AU2024232987A1

AU2024232987A1 - Suspension concentrates of phthalimide fungicides

Info

Publication number: AU2024232987A1
Application number: AU2024232987A
Authority: AU
Inventors: Viacheslav FIRER SLAVA; Diana POLIAK
Original assignee: Adama Makhteshim Ltd
Current assignee: Adama Makhteshim Ltd
Priority date: 2023-03-09
Filing date: 2024-03-07
Publication date: 2025-09-18
Also published as: WO2024184886A1; EP4676224A1; CO2025013019A2; MX2025010582A; CN120835749A

Abstract

The invention provides an agrochemical suspension concentrate composition comprising i) an amount of phthalimide fungicide, ii) an amount of a co-fungicide, iii) stabilization system comprising: a) anionic aromatic surfactant; b) non-ionic aromatic surfactant; c) pH modifier, and iv) optionally, an adjuvant.

Description

TITLE: SUSPENSION CONCENTRATES OF PHTHALIMIDE FUNGICIDES

FIELD OF INVENTION:

The present invention is related to chemically and physically stable suspension concentrate composition having increased efficacy against fungal pathogens, comprising: i) phthalimide fungicide, ii) an additional co-fungicide, iii) stabilization system, comprising: a) anionic aromatic surfactant; b) non-ionic aromatic surfactant; c) pH modifier, iv) optionally, an adjuvant. In addition, the present invention referred to a combination of at least one phthalimide fungicide with alkyl polyglucoside adjuvants of formula (I) and to the use of said adjuvants for increasing the efficacy of one or more phthalimide fungicides.

BACKGROUND:

Phthalimide fungicides belong to the class of organic multisite inhibitors and display a broad spectrum of antifungal activity. The list of currently used phthalimide fungicides include captan, folpet, captafol and thiochlorfenphim, which are hardly soluble in water and commercialized mostly as suspension concentrates and solid dispersible (WG) compositions. In addition, phthalimide fungicides are considered as a group of generally low risk of resistance. Therefore, combinations of phthalimide fungicide with other groups of fungicides suggested as very effective for controlling various pathogens on different crops. However, phthalimide fungicides are known to be sensitive to different parameters and mostly commercialized as solo compositions.

In light of the above, there is still a need for novel chemically and physically stable composition comprising phthalimide fungicide and additional co-fungicide.

SUMMARY:

The present invention provides an agrochemical suspension concentrate composition comprising: i) an amount of phthalimide fungicide ii) an amount of a co-fungicide iii) stabilization system comprising: a) anionic aromatic surfactant; b) non-ionic aromatic surfactant; c) pH modifier. iv) optionally, an adjuvant.

In addition, the present invention provides an agrochemical suspension concentrate composition comprising: i) an amount of phthalimide fungicide ii) an amount of a co-fungicide iii) stabilization system comprising: a) anionic aromatic surfactant; b) non-ionic aromatic surfactant; c) pH modifier. iv) an adjuvant.

In particular, the present invention provides an agrochemical suspension concentrate composition comprising from 1 % to 70% per weight based on the total weight of the composition of phthalimide fungicide selected from captan, folpet, captafol and thiochlorfenphim and the mixtures thereof; from 1 % to 30% per weight based on the total weight of the composition of co-fungicide selected from fluopicolide, fluopimomide, fluopyram, trichlamide, zoxamide and the mixtures thereof; a stabilization system comprising: a) from 0.1 % to 10% per weight of anionic aromatic surfactant; b) from 0.1 % to 10% per weight non-ionic aromatic surfactant; c) from 1% to 10% of pH modifier, based on the weight of total composition and optionally, an adjuvant.

The present invention further provides an agrochemical suspension concentrate composition comprising from 1 % to 70% per weight based on the total weight of the composition of phthalimide fungicide selected from captan, folpet, captafol and thiochlorfenphim and the mixtures thereof; from 1 % to 30% per weight based on the total weight of the composition of co-fungicide selected from fluopicolide, fluopimomide, fluopyram, trichlamide, zoxamide and the mixtures thereof; a stabilization system comprising: a) from 0.1 % to 10% per weight of anionic aromatic surfactant; b) from 0.1 % to 10% per weight non-ionic aromatic surfactant; c) from 1% to 10% of pH modifier, and from 1% to 20% per weight of adjuvant, based on the weight of total composition.

In addition, the present invention provides a method of use of an adjuvant of formula

(I)

(I) wherein Pyr is pyranose unit; x is 1-50; R is C8-C11 alkyl, for increasing the efficacy of one or more phthalimide fungicides in controlling and/or preventing phytopathogenic harmful fungi in a locus where the phytopathogenic harmful fungi is to be controlled.

Another aspect of the present invention provides a method of treating plants or plants parts with a combination of one or more phthalimide fungicides selected from captan, folpet, captafol and thiochlorfenphim with an adjuvant of Formula (I):

(I) wherein Pyr is pyranose unit; x is 1-50; R is C8-C11 alkyl, in a locus where the phytopathogenic harmful fungi is to be controlled.

SUBSTITUTE SHEET (RULE 26) The present invention is further directed to a method for controlling and/or preventing phytopathogenic harmful fungi comprising applying an effective amount of the composition disclosed herein to a locus where the phytopathogenic harmful fungi is to be controlled.

DESCRIPTION:

Definitions:

Prior to setting forth the present subject matter in detail, it may be helpful to provide definitions of certain terms to be used herein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as is commonly understood by one of skill in the art to which this subject matter pertains.

Reference will now be made in detail to embodiments, examples of which are illustrated in the accompanying drawings, wherein like reference numerals refer to like elements throughout. In this regard, the present embodiments may have different forms and should not be construed as being limited to the descriptions set forth herein. Accordingly, the embodiments are merely described below to explain aspects of the present disclosure.

As used herein, the term "pesticide" broadly refers to an agent that can be used to control and/or kill a pest. The term is understood to include but is not limited to fungicides, insecticides, nematicides, herbicides, acaricides, parasiticides or other control agents. For chemical classes and applications, as well as specific compounds of each class, see "The Pesticide Manual Thirteenth Edition" (British Crop Protection Council, Hampshire, UK, 2003), as well as "The e-Pesticide Manual, Version 3" (British Crop Protection Council, Hampshire, UK, 2003-04), the contents of each of which are incorporated herein by reference in their entirety.

As used herein, the term "fungicide" broadly refers to an agent that controls fungal disease by specifically inhibiting or killing the fungus causing the disease. As used herein, the term "effective amount" refers to an amount of the active component that is commercially recommended for use to control fungi. The commercially recommended amount for each active component, often specified as application rates of the commercial formulation, may be found on the label accompanying the commercial formulation. The commercially recommended application rates of the commercial formulation may vary depending on factors such as the plant species and the fungus to be controlled.

As used herein, the term "adjuvant" is defined as any substance that is not an active ingredient but which enhances or is intended to enhance the effectiveness of the active ingredient, for example pesticide, with which it is used. Adjuvants may include, but are not limited to, spreading agents, penetrants, compatibility agents, and drift retardants.

As used herein, the term "treating a plant or soil against fungal infection" includes, but is not limited to, protecting the plant or soil against fungal attack, preventing fungal infection of the plant or soil, controlling fungal disease infecting the plant or soil, and reducing fungal infection of the plant or soil.

As used herein the term "plant" or "crop" includes reference to agricultural crops including field crops (soybean, maize, wheat, rice, etc.), vegetable crops (potatoes, cabbages, etc.), fruits (peach, etc.), semi-perennial crops (sugarcane) and perennial crops (coffee and guava).

As used herein the term "plant" or "crop" includes reference to whole plants, plant organs (e.g. leaves, stems, twigs, roots, trunks, limbs, shoots, fruits etc.), plant cells, seedling or plant seeds. This term also encompasses plant crops such as fruits.

The term "plant" may also include the propagation material thereof, which may include all the generative parts of the plant such as seeds and vegetative plant material such as cuttings and tubers, which can be used for the multiplication of the plant. It may also include spores, corms, bulbs, rhizomes, sprouts, basal shoots, stolons, and buds and other parts of plants, including seedlings and young plants, which are to be transplanted after germination, rooting or after emergence from soil or any other kind of substrate, be it artificial or natural.

As used herein the term "propagation material" is to be understood to denote all the generative parts of the plant such as seeds and spores, vegetative structures such as bulbs, corms, tubers, rhizomes, roots stems, basal shoots, stolons and buds.

As used herein, the term "locus" includes not only areas where fungal infection/disease may already be shown, but also areas where fungal infection/disease have yet to show and also area under cultivation. "Locus" includes but is not limited to soil and other plant growth medium.

As used herein, the term "locus" includes a habitat, breeding ground, plant, propagation material, soil, area, material or environment in which a fungal disease is growing or may grow.

As used herein, the terms "control" or "controlling" or "treating" refers but is not limited to preventing fungal disease, protecting plants from fungal disease, delaying the onset of fungal disease, and combating or killingfungal disease. They also may include the curative and/or eradication action of compounds and compositions on underway fungal diseases. Controlling fungal disease infecting the plant, propagation material of the plant or locus of the plant, controlling a plant or soil disease caused by phytopathologic fungi (pathogen), controlling fungal attack on the plant or, propagation material of the plant or locus of the plant refers to curative application and/or protectant/preventive application and/or persistence application.

The term "applying" or "application", as used herein, refers but is not limited to applying the compounds and compositions of the invention to the plant, to a site of infestation by fungi, to a potential site of infestation by the fungi, which may require protection from infestation, or the environment around the habitat or potential habitat of the fungi. It also refers to the activity of compounds and compositions on plants and fungal tissues with which they come into contact. The application may be by methods described in the present invention such as by spraying, dipping, etc. Throughout the application, descriptions of various embodiments the term "comprising" is used; however, it will be understood by one of skill in the art, that in some specific instances, an embodiment can alternatively be described using the language "consisting essentially of" or "consisting of." The term "a" or "an" as used herein includes the singular and the plural, unless specifically stated otherwise. Therefore, the terms "a," "an" or "at least one" can be used interchangeably in this application.

Accordingly, unless indicated to the contrary, the numerical parameters set forth in the following specification and attached claims are approximations that may vary depending upon the desired properties sought to be obtained. At the very least, each numerical parameter should at least be construed in light of the number of reported significant digits and by applying ordinary rounding techniques.

In this regard, use of the term "about" herein specifically includes ±10% from the indicated values in the range. In addition, the endpoints of all ranges directed to the same component or property herein are inclusive of the endpoints, are independently combinable, and include all intermediate points and ranges.

Without further elaboration, it is supposed that one skilled in the art will be able to exploit the present disclosure to its fullest extent using the preceding description.

The matter of invention:

The present invention is related to an agrochemical suspension concentrate composition comprising: i) an amount of phthalimide fungicide ii) an amount of a co-fungicide iii) stabilization system comprising: a) anionic aromatic surfactant; b) non-ionic aromatic surfactant; c) pH modifier iv) water. In an embodiment, the amount of phthalimide fungicide in the agrochemical suspension concentrate composition is from 1 % to 70% per weight based on the total weight of the composition.

In another embodiment, the amount of phthalimide fungicide in the agrochemical suspension concentrate composition is from 25 % to 50% per weight based on the total weight of the composition.

In an embodiment, the amount of a co-fungicide in the agrochemical suspension concentrate composition is from 1 % to 30% per weight based on the total weight of the composition.

In another embodiment, the amount of a co-fungicide fungicide in the agrochemical suspension concentrate composition is from 1 % to 20% per weight based on the total weight of the composition.

In another embodiment, the amount of a co-fungicide fungicide in the agrochemical suspension concentrate composition is from 1 % to 15% per weight based on the total weight of the composition.

In another embodiment, the amount of a co-fungicide fungicide in the agrochemical suspension concentrate composition is from 1 % to 5% per weight based on the total weight of the composition.

In an embodiment, the present invention provides an agrochemical suspension concentrate composition, wherein the phthalimide fungicide is selected from captan, folpet, captafol and thiochlorfenphim and the mixtures thereof.

In another embodiment, the phthalimide fungicide is captan.

In an embodiment, the present invention provides an agrochemical suspension concentrate composition, wherein the co-fungicide is selected from fluopicolide, fluopimomide, fluopyram, trichlamide, zoxamide and the mixtures thereof.

In an embodiment, the co-fungicide is fluopicolide. In yet another embodiment, the agrochemical suspension concentrate composition disclosed herein comprises stabilization system, comprising: i) from 0.1 % to 10% per weight of anionic aromatic surfactant; ii) from 0.1 % to 10% per weight non-ionic aromatic surfactant; iii) from 1% to 10% of pH modifier, based on the weight of total composition.

In yet another embodiment, the agrochemical suspension concentrate composition disclosed herein comprises stabilization system, comprising: i) from 0.1 % to 5% per weight of anionic aromatic surfactant; ii) from 0.1 % to 10% per weight non-ionic aromatic surfactant; iii) from 1% to 10% of pH modifier, based on the weight of total composition.

In yet another embodiment, the agrochemical suspension concentrate composition disclosed herein comprises stabilization system, comprising: i) from 0.1 % to 5% per weight of anionic aromatic surfactant; ii) from 0.1 % to 5% per weight non-ionic aromatic surfactant; iii) from 1% to 10% of pH modifier, based on the weight of total composition.

In an embodiment, the stabilization system comprising: a) from 0.5 % to 2% per weight of anionic aromatic surfactant; b) from 0.5 % to 2% per weight non-ionic aromatic surfactant; c) from 1% to 10% of pH modifier, based on the weight of total composition.

In another embodiment, the stabilization system comprising: a) from 0.5 % to 2% per weight of anionic aromatic surfactant; b) from 0.5 % to 2% per weight non-ionic aromatic surfactant; c) from 2% to 5% of pH modifier, based on the weight of total composition.

In an embodiment, the present invention provides agrochemical suspension concentrate composition comprising pH modifier, which is a mixture of C2-C6 carboxylic acid and C2-C6 carboxylic acid salt.

In an embodiment, the weight ratio of C2-C6 carboxylic acid and C2-C6 carboxylic acid salt is from 1:3 to 1:6.

In an embodiment, the weight ratio of C2-C6 carboxylic acid and C2-C6 carboxylic acid salt is from 1:5 to 1:6. The non-limiting examples of C2-C6 carboxylic acid and C2-C6 carboxylic acid salt include acetic acid, propionic acid, butyric acid, citric acid, and the corresponding sodium, potassium and ammonium salts.

In an embodiment, the pH modifier comprising a mixture of acetic acid and acetic acid sodium, potassium or ammonium salt.

In another embodiment, the pH modifier comprising a mixture of citric acid and citric acid sodium, potassium or ammonium salt.

In an embodiment, the pH of the agrochemical suspension concentrate composition provided by the present invention is between 3 and 6.

In yet another embodiment, the present invention provides an agrochemical suspension concentrate composition, wherein the aromatic anionic surfactant is selected from the group of polyarylether phosphates, polyarylether sulfates, the corresponding sodium, potassium, and ammonium salts and the mixtures thereof.

In an embodiment, the aromatic anionic surfactant is selected from the group of alkoxylated styrylphenol phosphates, alkoxylated styrylphenol sulfates, the corresponding sodium, potassium and ammonium salts and the mixtures thereof.

In an embodiment, the amount of the aromatic anionic surfactant is from 0.1% to 0.5% per weight of total composition.

In an embodiment, the amount of the aromatic anionic surfactant is from 0.5% to 1% per weight of total composition.

In an embodiment, the amount of the aromatic anionic surfactant is from 1% to 2% per weight of total composition.

In an embodiment, the amount of the aromatic anionic surfactant is from 2% to 3% per weight of total composition.

In an embodiment, the amount of the aromatic anionic surfactant is from 3% to 4% per weight of total composition. In an embodiment, the amount of the aromatic anionic surfactant is from 4% to 6% per weight of total composition.

In an embodiment, the amount of the aromatic anionic surfactant is from 6% to 10% per weight of total composition.

In yet another embodiment, the present invention provides an agrochemical suspension concentrate composition, wherein the aromatic non-ionic surfactant is selected from the group of alkylphenol polyethylene glycol ethers, alkylphenol polyethylene glycol polypropylene glycol ethers and the mixtures thereof.

In an embodiment, the amount of the aromatic non-ionic surfactant is from 0.1% to 0.5% per weight of total composition.

In an embodiment, the amount of the aromatic non-ionic surfactant is from 0.5% to 1% per weight of total composition.

In an embodiment, the amount of the aromatic non-ionic surfactant is from 1% to 2% per weight of total composition.

In an embodiment, the amount of the aromatic non-ionic surfactant is from 2% to 3% per weight of total composition.

In an embodiment, the amount of the aromatic non-ionic surfactant is from 3% to 4% per weight of total composition.

In an embodiment, the amount of the aromatic non-ionic surfactant is from 4% to 6% per weight of total composition.

In an embodiment, the amount of the aromatic non-ionic surfactant is from 4% to 10% per weight of total composition.

In an embodiment, the weight ratio of the anionic aromatic surfactant and non-ionic aromatic surfactant is from 100: 1 to 1:100. In an embodiment, the weight ratio of the anionic aromatic surfactant and non-ionic aromatic surfactant is from 50: 1 to 1:50.

In an embodiment, the weight ratio of the anionic aromatic surfactant and non-ionic aromatic surfactant is from 25: 1 to 1:25.

In an embodiment, the weight ratio of the anionic aromatic surfactant and non-ionic aromatic surfactant is from 20: 1 to 1:20.

In an embodiment, the weight ratio of the anionic aromatic surfactant and non-ionic aromatic surfactant is from 15: 1 to 1:15.

In an embodiment, the weight ratio of the anionic aromatic surfactant and non-ionic aromatic surfactant is from 10: 1 to 1:10.

In an embodiment, the weight ratio of the anionic aromatic surfactant and non-ionic aromatic surfactant is from 8: 1 to 1:8.

In an embodiment, the weight ratio of the anionic aromatic surfactant and non-ionic aromatic surfactant is from 6: 1 to 1:6.

In an embodiment, the weight ratio of the anionic aromatic surfactant and non-ionic aromatic surfactant is from 5: 1 to 1:5.

In an embodiment, the weight ratio of the anionic aromatic surfactant and non-ionic aromatic surfactant is from 3: 1 to 1:3.

In an embodiment, the weight ratio of the anionic aromatic surfactant and non-ionic aromatic surfactant is from 2: 1 to 1:2.

In an embodiment, the weight ratio of the anionic aromatic surfactant and non-ionic aromatic surfactant is from 1.5: 1 to 1:1.5.

In an embodiment, the weight ratio of the anionic aromatic surfactant and non-ionic aromatic surfactant is 1:1. In yet another embodiment, the present invention provides an agrochemical suspension concentrate composition, wherein the amount of water in the composition is between about 20 % to about 90% per weight based on the total weight of the composition.

In an embodiment, the present invention provides an agrochemical suspension concentrate composition, wherein the weight ratio between the anionic surfactant and phthalimide fungicide is from 0.1:70 to 10:1.

In an embodiment, the weight ratio between the anionic aromatic surfactant and phthalimide fungicide is from 1:40 to 1:5.

In an embodiment, the weight ratio between the anionic aromatic surfactant and phthalimide fungicide is from 1:30 to 1:5.

In an embodiment, the weight ratio between the anionic aromatic surfactant and phthalimide fungicide is from 1:25 to 1:5.

In an embodiment, the weight ratio between the anionic aromatic surfactant and phthalimide fungicide is from 1:20 to 1:5.

In an embodiment, the weight ratio between the anionic aromatic surfactant and phthalimide fungicide is from 1:15 to 1:5.

In an embodiment, the weight ratio between the anionic aromatic surfactant and phthalimide fungicide is from 1:10 to 1:5.

In an embodiment, the present invention provides an agrochemical suspension concentrate composition, wherein the weight ratio between the non-ionic aromatic surfactant and phthalimide fungicide is from 0.1:70 to 10:1.

In an embodiment, the weight ratio between the non-ionic aromatic surfactant and phthalimide fungicide is from 1:40 to 1:5. In an embodiment, the weight ratio between the non-ionic aromatic surfactant and phthalimide fungicide is from 1:30 to 1:5.

In an embodiment, the weight ratio between the non-ionic aromatic surfactant and phthalimide fungicide is from 1:25 to 1:5.

In an embodiment, the weight ratio between the non-ionic aromatic surfactant and phthalimide fungicide is from 1:20 to 1:5.

In an embodiment, the weight ratio between the non-ionic aromatic surfactant and phthalimide fungicide is from 1:15 to 1:5.

In an embodiment, the weight ratio between the non-ionic aromatic surfactant and phthalimide fungicide is from 1:10 to 1:5.

In an embodiment, the weight ratio between the anionic aromatic surfactant and the cofungicide is from 0.1:30 to 10:1.

In an embodiment, the weight ratio between the non-ionic aromatic surfactant and the co-fungicide fungicide is from 0.1:30 to 10:1.

In an embodiment, the agrochemical suspension concentrate composition disclosed herein optionally comprises an adjuvant.

In another embodiment, the agrochemical suspension concentrate composition disclosed herein comprises an adjuvant.

In an embodiment, the amount of an adjuvant is from 1% to 20 % per weight of total composition.

In an embodiment, the amount of an adjuvant is from 5% to 15 % per weight of total composition.

In an embodiment, the adjuvant is at least one compound of Formula (I):

(I) wherein Pyr is pyranose unit; x is 1-50; R is C8-C11 alkyl.

The term "pyranose unit" as used herein referred to a six-membered sugar ring structure consisting of five carbon atoms and one oxygen atom.

In an embodiment, the weight ratio between the adjuvant and phthalimide fungicide is from 1:70 to 20:1.

In an embodiment, the weight ratio between the adjuvant and phthalimide fungicide is from 1:1 to 1:50.

In an embodiment, the weight ratio between the adjuvant and phthalimide fungicide is from 1:1 to 1:40.

In an embodiment, the weight ratio between the adjuvant and phthalimide fungicide is from 1:1 to 1:30.

In an embodiment, the weight ratio between the adjuvant and phthalimide fungicide is from 1:1 to 1:20.

In an embodiment, the weight ratio between the adjuvant and phthalimide fungicide is from 1:1 to 1:10.

In an embodiment, the weight ratio between the adjuvant and phthalimide fungicide is from 1:1 to 1:8.

In an embodiment, the weight ratio between the adjuvant and phthalimide fungicide is from 1:1 to 1:5.

SUBSTITUTE SHEET (RULE 26) In an embodiment, the agrochemical suspension concentrate compositions disclosed herein may comprise further additives such as surfactants, preservatives, antifreeze, defoamers, wetting agents and/or rheological modifiers. Suitable substances are all of those which can typically be used for this purpose in agrochemicals.

In some embodiments, the surfactant additive is selected from the group consisting of polyglycol ethers, polyalkylene oxide block copolymers, ethoxylated fatty alcohols, castor oil ethoxylates, polyether modified trisiloxanes, methyl methacrylate - polyethylene glycol graft copolymers, condensates of alkyl naphthalene sulfonate formaldehyde, lignosulfonates, silicone surfactants, polyelectrolyte block copolymers (as described in WO2017/098325), and any combination thereof.

In some embodiments, same surfactant may function in different roles (wetting, emulsifier, dispersing agent).

Another aspect of the present invention provides a method of use of an adjuvant of formula (I)

SUBSTITUTE SHEET (RULE 26) The present invention further provides a method of treating plants or plants parts with a combination of one or more phthalimide fungicides selected from captan, folpet, captafol and thiochlorfenphim with an adjuvant of Formula (I):

In an embodiment, the adjuvant is C8-C10 alkyl polyglucoside (CAS 68515-73-1), C9-C11 alkyl polyglucoside (CAS 132778-08-6) and the mixtures thereof.

The present invention further provides a method for controlling and/or preventing phytopathogenic harmful fungi comprising applying an effective amount of the agrochemical suspension concentrate composition disclosed herein to a locus where the phytopathogenic harmful fungi is to be controlled.

Non-limiting examples of pathogens of fungal diseases which may be treated in accordance with the invention include: diseases caused by powdery mildew pathogens, for example Blumeria species, for example Blumeria graminis, Podosphaera species, for example Podosphaera leucotricha, Sphaerotheca species, for example Sphaerotheca fuliginea, Uncinula species, for example Uncinula necator, for example Erysiphe species; diseases caused by rust disease pathogens, for example Gymnosporangium species, for example Gymnosporangium sabinae ; Hemileia species, for example Hemileia vastatrix; Phakopsora species, for example Phakopsora pachyrhizi or Phakopsora meibomiae Puccinia species, for example Puccinia recondita, Puccinia graminis oder Puccinia striif ormis, Uromyces species, for example Uromyces app endiculatus, diseases caused by

SUBSTITUTE SHEET (RULE 26) pathogens from the group of the Oomycetes, for example Albugo species, for example Albugo Candida , Bremia species, for example Bremia laciucaer, Peronospora species, for example Peronospora pisi or P. brassicaer, Phytophthora species, for example Phytophthora inf estans, Plasmopara species, for example Plasmopara viticola, Pseudoperonospora species, for example Pseudoperonospora humuli or Pseudoperonospora cubensis, Pythium species, for example Pythium ultimunv, leaf blotch diseases and leaf wilt diseases caused, for example, by Alternaria species, for example Alternaria solanv, Cercospora species, for example Cercospora beticola, Cladiosporium species, for example Cladiosporium cucumerinunr, Cochliobolus species, for example Cochliobolus sativus (conidial form: Drechslera, syn: Helminthosporium) or Cochliobolus miyabeanus, Colletotrichum species, for example Colletotrichum lindemuthaniunv, Corynespora species, for example Corynespora cassiicola, Cycloconium species, for example Cycloconium oleaginunv, Diaporthe species, for example Diaporthe citrv, Elsinoe species, for example Elsinoe f awcettii, Gloeosporium species, for example Gloeosporium laeticolor, Glomerella species, for example Glomerella cingulata, Guignardia species, for example Guignardia bidwellv, Leptosphaeria species, for example Leptosphaeria maculans, Magnaporthe species, for example Magnaporthe grisea, Microdochium species, for example Microdochium nivaler, Mycosphaerella species, for example Mycosphaerella graminicola (also known as Septoria tritici), Mycosphaerella arachidicola or Mycosphaerella fijiens, Phaeosphaeria species, for example Phaeosphaeria nodorunr, Pyrenophora species, for example Pyrenophora teres or Pyrenophora tritici repenth , Ramularia species, for example Ramularia collo-cygni or Ramularia areola, Rhynchosporium species, for example Rhynchosporium secalis, Septoria species, for example Septoria apii or Septoria lycopersicv, Stagonospora species, for example Stagonospora nodorunr, Typhula species, for example Typhula incarnata, Venturia species, for example Venturia inaequal, root and stem diseases caused, for example, by Corticium species, for example Corticium graminearum, Fusarium species, for example Fusarium oxysporum\Gaeumannomyces species, for example Gaeumannomyces graminis, Plasmodiophora species, for example Plasmodiophora brassica, Rhizoctonia species, for example Rhizoctonia solani, Sarocladium species, for example Sarocladium oryzae; Sclerotium species, for example Sclerotium oryzae, Tapesia species, for example Tapesia acuf ormis, Thielaviopsis species, for example Thielaviopsis basicola, ear and panicle diseases (including com cobs) caused, for example, by Alternaria species, for example Alternaria spp.; Aspergillus species, for example Aspergillus flavus, Cladosporium species, for example Cladosporium cladosporioides, Claviceps species, for example Claviceps purpurea, Fusarium species, for example Fusarium culmorunr, Gibberella species, for example Gibberella zeae Monographella species, for example Monographella nivalis, Stagnospora species, for example Stagnospora nodorunr, diseases caused by smut fungi, for example Sphacelotheca species, for example Sphacelotheca reiliana, Tilletia species, for example Tilletia caries or Tilletia controversy, Urocystis species, for example Urocystis occulta, Ustilago species, for example Ustilago nuda, fruit rot caused, for example, by Aspergillus species, for example Aspergillus flavus, Botrytis species, for example Botrytis cinerea, Monilinia species, for example Monilinia lotxa, Penicillium species, for example Penicillium expansum or Penicillium purpurogenum, Rhizopus species, for example Rhizopus stolonifer, Sclerotinia species, for example Sclerotinia sclerotiorum, Verticilium species, for example Verticilium alboatrum, seed- and soil-bome rot and wilt diseases, and also diseases of seedlings, caused, for example, by Alternaria species, for example Alternaria brasside ola Aphanomyces species, for example Aphanomyces euteiches, Ascochyta species, for example Ascochyta lends, Aspergillus species, or example Aspergillus flavus, Cladosporium species, for example Cladosporium herbarum, Cochliobolus species, for example Cochliobolus sativus (conidial form: Drechslera, Bipolaris Syn: Helminthosp orium), Colletotrichum species, for example Colletotrichum coccodes, Fusarium species, for example Fusarium culmorum, Gibberella species, for example Gibberella zeae Macrophomina species, for example Macrophomina p haseolina, Microdochium species, for example Microdochium nivale , Monographella species, for example Monographella nivalis, Penicillium species, for example Penicillium expansum, Phoma species, for example Phoma lingam, Phomopsis species, for example Phomopsis so ae Phytophthora species, for example Phytophthora cactorum, Pyrenophora species, for example Pyrenophora graminea, Pyricularia species, for example Pyricularia oryzac, Pythium species, for example Pythium ultimum, Rhizoctonia species, for example Rhizoctonia solanv, Rhizopus species, for example Rhizopus oryzae; Sclerotium species, for example Sclerotium rolfsii, Septoria species, for example Septoria nodorum, Typhula species, for example Typhula incarnata, Verticillium species, for example Verticillium dahliae, cancers, galls and witches' broom caused, for example, by Nectria species, for example Nectria galligena, wilt diseases caused, for example, by Verticillium species, for example Verticillium longisporunr, Fusarium species, for example Fusarium oxysporurrv, deformations of leaves, flowers and fruits caused, for example, by Exobasidium species, for example Exobasidium vexans, Taphrina species, for example Taphrina deformans, degenerative diseases in woody plants, caused, for example, by Esca species, for example Phaeomoniella chlamydospora, Phaeoacremonium aleophilum or Fomitiporiamediterranean Ganoderma species, for example Ganoderma boninense, diseases of plant tubers caused, for example, by Rhizoctonia species, for example Rhizoctonia solanv, Helminthosporium species, for example Helminthosporium solanv, diseases caused by bacterial pathogens, for example Xanthomonas species, for example Xanthomonas campestris pv. oryzae, Pseudomonas species, for example Pseudomonas syringae pv. lachrymans, Erwinia species, for example Erwinia amylovora, Liberibacter species, for example Liberibacter asiaticus, Xyella species, for example Xylella f astidiosa, Ralstonia species, for example Ralstonia solanacearum, Dickeya species, for example Dickeya solanv, Clavibacter species, for example Clavibacter michiganensis, Streptomyces species, for example Streptomyces scabies, diseases of soya beans: fungal diseases on leaves, stems, pods and seeds caused, for example, by Alternaria leaf spot (Alternaria spec atrans tenuissima), Anthracnose (Colletotrichum gloeosporoides dematium var. truncatum), brown spot (Septoria glycines), cercospora leaf spot and blight (Cercospora kikuchii), choanephora leaf blight (Choanephora infundibulifera trispora (Syn.j), dactuliophora leaf spot (Dactuliophora glycines), downy mildew (Peronospora manshurica), drechslera blight (Drechslera glycini), frogeye leaf spot (Cercospora sojina), leptosphaerulina leaf spot (Leptosphaerulina trifolii), phyllostica leaf spot (Phyllosticta sojaecola), pod and stem blight (Phomopsis sojae), powdery mildew (Microsphaera diffusa), pyrenochaeta leaf spot (Pyrenochaeta glycines), rhizoctonia aerial, foliage, and web blight (Rhizoctonia solani), mst (Phakopsora pachyrhizi, Phakopsora meibomiae), scab (Sphaceloma glycines), stemphylium leaf blight (Stemphylium botryosum), sudden death syndrome (Fusarium virguliforme), target spot (Corynespora cassiicola). Fungal diseases on roots and the stem base caused, for example, by black root rot (Calonectria crotalariae), charcoal rot (Macrophomina phaseolina), fusarium blight or wilt, root rot, and pod and collar rot (Fusarium oxysporum, Fusarium orthoceras, Fusarium semitectum, Fusarium equiseti), mycoleptodiscus root rot (Mycoleptodiscus terrestris), neocosmospora (Neocosmospora vasinfecta), pod and stem blight (Diaporthe phaseolorum), stem canker (Diaporthe phaseolorum var. caulivora), phytophthora rot (Phytophthora megasperma), brown stem rot (Phialophora gregata), pythiumrot (Pythium aphanidermatum, Pythium irregulare, Pythium debaryanum, Pythium myriotylum, Pythium ultimum), rhizoctonia root rot, stem decay, and damping-off (Rhizoctonia solani), sclerotinia stem decay (Sclerotinia sclerotiorum), sclerotinia southern blight (Sclerotinia rolfsii), thielaviopsis root rot (Thielaviopsis basicola).

In some embodiments, the phytopathogenic harmful fungi is selected from Septoria species, Fusarium species, Puccinia species, Erisyphe species, Drechslera species, Ramularia species, Mycosphaerella species and Rhynchosporium species.

In some embodiments, the phytopathogenic harmful fungi is selected from Puccinia recondita, Septoria tritici, Fusarium culmorum, Pyrenophora teres, Rhynchosporium secalis and Rhizoctonia solani.

In some embodiments, the locus is a field of crop, wherein the is selected from the group consisting of cotton, rice, flax, grapevines, fruit, vegetables, such as Rosaceae sp. (for example pome fruit such as apples and pears, but also stone fruit such as apricots, cherries, almonds and peaches, and berry fruits such as strawberries), Ribesioidae sp., Juglandaceae sp., Betulaceae sp., Anacardiaceae sp., Fagaceae sp., Moraceae sp., Oleaceae sp., Actinidaceae sp., Lauraceae sp., Musaceae sp. (for example banana trees and plantations), Rubiaceae sp. (for example coffee), Theaceae sp., Sterculiceae sp., Rutaceae sp. (for example lemons, organs and grapefruit); Solanaceae sp. (for example tomatoes), Liliaceae sp., Asteraceae sp. (for example lettuce), Umbelliferae sp., Cruciferae sp., Chenopodiaceae sp., Cucurbitaceae sp. (for example cucumbers), Alliaceae sp. (for example leeks, onions), Papilionaceae sp. (for example peas); main crop plants such as Gramineae sp. (for example maize, turfgrass, cereals such as wheat, rye, rice, barley, oats, sorghum/millet and triticale), Asteraceae sp. (for example sunflowers), Brassicaceae sp. (for example white cabbage, red cabbage, broccoli, cauliflower, Brussels sprouts, Pak Choi, kohlrabi, radishes, and rapeseed, mustard, horseradish and cress), Fabacae sp. (for example beans, peanuts), Papilionaceae sp. (for example soya beans), Solanaceae sp. (for example potatoes), Chenopodiaceae sp. (for example sugar beet, fodder beet, chard, beetroot); sugarcane, poppies, olives, coconuts, cocoa, tobacco and useful plants and ornamental plants in gardens and forests; and genetically modified varieties of each of these plants, and the seeds of these plants.

In some embodiments, the crop is selected from the group consisting of wheat, rye, rice, soybean, barley, oats, sorghum/millet, triticale, maize, potatoes, cabbage, rapeseed, beans, sugarcane, peanuts, peaches and sunflowers.

Examples are provided below to impede a more complete understanding of the present subject matter. The following examples illustrate the exemplary modes of making and practicing the present invention. However, the scope of the present invention is not limited to specific embodiments disclosed in these Examples, which are for purposes of illustration only. Other examples will be apparently constructed by one skilled in the art from consideration of the specification embodiments and examples.

EXPERIMENTAL PART:

Example A: Preparation of a polyanionic block copolymer PolyAgroA used in the suspension concentrate compositions of the present invention:

A sample of a polyanionic block copolymer as used in the present document is prepared following Example 1 of WO 2017/098325 Al (pages 46 to 48): PolyAgro A. PolyAgro A is a polyanionic di-block copolymer, with a total weight of 17000 g/mol, composed of a hydrophobic moiety and a hydrophilic moiety. The hydrophilic moiety is made of sodium 2- Acryloylamino-2- methylpropane-l-sulfonate (AMPS) monomers, which represent 77 w/w% of the total weight of the copolymer. The other 23 w/w% of the copolymer corresponds to the hydrophobic moiety which is made of ethyl acrylate monomers. The total amount of monomers in the copolymer (degree of polymerization, DPn) is 85 monomers, and wherein at least 60% by weight of the hydrophilic moiety are charged monomers.

PolyAgro A is obtained following procedure described below:

Into a 2L double jacketed reactor equipped with mechanical agitator and reflux condenser is added 11.26 g of O-etyl-S-(l-methoxycarbonylethyl)xanthate (CH3CH(C02CH3))S(C=S)OEt), 264.08g of Ethanol, and 356.32g of De-ionized water and 1400g of AMPS(Na) solution (50 percent active) and 1.52g of 4,4'-Azobis(4-cyanopentanoic acid). The reactor contents are heated to 70 degrees centigrade under agitation and nitrogen. The reaction mixture is aged at 70 degrees centigrade for a further hour whereupon it is cooled to ambient temperature and discharged. The measured solids content is 37.6 percent (115 degrees centigrade, 60 mins). GPC Mais: Mn=16300 Mw=2600 IP=1.6.

Into a 5L double jacketed reactor equipped with mechanical agitator and reflux condenser is added 2127g of the above solution and 330g of de-ionized water. The reactor contents are heated to 70 degrees centigrade under agitation and a nitrogen stream. Once 70 degrees centigrade is reached, 106.67g of ethyl acrylate (EA) are added over 2h and 37.37g of a 10 w/w% solution of 4,4'-Azobis(4-cyanopentanoic acid) is concomitantly added over 2.5h. After the addition of the initiator solution is finished, the reaction solution is further aged for one hour. Thereafter a shot of 44.85g of 10 w/w% solution of 4,4'-Azobis(4-cyanopentanoic acid) is added and the mixture aged at 70 degrees centigrade for a further hour whereupon it is cooled to ambient temperature and discharged. The measured solids content is 40.0 percent (115 degrees centigrade, 60 mins). Ethanol is removed from the polymer solution using a rotary evaporator. Water is added to achieve a polymer solution with a final solids content of 40.4 percent.

2600g of polymer solution is placed in-a 5L double jacketed reactor equipped with mechanical agitator and reflux condenser. The pH of the solution is increased to 8.5 using a 50 percent solution of NaOH. The mixture is heated to 70 degrees centigrade with stirring whereupon 48.4g of a 30 w/w% solution of hydrogen peroxide is added over 1 hour. Once additions are finished, the solution is aged for a further 3h whereupon it is cooled and discharged.

The residuals monomers are measured by HPLC and GC (AMPS = 22ppm, EA = 2ppm). The measured solids content is 37.5 percent. The polymer is used in the formulations according to the below examples from a ready aqua polymer solution at concentration of about 30 percent w/w.

Example #1: Process of preparation of inventive Composition 1:

1. Acetic acid and sodium acetate were mixed with half amount of required soft water until full dissolution.

2. Propylene glycol was added to the solution of acetic acid and sodium acetate and stirred, then dispersants, emulsifires and antifoam were added, and the resulting mixture was mixed until homogeneity achieved.

3. Captan and fluopicolide were added, the resulting mixture was milled and thickener and the rest amount of soft water were added to complete the composition.

Add thickener/water up to 100%.

The exact Composition 1 and ingredients weight % that were used for preparation are described in Table 1.

Table 1: Inventive Composition 1.

Example #2:

Comparative composition 2 (no Soprophor FL and no Emulsogen TS 540 included) listed below in Table 2 cannot be prepared based on the finding that the premix including both captan and fluopicolide forms solid large agglomerates and no milling is allowed. The exact comparative Composition 2 and ingredients weight % that were used for preparation are described in Table 2.

Table 2: Comparative composition 2

Example #3:

Comparative Composition 3 prepared without the presence of Emulsogen TS 540 according to the procedure of Example #1 is listed below in Table 3.

The exact comparative Composition 3 and ingredients weight % that were used for preparation are described in Table 3.

In case of comparative Composition 3, there is no milling problem observed, however, viscosity achieved unacceptable levels under storage conditions as represented in Table 4 below.

Table 3. Comparative composition 3.

Example #4.

Comparative Composition 4 prepared without the presence of Soprophor FL according to the procedure of Example #1 is listed below in Table 4.

The exact comparative Composition 4 and ingredients weight % that were used for preparation are described in Table 4.

Table 4. Comparative Composition 4

In case of comparative Composition 4, there is no milling problem observed, however, viscosity achieved unacceptable levels under storage conditions as represented in Table 5 below.

Table 5. Viscosity level of inventive Composition 1 and comparative Composition 3

Example #5: Efficacy of Fluopicolide 50 + Captan 500 SC (Composition 1) vs tank-mix of the corresponding solo commercial compositions against Late Blight of Tomato, caused by Phytophthora species. Materials and Methods:

Young transplants of Tomato -"Hadas" (2-3 leaves) were grown in pots at the greenhouse (25-35 °C with net shade, RH ~30-50%) for 10 days before the experiment. Foliar application of examined compositions was performed with an air sprayer on whole plants. Following 24 h, 20 leaf discs from each treatment, were placed on cotton pads in petri dishes and inoculated with Phytophthora species suspension (10^A5 CFU/ml). Then plates were incubated at 20 °C in full darkness. Disease incidence assessments were done during 4-11 DAI with microscope.

The results of the Efficacy trials against Late Blight of tomato, caused by Phytophthora species, are tabulated in Table 5 and are shown in the form of a bar diagram in Figure 1, where the following abbreviations are used:

*AUDPC - area under disease progress curve.

UTC - Untreated Control

Captan 480 SC (commercial product)

Fluopicolide 270 SC (commercial product)

Captan 480 SC+ Fluopicolide 270 SC (commercial products tank-mix)

Captan 500 + Fluopicolide 50 SC (Inventive Composition 1)

Numeric values obtained in the Example #4 are summarized in Table 5 below:

Table 5. Effect of Fluopicolide 50 + Captan 500 SC (Composition 1) application on disease development (Late Blight of tomato).

SUBSTITUTE SHEET (RULE 26)

As represented above, efficacy values of Composition 1 (shown on Table #1) were much higher compared to the efficacy of the corresponding solo commercial products and tankmixture of the corresponding solo commercial compositions.

SUBSTITUTE SHEET (RULE 26)

Claims

CLAIMS:

1. An agrochemical suspension concentrate composition comprising: i) an amount of phthalimide fungicide ii) an amount of a co-fungicide iii) stabilization system comprising: a) anionic aromatic surfactant; b) non-ionic aromatic surfactant; c) pH modifier iv) optionally, an adjuvant.

2. An agrochemical suspension concentrate composition comprising: i) an amount of phthalimide fungicide ii) an amount of a co-fungicide iii) stabilization system comprising: a) anionic aromatic surfactant; b) non-ionic aromatic surfactant; c) pH modifier iv) an adjuvant.

3. The agrochemical suspension concentrate composition according to any of claims 1- 2, wherein the amount of phthalimide fungicide is from 1 % to 70% per weight based on the total weight of the composition.

4. The agrochemical suspension concentrate composition according to any of claims 1- 2, wherein the amount of phthalimide fungicide is from 25 % to 50% per weight based on the total weight of the composition.

5. The agrochemical suspension concentrate composition according to any of claims 1- 2, wherein the amount of a co-fungicide fungicide is from 1 % to 30% per weight based on the total weight of the composition.

6. The agrochemical suspension concentrate composition according to any one of claims 1-2, wherein the amount of a co-fungicide fungicide is from 1 % to 5% per weight based on the total weight of the composition.

7. The agrochemical suspension concentrate composition according to any one of claims 1-6, wherein the phthalimide fungicide is selected from captan, folpet, captafol and thiochlorfenphim and the mixtures thereof.

8. The agrochemical suspension concentrate composition according to any one of claims 1-7, wherein the phthalimide fungicide is captan.

9. The agrochemical suspension concentrate composition according to any one of claims 1-8, wherein the co-fungicide is selected from fluopicolide, fluopimomide, fluopyram, trichlamide, zoxamide and the mixtures thereof.

10. The agrochemical suspension concentrate composition according to any one of claims 1-9, wherein the co-fungicide is fluopicolide.

11. The agrochemical suspension concentrate composition according to any one of claims 1-10, wherein the stabilization system comprising: a) from 0.1 % to 10% per weight of anionic aromatic surfactant; b) from 0.1 % to 10% per weight non-ionic aromatic surfactant; c) from 1% to 10% of pH modifier, based on the weight of total composition.

12. The agrochemical suspension concentrate composition according to any one of claims 1-11, wherein the stabilization system comprising: a) from 0.5 % to 2% per weight of anionic aromatic surfactant; b) from 0.5 % to 2% per weight non-ionic aromatic surfactant; c) from 1% to 10% of pH modifier, based on the weight of total composition.

13. The agrochemical suspension concentrate composition according to any one of claims 1-12, wherein the stabilization system comprising: a) from 0.5 % to 2% per weight of anionic aromatic surfactant; b) from 0.5 % to 2% per weight non-ionic aromatic surfactant; c) from 2% to 5% of pH modifier, based on the weight of total composition.

14. The agrochemical suspension concentrate composition according to any one of claims 1-13, wherein the pH modifier is a combination of C2-C6 carboxylic acid and C2-C6 carboxylic acid salt.

15. The agrochemical suspension concentrate composition according to any one of claims 1-14, wherein the pH modifier is a combination of acetic acid and acetic acid sodium, potassium or ammonium salt.

16. The agrochemical suspension concentrate composition according to any one of claims 1-15, wherein the pH modifier is a combination of citric acid and citric acid sodium, potassium or ammonium salt.

17. The agrochemical suspension concentrate composition according to any one of claims 1-16, wherein the pH of the composition is between 3 and 6.

18. The agrochemical suspension concentrate composition according to any one of claims 1-17, wherein aromatic anionic surfactant is selected from the group of polyarylether phosphates, polyarylether sulfates, the corresponding sodium, potassium, and ammonium salts and the mixtures thereof.

19. The agrochemical suspension concentrate composition according to any one of claims 1-18, wherein aromatic anionic surfactant is selected from the group of alkoxylated styrylphenol phosphates, alkoxylated styrylphenol sulfates, the corresponding alkaline metal and ammonium salts and mixtures thereof.

20. The agrochemical suspension concentrate composition according to any one of claims 1-19, wherein the aromatic non-ionic surfactant is selected from the group of alkylphenol polyethylene glycol ethers, alkylphenol polyethylene glycol polypropylene glycol ethers and the mixtures thereof.

21. The agrochemical suspension concentrate composition according to any one of claims 1-20, wherein the amount of an adjuvant is from 1% to 20 % per weight of total composition.

22. The agrochemical suspension concentrate composition according to any one of claims 1-21, wherein the amount of an adjuvant is from 2% to 15 % per weight of total composition.

23. The agrochemical suspension concentrate composition according to any one of claims 1-22, wherein the adjuvant is at least one compound of formula (I):

(I) wherein Pyr is pyranose unit; x is 1-50; R is C8-C11 alkyl.

24. The agrochemical suspension concentrate composition according to any one of claims 1-23, wherein the weight ratio between the adjuvant and phthalimide fungicide is froml:70 to 20:1 .

25. The agrochemical suspension concentrate composition according to any one of claims 1-24, further comprising water in the composition in an amount of between about 20 % to about 90% per weight based on the total weight of the composition.

26. The agrochemical suspension concentrate composition according to any one of claims 1-25, wherein the weight ratio between the anionic aromatic surfactant and phthalimide fungicide is from 0.1:70 to 10:1.

27. The agrochemical suspension concentrate composition according to any one of claims 1-26, wherein the weight ratio between the non-ionic aromatic surfactant and phthalimide fungicide is from 0.1:70 to 10:1 .

28. The agrochemical suspension concentrate composition according to any one of claims 1-27, wherein the weight ratio between the anionic aromatic surfactant and the cofungicide fungicide is from 0.1:30 to 10:1 .

29. The agrochemical suspension concentrate composition according to any one of claims 1-28, wherein the weight ratio between the non-ionic aromatic surfactant and the cofungicide fungicide is from 0.1:30 to 10:1 .

30. A method of use of an adjuvant of formula (I)

SUBSTITUTE SHEET (RULE 26)

31. A method of treating plants or plants parts with a combination of one or more phthalimide fungicides selected from captan, folpet, captafol and thiochlorfenphim with an adjuvant of Formula (I):

32. The method according to any of claims 30-31, wherein the locus is a crop field, and the crop is selected from the group consisting of wheat, rye, rice, soybean, barley, oats, sorghum/millet, triticale, maize, potatoes, cabbage, rapeseed, beans, sugarcane, peanuts, peaches and sunflowers.

SUBSTITUTE SHEET (RULE 26)

33. A method for controlling and/or preventing phytopathogenic harmful fungi comprising applying an effective amount of the composition according to any one of claims 1-29 to a locus where the phytopathogenic harmful fungi is to be controlled.

34. The method according to claim 33, wherein the locus is a crop field.

35. The method according to any one of claims 33 or 34, wherein the crop is selected from the group consisting of wheat, rye, rice, soybean, barley, oats, sorghum/millet, triticale, maize, potatoes, cabbage, rapeseed, beans, sugarcane, peanuts, peaches and sunflowers.

36. The method according to any of claims 30-35, wherein the phytopathogenic harmful fungi is selected from Septoria species, Fusarium species, Puccinia species, Erisyphe species, Drechslera species, Ramularia species, Mycosphaerella species and Rhynchosporium species.