AU3613789A - Condensed diazepinones - Google Patents
Condensed diazepinonesInfo
- Publication number
- AU3613789A AU3613789A AU36137/89A AU3613789A AU3613789A AU 3613789 A AU3613789 A AU 3613789A AU 36137/89 A AU36137/89 A AU 36137/89A AU 3613789 A AU3613789 A AU 3613789A AU 3613789 A AU3613789 A AU 3613789A
- Authority
- AU
- Australia
- Prior art keywords
- image
- hydrogen
- lower alkyl
- chlorine
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- DHZYXWMZLAKTQV-UHFFFAOYSA-N diazepin-3-one Chemical class O=C1C=CC=CN=N1 DHZYXWMZLAKTQV-UHFFFAOYSA-N 0.000 title abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052801 chlorine Inorganic materials 0.000 abstract 3
- 239000000460 chlorine Substances 0.000 abstract 3
- 208000006218 bradycardia Diseases 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 230000036471 bradycardia Effects 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Condensed diazepinones of the general formula I <IMAGE> in which <IMAGE> is one of the divalent radicals <IMAGE> <IMAGE> <IMAGE> <IMAGE> or <IMAGE> X<1> and X<2> can be the =CH-group or, if <IMAGE> is the radical (S), (U) or (W), also nitrogen atoms, A is a C1 to C6-alkylene radical, R<1> and R<2> are lower alkyl radicals or R<1> and R<2> together with the nitrogen atom are also a saturated 4- to 7-membered heteroaliphatic ring, R<3> is lower alkyl or hydrogen or chlorine, R<4> and R<1><0> are hydrogen or methyl, R<5> and R<6> are hydrogen, fluorine, chlorine, bromine or lower alkyl, R<7> is hydrogen, chlorine or methyl and R<8> and R<9> are hydrogen or lower alkyl, R<9> is additionally halogen, are suitable for the treatment of bradycardias and bradyarrhythmias.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3819444A DE3819444A1 (en) | 1988-06-08 | 1988-06-08 | NEW CONDENSED DIAZEPINONE, PROCESS FOR THEIR MANUFACTURE AND MEDICAMENTS CONTAINING THESE COMPOUNDS |
| DE3819444 | 1988-06-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU3613789A true AU3613789A (en) | 1990-02-01 |
| AU612851B2 AU612851B2 (en) | 1991-07-18 |
Family
ID=6356083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU36137/89A Ceased AU612851B2 (en) | 1988-06-08 | 1989-06-08 | Condensed diazepinones |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0345629B1 (en) |
| JP (1) | JPH0232074A (en) |
| KR (1) | KR900000366A (en) |
| AT (1) | ATE80630T1 (en) |
| AU (1) | AU612851B2 (en) |
| CA (1) | CA1320198C (en) |
| DD (1) | DD284014A5 (en) |
| DE (2) | DE3819444A1 (en) |
| DK (1) | DK277589A (en) |
| GR (1) | GR3006558T3 (en) |
| HU (1) | HU203754B (en) |
| IL (1) | IL90549A0 (en) |
| NZ (1) | NZ229409A (en) |
| ZA (1) | ZA894297B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU629355B2 (en) * | 1989-06-10 | 1992-10-01 | Dr. Karl Thomae Gmbh | Use of condensed diazepinones |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3818299A1 (en) * | 1988-05-30 | 1989-12-07 | Thomae Gmbh Dr K | NEW CONDENSED DIAZEPINONE, PROCESS FOR THEIR MANUFACTURE AND MEDICAMENTS CONTAINING THESE COMPOUNDS |
| WO1996013488A1 (en) * | 1994-10-31 | 1996-05-09 | Yamanouchi Pharmaceutical Co., Ltd. | Novel benzodiazepinone derivative and medicinal composition thereof |
| DE10205219A1 (en) * | 2002-02-08 | 2003-08-21 | Bayer Ag | Quinoxalinones and their use |
| AU2003248122A1 (en) * | 2002-07-25 | 2004-02-16 | Kotobuki Pharmaceutical Co., Ltd. | Sodium channel inhibitor |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3409237A1 (en) * | 1984-03-14 | 1985-09-19 | Dr. Karl Thomae Gmbh, 7950 Biberach | CONDENSED DIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
| DE3726908A1 (en) * | 1987-08-13 | 1989-02-23 | Thomae Gmbh Dr K | NEW CONDENSED DIAZEPINONE, PROCESS FOR THEIR MANUFACTURE AND MEDICAMENTS CONTAINING THESE COMPOUNDS |
| DE3802334A1 (en) * | 1988-01-27 | 1989-08-10 | Thomae Gmbh Dr K | NEW CONDENSED DIAZEPINONE, PROCESS FOR THEIR MANUFACTURE AND MEDICAMENTS CONTAINING THESE COMPOUNDS |
-
1988
- 1988-06-08 DE DE3819444A patent/DE3819444A1/en not_active Withdrawn
-
1989
- 1989-06-01 DE DE8989109892T patent/DE58902273D1/en not_active Expired - Lifetime
- 1989-06-01 AT AT89109892T patent/ATE80630T1/en not_active IP Right Cessation
- 1989-06-01 EP EP89109892A patent/EP0345629B1/en not_active Expired - Lifetime
- 1989-06-06 DD DD89329307A patent/DD284014A5/en not_active IP Right Cessation
- 1989-06-06 CA CA000601877A patent/CA1320198C/en not_active Expired - Fee Related
- 1989-06-06 NZ NZ229409A patent/NZ229409A/en unknown
- 1989-06-07 JP JP1145041A patent/JPH0232074A/en active Pending
- 1989-06-07 IL IL90549A patent/IL90549A0/en not_active IP Right Cessation
- 1989-06-07 KR KR1019890007771A patent/KR900000366A/en not_active Withdrawn
- 1989-06-07 DK DK277589A patent/DK277589A/en not_active Application Discontinuation
- 1989-06-07 HU HU892911A patent/HU203754B/en not_active IP Right Cessation
- 1989-06-07 ZA ZA894297A patent/ZA894297B/en unknown
- 1989-06-08 AU AU36137/89A patent/AU612851B2/en not_active Ceased
-
1992
- 1992-12-16 GR GR920402932T patent/GR3006558T3/el unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU629355B2 (en) * | 1989-06-10 | 1992-10-01 | Dr. Karl Thomae Gmbh | Use of condensed diazepinones |
Also Published As
| Publication number | Publication date |
|---|---|
| DD284014A5 (en) | 1990-10-31 |
| HU203754B (en) | 1991-09-30 |
| EP0345629B1 (en) | 1992-09-16 |
| DE3819444A1 (en) | 1989-12-14 |
| IL90549A0 (en) | 1990-01-18 |
| ZA894297B (en) | 1991-02-27 |
| GR3006558T3 (en) | 1993-06-30 |
| DE58902273D1 (en) | 1992-10-22 |
| AU612851B2 (en) | 1991-07-18 |
| HUT50470A (en) | 1990-02-28 |
| KR900000366A (en) | 1990-01-30 |
| EP0345629A3 (en) | 1990-08-16 |
| DK277589D0 (en) | 1989-06-07 |
| JPH0232074A (en) | 1990-02-01 |
| EP0345629A2 (en) | 1989-12-13 |
| NZ229409A (en) | 1990-12-21 |
| ATE80630T1 (en) | 1992-10-15 |
| CA1320198C (en) | 1993-07-13 |
| DK277589A (en) | 1989-12-09 |
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