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AU3279395A - Methods for treating and/or preventing alzheimer's disease using phenothiazines and/or thioxanthenes - Google Patents

Methods for treating and/or preventing alzheimer's disease using phenothiazines and/or thioxanthenes

Info

Publication number
AU3279395A
AU3279395A AU32793/95A AU3279395A AU3279395A AU 3279395 A AU3279395 A AU 3279395A AU 32793/95 A AU32793/95 A AU 32793/95A AU 3279395 A AU3279395 A AU 3279395A AU 3279395 A AU3279395 A AU 3279395A
Authority
AU
Australia
Prior art keywords
thioxanthenes
phenothiazines
disease
treating
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU32793/95A
Other versions
AU708682B2 (en
Inventor
Peter Davies
Inez J Vincent
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Albert Einstein College of Medicine
Original Assignee
Albert Einstein College of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albert Einstein College of Medicine filed Critical Albert Einstein College of Medicine
Publication of AU3279395A publication Critical patent/AU3279395A/en
Application granted granted Critical
Publication of AU708682B2 publication Critical patent/AU708682B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU32793/95A 1994-08-08 1995-08-07 Methods for treating and/or preventing Alzheimer's disease using phenothiazines and/or thioxanthenes Ceased AU708682B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US28733994A 1994-08-08 1994-08-08
US08/287339 1994-08-08
US34675794A 1994-11-30 1994-11-30
US08/346757 1994-11-30
PCT/US1995/010110 WO1996004915A1 (en) 1994-08-08 1995-08-07 Methods for treating and/or preventing alzheimer's disease using phenothiazines and/or thioxanthenes

Publications (2)

Publication Number Publication Date
AU3279395A true AU3279395A (en) 1996-03-07
AU708682B2 AU708682B2 (en) 1999-08-12

Family

ID=26964404

Family Applications (1)

Application Number Title Priority Date Filing Date
AU32793/95A Ceased AU708682B2 (en) 1994-08-08 1995-08-07 Methods for treating and/or preventing Alzheimer's disease using phenothiazines and/or thioxanthenes

Country Status (5)

Country Link
EP (1) EP0778773A1 (en)
KR (1) KR970704445A (en)
AU (1) AU708682B2 (en)
CA (1) CA2196529A1 (en)
WO (1) WO1996004915A1 (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9506197D0 (en) * 1995-03-27 1995-05-17 Hoffmann La Roche Inhibition of tau-tau association.
AU7260398A (en) * 1997-04-28 1998-11-24 University Of British Columbia, The Method and composition for modulating amyloidosis
GB9713484D0 (en) * 1997-06-27 1997-09-03 Smithkline Beecham Plc Neuroprotective vanilloid compounds
DE19842416A1 (en) * 1998-09-16 2000-04-13 Max Planck Gesellschaft Secondary amines for the prevention and therapy of diseases caused or intensified by oxidation processes
GB0017060D0 (en) * 2000-07-11 2000-08-30 Hunter Fleming Ltd Production, stabilisation and use of reduced forms of pharmaceutical compounds
GB0100119D0 (en) 2001-01-03 2001-02-14 Univ Aberdeen Materials and methods relating to protein aggregation in neurodegenerative disease
GB0101049D0 (en) 2001-01-15 2001-02-28 Univ Aberdeen Materials and methods relating to protein aggregation in neurodegenerative disease
GB0106953D0 (en) 2001-03-20 2001-05-09 Univ Aberdeen Neufofibrillary labels
GB0117326D0 (en) 2001-07-16 2001-09-05 Univ Aberdeen Napthoquinone-type inhibitors of protein aggregation
PT1470818E (en) * 2003-04-25 2006-11-30 Neuro3D Use of piperazine phenothiazine derivatives in the manufacture of a medicament with neuroprotector and/or neurotrophic effects on cns and/or pns
US7244764B2 (en) 2003-06-23 2007-07-17 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US7414076B2 (en) 2003-06-23 2008-08-19 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
JP5186212B2 (en) 2004-09-23 2013-04-17 ウィスタ ラボラトリーズ リミテッド Method for chemical synthesis and purification of diaminophenothiazinium compounds such as methylthioninium chloride (MTC)
CA2592320C (en) 2004-12-22 2015-11-24 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
ES2659030T3 (en) 2006-03-29 2018-03-13 Wista Laboratories Ltd. Thioninium compounds and their use
ES2349322T7 (en) 2006-03-29 2019-10-17 Wista Lab Ltd Salts of 3,7-diamino-10H-phenothiazine and their use
MY153198A (en) 2006-03-29 2015-01-29 Wista Lab Ltd Inhibitors of protein aggregation
KR101443573B1 (en) 2006-10-12 2014-11-03 비에이치아이 리미티드 파트너쉽 Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid
GB0701970D0 (en) 2007-02-01 2007-03-14 Wilson Stuart Treatment of protein aggregation diseases
ES2331282B1 (en) * 2008-06-25 2010-10-21 Consejo Superior De Investigaciones Cientificas (Csic) (45%) HYDRAZIDS OF HETEROCICLICAL SYSTEMS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES.
DE102010062810B4 (en) * 2010-09-07 2014-03-13 Immungenetics Ag 2- (R2-thio) -10- [3- (4-R1-piperazin-1-yl) -propyl] -10H-phenothiazines for the treatment of neurodegenerative diseases selected from beta-amyloidopathies and alpha-synucleinopathies
PL2673266T3 (en) 2011-02-11 2017-01-31 Wista Lab Ltd Phenothiazine diamino salts and their use
US8980884B2 (en) 2011-06-01 2015-03-17 Wisconsin Alumni Research Foundation Methods for treating Alzheimer's disease
JP2023549174A (en) * 2020-11-04 2023-11-22 グリアセルテック・インコーポレイテッド Composition for preventing or treating neuroinflammatory diseases containing chlorpromazine
WO2022104070A2 (en) * 2020-11-13 2022-05-19 Icahn School Of Medicine At Mount Sinai Phenothiazine compounds for the treatment of alzheimer's disease and other age-related and neurological diseases
CA3242478A1 (en) * 2022-01-04 2023-07-13 Immungenetics Ag SPECIFIC DOSAGE OF PHENOTHIAZINE COMPOUNDS INTENDED FOR USE IN THE TREATMENT OR PREVENTION OF ALZHEIMER'S DISEASE

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2837518A (en) * 1958-06-03 Phenthiazine compounds
US2902484A (en) * 1954-04-27 1959-09-01 Rhone Poulenc Sa Phenthiazine derivatives and processes for their preparation
NL108827C (en) * 1956-04-09

Also Published As

Publication number Publication date
KR970704445A (en) 1997-09-06
CA2196529A1 (en) 1996-02-22
EP0778773A1 (en) 1997-06-18
WO1996004915A1 (en) 1996-02-22
AU708682B2 (en) 1999-08-12

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired