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AU2277592A - Method of preparing starch esters for clinical, in particular parenteral, applications - Google Patents

Method of preparing starch esters for clinical, in particular parenteral, applications

Info

Publication number
AU2277592A
AU2277592A AU22775/92A AU2277592A AU2277592A AU 2277592 A AU2277592 A AU 2277592A AU 22775/92 A AU22775/92 A AU 22775/92A AU 2277592 A AU2277592 A AU 2277592A AU 2277592 A AU2277592 A AU 2277592A
Authority
AU
Australia
Prior art keywords
starch esters
mole
carbon atoms
clinical
range
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU22775/92A
Other versions
AU656014B2 (en
Inventor
Fatima Asskali
Harald Forster
Ernst Nitsch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laevosan GmbH and Co KG
Original Assignee
Laevosan GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laevosan GmbH and Co KG filed Critical Laevosan GmbH and Co KG
Publication of AU2277592A publication Critical patent/AU2277592A/en
Application granted granted Critical
Publication of AU656014B2 publication Critical patent/AU656014B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B31/00—Preparation of derivatives of starch
    • C08B31/02—Esters
    • C08B31/04—Esters of organic acids, e.g. alkenyl-succinated starch
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B35/00—Preparation of derivatives of amylopectin
    • C08B35/02—Esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

In order to prepare physiologically tolerated water-soluble starch esters, the invention proposes that starch is converted by acid hydrolysis or enzymatic hydrolysis to a partially hydrolysed form with a mean molecular weight in the range from 10,000 to 500,000 Daltons. This partial hydrolysate is then acylated, in aqueous solution, with the anhydride or halide of an aliphatic monocarboxylic acid with 2 to 4 carbon atoms or an aliphatic dicarboxylic acid with 3 to 6 carbon atoms, or mixtures thereof, and an alkalinization agent, to give a product with a substitution ratio in the range from 0.1 to 1.0 mole/mole. Salts are removed from the resulting reaction mixture. The starch esters thus obtained are highly suited for clinical use, in particular parenteral administration and administration in the diet.
AU22775/92A 1991-07-11 1992-07-09 Method of preparing starch esters for clinical, in particular parenteral, applications Ceased AU656014B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4123000 1991-07-11
DE4123000A DE4123000A1 (en) 1991-07-11 1991-07-11 METHOD FOR PRODUCING STARCHESTERS FOR CLINICAL, IN PARTICULAR PARENTERAL APPLICATION
PCT/EP1992/001553 WO1993001217A1 (en) 1991-07-11 1992-07-09 Method of preparing starch esters for clinical, in particular parenteral, applications

Publications (2)

Publication Number Publication Date
AU2277592A true AU2277592A (en) 1993-02-11
AU656014B2 AU656014B2 (en) 1995-01-19

Family

ID=6435928

Family Applications (1)

Application Number Title Priority Date Filing Date
AU22775/92A Ceased AU656014B2 (en) 1991-07-11 1992-07-09 Method of preparing starch esters for clinical, in particular parenteral, applications

Country Status (17)

Country Link
EP (1) EP0593605B1 (en)
JP (1) JPH06511506A (en)
AT (1) ATE160576T1 (en)
AU (1) AU656014B2 (en)
CA (1) CA2113162A1 (en)
CZ (1) CZ5994A3 (en)
DE (2) DE4123000A1 (en)
DK (1) DK0593605T3 (en)
ES (1) ES2112323T3 (en)
FI (1) FI940097A7 (en)
GR (1) GR3025927T3 (en)
HU (1) HUT72587A (en)
PL (1) PL170733B1 (en)
PT (1) PT100679B (en)
RU (1) RU2093522C1 (en)
SK (1) SK279878B6 (en)
WO (1) WO1993001217A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU657785B2 (en) * 1991-07-11 1995-03-23 Laevosan-Gesellschaft Mbh Pharmaceutical preparation for peritoneal dialysis

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4122999A1 (en) * 1991-07-11 1993-01-14 Laevosan Gmbh & Co Kg METABOLIZABLE PLASMA REPLACEMENT
DE4242926C2 (en) 1992-12-18 1994-12-15 Fresenius Ag Dialysis solution for peritoneal dialysis
FI942686A0 (en) * 1994-06-07 1994-06-07 Alko Ab Oy Composition of the starch acetate with a variety of compounds, for the production and distribution
DE4442605A1 (en) * 1994-11-30 1996-06-05 Degussa Swellable starch ester, process for its production and use
DE4442606C2 (en) * 1994-11-30 1998-09-17 Degussa Swellable starch ester, process for its production and use
RU2136293C1 (en) * 1998-08-04 1999-09-10 Открытое акционерное общество "Биохимик" Method of blood plasma substituent preparing
DE10256558A1 (en) * 2002-12-04 2004-09-16 Supramol Parenteral Colloids Gmbh Esters of polysaccharide aldonic acids, process for their preparation and use for coupling to active pharmaceutical ingredients
US7772391B2 (en) * 2005-06-16 2010-08-10 The Procter & Gamble Company Ethersuccinylated hydroxyl polymers
DE102010012183A1 (en) * 2010-03-19 2011-09-22 Fresenius Medical Care Deutschland Gmbh Esterified polysaccharide osmotica
WO2016137751A1 (en) * 2015-02-24 2016-09-01 The Procter & Gamble Company Process for molecular weight reduction of ethersuccinylated polysaccharides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2362282A (en) * 1942-09-12 1944-11-07 Wesley N Lindsay Method of acetylating starch
US2363382A (en) * 1943-08-27 1944-11-21 Charles W Attwood Scaffolding
US3639389A (en) * 1968-05-15 1972-02-01 Cpc International Inc Low d.e. starch hydrolysate derivatives
GB1476057A (en) * 1975-03-20 1977-06-10 Unicliffe Ltd Throat pastilles

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU657785B2 (en) * 1991-07-11 1995-03-23 Laevosan-Gesellschaft Mbh Pharmaceutical preparation for peritoneal dialysis

Also Published As

Publication number Publication date
CZ5994A3 (en) 1994-07-13
ES2112323T3 (en) 1998-04-01
HUT72587A (en) 1996-05-28
FI940097L (en) 1994-01-10
GR3025927T3 (en) 1998-04-30
FI940097A0 (en) 1994-01-10
FI940097A7 (en) 1994-01-10
EP0593605A1 (en) 1994-04-27
AU656014B2 (en) 1995-01-19
ATE160576T1 (en) 1997-12-15
RU2093522C1 (en) 1997-10-20
DE59209043D1 (en) 1998-01-08
WO1993001217A1 (en) 1993-01-21
PL170733B1 (en) 1997-01-31
DK0593605T3 (en) 1998-08-10
CA2113162A1 (en) 1993-01-21
HU9400064D0 (en) 1994-05-30
PT100679A (en) 1993-09-30
PT100679B (en) 1999-09-30
DE4123000A1 (en) 1993-01-14
SK2394A3 (en) 1994-08-10
SK279878B6 (en) 1999-05-07
EP0593605B1 (en) 1997-11-26
JPH06511506A (en) 1994-12-22

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired