08-23 2009-02-25 浙江医药股份有限公司新昌制药厂 结晶型恩替卡韦制剂及其制备方法和应用
CN101245068A (zh) * 2007-02-14 2008-08-20 浙江医药股份有限公司新昌制药厂 结晶型态的恩替卡韦及其制备方法和其药物组合物及用途
CN101284799B (zh) 2007-03-23 2013-04-03 浙江医药股份有限公司新昌制药厂 咖啡酰奎宁酸含氮衍生物及其制备方法和其药物组合物及用途
RU2443703C2 (ru) 2007-06-18 2012-02-27 Саншайн Лейк Фарма Ко., Лтд Бром-фенил замещенные тиазолилдигидропиримидины
CN101397333A (zh) 2007-09-27 2009-04-01 浙江医药股份有限公司新昌制药厂 去羟基万古霉素及其制备方法、和其药物组合物及其用途
US8716263B2 (en) 2008-12-23 2014-05-06 Gilead Pharmasset Llc Synthesis of purine nucleosides
EA201100851A1 (ru) 2008-12-23 2012-04-30 Фармассет, Инк. Аналоги нуклеозидов
EA019341B1 (ru) 2008-12-23 2014-02-28 Джилид Фармассет, Ллс. Фосфорамидаты нуклеозидов
KR101150254B1 (ko) * 2008-12-26 2012-06-12 한미사이언스 주식회사 신규 중간체 및 이를 활용한 엔테카비르 제조방법
CN101828693B (zh) 2009-03-09 2013-01-02 浙江医药股份有限公司新昌制药厂 制备低粘度高流动性类胡萝卜素油悬浮液的方法及其应用
CN101531660B (zh) * 2009-04-14 2012-07-04 安徽贝克联合制药有限公司 一种恩替卡韦一水合物的工业化生产工艺
US8569491B2 (en) * 2009-10-12 2013-10-29 Hanmi Science Co., Ltd Method for preparing entecavir and intermediate used therein
CN101693713B (zh) * 2009-10-28 2011-11-09 福建广生堂药业有限公司 一种恩替卡韦的晶型及其制备方法和药物应用
WO2011076412A1 (fr) 2009-12-23 2011-06-30 Ratiopharm Gmbh Forme d'administration orale contenant de l'entecavir
DE102009060194A1 (de) 2009-12-23 2011-06-30 ratiopharm GmbH, 89079 Orale Darreichungsform umfassend Entecavir
CN101781301B (zh) * 2010-01-15 2013-04-10 复旦大学 一种制备恩替卡韦的方法
MX2012011171A (es) 2010-03-31 2013-02-01 Gilead Pharmasset Llc Fosforamidatos de nucleosido.
CN102336754B (zh) * 2010-07-15 2017-04-12 浙江奥翔药业股份有限公司 恩替卡韦的合成方法及其中间体化合物
TWI588146B (zh) * 2010-08-30 2017-06-21 浙江奧翔藥業股份有限公司 恩替卡韋的合成方法及其中間體化合物
CN103304375B (zh) * 2012-03-12 2017-04-12 浙江奥翔药业股份有限公司 恩替卡韦的合成中间体及其制备方法
EP2832351A1 (fr) 2013-07-29 2015-02-04 Sanovel Ilac Sanayi ve Ticaret A.S. Comprimé multicouche comprenant du tenofovir et de l'entecavir
CN106749249A (zh) * 2017-01-13 2017-05-31 信泰制药（苏州）有限公司 恩替卡韦中间体的晶型
CN106749251A (zh) * 2017-01-17 2017-05-31 博瑞生物医药泰兴市有限公司 一种恩替卡韦中间体的合成与提纯方法
CN106749252B (zh) * 2017-01-23 2018-08-28 山东鲁抗医药股份有限公司 一种恩替卡韦中间体n8的提纯方法
CN108101908B (zh) * 2017-12-29 2020-10-09 郑州泰丰制药有限公司 一种氘代恩替卡韦的制备方法
CN108148061B (zh) * 2018-03-14 2019-08-23 湖北广济药业股份有限公司 恩替卡韦的工业化制备方法
CN110759912A (zh) * 2018-07-25 2020-02-07 连云港润众制药有限公司 恩替卡韦中间体的制备方法
CN110818714A (zh) * 2018-08-14 2020-02-21 连云港润众制药有限公司 一种恩替卡韦中间体的合成方法
CN118994160A (zh) * 2024-10-23 2024-11-22 浙江华纳药业有限公司 一种高纯恩替卡韦中间体7的生产工艺

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US3865848A (en) * 1969-10-13 1975-02-11 Searle & Co Methylenation reagent
US5206244A (en) * 1990-10-18 1993-04-27 E. R. Squibb & Sons, Inc. Hydroxymethyl (methylenecyclopentyl) purines and pyrimidines

Also Published As

Publication number Publication date
WO1998009964A1 (fr) 1998-03-12

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