AU2024204291B2 - Dual chamber syringe for staged injections - Google Patents
Dual chamber syringe for staged injectionsInfo
- Publication number
- AU2024204291B2 AU2024204291B2 AU2024204291A AU2024204291A AU2024204291B2 AU 2024204291 B2 AU2024204291 B2 AU 2024204291B2 AU 2024204291 A AU2024204291 A AU 2024204291A AU 2024204291 A AU2024204291 A AU 2024204291A AU 2024204291 B2 AU2024204291 B2 AU 2024204291B2
- Authority
- AU
- Australia
- Prior art keywords
- partition
- syringe
- sliding
- chamber
- distal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
- A61M5/31513—Piston constructions to improve sealing or sliding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M2005/1787—Syringes for sequential delivery of fluids, e.g. first medicament and then flushing liquid
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
#$%^&*AU2024204291B220250814.pdf#####
Abstract
The present invention reduces problematic intravascular injections of potent medicines or
vaccines. It allows an initial injection of normal saline or similar safe liquid before
introducing a potent medicine or vaccine. It also allows a clear distinction between
interstitial and intravascular placement of a hypodermic needle without the need for pulling
back the syringe plunger to check for the aspiration of blood. Additionally, it allows an
expansion of the interstitial space relative to the intravascular space before delivery of a
potent medicine or vaccine, thereby reducing the chance of an inadvertent injection into
the intravascular space.
Abstract
The present invention reduces problematic intravascular injections of potent medicines or
vaccines. It allows an initial injection of normal saline or similar safe liquid before
introducing a potent medicine or vaccine. It also allows a clear distinction between
interstitial and intravascular placement of a hypodermic needle without the need for pulling
back the syringe plunger to check for the aspiration of blood. Additionally, it allows an
expansion of the interstitial space relative to the intravascular space before delivery of a
potent medicine or vaccine, thereby reducing the chance of an inadvertent injection into
the intravascular space.
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FIGURE 1
FIGURE 2
FIGURE 3
FIGURE 4
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FIGURE 1
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FIGURE 2
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Description
3 1 4 2
11 8 2024204291
FIGURE FIGURE 11
5
D P 7 6 17
FIGURE FIGURE 22
P 9 11 8
FIGURE FIGURE 33
10 3
FIGURE FIGURE 4 4
1/3 1/3
A Dual Chamber Syringe for Staged Injections Patent 2024204291
[001] Injections of medicine by the medical, dental, veterinary or nursing professions. 2024204291
[002] For this description, distal means towards a syringe outlet and proximal means towards a syringe plunger.
[003] The inventor is a retired plastic surgeon who, during his career, performed thousands of injections of local anaesthetic with adrenaline. He intended to infiltrate the interstitial space and numb an area but, perhaps for 1 in 50 injections, a white vasoconstriction flare appeared around the injection site indicating an inadvertent intra-arterial placement. Considering the larger blood volume in veins and their lack of vasoconstriction, perhaps 1 in 30 intravenous injections occurred. Accordingly, taken together, there may have been approximately 1 in 20 injections involving the intravascular space.
[004] Improvements in hypodermic needle manufacture have led to the supply of very fine needles for injection. The very small outlet aperture of such needles may fit into the lumen of smaller blood vessels and further increase the incidence of inadvertent intravascular injections.
[005] The COVID-19 pandemic of 2020 to 2023 was successfully managed by a vaccination program. Unfortunately, serious post-vaccination adverse events such as myocarditis and pericarditis occurred. Many of these events were in young males 1-8 who were previously very fit. Fit young males may have strong muscles requiring an abundant blood supply. Accordingly, there is a possibility that the injected vaccine directly entered their larger arteries or veins. Such an event could be especially problematic for mRNA vaccines since they are presented as nanoparticles coated with lipids. A nanoparticle may fuse with an endothelial cell within a blood vessel supplying the heart and cause an inflammatory reaction.
[006] The traditional vaccination by injection involved an intramuscular placement of the hypodermic needle into the deltoid muscle and pulling back on the syringe plunger to check if blood was aspirated into the syringe or not. If blood was aspirated, the needle would be repositioned and checked again to ensure the needle was no longer in an artery or a vein before the vaccine was administered.
[007] The COVID-19 pandemic occurred after there had been improvements in the manufacture of hypodermic needles. The new needles were very fine so the blood aspiration test might fail. Accordingly, the aspiration test was not routinely advised or attempted. Perhaps inadvertent injection of vaccines into arteries or veins did occur during this time.
[008] Inadvertent intravascular injections of Covid vaccine may have caused the approximately 10% excess deaths overall seen in Australia during the 4 years after the introduction of the vaccines9. Autopsy findings of myocarditis with inflammation around spike protein in the heart indicate a probable systemic distribution of the vaccine1-8. This adverse event might not have happened if the injected vaccine safely drained from the interstitial space via lymphatic vessels to local lymph nodes. The purpose of this invention is to ensure better outcomes by limiting the chance of inadvertent intravascular placement of a 2024204291
vaccine or a potent medicine.
[009] Prior art dual chamber medical syringes may contain a sliding partition that must be penetrated by a sharp object to release a vaccine or potent medicine from a proximal chamber (US Patents 3896805; 0116871; 4702737; 0035351; 4067333; 0255521; 3911916). Unfortunately, the force required to penetrate the partition may jerk the needle point and cause it to enter the lumen of a blood vessel.
[010] This invention is a dual-chamber syringe that can smoothly deliver normal saline or similar solution from a distal chamber and then, without any needle jerking, deliver a vaccine or potent medicine from a proximal chamber.
[011] This invention uses very low resistance freely gliding parts within the syringe barrel to reduce the pressure required to depress the plunger when expelling liquid from the syringe into the air. The area of contact between the parts and the barrel is reduced as much as possible and low resistance materials such as PTFE might be used. An experienced injector may then be able differentiate the additional pressure needed to infiltrate a blood vessel versus the additional pressure needed to infiltrate muscle tissue.
[012] Prior art dual chamber syringes (US Patents 0256818, 5830193, 4496344, 3914419) are not user-fillable, drawing up medication into a proximal chamber and saline into a distal chamber, whereas this invention is user-fillable because the position of the freely gliding partition is controllable. This invention may be supplied sterile and empty.
[013] Filling the proximal chamber is done with the syringe pointing down to maintain the partition at the distal end of the syringe while gently drawing the vaccine or potent medicine into the syringe. Filling the distal chamber with saline or similar liquid is then done by removing the used needle, turning the syringe upwards and moving the partition down to just past the bypass or bypasses. This repositioning occurs through the effect of gravity and a negative pressure gradient across the partition that forms when the syringe plunger is pulled down. The gravitational effect will be enhanced if the partition has a heavy core. The negative pressure gradient will be greater if the bypasses are narrow and have a higher resistance to air flow than that of the syringe outlet without an attached needle. A fresh needle will be used for filling the distal chamber with the syringe pointing down.
[014] Novice injectors would use this syringe by slowly advancing the needle into the injection site while injecting fluid from the distal chamber. Should the needle pass through a blood vessel, fluid expansion of the tissue on the other side of the blood vessel will occur, compressing the pierced blood vessel and other blood vessels in the vicinity. Further advancement of the needle should stop once tissue swelling is detected, allowing injection of the proximal chamber contents into the now expanded tissue space.
[015] Experienced injectors may be able to differentiate the lower plunger pressure when 24 Jul 2025
the needle point is in a blood vessel and higher plunger pressure when the needle point is in tissue. Accordingly, they may insert the needle and, without further advancing, commence the injection but only inject the contents of the proximal chamber when tissue expansion is palpated.
[016] The sliding partition of this invention has projecting buffers or other irregular surfaces on the distal face to prevent occlusion of the syringe outlet after the distal chamber has been emptied. The syringe barrel has bypass spaces distally placed to allow filling and emptying 2024204291
of the proximal chamber while the partition is at the distal end. The length of the bypass or bypasses is just slightly longer than the partition dimension.
[017] The present invention is a syringe that reduces the occurrence of problematic injections of vaccines or potent medicines by allowing a convenient preliminary injection of saline or other safe liquid into an injection site before the injection of a vaccine or potent medicine. A preliminary injection that expands the interstitial space relative to the intravascular space statistically reduces the chance of a subsequent second injection entering the intravascular space.
[018] The present invention provides for the injection of a dose of saline or other safe liquid to expand the interstitial space before the injection of a dose of vaccine or potent medicine all through the same hypodermic needle
[019] The present invention provides additional safety by avoiding any syringe jerking occurring between the injection doses. A syringe jerk might inadvertently reposition the needle point into a blood vessel.
[020] A further safety feature of the present invention is the ability of an injector to detect whether the injected fluid is entering a blood vessel by palpating the injection site during the injection. A safe injection will produce a palpable tissue swelling as the fluid enters the interstitial space but there will be no tissue swelling if the fluid is draining away via a blood vessel.
[021] A version of this invention with easy sliding syringe components might offer even more safety by allowing an injector to better differentiate the higher pressure required to depress the plunger while injecting into interstitial tissue versus the lower pressure required when injecting into a blood vessel. The pressure differential will be enhanced as less pressure is required to overcome friction between the components.
BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 is a longitudinal section of an embodiment of the invention. A sliding partition has been placed in the lumen of a commonly available disposable syringe to create a distal chamber and a proximal chamber. A partition bypass has been carved out from the distal lumen side wall.
Figure 2 is an oblique view of a sliding partition which has buffers projecting from the distal 24 Jul 2025
surface to prevent blockage of the syringe outlet when the partition rests at the distal end of the syringe. A thin rim may be placed along the proximal surface edge of the plunger to securely seal off the proximal chamber from the distal chamber. Figure 3 is a longitudinal section of an embodiment of the invention. The syringe barrel is novel with a bypass molded into the distal sidewall. A sliding partition has been placed in the lumen of the syringe to securely create a distal chamber and a proximal chamber. Figure 4 is a longitudinal section of an embodiment of the invention like that depicted in 2024204291
Figure 3 after expelling the contents of the distal chamber through an attached hypodermic needle. The sliding partition is resting on the distal end of the barrel. Figure 5 depicts the details of a sliding partition and a plunger piston that slide easily within a syringe barrel due to the presence of narrow gaps at the barrel wall. Proper seals are provided by a thin rim placed along the proximal surface edge for the sliding partition and along the distal surface edge of the piston. Figure 6 is a cross section across plane a-a’ depicted in Figure 4. Three bypass channels are shown in this instance. Figure 7 depicts gradual filling of the proximal chamber with a potent medicine or a vaccine. Figure 8 depicts drawing down the sliding partition after removal of the needle. The sliding partition has blocked the bypass channel off from the proximal chamber. Figure 9 depicts filling the distal chamber with saline or similar liquid. Figure 10 depicts an injector palpating the desired tissue expansion before completing the injection. Figure 11 depicts a narrow blood vessel into which a fine needle can infiltrate a substance into the lumen whereas a larger needle only incises the blood vessel wall allowing blood to leak out.
[022] The present invention is designed to reduce the incidence of serious adverse events following an injection of a potent medicine or vaccine. Serious side effects can occur if a potent medicine or vaccine is inadvertently administered by the intravascular route when the intention was to place it in the interstitial space of a muscle, most commonly the deltoid muscle in the shoulder, or into the subcutaneous tissue.
[023] The present invention may use commonly available disposable plastic syringe parts, a barrel labelled 1 after a modification labelled 12 and a plunger labelled 2 as depicted in Figures 1, 3 and 4. A dual chamber syringe is then created by adding a sliding partition labelled 3 in Figures 1, 2, 3, 4, 7, 8 and 9, and labelled 3a in Figure 5.
[024] The dual chambers in a syringe are described as the distal chamber, closest to the syringe outlet, labelled 4 in Figures 1, 3 and 9, and the proximal chamber, closest to the plunger, labelled 5 in Figures 1, 3, 4, 5, 7, 8 and 9. The fluid in the distal chamber is expelled 24 Jul 2025 first from the syringe when the plunger labelled 2 is pressed into the syringe barrel labelled 1.
[025] A sliding partition depicted in Figure 2 and labelled 3 has an irregular distal surface to prevent obstruction of a syringe outlet, labelled 13 in Figure 3, when it rests at the distal end of a syringe. The projecting buffers labelled 14 are just one example while many other irregular distal surface contours could produce the same function.
[026] Figure 5 depicts an enlarged view of the sliding partition labelled 3 in Figures 1, 2, 3, 4, 7, 8 and 9 which becomes easier to move within a barrel wall labelled 9 by maintenance of 2024204291
a narrow space labelled 10 around the sliding partition now labelled 3a. A thin tapering lip labelled 11 then seals against the wall labelled 9 to prevent leakage of liquid from the proximal chamber labelled 5 into the distal chamber labelled 4. Any leakage might contaminate fluid within the distal chamber labelled 4 depicted in Figures 1, 3 and 9. The lip labelled 11 in Figure 5 may have a concave profile on the proximal side. Leaks from the distal chamber labelled 4 into the proximal chamber labelled 5 should not be problematic but, if they are, a similar lip may be placed along the distal surface margin of the partition labelled 3a and tilt it distally.
[027] Figure 5 also depicts an enlarged view of a syringe plunger labelled 2 with an attached piston labelled 14 which becomes easier to move within a barrel wall labelled 9 by maintenance of a narrow space labelled 15 around the piston. A thin tapering lip labelled 16 then seals against the wall labelled 9 to prevent leakage of liquid from the proximal chamber labelled 5 back past the plunger labelled 2. Should air leaks occur past the piston and into the proximal chamber labelled 5 when withdrawing the plunger back, a similar lip may be placed along the proximal surface margin of the piston and tilt it proximally.
[028] A syringe barrel modification depicted in Figures 1, 3, 4, 6, 7, 8 and 9 involves the addition of one or more partition bypasses labelled 12 placed at the distal end of barrel 1 to allow passage of fluid into or out of proximal chamber 5 when distal chamber 4 is empty and partition 3 is resting at the distal end of the syringe. The bypass depicted in Figure 1 is simply carved out from the inner surface of a syringe barrel. The bypasses depicted in Figures 3, 4, 6, 7, 8 and 9 are molded onto the barrel wall. The bypasses depicted in Figure 6 are viewed as a cross-section at the plane a-a’ depicted in Figure 4. The longitudinal width of a bypass 12 is slightly wider than the longitudinal width of partition 3 to allow sealing off proximal chamber 5 when partition 3 moves slightly proximally away from the rest position. The circumferential width of a bypass 12 may be narrow as depicted in Figure 6 to avoid catching the edge of partition 3 as it commences moving proximally away from the rest position against the distal end of the syringe or even narrower to produce a negative pressure gradient across partition 3 when the plunger 2 is pulled down to start filling chamber 4.
[029] Figure 7 depicts a syringe with a hypodermic needle labelled 17 attached for drawing liquid up into the proximal chamber labelled 5. A gentle aspiration of liquid follows a pathway shown by the arrow labelled 18. The syringe is held vertically pointing down to ensure the sliding partition labelled 3 stays down, resting on the distal end of the syringe, during this process.
[030] Figure 8 depicts a syringe with no needle attached. The arrow labelled 19 depicts an airflow through the syringe outlet labelled 13 when a brief but forceful pulldown is applied to the plunger labelled 2, repositioning partition 3 downwards to just past the bypass labelled 24 Jul 2025
12.
[031] Figure 9 depicts the inflow labelled 20 of a liquid into the distal chamber labelled 4 of a syringe. It is not always necessary to hold the syringe vertically pointing down as depicted.
[032] Figure 10 depicts an injector palpating for a desired tissue swelling while injecting fluid into a deltoid muscle.
[033] Figure 11 depicts a medium and a fine hypodermic needle entering a small blood 2024204291
vessel. The medium needle incises the side of the blood vessel allowing blood to leak out. The fine needle can produce an intravascular injection because the aperture is small enough to fit within the blood vessel lumen during delivery of a substance.
Claims (1)
- CLAIMS 24 Jul 2025In these claims, the term distal means towards the outlet end of a syringe and the term proximal means towards the plunger end of a syringe. Claim 1 A user-fillable dual chamber syringe that may be filled with saline solution in the distal chamber and medication in the proximal chamber so as to allow the user to determine (by the amount of force needed to inject the saline and the palpability of tissue swelling) if the injection intended to be intramuscular 2024204291has inadvertently entered a blood vessel before the medication is injected. Claim 2 The syringe of claim 1 wherein it contains a sliding partition that does not block the syringe outlet, and the syringe wall contains a partition bypass that opens when the partition rests at the distal end of the syringe barrel Claim 3 The sliding partition of claim 2 wherein the distal face has an irregular contour. Claim 4 The irregular contour of claim 3 consists of projecting buffers. Claim 5 The sliding partition of claim 2 wherein friction between the partition and the syringe wall is reduced by reduction of the contact area. Claim 6 The sliding partition of claim 5 wherein the contact is by a single thin tapered rim extending peripherally from the proximal edge of the partition. Claim 7 The tapered rim of claim 6 wherein the rim is tilted proximally. Claim 8 The tapered rim of claim 7 wherein the proximal surface has a slight concavity. Claim 9 The sliding partition of claim 5 wherein the wall contact is by multiple thin tapered rims extending peripherally from the edge of the partition. Claim 10 The sliding partition of claim 2 wherein it is made from low friction material such as PTFE. Claim 11 The sliding partition of claim 2 wherein it is made heavier by an internal weight to assist transitioning between filling the proximal chamber to filling the distal chamber. Claim 12 The partition bypass of claim 2 is either carved out from the inner wall of the syringe barrel or molded into the barrel wall. Claim 13 The partition bypass of claim 2 is slightly longer than the sliding partition, enabling fluid flow through the bypass when the partition is positioned at the syringe's distal end. Claim 14 The circumferential width of the partition bypass of Claim 2 is narrow to prevent possible fouling of the partition edge when the partition starts moving proximally away from the rest position. Claim 15 The syringe of claim 2 may contain multiple partition bypasses.Claim 16 The partition bypasses of claims 2 and 15 wherein the total resistance to 24 Jul 2025airflow through them is greater than through the syringe outlet. Claim 17 The syringe of Claim 1 contains an easy sliding plunger piston modified similarly to the sliding partition of Claims 5 to10. 2024204291FIGURE 1FIGURE 2FIGURE 31/4FIGURE 4FIGURE 5FIGURE 62/4FIGURE 7 FIGURE 8 FIGURE 93/4FIGURE 10FIGURE 114/4
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2023903118A AU2023903118A0 (en) | 2023-09-28 | Dual chamber syringe for staged injections | |
| AU2023903118 | 2023-09-28 | ||
| AU2023903172A AU2023903172A0 (en) | 2023-10-03 | A low-friction mobile easily penetrable partition for a dual chamber syringe | |
| AU2023903172 | 2023-10-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2024204291A1 AU2024204291A1 (en) | 2025-04-17 |
| AU2024204291B2 true AU2024204291B2 (en) | 2025-08-14 |
Family
ID=95339444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2024204291A Active AU2024204291B2 (en) | 2023-09-28 | 2024-06-23 | Dual chamber syringe for staged injections |
Country Status (1)
| Country | Link |
|---|---|
| AU (1) | AU2024204291B2 (en) |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3911916A (en) * | 1971-10-29 | 1975-10-14 | Peter A Stevens | Sequential injection syringe |
| US3914419A (en) * | 1973-08-02 | 1975-10-21 | American Cyanamid Co | Two compartment one unit consecutively injectable liquid vitamin package |
| US4067333A (en) * | 1975-08-07 | 1978-01-10 | Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte | Syringe for storage and application of at least two injection media |
| US4496344A (en) * | 1981-08-10 | 1985-01-29 | Duphar International Research B.V. | Multiple-compartment syringe |
| US4702737A (en) * | 1986-07-14 | 1987-10-27 | Pizzino Joanne L | Dual dose syringe |
| US5830193A (en) * | 1993-12-28 | 1998-11-03 | Higashikawa; Tetsuro | Syringe |
| US20020035351A1 (en) * | 2000-09-16 | 2002-03-21 | Lodice Christopher Charles | Single barrel double chamber syringe |
| US20040116871A1 (en) * | 2001-03-07 | 2004-06-17 | Patrice Vincent | Syringe for visco-elastic solutions |
| US20080255521A1 (en) * | 2007-04-12 | 2008-10-16 | Hisamitsu Pharmaceutical Co. Inc, | Prefilled syringe |
| US20180256818A1 (en) * | 2015-10-02 | 2018-09-13 | Hoffman-La Roche Inc. | Multi chamber syringe unit and method of preparing a multi chamber syringe |
-
2024
- 2024-06-23 AU AU2024204291A patent/AU2024204291B2/en active Active
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|---|---|---|---|---|
| US3911916A (en) * | 1971-10-29 | 1975-10-14 | Peter A Stevens | Sequential injection syringe |
| US3914419A (en) * | 1973-08-02 | 1975-10-21 | American Cyanamid Co | Two compartment one unit consecutively injectable liquid vitamin package |
| US4067333A (en) * | 1975-08-07 | 1978-01-10 | Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte | Syringe for storage and application of at least two injection media |
| US4496344A (en) * | 1981-08-10 | 1985-01-29 | Duphar International Research B.V. | Multiple-compartment syringe |
| US4702737A (en) * | 1986-07-14 | 1987-10-27 | Pizzino Joanne L | Dual dose syringe |
| US5830193A (en) * | 1993-12-28 | 1998-11-03 | Higashikawa; Tetsuro | Syringe |
| US20020035351A1 (en) * | 2000-09-16 | 2002-03-21 | Lodice Christopher Charles | Single barrel double chamber syringe |
| US20040116871A1 (en) * | 2001-03-07 | 2004-06-17 | Patrice Vincent | Syringe for visco-elastic solutions |
| US20080255521A1 (en) * | 2007-04-12 | 2008-10-16 | Hisamitsu Pharmaceutical Co. Inc, | Prefilled syringe |
| US20180256818A1 (en) * | 2015-10-02 | 2018-09-13 | Hoffman-La Roche Inc. | Multi chamber syringe unit and method of preparing a multi chamber syringe |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2024204291A1 (en) | 2025-04-17 |
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