AU2023414924A1 - Heterocyclic and heteroaryl compounds as inhibitors of nlrp3 - Google Patents
Heterocyclic and heteroaryl compounds as inhibitors of nlrp3 Download PDFInfo
- Publication number
- AU2023414924A1 AU2023414924A1 AU2023414924A AU2023414924A AU2023414924A1 AU 2023414924 A1 AU2023414924 A1 AU 2023414924A1 AU 2023414924 A AU2023414924 A AU 2023414924A AU 2023414924 A AU2023414924 A AU 2023414924A AU 2023414924 A1 AU2023414924 A1 AU 2023414924A1
- Authority
- AU
- Australia
- Prior art keywords
- nlrp3
- heterocyclic
- inhibitors
- heteroaryl compounds
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263477864P | 2022-12-30 | 2022-12-30 | |
| US63/477,864 | 2022-12-30 | ||
| US202363503344P | 2023-05-19 | 2023-05-19 | |
| US63/503,344 | 2023-05-19 | ||
| PCT/US2023/086506 WO2024145623A1 (en) | 2022-12-30 | 2023-12-29 | Heterocyclic and heteroaryl compounds as inhibitors of nlrp3 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2023414924A1 true AU2023414924A1 (en) | 2025-07-03 |
Family
ID=90097580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2023414924A Pending AU2023414924A1 (en) | 2022-12-30 | 2023-12-29 | Heterocyclic and heteroaryl compounds as inhibitors of nlrp3 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP4642784A1 (en) |
| JP (1) | JP2026502905A (en) |
| CN (1) | CN120826402A (en) |
| AU (1) | AU2023414924A1 (en) |
| MX (1) | MX2025007519A (en) |
| WO (1) | WO2024145623A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11618751B1 (en) | 2022-03-25 | 2023-04-04 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives |
| US11319319B1 (en) | 2021-04-07 | 2022-05-03 | Ventus Therapeutics U.S., Inc. | Compounds for inhibiting NLRP3 and uses thereof |
| US12331048B2 (en) | 2022-10-31 | 2025-06-17 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors |
| TW202502344A (en) * | 2023-06-02 | 2025-01-16 | 美商默沙東有限責任公司 | 5,6 unsaturated bicyclic heterocyles useful as inhibitors of nod-like receptor protein 3 |
| WO2024251073A1 (en) * | 2023-06-03 | 2024-12-12 | 成都赜灵生物医药科技有限公司 | Pyridazine compound and use thereof |
| WO2025153532A1 (en) | 2024-01-16 | 2025-07-24 | NodThera Limited | Nlrp3 inhibitors and glp-1 agonists combination therapies |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2021255895A1 (en) * | 2020-04-15 | 2022-12-15 | Janssen Pharmaceutica Nv | Pyrrolo[1,2-d][1,2,4]triazine-2-yl-acetamides as inhibitors of the nlrp3 inflammasome pathway |
| CN115433163A (en) * | 2021-06-05 | 2022-12-06 | 药捷安康(南京)科技股份有限公司 | NLRP3 inflammasome inhibitor and application thereof |
-
2023
- 2023-12-29 AU AU2023414924A patent/AU2023414924A1/en active Pending
- 2023-12-29 WO PCT/US2023/086506 patent/WO2024145623A1/en not_active Ceased
- 2023-12-29 EP EP23858435.3A patent/EP4642784A1/en active Pending
- 2023-12-29 CN CN202380094691.3A patent/CN120826402A/en active Pending
- 2023-12-29 JP JP2025537901A patent/JP2026502905A/en active Pending
-
2025
- 2025-06-25 MX MX2025007519A patent/MX2025007519A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN120826402A (en) | 2025-10-21 |
| EP4642784A1 (en) | 2025-11-05 |
| WO2024145623A1 (en) | 2024-07-04 |
| JP2026502905A (en) | 2026-01-27 |
| MX2025007519A (en) | 2025-09-02 |
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