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AU3539089A - Ligase-based amplification method - Google Patents

Ligase-based amplification method

Info

Publication number
AU3539089A
AU3539089A AU35390/89A AU3539089A AU3539089A AU 3539089 A AU3539089 A AU 3539089A AU 35390/89 A AU35390/89 A AU 35390/89A AU 3539089 A AU3539089 A AU 3539089A AU 3539089 A AU3539089 A AU 3539089A
Authority
AU
Australia
Prior art keywords
ligase
amplification method
based amplification
amplification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU35390/89A
Inventor
Leslie E. Orgel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Salk Institute for Biological Studies
Original Assignee
Salk Institute for Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Institute for Biological Studies filed Critical Salk Institute for Biological Studies
Publication of AU3539089A publication Critical patent/AU3539089A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6862—Ligase chain reaction [LCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • AIDS & HIV (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU35390/89A 1988-04-08 1989-04-07 Ligase-based amplification method Abandoned AU3539089A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17947888A 1988-04-08 1988-04-08
US179478 1988-04-08

Publications (1)

Publication Number Publication Date
AU3539089A true AU3539089A (en) 1989-11-03

Family

ID=22656760

Family Applications (1)

Application Number Title Priority Date Filing Date
AU35390/89A Abandoned AU3539089A (en) 1988-04-08 1989-04-07 Ligase-based amplification method

Country Status (2)

Country Link
AU (1) AU3539089A (en)
WO (1) WO1989009835A1 (en)

Families Citing this family (136)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5242794A (en) * 1984-12-13 1993-09-07 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
HK1006858A1 (en) * 1988-06-24 1999-03-19 Amgen Inc. Method and reagents for detecting nucleic acid sequences
US6004826A (en) * 1988-07-20 1999-12-21 David Segev Repair-mediated process for amplifying and detecting nucleic acid sequences
US5683896A (en) * 1989-06-01 1997-11-04 Life Technologies, Inc. Process for controlling contamination of nucleic acid amplification reactions
US5035996A (en) 1989-06-01 1991-07-30 Life Technologies, Inc. Process for controlling contamination of nucleic acid amplification reactions
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US5427930A (en) * 1990-01-26 1995-06-27 Abbott Laboratories Amplification of target nucleic acids using gap filling ligase chain reaction
US6013431A (en) 1990-02-16 2000-01-11 Molecular Tool, Inc. Method for determining specific nucleotide variations by primer extension in the presence of mixture of labeled nucleotides and terminators
IL97222A (en) * 1990-02-16 1995-08-31 Orion Yhtymae Oy Method and reagent for determining specific nucleotide variations
EP1507000B1 (en) * 1990-05-03 2010-03-03 Cornell Research Foundation, Inc. A thermostable ligase mediated DNA amplification system for the detection of genetic diseases
US5494810A (en) * 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
US5439793A (en) * 1990-07-19 1995-08-08 Syntex (U.S.A.) Inc. Method for producing a polynucleotide having an intramolecularly base-paired structure
CA2049879A1 (en) * 1990-08-30 1992-03-01 Keith C. Backman Controlled initial target-dependent production of templates for ligase chain reaction
GB9112251D0 (en) * 1991-06-07 1991-07-24 Amersham Int Plc Quantitative detection of nucleic acid amplification products
DK0519338T3 (en) 1991-06-20 1996-10-28 Hoffmann La Roche Improved Methods for Nucleic Acid Amplification
DE4129653A1 (en) * 1991-09-06 1993-03-11 Boehringer Mannheim Gmbh PROCESS FOR DETECTION OF SIMILAR NUCLEIC ACIDS
US5567583A (en) * 1991-12-16 1996-10-22 Biotronics Corporation Methods for reducing non-specific priming in DNA detection
US6033854A (en) * 1991-12-16 2000-03-07 Biotronics Corporation Quantitative PCR using blocking oligonucleotides
US5348853A (en) * 1991-12-16 1994-09-20 Biotronics Corporation Method for reducing non-specific priming in DNA amplification
US5869252A (en) * 1992-03-31 1999-02-09 Abbott Laboratories Method of multiplex ligase chain reaction
US6100099A (en) 1994-09-06 2000-08-08 Abbott Laboratories Test strip having a diagonal array of capture spots
US6180338B1 (en) 1992-08-04 2001-01-30 Beckman Coulter, Inc. Method, reagent and kit for the detection and amplification of nucleic acid sequences
US6207368B1 (en) 1992-08-04 2001-03-27 Beckman Coulter, Inc. Methods and reagents for controlling chain extension and ligation chain reactions
EP0694079B1 (en) * 1993-03-22 2000-05-17 The Perkin-Elmer Corporation Enzymatic ligation of 3'-amino-substituted olignucleotides
US5593826A (en) * 1993-03-22 1997-01-14 Perkin-Elmer Corporation, Applied Biosystems, Inc. Enzymatic ligation of 3'amino-substituted oligonucleotides
US6406841B1 (en) 1993-07-01 2002-06-18 Abbott Laboratories Methods for the detection of HTLV-II antibodies employing novel HTLV-II NRA envelope peptides
DE69506393T2 (en) * 1994-04-04 1999-07-01 Ciba Corning Diagnostics Corp., Medfield, Mass. HYBRIDISATION-LIGITATION METHOD FOR DETECTING SPECIFIC DNA SEQUENCES
WO1995029251A1 (en) * 1994-04-25 1995-11-02 Applied Technology Genetics Corporation Detection of mutation by resolvase cleavage
US5851770A (en) * 1994-04-25 1998-12-22 Variagenics, Inc. Detection of mismatches by resolvase cleavage using a magnetic bead support
US5631130A (en) * 1994-05-13 1997-05-20 Abbott Laboratories Materials and methods for the detection of Mycobacterium tuberculosis
US6787304B1 (en) 1994-12-28 2004-09-07 Georgetown University Fluorometric assay for detecting nucleic acid cleavage
US20030165908A1 (en) 1994-12-30 2003-09-04 Georgetown University Fluorometric assay for detecting nucleic acid cleavage
WO1996021144A1 (en) * 1994-12-30 1996-07-11 Georgetown University Fluorometric assay for detecting nucleic acid cleavage
US6015660A (en) * 1995-01-06 2000-01-18 The Regents Of The University Of California Borna disease viral sequences, diagnostics and therapeutics for nervous system diseases
US6113905A (en) * 1995-01-06 2000-09-05 The Regents Of The University Of California Borna disease viral sequences, diagnostics and therapeutics for nervous system diseases
US6077510A (en) * 1995-01-06 2000-06-20 Regents Of The University Of California Borna disease viral sequences, diagnostics and therapeutics for nervous system diseases
EP0843736B1 (en) * 1995-05-11 1999-12-22 Ulf Landegren Detection of mismatches by resolvase cleavage on a solid support
US5770368A (en) * 1996-05-09 1998-06-23 Metropolitan Water District Of Southern California Cryptosporidium detection method
US6436638B1 (en) 1996-05-09 2002-08-20 Metropolitan Water District Of Southern California Cryptosporidium detection method
CA2319712A1 (en) * 1998-02-04 1999-08-12 Variagenics, Inc. Mismatch detection techniques
HK1048339A1 (en) * 1999-03-18 2003-03-28 埃克西库恩公司 Detectionion of mutations in genes by specific lna primers
US7014994B1 (en) 1999-03-19 2006-03-21 Cornell Research Foundation,Inc. Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
DK1923471T3 (en) 1999-04-20 2013-04-02 Illumina Inc Detection of nucleic acid reactions on bead arrays
US8481268B2 (en) 1999-05-21 2013-07-09 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US7611869B2 (en) 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
EP1257668B1 (en) 2000-02-16 2008-10-29 Illumina, Inc. Parallel genotyping of multiple patient samples
CA2426824A1 (en) 2000-10-24 2002-07-25 The Board Of Trustees Of The Leland Stanford Junior University Direct multiplex characterization of genomic dna
US7838270B2 (en) 2001-05-22 2010-11-23 The University Of Chicago Target-dependent transcription using deletion mutants of N4 RNA polymerase
EP2246438B1 (en) 2001-07-12 2019-11-27 Illumina, Inc. Multiplex nucleic acid reactions
US20040259100A1 (en) 2003-06-20 2004-12-23 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
WO2005003304A2 (en) 2003-06-20 2005-01-13 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
NZ545000A (en) 2003-07-03 2008-08-29 Univ California Genome mapping of functional DNA elements and cellular proteins
JP2007538236A (en) 2004-05-21 2007-12-27 アトノミックス アクティーゼルスカブ Surface acoustic wave sensor containing hydrogel
CN103884698B (en) 2004-06-07 2017-04-12 先锋生物科技股份有限公司 Optical lens system and method for microfluidic devices
DE602006021056D1 (en) 2005-11-14 2011-05-12 Gen Probe Inc PARAMETRIC CALIBRATION PROCEDURE
US7981606B2 (en) 2005-12-21 2011-07-19 Roche Molecular Systems, Inc. Control for nucleic acid testing
US8383345B2 (en) 2008-09-12 2013-02-26 University Of Washington Sequence tag directed subassembly of short sequencing reads into long sequencing reads
US8828688B2 (en) 2010-05-27 2014-09-09 Affymetrix, Inc. Multiplex amplification methods
US9074251B2 (en) 2011-02-10 2015-07-07 Illumina, Inc. Linking sequence reads using paired code tags
WO2013082164A1 (en) 2011-11-28 2013-06-06 Life Technologies Corporation Enhanced ligation reactions
WO2012106546A2 (en) 2011-02-02 2012-08-09 University Of Washington Through Its Center For Commercialization Massively parallel continguity mapping
EP2877952B1 (en) 2012-07-27 2023-04-12 Gen-Probe Incorporated Dual reference calibration method and system for quantifying polynucleotides
US9181583B2 (en) 2012-10-23 2015-11-10 Illumina, Inc. HLA typing using selective amplification and sequencing
US9683230B2 (en) 2013-01-09 2017-06-20 Illumina Cambridge Limited Sample preparation on a solid support
EP2971069B1 (en) 2013-03-13 2018-10-17 Illumina, Inc. Methods and systems for aligning repetitive dna elements
CA2898456C (en) 2013-03-13 2020-11-10 Illumina, Inc. Methods and compositions for nucleic acid sequencing
EP2971090B1 (en) 2013-03-15 2020-05-06 Gen-Probe Incorporated Calibration method, apparatus and computer program product
CA2931533C (en) 2013-12-09 2023-08-08 Illumina, Inc. Methods and compositions for targeted nucleic acid sequencing
WO2015095226A2 (en) 2013-12-20 2015-06-25 Illumina, Inc. Preserving genomic connectivity information in fragmented genomic dna samples
KR102001554B1 (en) 2014-01-16 2019-07-18 일루미나, 인코포레이티드 Amplicon preparation and sequencing on solid supports
US9677132B2 (en) 2014-01-16 2017-06-13 Illumina, Inc. Polynucleotide modification on solid support
AU2014384731B2 (en) 2014-02-28 2017-12-14 Gen-Probe Incorporated Method of isolating nucleic acid from specimens in liquid-based cytology preservatives containing formaldehyde
GB2528344B (en) 2014-02-28 2018-10-31 Gen Probe Inc Method of isolating nucleic acid from specimens in liquid-based cytology preservatives containing formaldehyde
US20150353989A1 (en) 2014-06-09 2015-12-10 Illumina Cambridge Limited Sample preparation for nucleic acid amplification
GB201410420D0 (en) 2014-06-11 2014-07-23 Illumina Cambridge Ltd Methods for estimating cluster numbers
CN117867071A (en) 2014-06-13 2024-04-12 伊卢米纳剑桥有限公司 Methods and compositions for preparing sequence libraries
US10829814B2 (en) 2014-06-19 2020-11-10 Illumina, Inc. Methods and compositions for single cell genomics
JP6652512B2 (en) 2014-06-30 2020-02-26 イラミーナ インコーポレーテッド Methods and compositions using unilateral transfer
EP3175023B1 (en) 2014-07-30 2025-02-19 President and Fellows of Harvard College Method for determining nucleic acids
WO2016040602A1 (en) 2014-09-11 2016-03-17 Epicentre Technologies Corporation Reduced representation bisulfite sequencing using uracil n-glycosylase (ung) and endonuclease iv
CN107002121B (en) 2014-09-18 2020-11-13 亿明达股份有限公司 Methods and systems for analyzing nucleic acid sequencing data
RU2736728C2 (en) 2014-10-17 2020-11-19 Иллумина Кембридж Лимитед Transposition with preservation of gene adhesion
GB201419731D0 (en) 2014-11-05 2014-12-17 Illumina Cambridge Ltd Sequencing from multiple primers to increase data rate and density
CN107532205B (en) 2015-03-31 2021-06-08 伊卢米纳剑桥有限公司 Surface concatenation of templates
HK1251023A1 (en) 2015-04-07 2019-01-18 Polyskope Labs Detection of one or more pathogens
US12157910B2 (en) 2015-07-06 2024-12-03 Illumina Cambridge Limited Sample preparation for nucleic acid amplification
ES2861350T3 (en) 2016-03-28 2021-10-06 Illumina Inc Multi-plane microarrays
AU2017299803B2 (en) 2016-07-22 2023-06-29 Illumina, Inc. Single cell whole genome libraries and combinatorial indexing methods of making thereof
ES2882608T3 (en) 2017-04-23 2021-12-02 Illumina Inc Compositions and methods to improve sample identification in indexed nucleic acid libraries
FI3872187T3 (en) 2017-04-23 2022-12-15 Compositions and methods for improving sample identification in indexed nucleic acid libraries
ES2889585T3 (en) 2017-04-23 2022-01-12 Illumina Cambridge Ltd Compositions and methods to improve sample identification in indexed nucleic acid collections
US10995104B2 (en) 2017-05-30 2021-05-04 Roche Molecular System, Inc. Catalysts for reversing formaldehyde adducts and crosslinks
NZ759895A (en) 2017-06-07 2023-05-26 Illumina Inc Single cell whole genome libraries for methylation sequencing
US20200202977A1 (en) 2017-07-31 2020-06-25 Illumina, Inc. Sequencing system with multiplexed biological sample aggregation
AU2018312560B2 (en) 2017-08-01 2022-03-10 Illumina, Inc. Hydrogel beads for nucleotide sequencing
DK3752634T3 (en) 2018-02-13 2022-10-24 Illumina Inc DNA Sequencing Using Hydrogel Beads / DNA sequencing using hydrogel beads
CA3064622A1 (en) 2018-04-02 2019-10-10 Illumina, Inc. Compositions and methods for making controls for sequence-based genetic testing
WO2019204229A1 (en) 2018-04-20 2019-10-24 Illumina, Inc. Methods of encapsulating single cells, the encapsulated cells and uses thereof
WO2019222688A1 (en) 2018-05-17 2019-11-21 Illumina, Inc. High-throughput single-cell sequencing with reduced amplification bias
FI3810774T3 (en) 2018-06-04 2023-12-11 Illumina Inc Methods of making high-throughput single-cell transcriptome libraries
AU2019364545B2 (en) 2018-10-26 2025-09-04 Illumina, Inc. Modulating polymer beads for DNA processing
WO2020112604A2 (en) 2018-11-30 2020-06-04 Illumina, Inc. Analysis of multiple analytes using a single assay
EP3894583A4 (en) 2018-12-13 2022-11-09 President and Fellows of Harvard College AMPLIFICATION SYSTEMS AND METHODS FOR MERFISH AND OTHER APPLICATIONS
MX2021003746A (en) 2019-03-01 2021-06-23 Illumina Inc High-throughput single-nuclei and single-cell libraries and methods of making and of using.
MX2021007803A (en) 2019-07-12 2021-08-11 Illumina Cambridge Ltd Compositions and methods for preparing nucleic acid sequencing libraries using crispr/cas9 immobilized on a solid support.
US12480114B2 (en) 2019-07-12 2025-11-25 Illumina, Inc. Nucleic acid library preparation using electrophoresis
WO2021119124A1 (en) 2019-12-09 2021-06-17 Gen-Probe Incorporated Quantification of polynucleotide analytes from dried samples
MX2021011847A (en) 2019-12-19 2021-11-17 Illumina Inc High-throughput single-cell libraries and methods of making and of using.
AU2021249046A1 (en) 2020-03-30 2022-10-20 Illumina, Inc. Methods and compositions for preparing nucleic acid libraries
JP2023526062A (en) 2020-05-12 2023-06-20 イルミナ インコーポレイテッド Generation of Nucleic Acids with Modified Bases Using Recombinant Terminal Deoxynucleotidyl Transferase
WO2021252617A1 (en) 2020-06-09 2021-12-16 Illumina, Inc. Methods for increasing yield of sequencing libraries
CA3177299A1 (en) 2020-06-30 2022-01-06 Illumina Inc. Catalytically controlled sequencing by synthesis to produce scarless dna
WO2022031955A1 (en) 2020-08-06 2022-02-10 Illumina, Inc. Preparation of rna and dna sequencing libraries using bead-linked transposomes
JP2023537850A (en) 2020-08-18 2023-09-06 イルミナ インコーポレイテッド Sequence-specific targeted transposition and selection and selection of nucleic acids
IL300983A (en) 2020-09-11 2023-04-01 Illumina Cambridge Ltd Methods of enriching a target sequence from a sequencing library using hairpin adaptors
ES3015114T3 (en) 2021-02-04 2025-04-29 Illumina Inc Long indexed-linked read generation on transposome bound beads
WO2022212269A1 (en) 2021-03-29 2022-10-06 Illumina, Inc. Improved methods of library preparation
AU2022246569A1 (en) 2021-03-29 2023-09-14 Illumina, Inc. Compositions and methods for assessing dna damage in a library and normalizing amplicon size bias
MX2023010495A (en) 2021-03-30 2023-09-18 Illumina Inc Improved methods of isothermal complementary dna and library preparation.
AU2022249289A1 (en) 2021-03-31 2023-08-17 Illumina Cambridge Limited Methods of preparing directional tagmentation sequencing libraries using transposon-based technology with unique molecular identifiers for error correction
CN118103750A (en) 2021-08-31 2024-05-28 伊鲁米纳公司 Flow cell with enhanced pore imaging resolution
KR20250004634A (en) 2022-04-07 2025-01-08 일루미나, 인코포레이티드 Modified cytidine deaminase and method of use
US20250388894A1 (en) 2022-09-30 2025-12-25 Illumina, Inc. Methods of using cpg binding proteins in mapping modified cytosine nucleotides
EP4594481A1 (en) 2022-09-30 2025-08-06 Illumina, Inc. Helicase-cytidine deaminase complexes and methods of use
EP4594533A1 (en) 2022-09-30 2025-08-06 Biotheranostics, Inc. Biomarker assay to select breast cancer therapy
WO2024073047A1 (en) 2022-09-30 2024-04-04 Illumina, Inc. Cytidine deaminases and methods of use in mapping modified cytosine nucleotides
WO2024233375A1 (en) 2023-05-05 2024-11-14 Gen-Probe Incorporated Method and system for improving specificity of analyte detection using real-time nucleic acid amplification
WO2025072800A2 (en) 2023-09-28 2025-04-03 Illumina, Inc. Altered cytidine deaminases and methods of use
WO2025081064A2 (en) 2023-10-11 2025-04-17 Illumina, Inc. Thermophilic deaminase and methods for identifying modified cytosine
WO2025137222A1 (en) 2023-12-19 2025-06-26 Illumina, Inc. Methylation detection assay
WO2025264831A1 (en) 2024-06-18 2025-12-26 Illumina, Inc. Methods for increasing sequencing quality of gc-rich regions
WO2025264836A1 (en) 2024-06-18 2025-12-26 Illumina, Inc. Methods for increasing sequencing quality of gc-rich regions
WO2026006314A1 (en) 2024-06-28 2026-01-02 Illumina, Inc. Tagging target regions prior to nucleotide sequencing
WO2026006774A1 (en) 2024-06-28 2026-01-02 Illumina, Inc. Altered cytidine deaminases and methods of use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4663283A (en) * 1980-03-24 1987-05-05 Genentech, Inc. Method of altering double-stranded DNA
US4710465A (en) * 1984-04-19 1987-12-01 Yale University Junction-fragment DNA probes and probe clusters
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences

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