AU4075897A - A leptin binding protein and its use in methods for diagnosing and treating abnormalities of the endogenous leptin pathway - Google Patents
A leptin binding protein and its use in methods for diagnosing and treating abnormalities of the endogenous leptin pathwayInfo
- Publication number
- AU4075897A AU4075897A AU40758/97A AU4075897A AU4075897A AU 4075897 A AU4075897 A AU 4075897A AU 40758/97 A AU40758/97 A AU 40758/97A AU 4075897 A AU4075897 A AU 4075897A AU 4075897 A AU4075897 A AU 4075897A
- Authority
- AU
- Australia
- Prior art keywords
- leptin
- diagnosing
- methods
- binding protein
- pathway
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 102000016267 Leptin Human genes 0.000 title 1
- 108010092277 Leptin Proteins 0.000 title 1
- 230000005856 abnormality Effects 0.000 title 1
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 title 1
- 229940039781 leptin Drugs 0.000 title 1
- 102000005861 leptin receptors Human genes 0.000 title 1
- 108010019813 leptin receptors Proteins 0.000 title 1
- 230000037361 pathway Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/775—Apolipopeptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/02—Nutritional disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Child & Adolescent Psychology (AREA)
- Obesity (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69902996A | 1996-08-16 | 1996-08-16 | |
| US2368596P | 1996-08-16 | 1996-08-16 | |
| US60023685 | 1996-08-16 | ||
| US08699029 | 1996-08-16 | ||
| PCT/US1997/014597 WO1998006752A1 (en) | 1996-08-16 | 1997-08-15 | A leptin binding protein and its use in methods for diagnosing and treating abnormalities of the endogenous leptin pathway |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU4075897A true AU4075897A (en) | 1998-03-06 |
Family
ID=26697488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU40758/97A Abandoned AU4075897A (en) | 1996-08-16 | 1997-08-15 | A leptin binding protein and its use in methods for diagnosing and treating abnormalities of the endogenous leptin pathway |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU4075897A (en) |
| WO (1) | WO1998006752A1 (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1037927T3 (en) | 1997-12-08 | 2004-09-06 | Emd Lexigen Res Ct Corp | Heterodimeric fusion proteins useful for targeted immunotherapy and general immune stimulation |
| US6777388B1 (en) | 1998-08-21 | 2004-08-17 | Clf Medical Technology Acceleration Program, Inc. | Leptin-related peptides |
| US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| PL202058B1 (en) | 1999-08-09 | 2009-05-29 | Merck Patent Gmbh | Multiple cytokine−antibody complexes |
| JP2003514552A (en) | 1999-11-12 | 2003-04-22 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | Erythropoietin morphology with improved properties |
| DE60122286T2 (en) | 2000-02-11 | 2007-08-02 | Merck Patent Gmbh | INCREASING THE CIRCULATORY HALF-TIME OF ANTIBODY-BASED FUSION PROTEINS |
| US20010046686A1 (en) * | 2000-03-10 | 2001-11-29 | Wong Albert J. | Sensitive detection of wild-type and mutant EGFR by specific ELISA assays in any biological sample |
| ES2288967T3 (en) | 2000-06-29 | 2008-02-01 | Merck Patent Gmbh | REINFORCEMENT OF IMMUNE ANSWERS MEDIATED BY THE ANTIBODY-CYTOKIN FUSION PROTEIN THROUGH THE TREATMENT COMBINED BY AGENTS THAT IMPROVE THE INCORPORATION OF IMMUNOCITOQUINE. |
| BR0207854A (en) | 2001-03-07 | 2004-08-24 | Merck Patent Gmbh | Expression technology for proteins containing a hybrid isotype antibody moiety |
| WO2002079415A2 (en) | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
| HUP0400284A3 (en) | 2001-05-03 | 2012-09-28 | Merck Patent Gmbh | Recombinant tumor specific antibody and use thereof |
| PL206975B1 (en) | 2001-12-04 | 2010-10-29 | Merck Patent Gmbh | Immunocytokines with modulated selectivity |
| RU2366664C2 (en) | 2002-12-17 | 2009-09-10 | Мерк Патент Гмбх | Humanised antibody (h14,18) based on mouse antibody 14,18, contacting gd2, and its fusion with il-2 |
| WO2008136547A1 (en) * | 2007-05-07 | 2008-11-13 | University Of Ulsan Foundation For Industry Cooperation | Method of preventing or treating body weight disorders by employing clusterin |
| HRP20231076T1 (en) * | 2016-09-12 | 2023-12-22 | Amryt Pharmaceuticals Inc. | Methods of detecting anti-leptin neutralizing antibodies |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3933850A1 (en) * | 1989-10-06 | 1991-04-18 | Schering Ag | CYTOLYSIS INHIBITOR (ZLI), A DNA SEQUENCE ENCODING THIS BLOOD PLASMA PROTEIN, AND A PLASMIDE, A HOST ORGANISM AND A METHOD FOR OBTAINING THIS PROTEIN |
| US7063958B1 (en) * | 1996-01-16 | 2006-06-20 | The Rockefeller University | Nucleic acids db, the receptor for leptin |
-
1997
- 1997-08-15 WO PCT/US1997/014597 patent/WO1998006752A1/en not_active Ceased
- 1997-08-15 AU AU40758/97A patent/AU4075897A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998006752A1 (en) | 1998-02-19 |
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