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AU3791799A - Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia - Google Patents

Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia

Info

Publication number
AU3791799A
AU3791799A AU37917/99A AU3791799A AU3791799A AU 3791799 A AU3791799 A AU 3791799A AU 37917/99 A AU37917/99 A AU 37917/99A AU 3791799 A AU3791799 A AU 3791799A AU 3791799 A AU3791799 A AU 3791799A
Authority
AU
Australia
Prior art keywords
hyperglycemia
treatment
insulin resistance
acetic acids
acids useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU37917/99A
Inventor
Arlene Joan Dietrich
Iwan Gunawan
Zenan Li
Michael Sotirios Malamas
Jay Edward Wrobel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Publication of AU3791799A publication Critical patent/AU3791799A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU37917/99A 1998-05-12 1999-05-10 Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia Abandoned AU3791799A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7659698A 1998-05-12 1998-05-12
US09076596 1998-05-12
PCT/US1999/010211 WO1999058519A1 (en) 1998-05-12 1999-05-10 Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia

Publications (1)

Publication Number Publication Date
AU3791799A true AU3791799A (en) 1999-11-29

Family

ID=22133037

Family Applications (1)

Application Number Title Priority Date Filing Date
AU37917/99A Abandoned AU3791799A (en) 1998-05-12 1999-05-10 Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia

Country Status (6)

Country Link
EP (1) EP1077965A1 (en)
JP (1) JP2002514636A (en)
CN (1) CN1308621A (en)
AU (1) AU3791799A (en)
CA (1) CA2331120A1 (en)
WO (1) WO1999058519A1 (en)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6498182B2 (en) 2000-09-26 2002-12-24 Biovitrum Ab Compounds
EP1366012A4 (en) 2001-02-09 2005-11-02 Merck & Co Inc 2-ARYLOXY-2-ARYLALCANO ACIDS AS USED FOR THE TREATMENT OF DIAB TES AND LIPID DISORDERS
RU2186063C1 (en) * 2001-06-18 2002-07-27 Федеральное государственное унитарное предприятие "Новокузнецкий научно-исследовательский химико-фармацевтический институт" Method of synthesis of 2-butyl-3-(3,5-diiodo-4-hydro-xybenzoyl)benzofuran
US7291639B2 (en) 2001-06-20 2007-11-06 Wyeth Aryloxy-acetic acid compounds useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
PT1397130E (en) 2001-06-20 2007-11-13 Wyeth Corp Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
TWI224101B (en) 2001-06-20 2004-11-21 Wyeth Corp Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)
US20050065208A1 (en) * 2001-07-20 2005-03-24 Bodo Brandts Benzofuranes and their use in the treatment of atrial fibrillation
US6784205B2 (en) * 2002-03-01 2004-08-31 Sunesis Pharmaceuticals, Inc. Compounds that modulate the activity of PTP-1B and TC-PTP
JP2006514640A (en) 2002-12-10 2006-05-11 ワイス Substituted 3-alkyl and 3-arylalkyl 1H-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitors
CA2509222A1 (en) 2002-12-10 2004-06-24 Wyeth Substituted indole oxo-acetyl amino acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
MXPA05006288A (en) 2002-12-10 2005-08-19 Wyeth Corp Substituted 3-carbonyl-1h.
UA80453C2 (en) 2002-12-10 2007-09-25 Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1)
EP1569901B1 (en) 2002-12-10 2008-10-15 Wyeth ARYL, ARYLOXY, AND ALKYLOXY SUBSTITUTED i 1H /i -INDOL-3-YL GLYOXYLIC ACID DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1)
US7268159B2 (en) 2003-09-25 2007-09-11 Wyeth Substituted indoles
US7163954B2 (en) 2003-09-25 2007-01-16 Wyeth Substituted naphthyl benzothiophene acids
US7342039B2 (en) 2003-09-25 2008-03-11 Wyeth Substituted indole oximes
US7141592B2 (en) 2003-09-25 2006-11-28 Wyeth Substituted oxadiazolidinediones
US7411083B2 (en) 2003-09-25 2008-08-12 Wyeth Substituted acetic acid derivatives
US7582773B2 (en) 2003-09-25 2009-09-01 Wyeth Substituted phenyl indoles
US7332521B2 (en) 2003-09-25 2008-02-19 Wyeth Substituted indoles
US7265148B2 (en) 2003-09-25 2007-09-04 Wyeth Substituted pyrrole-indoles
US7420083B2 (en) 2003-09-25 2008-09-02 Wyeth Substituted aryloximes
US7534894B2 (en) 2003-09-25 2009-05-19 Wyeth Biphenyloxy-acids
US7446201B2 (en) 2003-09-25 2008-11-04 Wyeth Substituted heteroaryl benzofuran acids
US7442805B2 (en) 2003-09-25 2008-10-28 Wyeth Substituted sulfonamide-indoles
US7351726B2 (en) 2003-09-25 2008-04-01 Wyeth Substituted oxadiazolidinediones
US7141596B2 (en) 2003-10-08 2006-11-28 Incyte Corporation Inhibitors of proteins that bind phosphorylated molecules
FR2862646B1 (en) * 2003-11-20 2006-02-24 Merck Sante Sas NOVEL ANTIDIABETIC COMPOUNDS CONTAINING BENZOFURAN, BENZOTHIOPHENIC DERIVATIVES
FR2862645B1 (en) * 2003-11-20 2007-06-22 Merck Sante Sas ANTIDIABETIC COMPOUNDS CONTAINING BENZOFURAN, BENZOTHIOPHENIC DERIVATIVES
FR2864536B1 (en) 2003-12-24 2006-03-17 Clariant France Sa PROCESS FOR THE PREPARATION OF N-ALKYL-2 (HYDROXY-4-BENZOYL) -3 BENZOFURANES AND INTERMEDIATES FOR CARRYING OUT SAID METHOD
BRPI0514549A (en) 2004-08-23 2008-06-17 Wyeth Corp pyrrol-naphthyl acids as inhibitors of pai-1
WO2006023866A2 (en) 2004-08-23 2006-03-02 Wyeth Thiazolo-naphthyl acids as inhibitors of plasminogen activator inhibitor-1
JP2008510815A (en) 2004-08-23 2008-04-10 ワイス Oxazolo-naphthylic acid as plasminogen activator inhibitor type 1 (PAI-1), a modulator useful in the treatment of thrombosis and cardiovascular disease
CN101263115A (en) 2005-08-17 2008-09-10 惠氏公司 Substituted indoles and uses thereof
US10005750B2 (en) 2010-10-06 2018-06-26 J-Pharma Co., Ltd. Developing potent urate transporter inhibitors: compounds designed for their uricosuric action
CN102718735B (en) * 2012-05-28 2014-04-23 沈阳药科大学 2-Ethyl-3-(4-hydroxy)benzoylbenzofuran compound, composition and preparation method thereof
CA2899030C (en) 2013-02-19 2021-03-09 Novartis Ag Benzothiophene derivatives and compositions thereof as selective estrogen receptor degraders
CN108084186B (en) * 2016-11-16 2021-06-25 江苏新元素医药科技有限公司 URAT1 inhibitors and their applications
KR20230050232A (en) * 2021-10-07 2023-04-14 주식회사 이노보테라퓨틱스 Pharmaceutical composition for inhibiting HSP47 comprising benzofuranyl hydroxyphenyl methanone derivative
JPWO2023149549A1 (en) * 2022-02-03 2023-08-10

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3012042A (en) * 1956-12-21 1961-12-05 Belge Produits Chimiques Sa Benzofurans
DE3342624A1 (en) * 1983-11-25 1984-03-29 Heinfried Dr. 4019 Monheim Grote Benzarone derivatives, process for their preparation and medicaments containing these derivatives
FR2653431B1 (en) * 1989-10-23 1994-05-27 Sanofi Sa PROCESS FOR THE PREPARATION OF BENZOYL-3 BENZOFURAN DERIVATIVES.
US5089514A (en) * 1990-06-14 1992-02-18 Pfizer Inc. 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
SE9101509D0 (en) * 1991-05-17 1991-05-17 Karobio Ab RECEPTOR LIGANDS
DE4239429A1 (en) * 1992-11-24 1994-05-26 Merck Patent Gmbh Process for the preparation of immunoconjugates
GB9416219D0 (en) * 1994-08-11 1994-10-05 Karobio Ab Receptor ligands
AU2381397A (en) * 1996-04-19 1997-11-12 Novo Nordisk A/S Modulators of molecules with phosphotyrosine recognition units
DE19624292A1 (en) * 1996-06-18 1998-01-02 Merckle Gmbh Preparation of optically pure 1'-hydroxy-benz-bromoarone

Also Published As

Publication number Publication date
WO1999058519A1 (en) 1999-11-18
JP2002514636A (en) 2002-05-21
CN1308621A (en) 2001-08-15
EP1077965A1 (en) 2001-02-28
CA2331120A1 (en) 1999-11-18

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase