AU2015200680A1 - Pesticide compositions exhibiting enhanced activity - Google Patents

Abstract

Pest controlling compositions exhibiting enhanced pesticidal activity levels are disclosed. In one embodiment, a composition includes at least one pesticide, at least one proteinaceous material and at least one polymeric material. In this embodiment, the composition exhibits enhanced 5 pesticidal activity levels compared to a composition dissimilar only in not having the at least one proteinaceous material and the at least one polymeric material. Still, alternative embodiment pesticide compositions exhibiting enhanced activity levels are disclosed.

Description

P100/01 Regulation 3.2 AUSTRALIA Patents Act 1990 COMPLETE SPECIFICATION STANDARD PATENT Invention Title: Pesticide compositions exhibiting enhanced activity The following statement is a full description of this invention, including the best method of performing it known to us: INSECTICIDE COMPOSITION COMPRISING A MACROLACTONE, A POLYMER AND A PROTEINACEOUS MATERIAL CROSS REFERENCE TO RELATED APPLICATIONS The subject application claims priority to U.S. Provisional Application No. 5 61/214,952 filed April 30, 2009, the contents of which are incorporated herein by reference in their entirety. FIELD OF THE INVENTION 10 The invention disclosed in this document is related to the field of pesticides and their use in controlling pests. BACKGROUND OF THE INVENTION Pests cause millions of human deaths around the world each year. Furthermore, 15 there are more than ten thousand species of pests that cause losses in agriculture. These agricultural losses amount to billions of U.S. dollars each year. Termites cause damage to rioussirueisuch as hions Tiereer-mite a-m o tblid of U.S. dollars each year. As a final note, many stored food pests eat and adulterate stored food. These stored food losses amount to billions of U.S. dollars each year, but more 20 importantly, deprive people of needed food. Many pesticide compositions have been developed over time to destroy pests and alleviate the damages they cause. These compositions are often applied to the environment in which the insects or other pests live or where their eggs are present, including the air surrounding them, the food they eat, or objects which they contact, 25 Several of these compositions are vulnerable to chemical and physical degradation when 1A applied to these environments. If these types of degradation occur, the pesticidal activity of the pesticides can be adversely affected, commonly necessitating an increase in the concentration at which the pesticides are applied and/or more frequent applications of the pesticides. As a result, user costs and the cost to consumers can escalate. Therefore, a need exists for new pesticide 5 compositions that exhibit increased stability and enhanced activity compared to existing pesticide compositions when, for example, the pesticide compositions are applied to an environment to control pests. Reference to any prior art in the specification is not, and should not be taken as, an acknowledgment, or any form of suggestion, that this prior art forms part of the common general 10 knowledge in Australia or any other jurisdiction or that this prior art could reasonably be expected to be ascertained, understood and regarded as relevant by a person skilled in the art. As used herein, except where the context requires otherwise, the term "comprise" and variations of the term, such as "comprising", "comprises" and "comprised", are not intended to exclude other additives, components, integers or steps. 15 SUMMARY OF THE INVENTION The present invention concerns novel pesticide compositions and their use in controlling insects and certain other invertebrates. In one aspect of the invention there is provided a composition, comprising at least one macrocyclic lactone insecticide, at least one proteinaceous material and at least one polymeric 20 material, wherein the proteinaceous material is selected from the group consisting of bovine serum albumin, egg albumen, whey, gelatin and zein, the at least one polymeric material is selected from the group consisting of polyvinyl alcohol, derivatives of polyvinyl alcohol, polyvinyl pyrrolidone, and derivatives of polyvinyl pyrrolidone, and the composition exhibits enhanced pesticidal activity levels compared to a composition dissimilar only in not having the at least one proteinaceous 25 material and the at least one polymeric material. In another aspect of the invention there is provided a composition, comprising at least one macrocyclic lactone insecticide, at least one proteinaceous material and at least one polymeric material, wherein the proteinaceous material is selected from the group consisting of bovine serum albumin, egg albumen, whey, gelatin and zein, the polymeric material is selected from the group 30 consisting of a terpene polymer and a latex, and the composition exhibits enhanced pesticidal 2 activity levels compared to a composition dissimilar only in not having the at least one proteinaceous material and the at least one polymeric material. In another aspect of the invention there is provided a composition, comprising at least one macrocyclic lactone insecticide, at least one proteinaceous material and at least one polymeric 5 material, wherein the proteinaceous material is selected from the group consisting of bovine serum albumin, egg albumen, whey, gelatin and zein, the polymeric material is selected from the group consisting of polyvinyl alcohol, derivatives of polyvinyl alcohol, polyvinyl pyrrolidone, and derivatives of polyvinyl pyrrolidone. In one or more embodiments, the at least one pesticide is a photo-labile pesticide. 10 In one or more embodiments, the at least one pesticide is a spinosyn, such as spinetoram or spinosad. However, it should be appreciated that alternatives for the at least one pesticide are contemplated. In an embodiment, the proteinaceous material includes egg albumin and the polymeric material includes polyvinyl alcohol. 15 In an embodiment, the composition includes from about 2% to about 25% be weight of spinetoram, from about 15% to about 75% by weight of proteinaceous material, and from about 5% to about 70% by weight of polymeric material. In another embodiment, the composition includes from about 15% to about 60% spinetoram and from about 30% to about 75% by weight of polymeric material. 20 In this embodiment, the composition exhibits enhanced pesticidal 3 activity levels compared to a composition dissimilar only in not having the at least one polymeric material. In one form of this embodiment, the at least one pesticide is a photo labile pesticide. In a particular form, the at least one pesticide is a spinosyn such as spinetoram or spinosad. 5 In yet another embodiment, a method includes applying to a locus where control is desired an insect-inactivating amount of a pesticide composition. Still, further embodiments, forms, features, aspects, benefits, objects, and advantages of the present invention shall become apparent from the detailed description and examples provided. 4 DETAILED DESCRIPTION OF THE INVENTION Throughout this document, all temperatures are given in degrees Celsius, and all percentages are weight percentages unless otherwise stated. Pesticide compositions exhibiting increased stability and enhanced pesticidal 5 activity are described in this document. More particularly, in one or more embodiments, the pesticide compositions exhibit enhanced residual pesticidal activity. A pesticide is herein defined as any compound which shows some pesticidal or biocidal activity, or otherwise participates in the control or limitation of pest populations. Such compounds include fungicides, insecticides, nematocides, miticides, termiticides, rodenticides, 10 molluscides, arthropodicides, herbicides, biocides, as well as pheromones and attractants and the like. Examples of pesticides that can be included in the compositions described herein include, but are not limited to, antibiotic insecticides, macrocyclic lactone insecticides (for example, avermectin insecticide, mi 11 mycin insecticides, and spinosyn 15 insecticides), arsenical insecticides, botanical insecticides, carbamate insecticides (for examnle, henzofuranvl methyicarbamate insecticides, dimethylcarbamate insecticides, oxime carbamate insecticides, and phenyl methyicarbamate insecticides), diamide insecticides, desiccant insecticides, dinitrophenol insecticides, fluorine insecticides, formamidine insecticides, fumigant insecticides, inorganic insecticides, insect growth 20 regulators (for example, chitin synthesis inhibitors, juvenile hormone mimics, juvenile hormones, moulting hormone agonists, moulting hormones, moulting inhibitors, precocenes, and other unclassified insect growth regulators), nereistoxin analogue insecticides, nicotinoid insecticides (for example, nitroguanidine insecticides, 5 nitromethylene insecticides, and pyridylmethylamine insecticides), organochlorine insecticides, organophosphorus insecticides, oxadiazine insecticides, oxadiazolone insecticides, phthalimide insecticides, pyrazole insecticides, pyrethroid insecticides, pyrimidinamine insecticides, pyrrole insecticides, tetramic acid insecticides, tetronic acid 5 insecticides, thiazole insecticides, thiazolidine insecticides, thiourea insecticides, urea insecticides, as well as, other unclassified insecticides. Some of the particular insecticides that can be employed in the compositions described in this document include, but are not limited to, the following: 1,2 dichloropropane, 1,3 dichloropropene, abamectin, acephate, acetamiprid, acethion, 10 acetoprole, acrinathrin, acrylonitrile, alanycarb, aldicarb, aldoxycarb, aldrin, allethrin, allosamidin, allyxycarb, alpha-cypermethrin, alpha-endosulfan, amidithion, aminocarb, amiton, amitraz, anabasine, athidathion, azadirachtin, azamethiphos, azinphos-ethyl, azinphosmethyl, azothoate, barium hexafluorosilicate, barthrin, bendiocarb, benfuracarb, bensultap, beta-cyfluthrin, beta-cypermethrin, bifenthrin, bioallethrin, bioethanomethrin, 15 biopermethrin, bioresmethrin, bistrifluron, borax, boric acid, boric acid, bromfenvinfos, bromocyclen, bromo-DDT, bromophos, bromophosethyl, bufencarb, buprofezin, butacarb, butathiofos, butocarboxim, butonate, butoxycarboxim, cadusafos, calcium arsenate, calcium polysulfide, camphechlor, carbanolate, carbaryl, carbofuran, carbon disulfide, carbon tetrachloride, carbophenothion, carbosulfan, cartap, chlorantraniliprole, 20 chlorbicyclen, chlordane, chlordecone, chlordimeform, chlorethoxyfos, chlorfenapyr, chlorfenvinphos, chlorfluazuron, chlormephos, chloroform, chloropicrin, chlorphoxim, chlorprazophos, chlorpyrifos, chlorpyrifos-methyl, chlorthiophos, chromafenozide, cinerin I, cinerin II, cismethrin, cloethocarb, closantel, clothianidin, copper acetoarsenite, 6 copper arsenate, copper naphthenate, copper oleate, coumaphos, cournithoate, crotamiton, crotoxyphos, crufomate, cryolite, cyanofenphos, cyanophos, cyanthoate, cyclethrin, cycloprothrin, cyfluthrin, cyhalothrin, cypermethrin, cyphenothrin, cyromazine, cythioate, DDT, decarbofuran, deltamethrin, demephion, demephion-O, demephion-S, 5 demeton, demeton-methyl, demeton-O, demeton-O-methyl, demeton-S, demeton-S methyl, demeton-S-methylsulphon, diafenthiuron, dialifos, diatomaceous earth, diazinon, dicapthon, dichlofenthion, dichlorvos, dicresyl, dicrotophos, dicyclanil, dieldrin, diflubenzuron, dilor, dimefluthrin, dimefox, dimetan, dimethoate, dimethrin, dimethylvinphos, dimetilan, dinex, dinoprop, dinosam, dinotefuran, diofenolan, 10 dioxabenzofos, dioxacarb, dioxathion, disulfoton, dithicrofos, d-limonene, DNOC, doramectin, ecdysterone, emamectin, EMPC, empenthrin, endosulfan, endothion, endrin, EPN, epofenonane. eprinomectin, esfenvalerate, etaphos, ethiofencarb, ethion, ethiprole, ethoate-methyl, ethoprophos, ethyl formate, ethyl-DDD. ethylene dibromide, ethylene dichloride, ethylene oxide, etofenprox, etrimfos, EXD, famphur, fenamiphos, fenazaflor, 15 fenchlorphos,_fenethacarb, fenfluthrin, fenitrothion, fenobucarb, fenoxacrim, fenoxycarb, fenpirithrin fennranthrin fensmlfothion, fenthion, fenthion-ethyl, fenvalerate, fipronil, flonicamid, flubendiamide, flucofuron, flucycloxuron. flucythrinate, flufenerim, flufenoxuron, flufenprox, fluvalinate, fonofos, formetanate, formothion, formparanate, fosmethilan, fospirate, fosthietan, furathiocarb, furethrin, gamma-cyhalothrin, gamma 20 HCH, halfenprox, halofenozide, HCH, HEOD, heptachlor, heptenophos, heterophos, hexaflumuron, HHDN, hydramethylnon, hydrogen cyanide, hydroprene, hyquincarb, imidacloprid, imiprothrin, indoxacarb, iodomethane, IPSP, isazofos, isobenzan, isocarbophos, isodrin, isofenphos, isoprocarb, isoprothiolane, isothioate, isoxathion, 7 ivermectin, jasmolin I, jasmolin II, jodfenphos, juvenile hormone I, juvenile hormone II, juvenile hormone III, kelevan, kinoprene, lambda-cyhalothrin, lead arsenate, lepimectin, leptophos, lindane, lirimfos, lufenuron, lythidathion, malathion, malonoben, mazidox, mecarbam, mecarphon, menazon, mephosfolan, mercurous chloride, mesulfenfos, 5 metaflumizone, methacrifos, methamidophos, methidathion, methiocarb, methocrotophos, methomyl, methoprene, methoxychlor, methoxyfenozide, methyl bromide, methylchloroform, methylene chloride, metofluthrin, metolcarb, metoxadiazone, mevinphos, mexacarbate, milbemectin, milbemycin oxime, mipafox, mirex, monocrotophos, morphothion, moxidectin, naftalofos, naled, naphthalene, 10 nicotine, nifluridide, nitenpyram, nithiazine, nitrilacarb, novaluron, noviflumuron, omethoate, oxamyl, oxydemeton-methyl, oxydeprofos, oxydisulfoton, para dichlorobenzene, parathion, parathion-methyl, penfluron, pentachlorophenol, permethrin, phenkapton, phenothrin, phenthoate, phorate, phosalone, phosfolan, phosmet, phosnichlor, phosphamidon, phosphine, phoxim, phoxim-methyl, pirimetaphos, 15 pirimicarb, pirimiphos-ethyl, pirimiphos-methyl, potassium arsenite, potassium thiocyanate, pp'-DDT, prallethrin. precocene I, precocene II, precocene III, primidophos, profenofos, profluthrin, promacyl, promecarb, propaphos, propetamphos, propoxur, prothidathion, prothiofos, prothoate, protrifenbute, pyraclofos, pyrafluprole, pyrazophos, pyresmethrin, pyrethrin I, pyrethrin II, pyridaben, pyridalyl, pyridaphenthion, 20 pyrifluquinazon, pyrimidifen, pyrimitate, pyriprole, pyriproxyfen, quassia, quinalphos, quinalphosmethyl, quinothion, rafoxanide, resmethrin, rotenone, ryania, sabadilla, schradan, selamectin, silafluofen, silica gel, sodium arsenite, sodium fluoride, sodium hexafluorosilicate, sodium thiocyanate, sophamide, spinetoram, spinosad, spiromesifen, 8 spirotetramat, sulcofuron, sulfluramid, sulfotep, sulfuryl fluoride, suiprofos, tau fluvalinate, tazimcarb, TDE, tebufenozide, tebufenpyrad, tebupirimfos, teflubenzuron, tefluthrin, temephos, TEPP, terallethrin, terbufos, tetrachloroethane, tetrachlorvinphos, tetramethrin, theta-cypermethrin, thiacloprid, thiamethoxam, thicrofos, thiocarboxime, 5 thiocyclam, thiodicarb, thiofanox, thiometon, thiosultap, thuringiensin, tolfenpyrad, tralomethrin, transfluthrin, transpermethrin, triarathene, triazamate, triazophos, trichlorfon, trichlormetaphos-3, trichloronat, trifenofos, triflumuron, trimethacarb, triprene, vamidothion, vaniliprole, XMC, xylylcarb, zeta-cypermethrin, zolaprofos, and a-ecdysone. 10 Additionally, it is contemplated that any combination of the above insecticides can be employed in the compositions described herein. For more information consult "COMPENDIUM OF PESTICIDE COMMON NAMES" located at http://wvwwalanwoodnet/pesticides/index.html. Also consult "THE PESTICIDE MANUAL"" 14th Edition, edited by C D S Tomlin, copyright 2006 by British Crop 15 Production Council. Various pesticides are susceptible to chemical and physical degradation in the presence of certain environmental influences, such as heat and/or light. Pesticides that are susceptible to degradation with respect to the latter of these influences are commonly referred to as "photo-labile." With respect to at least some photo-labile pesticides, it is 20 believed that their degradation can be attributed to a reaction with singlet oxygen. Examples of pesticides that are reactive with singlet oxygen include, but are not limited to, certain olefins, aromatics, phenols, naphthols, furans, pyrans and other heterocycles containing oxygen; pyrroles, oxazoles, imidazoles, indoles and other heterocycles 9 containing nitrogen; aliphatic, alicyclic and aromatic amines; amino acids, peptides and proteins; and sulfur containing compounds such as mercaptans and sulfides; and the like. Further details regarding the determination of whether a pesticide is reactive with singlet oxygen are provided in International Patent Publication No. WO 2007/053760. It should 5 be appreciated that any one or combination of the aforementioned photo-labile, singlet oxygen reactive pesticides could be included in the compositions described herein. More particular examples of photo-labile, singlet oxygen reactive pesticides that could be included either alone or in combination with each other in the compositions described herein include, but are not limited to, natural products which are 10' microorganisms, microbial products, and materials derived or extracted from plants, animals, or mineral-bearing rocks. These natural products include products derived from naturally derived soil dwelling organisms such as actinomycete bacteria such as, for example, macrocyclic lactone insecticides. One exemplary macrocyclic lactone insecticide includes avermectins and derivatives thereof, such as abamectin, doramectin, 15 emamectin, eprinomectin, ivermectin and selamectin. Another exemplary macrocyclic lactone insecticide includes milbemycins and derivatives thereof, such as lepimectin, milbemectin, milbemycin oxime and moxidectin. Yet another exemplary macrocyclic lactone insecticide includes spinosyns, such as spinosad, and derivatives thereof such as synthetically produced spinetoram as disclosed in U.S. Patents 5,227,295; 5,670,364; 20 5,591,606; 6,001,981; 6,143,526; 6,455,504; 6,585,990; 6,919,464; 5,362,634; 5,539,089; and 5,202,242, each of which is hereby incorporated herein by reference in its entirety. Other natural products include sabadilla or veratrine, pyrethrum or pyrethrin, neem oil or azadirachtin, rotenone, ryania or ryanodine, Bacillus thuringiensis (B. t.), Bacillus 10 subtilis, pheromones, natural attractants and the like. Other pesticides that could be included in the compositions described herein can include synthetically produced pesticides which are reactive toward singlet oxygen. Examples include, but are not limited to indoxacarb, imazalil and fenpropimorph. In addition to the foregoing, it should 5 be appreciated that the compositions described herein could also include at least one pesticide which is reactive with singlet oxygen and at least one other pesticide which is not reactive with singlet oxygen or otherwise photo-labile. In one embodiment, a composition includes at least one or a mixture -of the aforementioned pesticides, at least one proteinaceous material and at least one polymeric 10 material. In this embodiment, the composition exhibits enhanced pesticidal activity compared to a composition dissimilar only in not having the proteinaceous material and the polymeric material. For example, it is contemplated that the activity or half-life of the composition is extended and therefore the same activity can be achieved with a lower amount of the composition when compared to a composition dissimilar only in not 15._ -. havingthe proteinaceous material and the polymeric material. Additionally or alternatively, it is contemplated that improved pesticidal control over time is achieved with the composition including the proteinaceous material and the polymeric material when compared to a composition dissimilar only in not having the proteinaceous material and the polymeric material. 20 As used herein, the term "proteinaceous material" is used to describe a material, composition or compound that is defined by a protein, includes at least one protein or is a basic element of a protein. In one form, the proteinaceous material may be a water soluble protein. Further non-limiting examples of proteinaceous materials include ii1 albumin, such as egg albumen or bovine serum albumin (BSA); casein; gelatin; zein; a whey composition, such as a mixture of lactose and whey protein; whey protein and amino acids such as cysteine, methionine, trytophan, histidine, and tyrosine, just to name a few possibilities. It is also contemplated that a mixture of two or more of the foregoing 5 non-linting proteinaceous material examples could be included in one or more of the compositions described in this document. As used herein, the term "polymeric material" is used to describe a material, compound or composition that is defined by or includes at least one polymer or a derivative thereof. In one non-limiting example, the polymeric material includes 10 polyvinyl alcohol. In other examples, the polymeric material may include derivatives of polyvinyl alcohol; polyvinyl pyrrolidone and/or one or more derivatives thereof; natural or synthetic latexes; a polysaccharide or a terpene polymer. In one specific example, the polymeric material is a high molecular weight vinyl-acrylic latex, such as UCARTM Latex 379G commercially available from Dow Chemical Company, 2030 Dow Center, 15 Midland, Michigan 48674. In another specific example, the polymeric material is a terpene polymer, such as NU FILM 17@ commercially available from Miller Chemical and Fertilizer Corporation, P.O. Box 333, 120 Radio Road, Hanover, Pennsylvania 17331. It should be appreciated that a mixture of two or more of the foregoing non hinting polymeric material examples could also be included in one or more of the 20 compositions described in this document. The proteinaceous material and polymeric material are typically present within the compositions described in this document in an activity enhancing amount. An activity-enhancing amount is an amount which increases the half life of the composition, 12 or alternatively will enable the composition to achieve the same control of pests at a level which is less than the amount required for the same pesticidal protection or control of the composition in the absence of the proteinaceous material and the polymeric material. In other words, the proteinaceous material and the polymeric material will either reduce the 5 rate required for protection or extend the residuality of the composition. In one embodiment, a composition may include a ratio, by weight, between the proteinaceous material and the pesticide between about 1:100 and about 100:1, about 1:50 and about 50:1, about 1:25 and about 25:1, about 1:5 and about 15:1, about 1:2 and about 12:1, about 1:1 and about 10:1, or about 2:1 and 8:1. In another embodiment, a 10 composition may include a ratio by weight between the polymeric material and the pesticide between about 1:100 and about 100:1, about 1:50 and about 50:1, about 1:25 and about 25:1, about 1:8 and about 15:1, about 1:4 and about 12 1, about 1:2 and about 10:1, or about 1:1 and about 8:1. In yet another embodiment, a composition may include a ratio, by weight, between the proteinaceous material and the polymeric material 15 between about -1:100-and about 100:1, about1:50 and-about50:1,.about 1:25and about 25:1, about i:12and about 12:1, about 1: .and about I0: about 1:6 and about :1, or about 1:4 and about 5:1. Still, it is also contemplated that a composition could include a combination of one or more the weight ratios set forth above between the proteinaceous material and the pesticide, the polymeric material and the pesticide and the proteinaceous 20 material and the polymeric material In one more particular embodiment, a composition includes a ratio, by weight, between the proteinaceous material and the pesticide between about 3:1 and about 10:1, between the polymeric material and the pesticide between about 1:4 and about 5:1 and 13 between the proteinaceous material and the polymeric material between about 1:1 and about 7:1. In another more particular embodiment, a composition includes a ratio, by weight, between the proteinaceous material and the pesticide between about 2:1 and about 8:1, between the polymeric material and the pesticide between about 1:2 and about 5 3:1 and between the proteinaceous material and the polymeric material between about 2:1 and about 5:1. Still, in yet another more particular embodiment, a composition includes a ratio, by -weight, between the proteinaceous material and the pesticide from about 4:1 to about 7:1, between the polymeric material and the pesticide from about 1:1 to about 2.5:1 and between the proteinaceous material and the polymeric material from about 2:1 to 10 about 5:1. In another particular embodiment, a composition includes a ratio, by weight, between the proteinaceous material and the pesticide between about 1:4 and about 8:1, between the polymeric material and the pesticide between about 2:1 and about 12:1 and between the proteinaceous material and the polymeric material between about 1:10 and 15 about 2:1. In yet another more particular embodiment, a composition includes a ratio, by weight, between the proteinaceous material and the pesticide between about 1:2 and about 4:1, between the polymeric material and the pesticide between about 4:1 and about 10:1 and between the proteinaceous material and the polymeric material between about 1:8 and about 1:1. In another particular embodiment, a composition includes a ratio, by 20 weight, between the proteinaceous material and the pesticide from about 1:1 to about 2:1, between the polymeric material and the pesticide from about 6:1 to about 8:1 and between the proteinaceous material and the polymeric material from about 1:6 to about 1:2. 14 It should be appreciated however that alternative values for the weight ratios between the proteinaceous material and the pesticide, the polymeric material and the pesticide and the proteinaceous material and the polymeric material are contemplated. For example, in one embodiment, it is contemplated that a composition may include a 5 ratio, by weight, between the proteinaceous material and the pesticide between about 1:100 and about 100:1, between the polymeric material and the pesticide between about 1:100 and about 100:1 and between the proteinaceous material and the polymeric material between about 1:100 and about 100:1. In another embodiment, it is contemplated that a composition may include a ratio, by weight, between the 10 proteinaceous material and the pesticide between about 1:50 and about 50:1, between the polymeric material and the pesticide between about 1:50 and about 50:1 and between the nroteinaceous material and the polymeric material between about 1:50 and about 50:1. Still, in another embodiment, it is contemplated that composition may include a ratio, by weight, between the proteinaceous material and the pesticide between about 1:25 and 15 about 25:1, betweenthe polymeric.material andthe pesIicide-between about 1:25 and about 25j:1 and between the proteiaeu maerr annh]oyercmtra between about 1:25 and about 25:1. In still another embodiment, a composition includes from about 1% to about 35% by weight of the pesticide, from about 5% to about 85% by weight of the proteinaceous 20 material and from about 2% to about 80% by weight of the polymeric material. In another embodiment, a composition includes from about 1% to about 30% by weight of the pesticide, from about 10% to about 80% by weight of the proteinaceous material and from about 3% to about 75% by weight of the polymeric material. In still another 15 embodiment, a composition includes from about 2% to about 25% by weight of the pesticide, from about 15% to about 75% by weight of the proteinaceous material and from about 5% to about 70% by weight of the polymeric material. In one more particular embodiment, a composition includes from about 1% to 5 about 35% by weight of the pesticide, from about 10% to about 85% by weight of the proteinaceous material and from about 1% to about 35% by weight of the polymeric material. In another more particular embodiment, a composition includes from about 1% to about 30% by weight of the pesticide, from about 15% to about 75% by weight of the proteinaceous material and from about 3% to about 30% by weight of the polymeric 10 material. In yet another particular embodiment, a composition includes from about 2% to about 25% by weight of the pesticide, from about 20% to about 70% by weight of the proteinaceous material and from about 5% to about 25% by weight of the polymeric material. In an even more particular embodiment, a composition includes from about 10% to about 20% by weight of the pesticide, from about 40% to about 60% by weight of 15 the proteinaceous material and from about 5% to about 20% by weight of the polymeric material. In one other embodiment, a composition includes from about 5% to about 25% by weight of the pesticide, from about 60% to about 80% by weight of the proteinaceous material and from about 5% to about 25% by weight of the polymeric material. In another embodiment, a composition includes from about 5% to about 15% by weight of 20 the pesticide, from about 65% to about 75% by weight of the proteinaceous material and from about 10% to about 20% by weight of the polymeric material. Still, in another more particular embodiment, a composition includes from about 2% to about 25% by weight of the pesticide, from about 5% to about 30% by weight of 16 the proteinaceous material and from about 55% to about 85% by weight of the polymeric material. In another more particular embodiment, a composition includes from about 3% to about 20% by weight of the pesticide, from about 5% to about 25% by weight of the proteinaceous material and from about 60% to about 80% by weight of the polymeric 5 material. In yet another particular embodiment, a composition includes from about 5% to about 15% by weight of the pesticide, from about 10% to about 20% by weight of the proteinaceous material and from about 65% to about 75% by weight of the polymeric material. Still, it should be appreciated that alternative values for the weight percentages of 10 the pesticide, proteinaceous material and polymeric material are contemplated. For example, in one embodiment, it is contemplated that a composition may include between about 0.1% and about 50% by weight of the pesticide, between about 2% and about 90% by weight of the proteinaceous material and between about 1% to about 90% by weight of the polymeric material. Still, in another embodiment, it is contemplated that a 15 composition-may include between about 0.1% and about 75% by weight of the pesticide, between about 0.1% and about 95% by weight of the proteinaceous material and between about 0.1% and about 95% by weight of the polymeric material. In another embodiment, a composition includes at least one or a mixture of the aforementioned pesticides and at least one polymeric material. In this embodiment, the 20 composition exhibits enhanced pesticidal activity compared to a composition dissimilar only in not having the polymeric material. For example, it is contemplated that the activity or half-life of the composition is extended and therefore the same activity can be achieved with a lower amount of the composition when compared to a composition 17 dissimilar only in not having the polymeric material. Additionally or alternatively, it is contemplated that improved pesticidal control over time is achieved with the composition including the polymeric material when compared to a composition dissimilar only in not having the polymeric material. 5 The polymeric material may be one or a mixture of more than one of the polymeric materials described above and is typically present within the composition in an activity enhancing amount. An activity enhancing amount is an amount which increases the half life of the composition, or alternatively will enable the composition to achieve the same control of pests at a level which is less than the amount required for the same 10 pesticidal protection or control of the composition in the absence of the polymeric material. In other words, the polymeric material will either reduce the rate required for protection or extend the residuality of the composition. In one form of this embodiment, the composition includes a ratio, by weight, between the polymeric material and the pesticide from about 1:4 to about 10:1. In 15 another form, the ratio, by weight, between the polymeric material and the pesticide is from about 1:4 to about 8:1. In a more particular form, the ratio, by weight, between the polymeric material and the pesticide is from about 1:2 to about 4:1. In an even more particular form, the ratio, by weight, between the polymeric material and the pesticide is from about 1:1 to about 2:1. It should be appreciated however that alternative values for 20 the weight ratios between the polymeric material and the pesticide are contemplated. For example, in one form, it is contemplated that a composition may include a ratio, by weight, between the polymeric material and the pesticide between about 1:100 and about 100:1. In another form, it is contemplated that a composition may include a ratio, by 18 weight, between the polymeric material and the pesticide between about 1:50 and about 50:1'. in yet another form, it is contemplated that a composition may include a ratio, by weight, between the polymeric material and the pesticide between about 1:25 and about 25:1. 5 In another form of this embodiment, the composition includes between about 5% and about 75% by weight of the pesticide and between about 20% and about 90% by weight of the polymeric material. In a more particular form, the composition includes between about 10% and about 70% by weight of the pesticide and between about 25% and about 80% by weight of the polymeric material. In another form, the composition 10 includes from about 15% to about 60% by weight of the pesticide and from about 30% to about 75% by weight of the polymeric material. Still, in another form, the composition includes from about 20% to about 50% by weight of the pesticide and from about 40% to about 70% by weight of the polymeric material. In yet another form, the composition includes from about 20% to about 45% by weight of the pesticide and from about 45% to 15 about 65% by weight-of the polymeric material. In another form, the composition includes fr U jabouuL ..5 %9 to about % bl y weight f the peticde and from about 50% to about 65% by weight of the polymeric material. It should be appreciated however that alternative weight ratios between the polymeric material and the pesticide, along with the weight percentages for the pesticide and polymeric material, are contemplated. 20 The compositions described above can be prepared and provided in any suitable manner and also include other components, further details of which will be provided below. in one exemplary form, the pesticide, polymeric material. proteinaceous material, if present, water and any other components, if present, are mixed together, homogenized 19 and provided as a liquid composition. The liquid composition may then be spray dried to provide a solid composition which may be in a powder or granular form, just to name a few possibilities. During the spray drying, the liquid composition is at least partially dehydrated or dried, with such dehydration or dyring resulting in the conversion of the 5 liquid composition to the solid composition which includes a smaller percentage by weight of water than the liquid composition. In one or more forms, the spray drying will remove all or substantially all of the water from the liquid composition as it is converted to the solid composition. However, it should be appreciated that residual water may be present in one or more forms of the solid composition. 10 For example, in one form, the solid composition includes between about 0.001% to about 20% by weight of water after the spray drying. In yet another form, the solid composition includes from about 0.001% to about 15% by weight of water after the spray drying. In still another form, the solid composition includes from about 0.001% to about 10% by weight of water after the spray drying. In another form, the solid composition 15 includes from about 0.001% to about 5% by weight of water after the spray drying. In yet another form, the solid composition includes from about 0.00 1% to about 4% by weight of water after the spray drying. Still, in another form the solid composition includes from about 0.001% to about 2% by weight of water after the spray drying. In another form, the solid composition includes from about 0.001% to about 1% by weight 20 of water after the spray drying. However, it should be appreciated that alternatives values for the weight percentage of water in the solid composition after the spray drying are contemplated. 20 Accordingly, in one embodiment, a method includes providing a liquid composition that includes at least one pesticide, at least one proteinaceous material, at least one polymeric material and water, and spray drying the liquid composition to provide a solid composition. In another embodiment, a method includes providing a 5 liquid composition that includes at least one pesticide, at least one polymeric material and water, and spray drying the liquid composition to provide a solid composition. In one particular form of these embodiments, the spray drying includes substantially removing all of the water from the liquid compositions as they are converted to the solid compositions. While not previously discussed, any other volatile materials besides water, 10 if present in the liquid compositions, will typically be entirely or substantially removed as the liquid compositions are converted to the solid compositions during the spray drying. However, it is contemplated that residual volatile materials other than water could be present in the solid compositins after the spray drying. Additionally, the pesticide and the proteinaceous and polymeric materials are generally not volatile and will generally 15... not be-affectedby-the spray drying.. Thus, it should-be appreciated that the solid coitin.s - ae spray dyi wil ilude rtio weight between the protenineu material and the pesticide, the polymeric material and the pesticide, and the proteinaceous material and polymeric material, as appropriate, that are the same as or substantially equivalent to the ratios by weight between these ingredients in the liquid composition. 20 PESTS In one or more additional embodiments, the invention disclosed in this document can be used to control pests. 21 In one embodiment, the invention disclosed in this document can be used to control pests of the Phylum Nematoda. In another embodiment, the invention disclosed in this document can be used to control pests of the Phylum Arthropoda. 5 In another embodiment, the invention disclosed in this document can be used to control pests of the Subphylum Chelicerata. In another embodiment, the invention disclosed in this document can be used to control pests of the Class Arachnida. In another embodiment, the invention disclosed in this document can be used to 10 control pests of the Subphylum Myriapoda. In another embodiment, the invention disclosed in this document can be used to control pests of the Class Symphyla. In another embodiment, the invention disclosed in this document can be used to control pests of the Subphylum Hexapoda. 15 In another embodiment, the invention disclosed in this document can be used to control pests of the Class Insecta. In another embodiment, the invention disclosed in this document can be used to control Coleoptera (beetles). A non-exhaustive list of these pests includes, but is not limited to, Acanthoscelides spp. (weevils), Acanthoscelides obtectus (common bean 20 weevil), Agrilus planipennis (emerald ash borer), Agriotes spp. (wireworms), Anoplophora glabripennis (Asian longhorned beetle), Anthonomus spp. (weevils), Anthonomus grandis (boll weevil), Aphidius spp., Apion spp. (weevils), Apogonia spp. (grubs), Ataenius spretulus (Black Turgrass Ataenius), Atomaria linearis (pygmy 22 ~- 1 '% A If L.r ( e t o tw e i mangold Ueetle), Iulacoplore spp., Bothynoderespunctiventris(beet root weevil), Bruchus spp. (weevils), Bruchus pisorum (pea weevil), Cacoesia spp., Callosobruchus maculatus (southern cow pea weevil), Carpophilus hemipteras (dried fruit beetle), Cassida vittata, Cerosterna spp., Cerotoma spp. (chrysomeids), Cerotoma trifurcata 5 (bean leaf beetle), Ceutorhynchus spp. (weevils), Ceutorhynchus assimilis (cabbage seedpod weevil), Ceutorhynchus napi (cabbage curculio), Chaetocnema spp. (chrysomelids), Colaspis spp. (soil beetles), Conoderus scalaris, Conoderus stigmosus, Conotrachelus nenuphar (plum curculio), Cotinus nitidis (Green June beetle), Crioceris asparagi (asparagus beetle), Cryptolestesferrugineus (rusty grain beetle), Cryptolestes 10 pusillus (flat grain beetle), Cryptolestes turcicus (Turkish grain beetle), Ctenicera spp. (wireworms), Curculio spp. (weevils), Cyclocephala spp. (grubs), Cylindrocpturus adspersus (sunflower stem weevil), Deporaus marginatus (mango leaf-cutting weevil), Dermestes lardarius (larder beetle), Dermestes maculates (hide beetle), Diabrotica spp. (chrysolemids), Epilachna varivestis (Mexican bean beetle), Faustinus cubae, Hylobius 15 pales (pales weevil), Hypera spp. (weevils), Hyperapostica (alfalfa weevil), Hyperdoes spp. (Hypernde weevii1), Hypothenemus hampei (coffee berry beetle), Ips sp. (engravers), Lasioderma serricorne (cigarette beetle), Leptinotarsa decemlineata (Colorado potato beetle), Liogenysfuscus, Liogenys suturalis, Lissorhoptrus oryzophilus (rice water weevil), Lyctus spp. (wood beetles/powder post beetles), Maecolaspisjoliveti, 20 Megascelis spp., Melanotus communis, Meligethes spp., Meligethes aeneus (blossom beetle), Melolontha melolontha (common European cockchafer), Oberea brevis, Oberea linearis, Oryctes rhinoceros (date palm beetle), Oryzaephilus mercator (merchant grain beetle), Oryzaephilus surinamensis (sawtoothed grain beetle), Otiorhynchus spp. 23 (weevils), Oulema melanopus (cereal leaf beetle), Oulema oryzae, Pantomorus spp. (weevils), Phyllophaga spp. (May/June beetle), Phvllophaga cuyabana, Phyllotreta spp. (chrysomelids), Phynchites spp., Popilliajaponica (Japanese beetle), Prostephanus truncates (larger grain borer), Rhizopertha dominica (lesser grain borer), Rhizotrogus 5 spp. (Eurpoean chafer), Rhynchophorus spp. (weevils), Scolytus spp. (wood beetles), Shenophorus spp. (Billbug), Sitona lineatus (pea leaf weevil), Sitophilus spp. (grain weevils), Sitophilus granaries (granary weevil), Sitophilus oryzae (rice weevil), Stegobium paniceum (drugstore beetle), Tribolium spp. (flour beetles), Tribolium castaneum (red flour beetle), Tribolium confusum (confused flour beetle), Trogoderma 10 variabile (warehouse beetle), and Zabrus tenebioides. In another embodiment, the invention disclosed in this document can be used to control Dermaptera (earwigs). In another embodiment, the invention disclosed in this document can be used to control Dictyoptera (cockroaches). A non-exhaustive list of these pests includes, but is 15 not limited to, Blattella germanica (German cockroach), Blatta orientalis (oriental cockroach), Parcoblatta pennylvanica, Periplaneta americana (American cockroach), Periplaneta australoasiae (Australian cockroach), Periplaneta brunnea (brown cockroach), Periplanetafuliginosa (smokybrown cockroach), Pyncoselus suninamensis (Surinam cockroach), and Supella longipalpa (brownbanded cockroach). 20 In another embodiment, the invention disclosed in this document can be used to control Diptera (true flies). A non-exhaustive list of these pests includes, but is not limited to, Aedes spp. (mosquitoes), Agromyzafrontella (alfalfa blotch leafminer), Agromyza spp. (leaf miner flies), Anastrepha spp. (fruit flies), Anastrepha suspensa 24 (Caribbean fruit fly), Anopheles spp. (mosquitoes), Batrocera spp. (fruit flies), Bactrocera cucurbitae (melon fly), Bactrocera dorsalis (oriental fruit fly), Ceratitis spp. (fruit flies), Ceratitis capitata (Mediterranea fruit fly), Chrysops spp. (deer flies), Cochliomyia spp. (screwworms), Contarinia spp. (Gall midges), Culex spp. (mosquitoes), 5 Dasineura spp. (gall midges), Dasineura brassicae (cabbage gall midge), Delia spp., Delia platura (seedcorn maggot), Drosophila spp. (vinegar flies), Fannia spp. (filth flies), Fannia canicularis (little house flv), Fannia scalaris (latrine fly), Gasterophilus intestinalis (horse bot fly), Gracilliaperseae, Haematobia irritans (horn fly), Hylemyia spp. (root maggots), Hypoderma lineatum (common cattle grub), Liriomyza spp. 10 (leafmfiner flies), Liriomyza brassica (serpentine leafniner), Melophagus ovinus (sheep ked), Musca spp. (muscid flies), Musca autumnalis (face fly), Musca domestica (house fly), Qestrus ovis (sheep bot fly), Oscinellafrit (frit fly),Pegomyia betae (beet leafminer), Phorbia sp., Psila rose (carrot rust fly), Rhagoletis cerasi (cherry frit fly), Rhagoletis pomonella (apple maggot), Sitodiplosis mosellana (orange wheat blossom 15 midge), Stomoxys- calcitransstable fly), Tabanus spp. (horse-flies), and Tipula spp. (crane flies). In another embodiment, the invention disclosed in this document can be used to control Hemiptera (true bugs). A non-exhaustive list of these pests includes, but is not limited to, Acrosternum hilare (green stink bug), Blissus leucopterus (chinch bug), 20 Calocoris norvegicus (potato mirid), Cimex hem ipterus (tropical bed bug), Cimex lectularius (bed bug), Dagbertusfasciatus, Dichelops furcatus, Dysdercus suturellus (cotton stainer), Edessa meditabunda, Eurygaster maura (cereal bug), Euschistus heroes, Euschistus servus (brown stink bug), Helopeltis antonii, Helopeltis theivora (tea blight 25 plantbug), Lagynotomus spp. (stink bugs), Leptocorisa oratorius, Leptocorisa varicornis, Lygus spp. (plant bugs), Lygus hesperus (western tarnished plant bug), Maconellicoccus hirsutus, Neurocolpus Iongirostris, Nezara viridula (southern green stink bug), Phytocoris spp. (plant bugs), Phytocoris californicus, Phytocoris relativus, Piezodorus 5 guildingi, Poecilocapsus lineatus (fourlined plant bug), Psallus vaccinicola, Pseudacysta perseae, Scaptocoris castanea, and Triatoma spp. (bloodsucking conenose bugs/kissing bugs). In another embodiment, the invention disclosed in this document can be used to control Homoptera (aphids, scales, whiteflies, leafhoppers). A non-exhaustive list of 10 these pests includes, but is not limited to, A crythosiphon pisum (pea aphid), A delges spp. (adelgids), Aleurodes proletella (cabbage whitefly), Aleurodicus disperses, Aleurothrixus floccosus (woolly whitefly), Aluacaspis spp., Amrasca bigutella bigutella, Aphrophora spp. (leafhoppers), Aonidiella aurantii (California red scale), Aphis spp. (aphids), Aphis gossypii (cotton aphid), Aphis pomi (apple aphid), Aulacorthum solani (foxglove aphid), 15 Bemisia spp. (whiteflies), Bemisia argentifolii, Bemisia tabaci (sweetpotato whitefly), Brachycolus noxius (Russian aphid), Brachycorynella asparagi (asparagus aphid), Brevennia rehi, Brevicoryne brassicae (cabbage aphid), Ceroplastes spp. (scales), Ceroplastes rubens (red wax scale), Chionaspis spp. (scales), Chrysomphalus spp. (scales), Coccus spp. (scales), Dysaphis plantaginea (rosy apple aphid), Empoasca spp. 20 leafhopperss), Eriosoma lanigerum (woolly apple aphid), Icerya purchasi (cottony cushion scale), Idioscopus nitidulus (mango leafhopper), Laodelphax striatellus (smaller brown planthopper), Lepidosaphes spp., Macrosiphum spp., Macrosiphum euphorbiae (potato aphid), Macrosiphum granarium (English grain aphid), Macrosiphum rosae (rose 26 aphid), Macrosteles quadrilineatus (aster leafhopper), Mahanarvafrimbiolata, Metopolophium dirhodum (rose grain aphid), Mictis longicornis, Myzus persicae (green peach aphid), Nephotettix spp. leafhopperss), Nephotettix cinctipes (green leafhopper), Nilaparvata lugens (brown planthopper), Parlatoria pergandii (chaff scale), Parlatoria 5 ziziphi (ebony scale), Peregrinus maidis (corn delphacid), Philaenus spp. (spittlebugs), Phylloxera vitifoliae (grape phylloxera), Physokermes piceae (spruce bud scale), Planococcus spp. (mealybugs), Pseudococcus spp. (mealybugs), Pseudococcus brevipes (pine apple mealybug), Quadraspidiotus perniciosus (San Jose scale), Rhapalosiphurm spp. (aphids), Rhapalosiphum maida (corn leaf aphid), Rhapalosiphumpadi (oat bird 10 cherry aphid), Saissetia spp. (scales), Saissetia oleae (black scale), Schizaphis graminum (greenbug), Sitobion avenae (English grain aphid), Sogatellafurcifera (white-backed planthopper), Therioaphis sp. (aphids), Toumeyella spp. (scales), Toxoptera spp. (aphids), Trialeurodessnp. (whiteflies) Trialeurodes vaporariorum (greenhouse whitefly), Trialeurodes abutiloneus (bandedwing whitefly), Unaspis spp. (scales), 15. Unaspis yanonensis (arrowhead scale), and Zulia entreriana. ,11. Cu "Ie eM dint, invpnticon diclnopd htisdcument can he used to control Hymenoptera (ants, wasps, and bees). A non-exhaustive list of these pests includes, but is not limited to, Acromyrrmex spp., Athalia rosae, Atta spp. (Ieafcutting ants), Camponotus spp. (carpenter ants), Diprion spp. (sawflies), Formica spp. (ants), 20 Iridomyrmex humilis (Argentine ant), Monomorium ssp., Monomorium minumum (little black ant), Monomorium pharaonis (Pharaoh ant), Neodiprion spp. (sawflies), Pogonomyrmex spp. (harvester ants), Polistes spp. (paper wasps), Solenopsis spp. (fire 27 ants), Tapoinoma sessile (odorous house ant), Tetranomorium spp. (pavement ants), Vespula spp. (yellow jackets), and Xylocopa spp. (carpenter bees). In another embodiment, the invention disclosed in this document can be used to control Isoptera (termites). A non-exhaustive list of these pests includes, but is not 5 limited to, Coptotermes spp., Coptotermes curvignathus, Coptotermesfrenchii, Coptotermesformosanus (Formosan subterranean termite), Cornitermes spp. (nasute termites), Cryptotermes spp. (drywood termites), Heterotermes spp. (desert subterranean termites), Heterotermes aureus, Kalotermes spp. (drywood termites). Incistitermes spp. (drywood termites), Macrotermes spp. (fungus growing termites), Marginitermes spp. 10 (drywood termites), Microcerotermes spp. (harvester termites), Microtermes obesi, Procornitermes spp., Reticulitermes spp. (subterranean termites), Reticulitermes banyulensis, Reticulitermes grassei, Reticulitermesflavipes (eastern subterranean termite), Reticulitermes hageni, Reticulitermes hesperus (western subterranean termite), Reticulitermes santonensis, Reticulitermes speratus, Reticulitermes tibialis, 15 Reticulitermes virginicus, Schedorhinotermes spp., and Zootermopsis spp. (rotten-wood termites). In another embodiment, the invention disclosed in this document can be used to control Lepidoptera (moths and butterflies). A non-exhaustive list of these pests includes, but is not limited to, Achoeajanata, Adoxophyes spp., Adoxophyes orana, 20 Agrotis spp. (cutworms), Agrotis ipsilon (black cutworm), Alabama argillacea (cotton leafworm), Amorbia cuneana, Amyelosis transitella (navel orangeworm), Anacamptodes defectaria, Anarsia lineatella (peach twig borer), Anomis sabulijera (jute looper), A nticarsia gemmatalis (velvetbean caterpillar), Archips argyrospila (fruit tree leafroller), 28 Archips rosana (rose leaf roller), Argyrotaenia spp. (tortricid moths), Argyrotaenia citrana (orange tortrix), Autographa gamma, Bonagota cranaodes, Borbo cinnara (rice leaf folder), Bucculatrix thurberiella (cotton leaf perforator), Caloptilia spp. (leaf miners), Capua reticulana, Carposina niponensis (peach fruit moth), Chilo spp., 5 Chlumetia transversa (mango shoot borer), Choristoneura rosaceana (oblique banded leaf roller), Chrysodeixis spp., Cnaphalocerus medinalis (grass leafroller), Coiias spp., Conpomorpha cramerella, Cossus cossus (carpenter moth), Crambus spp. (Sod webworms), Cydiafunebrana (plum fruit moth), Cydia molesta (oriental fruit moth), Cydia nignicana (pea moth), Cydiapomonella (codling moth), Darna diducta, Diaphania 10 spp. (stem borers), Diatraea spp. (stalk borers), Diatraea saccharalis (sugarcane borer), Diatraea graniosella (southwester corn borer), Earias spp. bollwormss), Earias insulata (Egyptian bollworm), Earias vitella (rough northern bollworm), Ecdytopopha aurantianum, Elasmopalpus lignosellus (lesser cornstalk borer), Epiphysias postruttana (light brown apple moth), Ephestia spp. (flour moths), Ephestia cautela (almond moth), 15 Ephestia elutella (tobbaco moth), Ephestia kuehniella (Mediterranean flour moth), Epimeces spp., Epintia aprema, Erionota thrax (banana skipper), Eupoecilia ambiguella (grape berry moth), Euxoa auxiliaris (army cutworm), Feltia spp. (cutworms), Gortyna spp. (stemborers), Grapholita molesta (oriental fruit moth), Hedylepta indicata (bean leaf webber), Helicoverpa spp. (noctuid moths), Helicoverpa 20 armigera (cotton bollworm), Helicoverpa zea (bollworm/corn earworm), Heliothis spp. (noctuid moths), Heliothis virescens (tobacco budworm), Hellula undalis (cabbage webworm), Indarbela spp. (root borers), Keiferia lycopersicella (tomato pinworm), Leucinodes orbonalis (eggplant fruit borer), Leucoptera mahfoliella, Lithocollectis spp., 29 Lobesia botrana (grape fruit moth), Loxagrotis spp. (noctuid moths), Loxagrotis albicosta (western bean cutworm), Lymantria dispar (gypsy moth), Lyonetia clerkella (apple leaf miner), Mahasena corbetti (oil palm bagworm), Malacosoma spp. (tent caterpillars), Mamestra brassicae (cabbage armyworm), Maruca testulalis (bean pod 5 borer), Metisa plana (bagworm), Mythimna unipuncta (true armyworm), Neoleucinodes elegantalis (small tomato borer), Nymphula depunctalis (rice caseworm), Operophthera brumata (winter moth), Ostrinia nubilalis (European corn borer), Oxydia vesulia, Pandemis cerasana (common currant tortrix), Pandemis heparana (brown apple tortrix), Papilio demodocus, Pectinophora gossypiella (pink bollworrn), Peridroma spp. 10 (cutworms), Peridroma saucia (variegated cutworm), Perileucoptera coffeella (white coffee leafminer), Phthorimaea operculella (potato tuber moth), Phyllocnisitis citrella, Phyllonorycter spp. (leafminers), Pieris rapae (imported cabbageworm), Plathypena scabra, Plodia interpunctella (Indian meal moth), Plutella xylostella (diamondback moth), Polychrosis viteana (grape berry moth), Prays endocarpa, Prays oleae (olive 15 moth), Pseudaletia spp. (noctuid moths), Pseudaletia unipunctata (armyworm), Pseudoplusia includens (soybean looper), Rachiplusia nu, Scirpophaga incertulas, Sesamia spp. (stemborers), Sesamia inferens (pink rice stem borer), Sesamia nonagrioides, Setora nitens, Sitotroga cerealella (Angoumois grain moth), Sparganothis pilleriana, Spodoptera spp. (armyworms), Spodoptera exigua (beet armyworm), 20 Spodopterafugiperda (fall armyworm), Spodoptera oridania (southern armyworm), Synanthedon spp. (root borers), Thecla basilides, Thermisia gemmatalis, Tineola bisselliella (webbing clothes moth), Trichoplusia ni (cabbage looper), Tuta absoluta, 30 Yponomeuia spp., Zeuzera coffeae (red branch borer), and Zeuzera pyrina (leopard moth). In another embodiment, the invention disclosed in this document can be used to control Mallophaga (chewing lice). A non-exhaustive list of these pests includes, but is 5 not limited to, Bovicola ovis (sheep biting louse), Menacanthus stramineus (chicken body louse), and Menopon gallinea (common hen house). In another embodiment, the invention disclosed in this document can be used to control Orthoptera (grasshoppers, locusts, and crickets). A non-exhaustive list of these pests includes, but is not limited to, Anabrus simplex (Mormon cricket), 10 Gryllotalvidae (mole crickets), Locusta migratoria, Melanoplus spp. (grasshoppers), Microcentrum retinerve (angular winged katydid), Pterophylla spp. (kaydids), chistocerca gregaria, Scudderiafurcata (fork tailed bush katydid), and Valanga In another embodiment, the invention disclosed in this document can be used to 15 control Phbthiraptera (sucking lice). A non-exhaustivelist of these pests includes, but is not limited to, Oppp. (catle and h'g i-), Linognathus ovillus (sheep louse), Pediculus humanus capitis (human body louse), Pediculus humanus humanus (human body lice), and Pthirus pubis (crab louse). In another embodiment, the invention disclosed in this document can be used to 20 control Siphonaptera (fleas). A non-exhaustive list of these pests includes, but is not limited to, Ctenocephalides canis (dog flea), Ctenocephalides felis (cat flea), and Pulex irritans (human flea). 31 In another embodiment, the invention disclosed in this document can be used to control Thysanoptera (thrips). A non-exhaustive list of these pests includes, but is not limited to, Frankliniellafusca (tobacco thrips), Frankliniella occidentalis (western flower thrips), Frankliniella shultzei Frankliniella williamsi (corn thrips), Heliothrips 5 haemorrhaidalis (greenhouse thrips), Riphiphorothrips cruentatus, Scirtothrips spp., Scirtothrips citri (citrus thrips), Scirtothrips dorsalis (yellow tea thrips), Taeniothrips rhopalantennalis, and Thrips spp. In another embodiment, the invention disclosed in this document can be used to control Thysanura (bristletails). A non-exhaustive list of these pests includes, but is not 10 limited to, Lepisma spp. (silverfish) and Thermobia spp. (firebrats). In another embodiment, the invention disclosed in this document can be used to control Acarina (mites and ticks). A non-exhaustive list of these pests includes, but is not limited to, Acarapsis woodi (tracheal mite of honeybees), Acarus spp. (food mites), Acarus siro (grain mite), Aceria mangiferae (mango bud mite), Aculops spp., A culops 15 lycopersici (tomato russet mite), Aculops pelekasi, Aculus pelekassi, Aculus schlechtendali (apple rust mite), Amblyomma americanum (lone star tick), Boophilus spp. (ticks), Brevipalpus obovatus (privet mite), Brevipalpus phoenicis (red and black flat mite), Demodex spp. (mange mites), Dermacentor spp. (hard ticks), Dermacentor variabilis (american dog tick), Dermatophagoides pteronyssinus (house dust mite), 20 Eotetranycus spp., Eotetranychus carpini (yellow spider mite), Epitimerus spp., Eriophyes spp., Ixodes spp. (ticks), Metatetranycus spp., Notoedres cati, Oligonychus spp., Oligonychus coffee, Oligonychus ilicus (southem red mite), Panonychus spp., Panonychus citri (citrus red mite), Panonychus ulmi (European red mite), Phyllocoptruta 32 oleivora (citrus rust mite), Polyphagotarsonemun latus (broad mite), Rhipicephalus sanguineus (brown dog tick), Rhizoglyphus spp. (bulb mites), Sarcoptes scabiei (itch mite), Tegolophusperseaflorae, Tetranychus spp., Tetranychus urticae (twospotted spider mite), and Varroa destructor (honey bee mite). 5 In another embodiment, the invention disclosed in this document can be used to control Nematoda (nematodes). A non-exhaustive list of these pests includes, but is not limited to, Aphelenchoides spp. (bud and leaf & pine wood nematodes), Belonolaimus spp. (sting nematodes), Criconemella spp. (ring nematodes), Dirofilaria immitis (dog heartworm), Ditylenchus spp. (stem and bulb nematodes), Heterodera spp. (cyst 10 nematodes), Heterodera zeae (corn cyst nematode), Hirschmanniella spp. (root nematodes), Hoplolaimus spp. (lance nematodes), Meloidogyne spp. (root knot nematodes), Meloidogyne incognita (root knot nematode), Onchocerca volvulus (hook tail worm), ?ratylenchus spp. (lesion nematodes), Radopholus spp. (burrowing nematodes), and Rotylenchus renifbrmis (kidney-shaped nematode). 15 In another embodiment, the invention disclosed in this document can be used to control Symphyla (symphylans). A -.~novn-ehuive list of these npts includes, hbut is not limited to, Scutigerella immaculata. For more detailed information consult "HANDBOOK OF PEST CONTROL THE BEHAVIOR, LIFE HISTORY, AND CONTROL OF HOUSEHOLD PESTS" 20 by Arnold Mallis, 9th Edition, copyright 2004 by GIE Media Inc. MIXTURES 33 The compositions disclosed in this document can also be used, for reasons of economy, physical and chemical stability and synergy, with acaricides, algicides, antifeedants, avicides, bactericides, bird repellents, chemosterilants, fungicides, herbicide safeners, herbicides, insect attractants, insect repellents, mammal repellents, mating 5 disrupters, molluscicides, other insecticides, other pesticides, plant activators, plant growth regulators, rodenticides, synergists, defoliants, desiccants, disinfectants, semiochemicals, and virucides (these categories not necessarily mutually exclusive). FORMULATIONS 10 The compositions described in this document may also be provided with phytologically-acceptable inert ingredients to provide or complement a carrier and can be formulated into, for example, baits, concentrated emulsions, dusts, emulsifiable concentrates, fumigants, gels, granules, microencapsulations, seed treatments, suspension concentrates, suspoemulsions, tablets, water soluble liquids, water dispersible granules or 15 dry flowables, wettable powders, and ultra low volume solutions. For further information on formulation types see "CATALOGUE OF PESTICIDE FORMULATION TYPES AND INTERNATIONAL CODING SYSTEM" Technical Monograph n*2, 5th Edition by CropLife International (2002). Pesticide compositions can be frequently applied as aqueous suspensions or 20 emulsions prepared from concentrated formulations of such compositions. Such water soluble, water-suspendable, or emulsifiable formulations are either solids, usually known as wettable powders, or water dispersible granules, or liquids usually known as emulsifiable concentrates, aqueous suspensions or oil suspensions. Wettable powders, 34 which may be compacted to form water dispersible granules, comprise an intimate mixture of the pesticide composition, a carrier, and surfactants. The carrier is usually chosen from among the attapulgite clays, the montmorillonite clays, the diatomaceous earths, or the purified silicates. Effective surfactants, which can comprise from about 5 0.5% to about 10% of the wettable powder, are found among sulfonated lignins, condensed naphthalenesulfonates, naphthalenesulfonates, alkylbenzenesulfonates, alkyl sulfates, and nonionic surfactants such as ethylene oxide adducts of alkyl phenols. Emulsifiable concentrates comprise a convenient concentration of a pesticide composition dissolved in a carrier that is either a water miscible solvent or a mixture of 10 water-immiscible organic solvent and emulsifiers. Useful organic solvents include aromatics, especially xylenes and petroleum fractions, especially the high-boiling naphthalenic and olefinic portions of petroleum such as heavy aromatic naphtha. Other organic solvents may also be used, such as the terpenic solvents including rosin derivatives, aliphatic ketones such as cyclohexanone, and complex alcohols such as 2 15 ethoxyethanol. Suitable emulsifiers for emulsifiable concentrates are chosen from c onrv enrt ionial ani o ni c an n .o nionic s u rffa Ctanit s. Aqueous suspensions comprise suspensions of water-insoluble pesticide compositions dispersed in an aqueous carrier. Suspensions are prepared by finely grinding the pesticide composition and vigorously mixing it into a carrier comprised of 20 water and surfactants. Ingredients, such as inorganic salts and synthetic or natural gums, may also be added, to increase the density and viscosity of the aqueous carrier. It is often most effective to grind and mix the nesticide composition at the same time by preparing 35 the aqueous mixture and homogenizing it in an implement such as a sand mill, ball mill, or piston-type homogenizer. Pesticide compositions may also be applied as granular formulations that are particularly useful for applications to the soil. Granular formulations contain the 5 pesticide composition dispersed in a carrier that comprises clay or a similar substance. Such formulations are usually prepared by dissolving the pesticide composition in a suitable solvent and applying it to a granular carrier which has been pre-formed to the appropriate particle size, in the range of from about 0.5 to 3 mm. Such formulations may also be formulated by making a dough or paste of the carrier and pesticide composition 10 and crushing and drying to obtain the desired granular particle size. Dusts containing a pesticide composition are prepared by intimately mixing the pesticide composition in powdered form with a suitable dusty agricultural carrier, such as kaolin clay, ground volcanic rock, and the like. Dusts can be applied as a seed dressing, or as a foliage application with a dust blower machine. 15 It is equally practical to apply a pesticide composition in the form of a solution in an appropriate organic solvent, usually petroleum oil, such as the spray oils, which are widely used in agricultural chemistry. Pesticide compositions can also be applied in the form of an aerosol formulation. In such formulations, the pesticide composition is dissolved or dispersed in a carrier, 20 which is a pressure-generating propellant mixture. The aerosol formulation is packaged in a container from which the mixture is dispensed through an atomizing valve. Pesticide baits are formed when the pesticide composition is mixed with food or an attractant or both. When the pests eat the bait they also consume the pesticide 36 composition. Baits may take the form of granules, gels, flowable powders, liquids, or solids. They may be used in or around pest harborages. Fumigants are pesticides that have a relatively high vapor pressure and hence can exist as a gas in sufficient concentrations to kill pests in soil or enclosed spaces. The 5 toxicity of the fumigant is proportional to its concentration and the exposure time. They are characterized by a good capacity for diffusion and act by penetrating the pest's respiratory system or being absorbed through the pest's cuticle. Fumigants are applied to control stored product pests under gas proof sheets, in gas sealed rooms or buildings or in special chambers. 10 Oil solution concentrates are made by dissolving a pesticide composition in a solvent that will hold the pesticide composition in solution. Oil solutions of a pesticide composition usually provide faster knockdown and kill of pests than other formulations due to the solvents themselves having pesticidal action and the dissolution of the waxy covering of the integument increasing the speed of uptake of the pesticide. Other 15 advantages of oilsolutions include better storage stability, better penetration of crevices, and better adhesion to greasy surfaces. Another embodiment is an oil-in-water emulsion, wherein the emulsion comprises oily globules which are each provided with a lamellar liquid crystal coating and are dispersed in an aqueous phase, wherein each oily globule comprises at least one 20 compound which is agriculturally active, and is individually coated with a monolamellar or oligolamellar layer comprising: (1) at least one non-ionic lipophilic surface-active agent, (2) at least one non-ionic hydrophilic surface-active agent and (3) at least one ionic surface-active agent, wherein the globules having a mean particle diameter of less than 37 800 nanometers. Further information on the embodiment is disclosed in U.S. patent publication 20070027034 published February 1, 2007, having Patent Application serial number 11/495,228. For ease of use this embodiment will be referred to as "OIWE". For further information consult "INSECT PEST MANAGEMENT" 2nd Edition 5 by D. Dent, copyright CAB International (2000). Additionally, for more detailed information consult "HANDBOOK OF PEST CONTROL - THE BEHAVIOR, LIFE HISTORY, AND CONTROL OF HOUSEHOLD PESTS" by Arnold Mallis, 9th Edition, copyright 2004 by GIE Media Inc. 10 OTHER FORMULATION COMPONENTS Generally, when the compositions disclosed in this document are used in a formulation, such formulation can also contain other components. These components include, but are not limited to, (this is a non-exhaustive and non-mutually exclusive list) wetters, spreaders, stickers, penetrants, buffers, sequestering agents, drift reduction 15 agents, compatibility agents, anti-foam agents, cleaning agents, rheology agents, stabilizers, dispersing agents, and emulsifiers. A few components are described forthwith. A wetting agent is a substance that when added to a liquid increases the spreading or penetration power of the liquid by reducing the interfacial tension between the liquid 20 and the surface on which it is spreading. Wetting agents are used for two main functions in agrochemical formulations: during processing and manufacture to increase the rate of wetting of powders in water to make concentrates for soluble liquids or suspension concentrates; and during mixing of a product with water in a spray tank to reduce the 38 wetting time of wettable powders and to improve the penetration of water into water dispersible granules. Examples of wetting agents used in wettable powder, suspension concentrate, and water-dispersible granule formulations are: sodium lauryl sulphate; sodium dioctyl sulphosuccinate; alkyl phenol ethoxylates; and aliphatic alcohol 5 ethoxylates. A dispersing agent is a substance which adsorbs onto the surface of particles and helps to preserve the state of dispersion of the particles and prevents them from reaggregating. Dispersing agents are added to agrochemical formulations to facilitate dispersion and suspension during manufacture, and to ensure the particles redisperse into 10 water in a spray tank. They are widely used in wettable powders, suspension concentrates and water-dispersible granules. Surfactants that are used as dispersing agents have the ability to adsorb strongly onto a particle surface and provide a charged or steric barrier to reaggregation of particles. The most commonly used surfactants are anionic, non-ionic, or mixtures of the two types. For wettable powder formulations, the 15 most common dispersing agents are sodium lignosulphonates. For suspension concentrates, very good adsorption and stabilization are obtained using polyelectrolytes, such as sodium naphthalene sulphonate formaldehyde condensates. Tristyrylphenol ethoxylate phosphate esters are also used. Non-ionics such as alkylarylethylene oxide condensates and EO-PO block copolymers are sometimes combined with anionics as 20 dispersing agents for suspension concentrates. In recent years, new types of very high molecular weight polymeric surfactants have been developed as dispersing agents. These have very long hydrophobic 'backbones' and a large number of ethylene oxide chains forming the 'teeth' of a 'comb' surfactant. These high molecular weight polymers can 39 give very good long-term stability to suspension concentrates because the hydrophobic backbones have many anchoring points onto the particle surfaces. Examples of dispersing agents used in agrochemical formulations are: sodium lignosulphonates; sodium naphthalene sulphonate formaldehyde condensates; tristyrylphenol ethoxylate 5 phosphate esters; aliphatic alcohol ethoxylates; alky ethoxylates; EO-PO block copolymers; and graft copolymers. An emulsifying agent is a substance which stabilizes a suspension of droplets of one liquid phase in another liquid phase. Without the emulsifying agent the two liquids would separate into two immiscible liquid phases. The most commonly used emulsifier 10 blends contain alkylphenol or aliphatic alcohol with 12 or more ethylene oxide units and the oil-soluble calcium salt of dodecylbenzene sulphonic acid. A range of hydrophile lipophile balance ("HLB") values from 8 to 18 will normally provide good stable emulsions. Emulsion stability can sometimes be improved by the addition of a small amount of an EO-PO block copolymer surfactant. 15 A solubilizing agent is a surfactant which will form micelles in water at concentrations above the critical micelle concentration. The micelles are then able to dissolve or solubilize water-insoluble materials inside the hydrophobic part of the micelle. The types of surfactants usually used for solubilization are non-ionics: sorbitan monooleates; sorbitan monooleate ethoxylates; and methyl oleate esters. 20 Surfactants are sometimes used, either alone or with other additives such as mineral or vegetable oils as adjuvants to spray-tank mixes to improve the biological performance of the pesticide on the target. The types of surfactants used for bioenhancement depend generally on the nature and mode of action of the pesticide. 40 However, they are often non-ionics such as: alky ethoxylates; linear aliphatic alcohol ethoxylates; aliphatic amine ethoxylates. Organic solvents are used mainly in the formulation of emulsifiable concentrates, ULV formulations, and to a lesser extent granular formulations. Sometimes mixtures of 5 solvents are used. The first main groups of solvents are aliphatic paraffinic oils such as kerosene or refined paraffins. The second main group and the most common comprises the aromatic solvents such as xylene and higher molecular weight fractions of C9 and C1 0 aromatic solvents. Chlorinated hydrocarbons are useful as cosolvents to prevent crystallization of pesticides when the formulation is emulsified into water. Alcohols are 10 sometimes used as cosolvents to increase solvent power. Thickeners or gelling agents are used mainly in the formulation of suspension concentrates, emulsions and suspoemulsions to modify the rheology or flow properties of the liquid and to prevent separation and settling of the dispersed particles or droplets. Thickening, gelling, and anti-settling agents generally fall into two categories, namely 15 water-insoluble particulates and water-soluble polymers. It is possible to produce suspension concentrate formulations using clays and silicas. Examples of these types of materials, include, but are limited to, montmorillonite, e.g. bentonite; magnesium aluminum silicate; and attapulgite. Water-soluble polysaccharides have been used as thickening-gelling agents for many years. The types of polysaccharides most commonly 20 used are natural extracts of seeds and seaweeds are synthetic derivatives of cellulose. Examples of these types of materials include, but are not limited to, guar gum; locust bean gum; carrageenam; alginates; methyl cellulose; sodium carboxymethyl cellulose (SCMC); hydroxyethyl cellulose (HEC). Other types of anti-settling agents are based on 41 modified starches, polyacrylates, polyvinyl alcohol and polyethylene oxide. Another good anti-settling agent is xanthan gum. Microorganisms cause spoilage of formulated products. Therefore preservation agents are used to eliminate or reduce their effect. Examples of such agents include, but 5 are not limited to: propionic acid and its sodium salt; sorbic acid and its sodium or potassium salts; benzoic acid and its sodium salt; p-hydroxy benzoic acid sodium salt; methyl p-hydroxy benzoate; and 1,2-benzisothiazalin-3-one (BIT). The presence of surfactants, which lower interfacial tension, often causes water based formulations to foam during mixing operations in production and in application 10 through a spray tank. In order to reduce the tendency to foam, anti-foam agents are often added either during the production stage or before filling into bottles. Generally, there are two types of anti-foam agents, namely silicones and non-silicones. Silicones are usually aqueous emulsions of dimethyl polysiloxane while the non-silicone anti-foam agents are water-insoluble oils, such as octanol and nonanol, or silica. In both cases, the 15 function of the anti-foam agent is to displace the surfactant from the air-water interface. For further information see "CHEMISTRY AND TECHNOLOGY OF AGROCHEMICAL FORMULATIONS" edited by D.A. Knowles, copyright 1998 by Kluwer Academic Publishers. Also see "INSECTICIDES IN AGRICULTURE AND ENVIRONMENT - RETROSPECTS AND PROSPECTS" by A.S. Perry, I. 20 Yamamoto, I. Ishaaya, and R. Perry, copyright 1998 by Springer-Verlag. APPLICATIONS 42 The actual amount of a pesticide composition to be applied to loci of pests is generally not critical and can readily be determined by those skilled in the art. In general, concentrations from about 0.01 grams of pesticide per hectare to about 5000 grams of pesticide per hectare are expected to provide good control. 5 The locus to which a pesticide composition is applied can be any locus inhabited by a pest, for example, vegetable crops, fruit and nut trees, grape vines, ornamental plants, domesticated animals, the interior or exterior surfaces of buildings, and the soil around buildings. Controlling pests generally means that pest populations, activity, or both, are reduced in a locus. This can come about when: pest populations are repulsed 10 from a locus; when pests are incapacitated in or around a locus; or pests are exterminated, in whole or in part, in or around a locus. Of course a combination of these results can occur. Generally, pest populations, activity, or both are desirably reduced more than fifty percent, preferably more than 90 percent. Generally, with baits, the baits are Placed in the ground where, for example, 15 termites can come into contact with the bait. Baits can also be applied to a surface of a building, (horizontal, vertical, or slanted, surface) where, for example, ants, termites, cockroaches, and flies, can come into contact with the bait. Because of the unique ability of the eggs of some pests to resist pesticide compositions repeated applications may be desirable to control newly emerged larvae. 20 Systemic movement of pesticides in plants may be utilized to control pests on one portion of the plant by applying the pesticide composition to a different portion of the plant. For example, control of foliar-feeding insects can be controlled by drip irrigation or furrow application, or by treating the seed before planting. Seed treatment can be '3 applied to all types of seeds, including those from which plants genetically transformed to express specialized traits will germinate. Representative examples include those expressing proteins toxic to invertebrate pests, such as Bacillus thuringiensis or other insecticidal toxins, those expressing herbicide resistance, such as "Roundup Ready" seed, 5 or those with "stacked" foreign genes expressing insecticidal toxins, herbicide resistance, nutrition-enhancement or any other beneficial traits. Furthermore, such seed treatments with the invention disclosed in this document can further enhance the ability of a plant to better withstand stressful growing conditions. This results in a healthier, more vigorous plant, which can lead to higher yields at harvest time. 10 It should be readily apparent that the invention can be used with plants genetically transformed to express specialized traits, such as Bacillus thuringiensis or other insecticidal toxins, or those expressing herbicide resistance, or those with "stacked" foreign genes expressing insecticidal toxins, herbicide resistance, nutrition-enhancement or any other beneficial traits. 15 The invention disclosed in this document is suitable for controlling endoparasites and ectoparasites in the veterinary medicine sector or in the field of animal keeping. Compositions are applied in a known manner, such as by oral administration in the form of, for example, tablets, capsules, drinks, granules, by dermal application in the form of, for example, dipping, spraying, pouring on, spotting on, and dusting, and by parenteral 20 administration in the form of, for example, an injection. The invention disclosed in this document can also be employed advantageously in livestock keeping, for example, cattle, sheep, pigs, chickens, and geese. Suitable 44 formulations are administered orally to the animals with the drinking water or feed. The dosages and formulations that are suitable depend on the species. Before a pesticide composition can be used or sold commercially, such composition undergoes lengthy evaluation processes by various governmental authorities 5 (local, regional, state, national, international). Voluminous data requirements are specified by regulatory authorities and must be addressed through data generation and submission by the product registrant or by another on the product registrant's behalf. These governmental authorities then review such data and if a determination of safety is concluded,'provide the potential user or seller with product registration approval. 10 Thereafter, in that locality where the product registration is granted and supported, such user or seller may use or sell such pesticide. EXAMPLES The following examples are for illustration purposes and are not to be construed 15 as limiting the invention disclosed in this document to only the embodiments disclosed in these examples. EXAMPLE COMPOSITIONS Example compositions A-I described below each include spinetoram. Spinetoram is a mixture of 50-90% (2R,3aR,5aR,5bS,9S, I 3S,14R, 16aSl6bR)-2-(6-deoxy-3-0-ethyl 20 2,4-di-O-methyl-a-L-mannopyranosyloxy)-1 3

-[(

2 R,5S, 6 R)-5-(dimethylamino)tetrahydro 6-methylpyran-2-yloxy]-9-ethyl-2,3,3a,4,5,5a,5b,6,9,10,11,12,13,14,16a.16b hexadecahd 14-methyL-1-s2-doxacyclododecine-7,15 -di one and 50 10% (2R,3aR,5aS,5bS,9S,13S,14R,16aS,1 6bS)-2-(6-deoxy-3-0-ethyl-2,4-di-O-methyl-a 45 L-mannopyranosyloxy)- 13-[(2R,5S,6R)-5-(dimethylamino)tetrahydro-6-methylpyran- 2 yloxy]-9-ethyl-2, 3 ,3a,5a,5b,6,9,10,11,12,13,14,16a, 1 6b-tetradecahydro-4,14-dimethyl IH-as-indaceno[3,2-d]oxacyclododecine-7,15-dione. Spinetoram is synthetically derived from a natural product and is typically accompanied by various impurities. Accordingly, 5 for each of the compositions prepared below in Examples A-I, an assay was performed on the spinetoram used to make the Examples to determine the presence of impurities. For each assay, a calibration stock solution sample was prepared by adding approximately 43 mg of an analytically standard form of spinetoram with 10.0 mL of purified water into a 125 mL glass jar. The glass jar was gently swirled until the 10 spinetoram was dispersed into the purified water. 100.0 mL of methanol was then added to the water/spinetoram mixture in the glass jar. A second solution was prepared by adding 10 mL of purified water and approximately 50 mg of the spinetoram product used in each of Examples A-I to a 125 mL glass jar. The glass jar was gently swirled until the spinetoram dispersed into the purified water. 100.0 mL of methanol was then added to 15 the mixture. Each sample was then analyzed using liquid chromatography performed with the following instrumentation and under the following conditions: Chromatograph: Agilent (formally Hewlett Packard) model 1100 or equivalent Column: Phenomenex Luna, C8(2) 3pm, 150 m x 4.6 mm column Mobile Phase A: water with 2 g/L ammonium acetate, pH adjusted to 5.5 with 20 acetic acid Mobile Phase B: acetonitrile/methanol (80:20, v:v) Isocratic elution: 20% A / 80% B Flow: 1.0 mL/minute 25 Injection volume: 10.0 pL Detector: UV @ 250 nm Run Time: 20 minutes Integrator: Agilent EZChrom Elite data acquisition system; or equivalent 46 Based on the results of the liquid chromatography, the weight percentage of the pure spinetoram component of each of the spinetoram products used in Examples A-I was calculated. The weight percentage of impurities was then calculated by subtracting the weight percentage of the pure spinetoram component from 100. The weight percentage 5 of spinetoram impurities in each of Examples A-I, based from these calculations, is provided below. Example A: A liquid composition including spinetoram, egg albumen and polyvinyl alcohol, 10 among other ingredients, was prepared according to the following. Spinetoram, Reax@ 88A, a dispersant commercially available from MeadWestvaco Corporation, P.O. Box 118005, Charleston, SC 29423, Geropon@ SDS, a surfactant commercially available "I Ic.0 Cedar Z''T~. 1.,...%_T from Rhodia, In., Broo Drive. Cranuy N 08512, and a balance of water to provide a suspension concentrate having 25-50% w/w of spinetoram were mixed 15 together. The resulting mixture was milled in an Eiger Mini Motormill media mill from Eiger Machinery, Inc., 888 East Belvidere Road, Grayslake, Illinois, 60030, to a particle size of 1-10 pm (volume weighted mean diameter). The particle size was measured using a Malvern Mastersizer 2000 laser diffraction particle analyzer from Malvern Instruments Ltd., Enigma Business Park, Grovewood Road, Malvem, Worcestershire WR 14 1 XZ 20 United Kingdom. After milling, egg albumen from Grade II chicken egg whites from Sigma Aldrich Corporation. 3050 Spruce St., St. Louis, MO, 63103 and a 15% w/w aqueous solution of Celvol@ 205 polyvinyl alcohol from Celanese Corporation, 1601 West LBJ Freeway, Dallas, Texas, 75234, were added to the mixture under agitation. 47 The 15% w/w aqueous solution of Celvol@ 205 polyvinyl alcohol was prepared according to manufacturer instructions. The total solids concentration of the mixture was adjusted in the range of 20-50% by weight by adding water. The mixture was then homogenized with a Silverson L4RT-A homogenizer from Silverson Machines Inc., 355 5 Chestnut St., East Longmeadow, MA, 01028, for about 15-30 minutes. The weight percentages for the foregoing ingredients, calculated by comparing the weight of each respective ingredient relative to the total weight of the composition, are provided in Table 1. Table I also provides the weight percentage of spinetoram impurities in the composition based on the values determined by the assay procedure described above. 10 Table 1 Example A Ingredients Wt. % Spinetoram 3.1 Spinetoram impurities 0.63 Egg Albumen 21.86 PVA 4.96 Reax@ 88A 0.37 Geropon@ SDS 0.07 Water 69.01 The liquid composition of Example A was later used for bio-efficacy experiments, but an assay was performed beforehand to determine its proportion by weight of pure 15 spinetoram so appropriate concentrations for testing could be prepared. For this assay procedure, a calibration stock solution sample was prepared by adding approximately 43 mg of an analytically standard form of spinetorarn with 10.0 mL of purified water into a 125 mL glass jar. The glass jar was gently swirled until the spinetoram was dispersed into the purified water. 100.0 mL of methanol was then added to the water/spinetoram 20 mixture in the glass jar. A second solution was prepared by adding 10 mL of purified 48 water and approximately 130 mg of the composition to a 125 mL glass jar. The glass jar was gently swirled until the composition dispersed into the purified water. 100.0 mL of methanol was then added to the mixture and the mixture was shaken for at least about 5 minutes on a mechanical shaker. An aliquot of the mixture was then filtered through a 5 0.45 prm nylon syringe filter, with the first few filtered drops being discarded, and the remaining filtrate providing a sample for liquid chromatography. Each sample was then analyzed using liquid chromatography performed with the following instrumentation and under the following conditions: Chromatograph: Agilent (formally Hewlett Packard) model 1100 or equivalent 10 Column: Phenomenex Luna, C8(2) 3pm, 150 m x 4.6 mm column Mobile Phase A: water -with 2 g/L aminonium acetate, pH adjusted to 5.5 with acetic acid Mobile Phase B: acetonitrile/methanol (80:20, v:v) Isocratic elution: 20% A / 80% B 15 Flow: 1.0 mL/minute Injection volume: 10.0 pL Detector: UV @ 250 n 20 Integrator: Agilent EZChrom Elite data acquisition system, or equivalent Based on the results of the liquid chromatography, the weight percentage of the pure spinetoram component for the composition of Example A was calculated to be 3.1%. 25 Example B: A liquid composition including spinetoram, egg albumen and polyvinyl alcohol, among other ingredients, was prepared according to the following. Spinetoram. Reax@ 88A, Geropon@ SDS and a balance of water to provide a suspension concentrate having - ----- 25-50% w/w of spinetoram were mixed togths. The resulting mixture was milled in an 30 Eiger Mini Motormill media mill from Eiger Machinery, Inc. to a particle size of 1-10 49 pm (volume weighted mean diameter). The particle size was measured using a Malvern Mastersizer 2000 laser diffraction particle analyzer from Malvern Instruments Ltd. After milling, egg albumen from Grade II chicken egg whites from Sigma Aldrich Corporation and a 15% w/w aqueous solution of Celvol@ 205 polyvinyl alcohol from Celanese 5 Corporation were added to the mixture under agitation. The 15% w/w aqueous solution of Celvol@ 205 polyvinyl alcohol was prepared according to manufacturer instructions. The total solids concentration of the mixture was adjusted in the range of 20-50% by weight by adding water. The mixture was then homogenized with a Silverson L4RT-A homogenizer from Silverson Machines Inc. for about 15-30 minutes. The weight 10 percentages for the foregoing ingredients, calculated by comparing the weight of each respective ingredient relative to the total weight of the composition exclusive of water, are provided in Table 2. Table 2 also provides the weight percentage of spinetoram impurities in the composition based on the values determined by the assay procedure described above. 15 Table 2 Example B Ingredients Wt. % Spinetoram 10.0 Spinetoram impurities 2.05 Egg Albumen 70.51 PVA 16.0 Reax@ 88A 1.20 Geropon@ SDS 0.24 The liquid composition was then spray-dried using a Buchi@ Model 190 bench top spray dryer from Buchi Corporation, 19 Lukens Drive, Suite 400, New Castle, DE 20 19720, at about a 300-400 ml/hr feed rate, 4-6 bar nozzle pressure, 115-1400 C inlet 50 temperature and 50-100* C outlet temperature to provide a solid composition. It is believed that the spray drying process removes all or substantially all of the water and other volatile ingredients from the-liquid composition as it is converted to the solid composition. Since none of the ingredients in Example B apart from the water is 5 believed to be volatile, it is contemplated that the solid composition includes weight percentages for each of the ingredients substantially similar to those provided in Table 2. The solid composition of Exanple B was later used for bio-efficacy experiments, but an assay was performed beforehand to determine its proportion by weight of pure spinetoram so appropriate concentrations for testing could be prepared. 10 For this assay procedure, a calibration stock solution sample was prepared by adding approximately 43 mg of an analytically standard form of spinetoram with 10.0 mL of purified water into a 125 mL glass jar. The glass jar was gently swirled until the spinetoran was dispersed into the purified water. 100.0 mL of methanol was then added to the water/spinetoram mixture in the glass jar. A second solution was prepared by 15 adding 10 mL of purified water and approximately 130 mg of the solid composition to a 125 mL glass jar. The glass jar was gently swirled until the solid composition dispersed into the purified water. 100.0 mL of methanol was then added to the mixture and the mixture was shaken for at least about 5 minutes on a mechanical shaker. An aliquot of the mixture was then filtered through a 0.45 ptm nylon syringe filter, with the first few 20 filtered drops being discarded, and the remaining filtrate providing a sample for liquid chromatography. Each sample was then analyzed using liquid chromatography pfourmed witL Ui itumeUUntation andiAn accor 0- -- t te s ra e in Example A. Based on the results of the liquid chromatography, the weight percentage 51 of the pure spinetoram component for the solid composition of Example B was calculated to be 9.8%. Example C: 5 A liquid composition including spinetoram, egg albumen and polyvinyl alcohol, among other ingredients, was prepared according to the following. Spinetoram, Reax@ 88A, Geropon@ SDS and a balance of water to provide a suspension concentrate having 25-50% w/w of spinetoram were mixed together. The resulting mixture was milled in an Eiger Mini Motormill media mill from Eiger Machinery, Inc. to a particle size of 1-10 10 pm (volume weighted mean diameter). The particle size was measured using a Malvern Mastersizer 2000 laser diffraction particle analyzer from Malvern Instruments Ltd. After milling, egg albumen from Grade II chicken egg whites from Sigma Aldrich Corporation and a 15% w/w aqueous solution of Celvol@ 205 polyvinyl alcohol from Celanese Corporation were added to the mixture under agitation. The 15% w/w aqueous solution 15 of Celvol@ 205 polyvinyl alcohol was prepared according to manufacturer instructions. The total solids concentration of the mixture was adjusted in the range of 20-50% by weight by adding water. The mixture was then homogenized with a Silverson L4RT-A homogenizer from Silverson Machines Inc. for about 15-30 minutes. The weight percentages for the foregoing ingredients, calculated by comparing the weight of each 20 respective ingredient relative to the total weight of the composition, are provided in Table 3. Table 3 also provides the weight percentage of spinetoram impurities in the composition based on the values determined by the assay procedure described above. Table 3 Example C 52 Ingredients Wt. % Spinetoramn 4.0 Spinetoram impurities 0.8 Egg Elbumen 28.22 PVA 6.4 Reax@ 88A 0.48 Geropon SDS 0.1 Water 60.0 The liquid composition of Example C was later used for bio-efficacy experiments, but an assay was performed beforehand to determine its proportion by weight of pure spinetoram so appropriate concentrations for testing could be prepared. The assay was 5 performed according to the procedure described above with respect to Example A and the weight percentage of the pure spinetoram component for the composition was calculated to be 4.0%. Example D: 10 A liquid composition including spinetoram, egg albumen and polyvinyl alcohol, among other ingredients, was prepared according to the following. Spinetoram, Reax@ 88A, Geropon@ SDS and a balance of water to provide a suspension concentrate having 25-50% w/w of spinetoram were mixed together. The resulting mixture was milled in an Eiger Mini Motormill media mill from Eiger Machinery, Inc. to a particle size of 1-10 5 im (volume weighted mean diameter). The particle size was measured using a Malvern Mastersizer 2000 laser diffraction particle analyzer from Malvern Instruments Ltd. After milling, egg albumen from Grade II chicken egg whites from Sigma Aldrich Corporation and a 15% w/w aqueous solution of Celvol@ 205 polyvinyl alcohol from Celanese Corporation were added to the mixture under agitation. The 5% w/waqu ssol 53 of Celvol@ 205 polyvinyl alcohol was prepared according to manufacturer instructions. The total solids concentration of the mixture was adjusted in the range of 20-50% by weight by adding water. The mixture was then homogenized with a Silverson L4RT-A homogenizer from Silverson Machines Inc. for about 15-30 minutes. The weight 5 percentages for the foregoing ingredients, calculated by comparing the weight of each respective ingredient relative to the total weight of the composition exclusive of water, are provided in Table 4. Table 4 also provides the weight percentage of spinetoram impurities in the compositon based on the values determined by tue assay procedure described above. 10 Table 4 Example D Ingredients Wt. % Spinetoram 10.0 Spinetoram impurities 2.0 Egg Albumen 70.56 PVA 16.0 Reax@ 88A 1.2 Geropon SDS 0.24 The liquid composition was then spray-dried using a Buchi@ Model 190 bench top spray dryer from Buchi Corporation at about a 300-400 ml/hr feed rate, 4-6 bar 15 nozzle pressure, 115-1400 C inlet temperature and 50-100* C outlet temperature to provide a solid composition. It is believed that the spray drying process removes all or substantially all of the water and other volatile ingredients from the liquid composition as it is converted to the solid composition. Since none of the ingredients in Example D apart from the water is believed to be volatile, it is contemplated that the solid 20 composition includes weight percentages for each of the ingredients substantially similar 54 to those provided in Table 4. The solid composition of Example D was later used for bio efficacy experiments, but an assay was performed beforehand to determine its proportion by weight of pure spinetoram so appropriate concentrations for testing could be prepared. The assay was performed according to the procedure described above with respect to 5 Example B and the weight percentage of the pure spinetoram component for the solid composition was calculated to be 9.6%. Example E: A liquid composition including spinetoram, egg albumen and polyvinyl alcohol, 10 among other ingredients, was prepared according to the following. Spinetoram, Reax@ 88A, Geropon@ SDS and a balance of water to provide a suspension concentrate having 25-50% w/w of spinetoram were mixed together. The resulting mixture was milled in an Eirini M l ma mil frm Eiger Mchinery, Inc. to a particle si f-1 .l, . VjIJi, IVIULJI3II- AI A-- - -e of9- 1-0 pm (volume weighted mean diameter). The particle size was measured using a Malvern 15 Mastersizer 2000 laser diffraction particle analyzer from Malvern Instruments Ltd. After milling, egg albumen from Grade Il chicken egg whites from Sigma Aldrich Corporation and a 15% w/w aqueous solution of Celvol@ 205 polyvinyl alcohol from Celanese Corporation were added to the mixture under agitation. The 15% w/w aqueous solution of Celvol@ 205' polyvinyl alcohol was prepared according to manufacturer instructions. 20 The total solids concentration of the mixture was adjusted in the range of 20-50% by weight by adding water. The mixture was then homogenized with a Silverson L4RT-A homogeni7r from Silverson Machines Ine. for about 15-30 minutes. The weight percentages for the foregoing ingredients, calculated by comparing the weight of each 55 respective ingredient relative to the total weight of the composition exclusive of water, are provided in Table 5. Table 5 also provides the weight percentage of spinetoram impurities in the composition based on the values determined by the assay procedure described above. 5 Table 5 Example E Ingredients Wt. % Spinetoram 10.0 Spinetoram impurities 2.05 Egg Albumen 10.51 PVA 69.7 Reax@ 88A 1.20 Geropon SDS 0.24 The liquid composition was then spray-dried using a Buchi@ Model 190 bench top spray dryer from Buchi Corporation at about a 300-400 ml/hr feed rate, 4-6 bar 10 nozzle pressure, 115-1400 C inlet temperature and 50-100* C outlet temperature to provide a solid composition. It is believed that the spray drying process removes all or substantially all of the water and other volatile ingredients from the liquid composition as it is converted to the solid compositions. Since none of the ingredients in Example E apart from the water is believed to be volatile, it is contemplated that the solid 15 composition includes weight percentages for each of the ingredients substantially similar to those provided in Table 5. The solid composition of Example E was later used for bio efficacy experiments, but an assay was performed beforehand to determine its proportion by weight of pure spinetoram so appropriate concentrations for testing could be prepared. The assay was performed according to the procedure described above with respect to 56 Example B and the weight percentage of the pure spinetoram component for the solid composition was calculated to be 7.1%. Example F: 5 A liquid composition including spinetoram, egg albumen and polyvinyl alcohol, among other ingredients, was prepared according to the following. Spinetoram, Reax@ 88A, Geropon@ SDS and a balance of water to provide a suspension concentrate having 25-50% w/w of spinetoram were mixed together. The resulting mixture was milled in an Eiger Mini Motormill media mill from Eiger Machinery, Inc. to a particle size of 1-10 10 um (volume weighted mean diameter). The particle size was measured using a Malvern Mastersizer 2000 laser diffraction particle analyzer from Malvern Instruments Ltd. After milling, egg albumen from Grade II chicken egg whites from Sigma Aldrich Corporation a i 1 ICU -'i- vyO--1 205~'~ no -viny alcohol m t..elanese Corporation were added to the mixture under agitation. The 15% w/w aqueous solution 15 of Celvol@ 205 polyvinyl alcohol was prepared according to manufacturer instructions. The total solids concentration of the mixture was adjusted in the range of 20-50% by weight by adding water. The mixture was then homogenized with a Silverson L4RT-A homogenizer from Silverson Machines Inc. for about 15-30 minutes. The weight percentages for the foregoing ingredients, calculated by comparing the weight of each 20 respective ingredient relative to the total weight. of the composition exclusive of water, are provided in Table 6. Table 6 also provids the we ight percentage of spinetoranm impurities in the composition chased on the vais determined by the assay procedure described above. 57 Table 6 Example.F Ingredients Wt. % Spinetoramn 20.0 Spinetoram impurities 4.10 Egg Albumen 58.11 PVA 14.90 Reax@ 88A 2.41 Geropon SDS 0.48 The liquid composition was then spray-dried using a Buchi@ Model 190 bench 5 top spray dryer from Buchi Corporation at about a 300-400 ml/hr feed rate, 4-6 bar nozzle pressure, 115-140" C inlet temperature and 50-100* C outlet temperature to provide a solid composition. It is believed that the spray drying process removes all or substantially all of the water and other volatile ingredients from the liquid composition as it is converted to the solid composition. Since none of the ingredients in Example F apart 10 from the water is believed to be volatile, it is contemplated that the solid composition includes weight percentages for each of the ingredients substantially similar to those provided in Table 6. The solid composition of Example F was later used for bio-efficacy experiments, but an assay was performed beforehand to determine its proportion by weight of pure spinetoram so appropriate concentrations for testing could be prepared. 15 The assay was performed according to the procedure described above with respect to Example B and the weight percentage of the pure spinetoram component for the solid composition was calculated to be 19.6%. Example G: 58 A liquid composition including spinetoram, egg albumen and a vinyl acrylic latex, among other ingredients, was prepared according to the following. Spinetoram, Reax@ 88A, Geropon@ SDS and a balance of water to provide a suspension concentrate having 25-50% w/w of spinetoram were mixed together. The resulting mixture was milled in an 5 Eiger Mini Motormill media mill from Eiger Machinery, Inc. to a particle size of 1-10 pm (volume weighted mean diameter). The particle size was measured using a Malvern Mastersizer 2000 laser diffraction particle analyzer from Malvern Instruments Ltd. After milling, egg albumen from Grade II chicken egg whites from Sigma Aldrich Corporation, Min-U-Gel* 400, a magnesium aluminum siliate from Active Minerals Internatinal, LLC, 10 6 North Park Drive, Suite 105, Hunt Valley, MD, 21030, and a vinyl acrylic latex in the form of UCARM Latex 379G from Dow Chemical Company, 2030 Dow Center, Midland, Michigan 48674 were added to the mixture under agitation. The total solids convention Of the mixture was adjusted;in the range of 20-50% by weight by adding water. The mixture was then homogenized with a Silverson L4RT-A homogenizer from A5 Silverson Machines Inc. for about 15-30 minutes. The weight percentages for the foregoing ingredients, calculated by comparing the weight of each respective ingredient relative to the total weight of the composition exclusive of water, are provided in Table 7. Table 7 also provides the weight percentage of spinetoram impurities in the composition based on the values determined by the assay procedure described above: 20 Table 7 Example G Ingredients Wt. % Spinetoram 10.0 Spinetoram impurities 2.05 Egg albumen 47.07 Min-U-Gel® 400 16.00 59 Vinyl acrylic latex 22.0 Reax@ 88A 2.40 Geropon@ SDS 0.48 The liquid composition was then spray-dried using a Buchi@ Model 190 bench top spray dryer from Buchi Corporation at about a 300-400 ml/hr feed rate, 4-6 bar nozzle pressure, 115-140* C inlet temperature and 50-100* C outlet temperature to 5 provide a solid composition. It is believed that the spray drying process removes all or substantially all of the water and other volatile ingredients from the liquid composition as it is converted to the solid composition. Since none of the ingredients in Example G apart from the water is believed to be volatile, it is contemplated that the solid composition includes weight percentages for each of the ingredients substantially similar 10 to those provided in Table 7. The solid composition of Example G was later used for bio efficacy experiments, but an assay was performed beforehand to determine its proportion by weight of pure spinetoram so appropriate concentrations for testing could be prepared. The assay was performed according to the procedure described above with respect to Example B and the weight percentage of the pure spinetoram component for the solid 15 composition was calculated to be 10.5%. Example H: A liquid composition including spinetoram, egg albumen and a terpene polymer, among other ingredients, was prepared according to the following. Spinetoram, Reax@ 20 88A, Geropon@ SDS and a balance of water to provide a suspension concentrate having 2550% w/w of spinetoram were mixed together. I he resutiiig mixture was milled in an Eiger Mini Motormill media mill from Eiger Machinery, Inc. to a particle size of 1-10 60 pm (volume weighted mean diameter). The particle size was measured using a Malvern Mastersizer 2000 laser diffraction particle analyzer from Malvern Instruments Ltd. After milling, egg albumen from Grade II chicken egg whites from Sigma Aldrich Corporation and a terpene polymer in the form of NU FILM 17@ from Miller Chemical and Fertilizer 5 Corporation, P.O. Box 333, 120 Radio Road, Hanover, Pennsylvania 17331, were added to the mixture under agitation. The total solids concentration of the mixture was adjusted in the range of 20-50% by weight by adding water. The mixture was then homogenized wiLI a Silversun R-A homogene from Silverson Machi Inc. for abut 1 minutes. The weight percentages for the foregoing ingredients, calculated by comparing 10 the weight of each respective ingredient relative to the total weight of the composition exclusive of water, are provided in Table 8. Table 8 also provides the weight percentage of spinetoram impurities in the composition based on the values determined by the assay procedure described above. Table 8 15 Example H W_._% Ingredients %____ Spinetoram 10.0 Spinetoram impurities 2.05 Egg albumen 48.95 Nu-Film 17 24.00 Reax@ 88A 13.20 Geropon SDS | 1.80 The liquid composition was then spray-dried using a Buchi@ Model 190 bench top spray dryer from Buchi Corporation at about a 300-400 ml/hr feed rate, 4-6 bar nozzle pressure, 115-1400 C inlet temperature and 50-100* C outlet temperature to 20 provide a solid composition. It is believed that the spray drying process removes all or substantially all of the water and other volatile ingredients from the liquid composition as 61 it is converted to the solid composition. Since none of the ingredients in Example H apart from the water is believed to be volatile, it is contemplated that the solid composition includes weight percentages for each of the ingredients substantially similar to those provided in Table 8. The solid composition of Example H was later used for bio 5 efficacy experiments, but an assay was performed beforehand to determine its proportion by weight of pure spinetoram so appropriate concentrations for testing could be prepared. The assay was performed according to the procedure described above with respect to Example B and the weight percentage of the pure.spiet.r..coponlent for the solid composition was calculated to be 10.4%. 10 Example I: A liquid composition including spinetoram and polyvinyl alcohol, among other ingredients, was prepared according to the following. Spinetoram, Reax@ 88A, Geropon@ SDS and a balance of water to provide a suspension concentrate having 25 15 50% w/w of spinetoram were mixed together. The resulting mixture was milled in an Eiger Mini Motormill media mill from Eiger Machinery, Inc. to a particle size of 1-10 ptm (volume weighted mean diameter). The particle size was measured using a Malvern Mastersizer 2000 laser diffraction particle analyzer from Malvern Instruments Ltd. After milling, a 15% w/w aqueous solution of Celvol@ 205 polyvinyl alcohol from Celanese 20 Corporation was added to the mixture under agitation. The 15% w/w aqueous solution of Celvol@ 205 polyvinyl alcohol was prepared according to manufacturer instructions. The total solids concentration of the mixture was adjusted in the range of 20-50% by weight by adding water. The mixture was then homogenized with a Silverson L4RT-A 62 homogenizer from Silverson Machines Inc. for about 15-30 minutes. The weight por the foregoing ingrdints, calculated by comparing the weight of each respective ingredient relative to the total weight of the composition exclusive of water, are provided in Table 9. Table 9 also provides the weight percentage of spinetoram 5 impurities in the composition based on the values determined by the assay procedure described above. Table 9 Example I Ingredfients W t. %0 Spinetoram 33.50 Spinetoram impurities 4.92 PVA 56.97 Reax@ 88A 3.84 Geropon SDS 0.77 10 The liquid composition was then spray-dried using a Buchi@ Model 190 bench top spray drVer from Buchi Corporation at about a 300-400 ml/hr feed rate, 4-6 bar nozzle pressure, 115-140* C inlet temperature and 50-100* C outlet temperature to provide a solid composition. It is believed that the spray drying process remOves all or substantially al1 of the water and other volatile ingredients from the liquid composition as 15 it is converted to the solid composition. Since none of the ingredients in Example I apart from the water is believed to be volatile, it is contemplated that the solid composition includes weight percentages for each of the ingredients substantially similar to those provided in Table 9. The solid composition of Example I was later used for bio-efficacy experiments, but an assay was performed beforehand to determine its proportion by 20 weight of pure spinetoram so appropriate concentrations for testing could be prepared. The assay was performed according to the procedure described above with respect to 63 Example B and the weight percentage of the pure spinetoram component for the solid composition was calculated to be 27.7%. 5 BIO-EFFICACY TESTING Biological efficacy experiments in Examples I-V were conducted according to the following parameters. A spinetoram control solution was prepared utilizing either Radiant, a suspension concentrate formulation of spinetoram, or Delegate®, a water dispersible granule formulation of spinetoram, in water to obtain a spinetoram 10 concentration in solution of 125 ppm. Radiant and Delegate® are commercially available from Dow AgroSciences LLC, 9330 Zionsville Road, Indianapolis, IN, 46268. Test solutions were also prepared utilizing the liquid compositions of Examples A and C and the solid compositions of Examples B and D-I (collectively the Example A-I solutions) in water to obtain a spinetoram concentration in each solution of 125 ppm. 15 These solutions, plus a water-only control, were applied to potted pepper plants (Capsicum annuum) using a Mandel track sprayer calibrated to deliver the equivalent of 200 L/Ha of spray. Treated plants were allowed to dry and then were aged outdoors in natural sunlight or under a set of lamps emitting ultraviolet light at levels comparable to natural sunlight. At the appropriate time after treatment, i.e., at 4, 7 and 10 or 4, 7 and 11 20 days after treatment, 2.5 cm diameter disks were cut from treated leaves. One leaf disk was placed in each well of a 32 well plastic tray, which also contained a thin layer of agar to provide moisture. There were 8 replicate disks per treatment. Each well was infested with three second instar beet armyworm (Spodoptera exigua) larvae, and the well was 64 sealed with plastic film. Larvae were held in an environmental chamber at 25"C/40 percent relative humidity. At 48 hours after infestation, the larvae were graded for mortality. A larva was considered dead if it could not move after being prodded, and the percent mortality (percent control) was calculated. 5 For each of Examples I-V, Table 10 below provides the percent control of the insect associated with the spinetoram control solution relative to an untreated standard. For Example A-I solutions, Table 10 provides the improvement in percent control relative to the spinetoram control solution (i.e., (percent control by Example A-I solutions) - (percent control by spinetoram control solution)). Table 10 also provides the 10 average improvement over the spinetoram control solution which was calculated by summing the individual improvements for each of the days relative to the control and then dividing by the number of measurements. For Examples 1, II and V, the spinetoram control solution included Radiant@ and for Examples II and IV, the spinetoram control solution included Delegate@. 15 Table 10 Solution 3 4 5 6 7 9 10 11 12 13 14 Average Solution DAT DAT DAT DAT DAT DAT DAT DAT DAT j DAT DAT TImprovement Example I Spinetoram Control Solution 88 25 8 Example A Solution 8 54 3 3 32 Example B Solution 8 50 29 2 Example II Spinetoramn Contro-- i-- - I Solution 67 33 25 Exampie2C 21 - - 29 -_21 65 Solution Example D Solution ~_ 33 58 29 40 Example I Spinetoram Control - - Solution 92 .21 17 Example F _ Solution 4 1 1 29 1 1 29 1 -_ 21 Example IV Spinetoram Control - - Solution 92 _ 67 33 Example E 4 - 17 50 24 Solution Example _ -13 8 17 4 Solution Exam le V Spinetoram Control -- ~ Solution 33 8 4 Example G Solution 34 38 4 25 Example H Solution ~~ 30 30 4 21 The headings in this document are for convenience only and must not be used to interpret any portion thereof. Any theory, mechanism of operation, proof, or finding stated herein is meant to 5 further enhance understanding of the present invention and is not intended to make the present invention in any way dependent upon such theory, mechanism of operation, proof, or finding. It should be understood that while the use of the word preferable, preferably or preferred in the description above indicates that the feature so described may be more desirable, it nonetheless may not be necessary and embodiments lacking the ,-0 same may be contemplated as within the scope of die inventions at scope being defined 66 by the claims that follow. In reading the claims it is intended that when words such as "a," "an," "at least one," "at least a portion" are used there is no intention to limit the claim to only one item unless specifically stated to the contrary in the claim. Further, when the language "at least a portion" and/or "a portion" is used the item may include a 5 portion and/or the entire item unless specifically stated to the contrary. While the invention has been illustrated and described in detail in the drawings and foregoing description, the same is to be considered as illustrative and not restrictive in character, it ' : -. A'AA - -- 141 1 .. A 1--- i.--- ___ -A -221U being UdIsLooU UaL only Lie selecteU eoi eniiits 1ave be11 shownl and describeu that all changes, modifications and equivalents that come within the spirit of the 10 invention as defined herein or by any of the following claims are desired to be protected. 67

Claims (14)

1. A composition, comprising at least one macrocyclic lactone insecticide, at least one proteinaceous material and at least one polymeric material, wherein the proteinaceous material is selected from the group consisting of bovine serum albumin, egg albumen, whey, gelatin and zein, 5 the at least one polymeric material is selected from the group consisting of polyvinyl alcohol, derivatives of polyvinyl alcohol, polyvinyl pyrrolidone, and derivatives of polyvinyl pyrrolidone, and the composition exhibits enhanced pesticidal activity levels compared to a composition dissimilar only in not having the at least one proteinaceous material and the at least one polymeric material. 10

2. The composition of claim 1, wherein the at least one macrocyclic lactone insecticide is a spinosyn selected from the group consisting of spinetoram and spinosad.

3. The composition of claim 1 or 2, which comprises a ratio by weight between the at least one proteinaceous material and the at least one pesticide between about 2:1 to about 8:1, a ratio by weight between the at least one polymeric material and the at least one pesticide between about 1:2 15 to about 3:1, and a ratio by weight between the at least one proteinaceous material and the at least one polymeric material between about 2:1 to about 5:1.

4. The composition of claim 1 or 2, which comprises a ratio by weight between the at least one proteinaceous material and the at least one pesticide between about 1:2 to about 4:1, a ratio by weight between the at least one polymeric material and the at least one pesticide between about 4:1 20 to about 10:1, and a ratio by weight between the at least one proteinaceous material and the at least one polymeric material between about 1:8 to about 1:1.

5. The composition of claim 1 or 2, which comprises from about 2% to about 25% by weight of the at least one macrocyclic lactone insecticide.

6. The composition of claim 1 or 2, which comprises from about 5% to about 70% by weight 25 of the at least one polymeric material.

7. The composition of claims 5 or 6, which comprises from about 15% to about 75% by weight of the at least one proteinaceous material.

8. A composition, comprising at least one macrocyclic lactone insecticide, at least one proteinaceous material and at least one polymeric material, wherein the proteinaceous material is 68 selected from the group consisting of bovine serum albumin, egg albumen, whey, gelatin and zein, the polymeric material is selected from the group consisting of a terpene polymer and a latex, and the composition exhibits enhanced pesticidal activity levels compared to a composition dissimilar only in not having the at least one proteinaceous material and the at least 5 one polymeric material.

9. The composition of claim 8, wherein the at least one macrocyclic lactone insecticide is a spinosyn selected from the group consisting of spinetoram and spinosad.

10. The composition of claim 8 or 9, wherein the latex is a vinyl acrylic latex.

11. The composition of any one of claims 8 to 10, wherein the at least one proteinaceous 10 material includes egg albumen.

12. A composition, comprising at least one macrocyclic lactone insecticide, at least one proteinaceous material and at least one polymeric material, wherein the proteinaceous material is selected from the group consisting of bovine serum albumin, egg albumen, whey, gelatin and zein, the polymeric material is selected from the group consisting of polyvinyl alcohol, 15 derivatives of polyvinyl alcohol, polyvinyl pyrrolidone, and derivatives of polyvinyl pyrrolidone.

13. The composition of claim 12, wherein the at least one macrocyclic lactone insecticide is chosen from spinosad or spinetoram, the at least one proteinaceous material comprises egg albumen, and the at least one polymeric material comprise polyvinyl alcohol.

14. A method, comprising spray drying a liquid composition according to any one of claims 20 1-13 to provide a solid composition. 69