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AU3345995A - Cyclic benzazepine urea derivatives with aggregation-inhibiting effect - Google Patents

Cyclic benzazepine urea derivatives with aggregation-inhibiting effect

Info

Publication number
AU3345995A
AU3345995A AU33459/95A AU3345995A AU3345995A AU 3345995 A AU3345995 A AU 3345995A AU 33459/95 A AU33459/95 A AU 33459/95A AU 3345995 A AU3345995 A AU 3345995A AU 3345995 A AU3345995 A AU 3345995A
Authority
AU
Australia
Prior art keywords
benzazepine
aggregation
cyclic
inhibiting effect
urea derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU33459/95A
Inventor
Volkhard Austel
Brian Guth
Frank Himmelsbach
Helmut Pieper
Johannes Weisenberger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of AU3345995A publication Critical patent/AU3345995A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU33459/95A 1994-08-17 1995-08-16 Cyclic benzazepine urea derivatives with aggregation-inhibiting effect Abandoned AU3345995A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4429079A DE4429079A1 (en) 1994-08-17 1994-08-17 Cyclic urea derivatives, pharmaceutical compositions containing them and processes for their preparation
DE4429079 1994-08-17
PCT/EP1995/003233 WO1996005194A1 (en) 1994-08-17 1995-08-16 Cyclic benzazepine urea derivatives with aggregation-inhibiting effect

Publications (1)

Publication Number Publication Date
AU3345995A true AU3345995A (en) 1996-03-07

Family

ID=6525854

Family Applications (1)

Application Number Title Priority Date Filing Date
AU33459/95A Abandoned AU3345995A (en) 1994-08-17 1995-08-16 Cyclic benzazepine urea derivatives with aggregation-inhibiting effect

Country Status (9)

Country Link
EP (1) EP0777667A1 (en)
JP (1) JPH10504298A (en)
AU (1) AU3345995A (en)
CA (1) CA2197789A1 (en)
CO (1) CO4410324A1 (en)
DE (1) DE4429079A1 (en)
IL (1) IL114980A0 (en)
MX (1) MX9700020A (en)
WO (1) WO1996005194A1 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19624069A1 (en) * 1996-06-17 1997-12-18 Thomae Gmbh Dr K Benzazepine derivatives, pharmaceutical compositions containing them and methods for their preparation
PE20020689A1 (en) 2000-11-17 2002-08-03 Upjohn Co OXAZOLIDINONES WITH A HETEROCYCLE OF 6 OR 7 MEMBERS UNITED WITH ANNULAR LINK TO BENZENE
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
KR100897642B1 (en) 2002-12-20 2009-05-14 글락소 그룹 리미티드 Benzazepine Derivatives for the Treatment of Neurological Disorders
EP2332921B1 (en) 2003-06-17 2016-03-02 Arena Pharmaceuticals, Inc. 8-Chloro-1 -methyl-2,3,4,5-tetrahydro-1 H-3benzazapine Hydrochloride
JP4782003B2 (en) 2003-06-17 2011-09-28 アリーナ ファーマシューティカルズ， インコーポレイテッド Benzazepine derivatives useful for the treatment of 5HT2C receptor related diseases
GB0329214D0 (en) * 2003-12-17 2004-01-21 Glaxo Group Ltd Novel compounds
GB0405628D0 (en) * 2004-03-12 2004-04-21 Glaxo Group Ltd Novel compounds
NZ555981A (en) 2004-12-21 2011-01-28 Arena Pharm Inc Crystalline forms of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
EP2111859A1 (en) 2004-12-23 2009-10-28 Arena Pharmaceuticals, Inc. 5HT2C receptor modulator compositions and methods of use
US8168782B2 (en) 2006-04-03 2012-05-01 Arena Pharmaceuticals, Inc. Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and intermediates related thereto
JP5404414B2 (en) 2006-12-05 2014-01-29 アリーナ ファーマシューティカルズ， インコーポレイテッド Method for preparing (R) -8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and its intermediates
CN102015591B (en) 2008-03-04 2014-01-29 艾尼纳制药公司 Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-choro-i-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
CN102648170A (en) 2009-06-18 2012-08-22 艾尼纳制药公司 Processes for the preparation of 5-HT2C receptor agonists
KR20130112848A (en) 2010-06-02 2013-10-14 아레나 파마슈티칼스, 인크. Processes for the preparation of 5-ht2c receptor agonists
JP2013536859A (en) 2010-09-01 2013-09-26 アリーナ ファーマシューティカルズ， インコーポレイテッド Non-hygroscopic salt of 5-HT2C agonist
US20130315994A1 (en) 2010-09-01 2013-11-28 Zezhi Jesse Shao Modified-release dosage forms of 5-ht2c agonists useful for weight management
CA2808909A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Salts of lorcaserin with optically active acids
SG10201506896RA (en) 2010-09-01 2015-10-29 Arena Pharm Inc Administration of lorcaserin to individuals with renal impairment
MY181736A (en) 2012-10-09 2021-01-05 Arena Pharm Inc Method of weight management
US10853589B2 (en) 2014-04-25 2020-12-01 Mentor Acquisition One, Llc Language translation with head-worn computing
WO2019090088A1 (en) 2017-11-02 2019-05-09 Calico Life Sciences Llc Modulators of the integrated stress pathway
IL274406B2 (en) * 2017-11-02 2024-04-01 Calico Life Sciences Llc Combined pressure pathway modulators

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4107857A1 (en) * 1991-03-12 1992-09-17 Thomae Gmbh Dr K CYCLIC UREA DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
DE4127404A1 (en) * 1991-08-19 1993-02-25 Thomae Gmbh Dr K CYCLIC IMINODERIVATES, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
DE4332168A1 (en) * 1993-02-22 1995-03-23 Thomae Gmbh Dr K Cyclic derivatives, pharmaceutical compositions containing these compounds and process for their preparation

Also Published As

Publication number Publication date
CO4410324A1 (en) 1997-01-09
IL114980A0 (en) 1995-12-08
JPH10504298A (en) 1998-04-28
CA2197789A1 (en) 1996-02-22
DE4429079A1 (en) 1996-02-22
WO1996005194A1 (en) 1996-02-22
EP0777667A1 (en) 1997-06-11
MX9700020A (en) 1997-12-31

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