AU2017400271B2 - Sulfoximine glycosidase inhibitors - Google Patents
Sulfoximine glycosidase inhibitors Download PDFInfo
- Publication number
- AU2017400271B2 AU2017400271B2 AU2017400271A AU2017400271A AU2017400271B2 AU 2017400271 B2 AU2017400271 B2 AU 2017400271B2 AU 2017400271 A AU2017400271 A AU 2017400271A AU 2017400271 A AU2017400271 A AU 2017400271A AU 2017400271 B2 AU2017400271 B2 AU 2017400271B2
- Authority
- AU
- Australia
- Prior art keywords
- diastereomers
- mmol
- formula
- mixture
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2017/054280 WO2017144639A1 (fr) | 2016-02-25 | 2017-02-24 | Inhibiteurs de glycosidases |
| AUPCT/EP2017/054280 | 2017-02-24 | ||
| AUPCT/EP2017/054268 | 2017-02-24 | ||
| PCT/EP2017/054268 WO2017144633A1 (fr) | 2016-02-25 | 2017-02-24 | Inhibiteurs de glycosidases |
| PCT/EP2017/071385 WO2018153508A2 (fr) | 2017-02-24 | 2017-08-24 | Inhibiteurs de la sulfoximine glycosidase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2017400271A1 AU2017400271A1 (en) | 2019-08-22 |
| AU2017400271B2 true AU2017400271B2 (en) | 2020-09-24 |
Family
ID=59686981
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2017400271A Active AU2017400271B2 (en) | 2017-02-24 | 2017-08-24 | Sulfoximine glycosidase inhibitors |
Country Status (5)
| Country | Link |
|---|---|
| EP (2) | EP3585779A1 (fr) |
| AU (1) | AU2017400271B2 (fr) |
| MX (1) | MX2019010085A (fr) |
| SG (1) | SG11201907774VA (fr) |
| WO (2) | WO2018153507A1 (fr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201701315VA (en) | 2014-08-28 | 2017-03-30 | Asceneuron Sa | Glycosidase inhibitors |
| CN108884077A (zh) | 2016-02-25 | 2018-11-23 | 阿森纽荣股份公司 | 糖苷酶抑制剂 |
| JP2019506430A (ja) | 2016-02-25 | 2019-03-07 | エースニューロン・ソシエテ・アノニム | グリコシダーゼ阻害剤 |
| US11261183B2 (en) | 2016-02-25 | 2022-03-01 | Asceneuron Sa | Sulfoximine glycosidase inhibitors |
| WO2017144637A1 (fr) | 2016-02-25 | 2017-08-31 | Asceneuron S. A. | Sels d'addition d'acide de dérivés de pipérazine |
| US11213525B2 (en) | 2017-08-24 | 2022-01-04 | Asceneuron Sa | Linear glycosidase inhibitors |
| WO2020039027A1 (fr) | 2018-08-22 | 2020-02-27 | Asceneuron S. A. | Inhibiteurs de pyrrolidine glycosidase |
| US11795165B2 (en) | 2018-08-22 | 2023-10-24 | Asceneuron Sa | Tetrahydro-benzoazepine glycosidase inhibitors |
| US12195455B2 (en) * | 2018-08-22 | 2025-01-14 | Asceneuron Sa | Succinate and fumarate acid addition salts of piperazine derivatives |
| WO2020039029A1 (fr) | 2018-08-22 | 2020-02-27 | Asceneuron S. A. | Composés spiro utilisés en tant qu'inhibiteurs de glycosidases |
| WO2025131275A1 (fr) | 2023-12-20 | 2025-06-26 | Asceneuron Sa | (2-(4-(1-(benzo[d]thiazol-5-yl)éthyl)pipérazin-1-yl) pyrimidin-5-yl)(imino)(méthyl)-lamda6-sulfanone destiné à être utilisé dans le traitement de la colite, de la maladie de parkinson, de la tauopathie, de la sla et de la maladie d'alzheimer |
| CN119839282B (zh) * | 2025-01-22 | 2025-12-02 | 安徽大学 | 一种银纳米团簇及其在甲醇检测中的应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3489757A (en) * | 1965-02-20 | 1970-01-13 | Merck Ag E | 1-alkylenedioxy aralkyl-4-(thiazolyl-2)-piperazines |
| WO2005110982A2 (fr) * | 2004-04-07 | 2005-11-24 | Neurogen Corporation | Analogues substitues 1-benzyl-4-substitues piperazine |
| WO2014159234A1 (fr) * | 2013-03-14 | 2014-10-02 | Merck Patent Gmbh | Inhibiteurs de glycosidases |
| WO2016030443A1 (fr) * | 2014-08-28 | 2016-03-03 | Asceneuron Sa | Inhibiteurs de glycosidases |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL127996C (fr) | 1963-11-19 | |||
| CA2308057A1 (fr) | 1997-10-24 | 1999-05-06 | Neurogen Corporation | Piperazines de 1-(2-naphtyle) et de 1-(2-azanaphtyle)-4-(1-phenylmethyle)en tant que ligands pour le sous-type du recepteur de la dopamine d4 |
| IL158941A0 (en) * | 2001-05-22 | 2004-05-12 | Neurogen Corp | Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues |
| EP2057171A4 (fr) | 2006-08-31 | 2010-04-21 | Univ Fraser Simon | Inhibiteurs sélectifs de glycosidases et leurs utilisations |
| JP5525447B2 (ja) | 2007-10-26 | 2014-06-18 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｐａｒｐ阻害剤としてのキノリノン誘導体 |
| EP2890678A4 (fr) | 2012-08-31 | 2016-01-27 | Alectos Therapeutics Inc | Inhibiteurs de glycosidases et leurs utilisations |
| WO2017144637A1 (fr) * | 2016-02-25 | 2017-08-31 | Asceneuron S. A. | Sels d'addition d'acide de dérivés de pipérazine |
| JP2019506430A (ja) * | 2016-02-25 | 2019-03-07 | エースニューロン・ソシエテ・アノニム | グリコシダーゼ阻害剤 |
| CN108884077A (zh) * | 2016-02-25 | 2018-11-23 | 阿森纽荣股份公司 | 糖苷酶抑制剂 |
-
2017
- 2017-08-24 WO PCT/EP2017/071384 patent/WO2018153507A1/fr not_active Ceased
- 2017-08-24 EP EP17755535.6A patent/EP3585779A1/fr not_active Withdrawn
- 2017-08-24 WO PCT/EP2017/071385 patent/WO2018153508A2/fr not_active Ceased
- 2017-08-24 AU AU2017400271A patent/AU2017400271B2/en active Active
- 2017-08-24 EP EP17758140.2A patent/EP3585783A2/fr active Pending
- 2017-08-24 MX MX2019010085A patent/MX2019010085A/es unknown
- 2017-08-24 SG SG11201907774VA patent/SG11201907774VA/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3489757A (en) * | 1965-02-20 | 1970-01-13 | Merck Ag E | 1-alkylenedioxy aralkyl-4-(thiazolyl-2)-piperazines |
| WO2005110982A2 (fr) * | 2004-04-07 | 2005-11-24 | Neurogen Corporation | Analogues substitues 1-benzyl-4-substitues piperazine |
| WO2014159234A1 (fr) * | 2013-03-14 | 2014-10-02 | Merck Patent Gmbh | Inhibiteurs de glycosidases |
| WO2016030443A1 (fr) * | 2014-08-28 | 2016-03-03 | Asceneuron Sa | Inhibiteurs de glycosidases |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018153508A2 (fr) | 2018-08-30 |
| AU2017400271A1 (en) | 2019-08-22 |
| EP3585783A2 (fr) | 2020-01-01 |
| WO2018153508A3 (fr) | 2019-02-21 |
| EP3585779A1 (fr) | 2020-01-01 |
| SG11201907774VA (en) | 2019-09-27 |
| WO2018153507A1 (fr) | 2018-08-30 |
| MX2019010085A (es) | 2019-11-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2017400271B2 (en) | Sulfoximine glycosidase inhibitors | |
| US12187741B2 (en) | Glycosidase inhibitors | |
| CA3053200C (fr) | Inhibiteurs de la sulfoximine glycosidase | |
| US12157734B2 (en) | Sulfoximine glycosidase inhibitors | |
| JP7082446B2 (ja) | スルホキシイミングリコシダーゼ阻害剤 | |
| US11213525B2 (en) | Linear glycosidase inhibitors | |
| WO2020039029A1 (fr) | Composés spiro utilisés en tant qu'inhibiteurs de glycosidases | |
| WO2020039027A1 (fr) | Inhibiteurs de pyrrolidine glycosidase | |
| EP3672958B1 (fr) | Inhibiteurs de glycosidases annelés | |
| US20220143042A1 (en) | Fused glycosidase inhibitors | |
| BR112019017514B1 (pt) | Composto sulfoximina, mistura, método para inibir uma glicosidase, e, composição farmacêutica |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |