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AU2149397A - Method for producing epothilones, and intermediate products obtained during the production process - Google Patents

Method for producing epothilones, and intermediate products obtained during the production process

Info

Publication number
AU2149397A
AU2149397A AU21493/97A AU2149397A AU2149397A AU 2149397 A AU2149397 A AU 2149397A AU 21493/97 A AU21493/97 A AU 21493/97A AU 2149397 A AU2149397 A AU 2149397A AU 2149397 A AU2149397 A AU 2149397A
Authority
AU
Australia
Prior art keywords
production process
obtained during
products obtained
intermediate products
producing epothilones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU21493/97A
Other versions
AU716610B2 (en
Inventor
Armin Bauer
Oliver M. Bohm
Martin Cordes
Anja Limberg
Dieter Schinzer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19636343A external-priority patent/DE19636343C1/en
Priority claimed from DE19645361A external-priority patent/DE19645361A1/en
Priority claimed from DE19645362A external-priority patent/DE19645362A1/en
Application filed by Novartis AG filed Critical Novartis AG
Publication of AU2149397A publication Critical patent/AU2149397A/en
Application granted granted Critical
Publication of AU716610B2 publication Critical patent/AU716610B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU21493/97A 1996-08-30 1997-01-15 Method for producing epothilones, and intermediate products obtained during the production process Ceased AU716610B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
DE19636343 1996-08-30
DE19636343A DE19636343C1 (en) 1996-08-30 1996-08-30 New (di:methyl)-dioxanyl-methyl-pentanone and related compounds
DE19645361 1996-10-28
DE19645361A DE19645361A1 (en) 1996-08-30 1996-10-28 Production of epothilone compounds with taxol-like activity
DE19645362A DE19645362A1 (en) 1996-10-28 1996-10-28 Production of epothilone compounds with taxol-like activity
DE19645362 1996-10-28
PCT/DE1997/000111 WO1998008849A1 (en) 1996-08-30 1997-01-15 Method for producing epothilones, and intermediate products obtained during the production process

Publications (2)

Publication Number Publication Date
AU2149397A true AU2149397A (en) 1998-03-19
AU716610B2 AU716610B2 (en) 2000-03-02

Family

ID=27216622

Family Applications (1)

Application Number Title Priority Date Filing Date
AU21493/97A Ceased AU716610B2 (en) 1996-08-30 1997-01-15 Method for producing epothilones, and intermediate products obtained during the production process

Country Status (5)

Country Link
EP (1) EP0923583A1 (en)
JP (1) JP2001500851A (en)
AU (1) AU716610B2 (en)
NZ (1) NZ334821A (en)
WO (1) WO1998008849A1 (en)

Families Citing this family (149)

* Cited by examiner, † Cited by third party
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