AU2011100558A4 - Herbal compositions and uses for symptomatic relief of tinnitus, migraine, headaches, vertigo, insomnia and sleeplessness - Google Patents

Abstract

Abstract The present innovation relates generally to a composition for the symptomatic relief of tinnitus, migraine, headaches, vertigo, insomnia and sleeplessness, such as but not limited to providing temporary relief of the pain of migraine and headaches, reducing tinnitus and vertigo, improving insomnia and sleeplessness in mammals. More particularly, the present innovation is directed to compositions comprising herbs or extracts of herbs or botanical or horticultural equivalents of the herbs or chemical or functional equivalents of the herbal extracts useful for reducing arthritic pain and joint inflammation, such as but not limited to providing the symptomatic relief of tinnitus, migraine, headaches, vertigo, insomnia and sleeplessness, such as but not limited to providing temporary relief of the pain of migraine and headaches, reducing tinnitus and vertigo, improving insomnia and sleeplessness in mammals. The present innovation further contemplates a method of uses in mammals by administration of a herbal composition or its chemical or functional equivalent.

Description

Specification of G & W Aust NeuroZeal Capsule Applicants: Guorang Hu and Wangcheng Hu Country: Australia Application: Australian Innovation Patent Title: Herbal compositions and uses for symptomatic relief of tinnitus, migraine, headaches, vertigo, insomnia and sleeplessness Field of Innovation The present innovation relates generally to a composition for the symptomatic relief of tinnitus, migraine, headaches, vertigo, insomnia and sleeplessness, such as but not limited to providing temporary relief of the pain of migraine and headaches, reducing tinnitus and vertigo, improving insomnia and sleeplessness in mammals. More particularly, the present innovation is directed to compositions comprising herbs or extracts of herbs or botanical or horticultural equivalents of the herbs or chemical or functional equivalents of the herbal extracts useful for the symptomatic relief of tinnitus, migraine, headaches, vertigo, insomnia and sleeplessness, such as but not limited to providing temporary relief of the pain of migraine and headaches, reducing tinnitus and vertigo, improving insomnia and sleeplessness in mammals. The present innovation further contemplates a method of uses in mammals by administration of a herbal composition or its chemical or functional equivalent. Background of the Innovation Herbal formulations comprising extracts of more than one herbal plant have been used for centuries in Traditional Chinese Medicine (TCM). Use of herbal formulations is a major principle of TCM in the utilization of herbs in the management of diseases. There is now an increasing acceptance of their value and therapeutic efficacy in Western medicine. TCM has its unique and philosophical theory in etiology, diagnosis, pharmacology and therapeutics. In fact, many concepts surrounding TCM have particular relevance to Western medicine such as viewing parts of the body as an organic whole, considering inter-relations and influences between organs and being aware of relevant adaptation of the human body to the natural environment. As such, integration of ancient wisdom and modern sciences in herbal formulations has become a valuable approach to the research and development of useful herbal preparations in the management of sub-optimal and chronic health conditions. Both applicants of this Innovation are senior medical doctors and have long been practising TCM and are experienced in the treatment of the age-related and sub-optimal health disorders. One of the applicants of this Innovation Dr. GR Hu has twenty years of research study experiences at the University of Sydney and more than 40 years of clinical practice in herbal medicines, and also been granted PhD in medicine in TCM clinical research at the Department of Medicine, Sydney University. Combined with the latest scientific findings and modern pharmaceutical technology, the applicants have developed a series of leading edge herbal medications in the fields of ageing, allergies, arthritis, male function, and regulation of sugar and cholesterol, in which one has been internationally patented in the US, Singapore, China and Australia, another six have been granted Innovation patents. Now a new formulation for the symptomatic relief of tinnitus, migraine, headaches, vertigo, insomnia and sleeplessness in mammals has been developed, and lead up to the present innovation patent application. This Innovation is developed upon a latest scientifically formulated herbal formulation by the applicants for the symptomatic relief of tinnitus, migraine, headaches, vertigo, insomnia and sleeplessness. The herbs in this formula have long been used as traditional medicines for the relief of Tinnitus, Headaches, Migraine, Iinsomnia and Vertigo. Extensive research has shown that the main active components of these herbs have effective anti-inflammatory, blood circulation improving, pain and sleeplessness relieving properties that may assist in the management of Tinnitus, Headaches, Migraine, Insomnia, Dizziness & Vertigo, as well as help maintain healthy memory and cognitive function.

Summary of the innovation One aspect of the present innovation provides a composition comprising herbs or extracts of herbs or botanical or horticultural equivalents of herbs or chemical or functional equivalents of the extract wherein said composition is effective for the symptomatic relief of tinnitus, migraine, headaches, vertigo, insomnia and sleeplessness, as well as for the maintenance of healthy memory and cognitive function in mammals. A further aspect of the present innovation provides a composition comprises four or more herbs or extracts of four or more herbs selected from the list comprising: Salvia miltiorrhiza root Paeonia lactiflora root Uncaria rhyncophylla hook-bearing branch Paeonia suffruticosa root bark Ginkgo biloba leaf Pueraria lobata root Gastrodia elata tuber Epimedium sagittatum leaf Panax notoginseng root Ledebouriella divaricate root Angelica dahurica root Schizandra chinensis fruit Ligusticum wallichii rhizome Anemarrhena asphodeloides Rhizome Rehmannia glutinosa rhizome Polygonatum sibiricum rhizome Tanacetum parthenium herb Another aspect of the present innovation contemplates a method of oral use in mammals by administration of a herbal composition or its chemical or functional equivalent for the symptomatic relief of tinnitus, migraine, headaches, vertigo, insomnia and sleeplessness in mammals, and the said method comprising administering an effective amount of the composition as hereinbefore described for a time and under conditions sufficient for the relief of the pain of migraine and headaches, reducing tinnitus and vertigo, improving insomnia and sleeplessness, and maintenance of healthy memory and cognitive function in mammals. Detailed description of the preferred embodiments In a most preferred embodiment, the composition comprises the following herbs or extracts thereof in approximate percentage amounts shown in parentheses: Name Ingredient Amount Information (%, W/W) Salvia miltiorrhiza Root, Dry 5-50 Paeonia lactiflora Root, Dry 5-50 Uncaria rhyncophylla Hook-bearing branch, Dry 5-50 Paeonia suffruticosa Root bark, Dry 5-30 Ginkgo biloba Leaf, Dry 5-30 Pueraria lobata Root, Dry 5-30 Gastrodia elata Tuber, Dry 5-20 Epimedium sagittatum Leaf, Dry 5-20 Panax notoginseng Root, Dry 5-20 Ledebouriella divaricate Root, Dry 5-20 Angelica dahurica Root, Dry 5-20 Schizandra chinensis Fruit, Dry 5-20 Ligusticum wallichii Rhizome, Dry 5-20 Anemarrhena asphodeloides Rhizome, Dry 5-20 Rehmannia glutinosa Rhizome, Dry 5-20 Polygonatum sibiricum Rhizome, Dry 5-20 Tanacetum parthenium Herb, Dry 3-10 The compositions of the present innovation may also comprise one or more pharmacologically acceptable carriers and/or diluents. Such carriers and/or diluents include any and all solvents, water, dispersion media, coatings, antibacterial and antifungal agents, isotonic and absorption or penetration enhancing agents and the like. Preferably, the diluent is water or a water or alcohol based extraction of the herbs. The composition may be in the form of capsules, tablets, buccal tablets, troches, elixirs, suspensions, syrups, wafers, plaster, cream and the like. They may also be in a form which may be inhaled or given by nasal spray, aerosol droplets or vapour infusion. Particularly important conditions to treat are Tinnitus, Migraine, Headaches, Vertigo and Insomnia, as well as to help maintain healthy memory and cognitive function. In a particularly preferred embodiment, the herbs are contained and subject to conventional extraction techniques. Such techniques include water extraction, solvent extraction, alcohol extraction and/or acid or base extraction. The resulting extract is then preferably incorporated into a capsule. Mammals contemplated herein include humans, primates, laboratory test animals (eg. mice, rabbits, guinea pigs, hamsters), livestock animals (eg. cows, sheep, horses, pigs), companion animals (eg. dogs, cats) or captive wild animals. Preferably, the mammal is a human. Preferably, the compositions are provided orally such as in capsule forms, where multiple capsules are performed hourly, daily, weekly or monthly.

Example 1 The NeuroZeal Capsule herbal formulation comprises extracts from seventeen herbs. The herbs employed and their percentage amounts are shown in Table 1. Table 1 NeuroZeal Capsule herbal formulation Herb Ingredient % Amount Information (w/w) Salvia miltiorrhiza Root, Dry 13.89 Paeonia lactiflora Root, Dry 13.89 Paeonia suffruticosa Root bark, Dry 11.11 Ginkgo biloba Leaf, Dry 11.11 Pueraria lobata Root, Dry 11.11 Gastrodia elata Tuber, Dry 9.26 Uncaria rhyncophylla Hook-bearing branch, Dry 5.55 Epimedium sagittatum Leaf, Dry 4.63 Panax notoginseng Root, Dry 2.78 Ledebouriella divaricate Root, Dry 2.78 Angelica dahurica Root, Dry 2.78 Schizandra chinensis Fruit, Dry 2.78 Ligusticum wallichii Rhizome, Dry 1.85 Anemarrhena asphodeloides Rhizome, Dry 1.85 Rehmannia glutinosa Rhizome, Dry 1.85 Polygonatum sibiricum Rhizome, Dry 1.85 Tanacetum parthenium Herb, Dry 0.93 Example 2 Herbal extraction techniques were performed according to specific protocols and were designed to maintain maximal levels of active components. Extracts of the seventeen herbs listed in Table 1 were formulated and capsulated, then sealed in bottles.

Claims (4)

1. A composition comprising herbs or extracts of herbs or botanical or horticultural equivalents of herbs or chemical or functional equivalents of the extract wherein said composition is effective for Tinnitus, Headaches, Migraine, Insomnia, Dizziness & Vertigo, as well as for the maintenance of healthy memory and cognitive function in mammals.

2. A composition according to claim 1 comprises the following herbs: Salvia miltiorrhiza root Paeonia lactiflora root Uncaria rhyncophylla hook-bearing branch Paeonia suffruticosa root bark Ginkgo biloba leaf Pueraria lobata root Gastrodia elata tuber Epimedium sagittatum leaf Panax notoginseng root Ledebouriella divaricate root Angelica dahurica root Schizandra chinensis fruit Ligusticum wallichii rhizome Anemarrhena asphodeloides Rhizome Rehmannia glutinosa rhizome Polygonatum sibiricum rhizome Tanacetum parthenium herb

3. A method according to claim 1 for the symptomatic relief of Tinnitus, Headaches, Migraine, Insomnia, Dizziness & Vertigo, as well as for the maintenance of healthy memory and cognitive function in mammals.

4. The said method comprising administering an effective amount of the composition as hereinbefore described for a time and under conditions sufficient to treat said Tinnitus, Headaches, Migraine, Insomnia, Dizziness & Vertigo, as well as to help maintain healthy memory and cognitive function in mammals.