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AU3125695A - Neurologically active aminosteroids - Google Patents

Neurologically active aminosteroids

Info

Publication number
AU3125695A
AU3125695A AU31256/95A AU3125695A AU3125695A AU 3125695 A AU3125695 A AU 3125695A AU 31256/95 A AU31256/95 A AU 31256/95A AU 3125695 A AU3125695 A AU 3125695A AU 3125695 A AU3125695 A AU 3125695A
Authority
AU
Australia
Prior art keywords
aminosteroids
neurologically active
neurologically
active
active aminosteroids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU31256/95A
Inventor
Gordon L. Bundy
Eric Jon Jacobsen
Michael A Wynalda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of AU3125695A publication Critical patent/AU3125695A/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J5/00Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0007Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
    • C07J5/0023Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16
    • C07J5/003Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group including 16-alkylidene substitutes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J43/00Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
AU31256/95A 1994-07-21 1995-07-18 Neurologically active aminosteroids Abandoned AU3125695A (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US27863394A 1994-07-21 1994-07-21
US278633 1994-07-21
US36181894A 1994-12-22 1994-12-22
US361818 1994-12-22
US47387395A 1995-06-07 1995-06-07
PCT/US1995/008646 WO1996003421A1 (en) 1994-07-21 1995-07-18 Neurologically active aminosteroids
US473873 2006-06-23

Publications (1)

Publication Number Publication Date
AU3125695A true AU3125695A (en) 1996-02-22

Family

ID=27403009

Family Applications (1)

Application Number Title Priority Date Filing Date
AU31256/95A Abandoned AU3125695A (en) 1994-07-21 1995-07-18 Neurologically active aminosteroids

Country Status (3)

Country Link
JP (1) JP2002500616A (en)
AU (1) AU3125695A (en)
WO (1) WO1996003421A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100359556B1 (en) * 1994-09-01 2002-12-18 파마시아 앤드 업존 캄파니 Cosolvent parenteral formulation of tirilazad
AU2012323888A1 (en) 2011-10-14 2014-05-29 Sage Therapeutics, Inc. 3,3 disubstituted 19-nor pregnane compounds, compositions, and uses thereof
RU2681835C2 (en) 2012-01-23 2019-03-13 Сейдж Терапьютикс, Инк. Neuroactive steroid formulations and methods of treating cns disorders
IL294306B2 (en) 2012-08-21 2024-01-01 Sage Therapeutics Inc Treatment methods for epilepsy and status epilepticus
US9725481B2 (en) 2013-04-17 2017-08-08 Sage Therapeutics, Inc. 19-nor C3, 3-disubstituted C21-C-bound heteroaryl steroids and methods of use thereof
CN117304245A (en) 2013-04-17 2023-12-29 萨奇治疗股份有限公司 Neuroactive 19-norsteroids and methods of use
WO2014169836A1 (en) 2013-04-17 2014-10-23 Sage Therapeutics, Inc. 19-nor neuroactive steroids and methods of use thereof
BR112015026380A8 (en) 2013-04-17 2019-12-31 Sage Therapeutics Inc 19-nor c3,3-disubstituted c21-n-pyrazolyl steroids and methods of using these
AU2014290400B2 (en) 2013-07-19 2019-12-05 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
EP3488852B1 (en) 2013-08-23 2020-10-28 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
US10246482B2 (en) 2014-06-18 2019-04-02 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
JOP20200195A1 (en) 2014-09-08 2017-06-16 Sage Therapeutics Inc Neuroactive steroids and formulations, and their uses
AU2015331597B2 (en) 2014-10-16 2020-04-30 Sage Therapeutics, Inc. Compositions and methods for treating CNS disorders
CN117024502A (en) 2014-10-16 2023-11-10 萨奇治疗股份有限公司 Compositions and methods for targeting CNS disorders
EP3719029A1 (en) 2014-11-27 2020-10-07 Sage Therapeutics, Inc. Compositions for inducing sedation
DK3250210T3 (en) 2015-01-26 2021-03-08 Sage Therapeutics Inc COMPOSITIONS AND METHODS FOR TREATING CNS DISORDERS
WO2016134301A2 (en) 2015-02-20 2016-08-25 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
KR20220084418A (en) 2016-03-08 2022-06-21 세이지 테라퓨틱스, 인크. Neuroactive steroids, compositions, and uses thereof
NZ749664A (en) 2016-07-11 2025-08-29 Sage Therapeutics Inc C17, c20, and c21 substituted neuroactive steroids and their methods of use
JP7065825B2 (en) 2016-07-11 2022-05-12 セージ セラピューティクス, インコーポレイテッド C7, C12, and C16 replacement neurostimulatory steroids and how to use them
AR119047A1 (en) 2019-05-31 2021-11-17 Sage Therapeutics Inc NEUROACTIVE STEROIDS AS GABAA MODULATORS AND THEIR USE IN THE TREATMENT OF CNS DISORDERS

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987001706A2 (en) * 1985-09-12 1987-03-26 The Upjohn Company C20 through c26 amino steroids
JP2832632B2 (en) * 1990-05-18 1998-12-09 本田技研工業株式会社 Transmission in motorcycle

Also Published As

Publication number Publication date
WO1996003421A1 (en) 1996-02-08
JP2002500616A (en) 2002-01-08

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