AU2009351623A1 - Pteridines and their use as agrochemicals - Google Patents

Abstract

The present disclosure relates to 1- or 2-(4-(aryloxy)-phenyl)ethylamino-, oxy- or sulfanyl)pteridines and 1- or 2-(4-(heteroaryloxy)-phenyl)ethylamino-, oxy- or sulfanyl)pteridines and their use as agrochemicals and animal health products.

Description

WO 2011/025505 PCT/US2009/055522 1 PTERIDINES AND THEIR USE AS AGROCHEMICALS FIELD OF THE INVENTION The present disclosure relates to 1- or 2-(4-(aryloxy)-phenyl)ethylamino-, oxy- or sulfanyl)pteridines and 1- or 2-(4-(heteroaryloxy)-phenyl)ethylamino-, oxy- or sulfanyl)pteridines and their use as agrochemicals and animal health products. BACKGROUND AND SUMMARY The present disclosure provides novel organic compounds that may demonstrate activity as pesticides, meaning that they may control fungi, insects, mites, and/or animal parasites. The disclosure also provides novel pesticide methods and compositions utilizing the novel compounds. More specifically, the invention provides new compounds of the formula (I-A): 2 R NR N .z--- R~ X N N X I-A wherein: R is H, CH 3 , phenyl, or a heterocycle comprising a 5 or 6 membered single ring or a fused ring system comprising at least one 5 or 6 membered heterocycle optionally substituted with H, halo, lower alkyl, lower alkoxy, benzyloxy, lower alkenyl, lower alkynyl, haloalkyl, haloalkoxy, NO 2 , CN, lower alkoxycarbonyl, lower alkylcarbonyl, lower alkyl-SOq, and aldoximes and lower alkyloximes, optionally substituted on oxygen by lower alkyl. Z is H, a C-C single bond, CH 2 , NH, 0, S, CN, CH 2 0, OCH 2 , CH 2

CH

2 O, or

OCH

2

CH

2 ; m is 4; WO 2011/025505 PCT/US2009/055522 2 p is 0 or 1; q is an integer from 0 to 2; R1 is independently H, halo, lower alkyl, lower alkenyl, lower alkynyl, hydroxy, lower alkoxy, haloalkyl, haloalkoxy, NO 2 , CN, lower alkylcarbonyl, lower alkoxycarbonyl, mercapto, lower alkylthio, aldoximes and lower alkyloximes, optionally substituted on oxygen by lower alkyl; Y is a C-C single bond, C(R 5 )O or CR 5); n is 2; alternatively R,, Z, and R, may be taken together to form a fused 5 or 6 membered heterocycle optionally substituted with H, halo, lower alkyl, lower alkoxy, benzyloxy, lower alkenyl, lower alkynyl, haloalkyl, haloalkoxy, NO 2 , CN, lower alkylcarbonyl, lower alkoxycarbonyl and lower alkyl-SOq; R2 are independently H or lower alkyl;

R

4 is H, halogen, lower alkyl, lower alkoxy or lower haloalkyl; R are independently H or lower alkyl;

X

1 is NR 3 , 0, and S, where R 3 is selected from H, lower alkyl, lower alkylcarbonyl, lower alkoxycarbonyl, hydroxy, lower alkoxy, lower alkyl-SOq, phenyl-SOq or substituted phenyl-SOq; X2 is H, halogen or lower alkyl; and X3 is H, halogen or lower alkyl; with the proviso that when Y is C(R 5 ) , R 2 n and Rm may be taken together to form WO 2011/025505 PCT/US2009/055522 3 R R 4N C :Xl N z' Rp X N N X The invention also provides new compounds of formula (I-B): 2 Rm 1n R m-1 R N : N N , z ~.- R X N N X I-B wherein: R is H, CH 3 , haloalkyl, phenyl, or a heterocycle comprising a 5 or 6 membered single ring or a fused ring system comprising at least one 5 or 6 membered heterocycle optionally substituted with H, halo, lower alkyl, lower alkoxy, benzyloxy, lower alkenyl, lower alkynyl, haloalkyl, haloalkoxy, NO 2 , CN, lower alkoxycarbonyl, lower alkylcarbonyl, lower alkyl SOq, aldoximes and lower alkyloximes, optionally substituted on oxygen by lower alkyl; Z is H, a C-C single bond, CH 2 , NH, 0, S, CN, CH 2 0, OCH 2 , CH 2

CH

2 0, or

OCH

2

CH

2 ; m is 4; p is 0 or 1; q is an integer from 0 to 2; R1 is independently H, halo, lower alkyl, lower alkenyl, lower alkynyl, hydroxy, lower alkoxy, haloalkyl, haloalkoxy, NO 2 , CN, lower alkylcarbonyl, lower alkoxycarbonyl, mercapto, lower alkylthio, aldoximes and lower alkyloximes, optionally substituted on oxygen by lower alkyl; WO 2011/025505 PCT/US2009/055522 4 Y is a C-C single bond, C(R 5 )O or CR5n); n is 2; alternatively R,, Z, and R, may be taken together to form a fused 5 or 6 membered heterocycle optionally substituted with H, halo, lower alkyl, lower alkoxy, benzyloxy, lower alkenyl, lower alkynyl, haloalkyl, haloalkoxy, NO 2 , CN, lower alkylcarbonyl, lower alkoxycarbonyl and lower alkyl-SOq; R2 are independently H or lower alkyl;

R

4 is H, halogen, lower alkyl, lower alkoxy or lower haloalkyl; R are independently H or lower alkyl;

X

1 is NR 3 , 0, and S, where R 3 is selected from H, lower alkyl, lower alkylcarbonyl, lower alkoxycarbonyl, hydroxy, lower alkoxy, lower alkyl-SOq, phenyl-SOq or substituted phenyl-SOq; X2 is H, halogen or lower alkyl; and X3 is H, halogen or lower alkyl; with the proviso that when Y is C(R 5) , R 2n and Rln may be taken together to form R m RN N z-- Rp X N N X The invention also provides new pesticide methods and compositions utilizing the compounds of formula (I-A) and compounds of formula (I-B). The invention includes fungicidal, insecticidal, acaricidal, and anti-parasitic compositions comprising an effective amount of a compound of the present invention in a mixture with an agriculturally acceptable or pharmaceutically acceptable adjuvant or carrier.

WO 2011/025505 PCT/US2009/055522 5 The invention also includes methods of controlling a fungus, insect, mite, or parasite comprising applying an effective amount of a compound of the present invention to the fungus, insect or mite, soil, plant, root, foliage, seed, locus, or animal (for which purpose they may be administered orally, parenterally, percutaneously or topically) in which the infestation is to be prevented or cured. DETAILED DESCRIPTION OF THE INVENTION The compounds of the present invention are directed to compounds of formula (I-A) and (I-B) 2 X R N R N N z'.-RP N z..--Rp X N N X X N N 'X I-A I-B Wherein p is 1 and R may be an optionally substituted phenyl or a heterocycle comprising a 5 or 6 membered single ring or a fused ring system comprising at least one 5 or 6 membered heterocycle. More specifically, R may be selected from the list including but not limited to: optionally substituted pyridinyl 7 R N r optionally substituted pyrazinyl 7 R N r

N

WO 2011/025505 PCT/US2009/055522 6 optionally substituted pyrimidinyl 7 N Rr N optionally substituted pyridazinyl 7 R optionally substituted thiazolyl 7 N Rr S optionally substituted 1,2,3-thiadiazolyl 7 R r N S optionally substituted 1,2,4-thiadiazolyl 7 Rr N S optionally substituted 1,3,4-thiadiazolyl 7 N-N R S as well as pyridinyl-N-oxide, thienyl, furyl, oxazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, furazanyl, pyrrolyl, pyrazolyl, and imidazolyl, where r is 4 in the case of pyridinyl, 3 in the case of pyrazinyl, pyrimidinyl, and pyridazinyl, 2 in the case of thiazolyl and 1 in the case of thiadiazolyl, and R 7 are independently H, halo, lower alkyl, lower alkoxy, benzyloxy, lower alkenyl, lower alkynyl, haloalkyl, haloalkoxy, NO 2 , CN, lower alkoxycarbonyl, lower WO 2011/025505 PCT/US2009/055522 7 alkylcarbonyl, aldoximes and lower alkyloximes, optionally substituted on oxygen by lower alkyl. and lower alkyl-SOq and q is an integer from 0 to 2. Throughout this document, all temperatures are given in degrees Celsius, and all percentages are weight percentages unless otherwise stated. The terms "alkyl," "alkenyl" and "alkynyl," as well as derivative terms such as "alkoxy" and "alkylthio," as used herein, include within their scope straight chain, branched chain and cyclic moieties. The terms "alkenyl" and "alkynyl" are intended to include one or more unsaturated bonds. The term "halo" refers to F, Cl, Br, and I atoms. The term "lower alkyl" refers to C 1 to C 6 straight hydrocarbon chains and C 3 to C 6 branched and cyclic hydrocarbon groups. The terms "lower alkenyl" and "lower alkynyl" refer to C 2 to C 6 straight hydrocarbon chains and C 3 (or C 4 in the case of lower alkynyl) to C 6 branched hydrocarbon groups containing at least one unsaturated bond. The terms "lower alkoxy" and "lower alkylthio" refer to O-lower alkyl and S-lower alkyl groups. The term "haloalkyl" refers to lower alkyl groups substituted with one or more halo atoms. The term "haloalkoxy" refers to lower alkoxy groups substituted with one or more halo atoms. The term "substituted phenyl" refers to phenyl substituted with lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, lower alkylthio, halo, hydroxy, NO 2 , haloalkyl, haloalkoxy, haloalkylthio, CN, phenyl, substituted phenyl, 0-phenyl, 0-substituted phenyl,

C

1

-C

4 alkanoyloxy, C 1

-C

4 alkoxycarbonyl, lower alkylcarbonyl, benzyloxy, or and lower alkyl-SOq and q is an integer from 0 to 2.

WO 2011/025505 PCT/US2009/055522 8 The term "fused ring system" refers to two rings joined, as defined in Moss, G.P. Pure and Applied Chemistry, 1998, 70, 143: "For ring systems... two rings which have two atoms and one bond in common may be regarded as being derived from the two rings as separate entities. The process of joining rings in this way is termed fusion." In the present invention, whenever multiple substituents are independently selected it is to be understood that they are selected so as to be sterically compatible with each other. Steric compatibility refers to the absence of steric hindrance as this term is defined in The Condensed Chemical Dictionary, 7th edition, Reinhold Publishing Co., N.Y. page 893 (1966), which definition is as follows: steric hindrance. A characteristic of molecular structure in which the molecules have a spatial arrangement of their atoms such that a given reaction with another molecule is prevented or retarded in rate. Steric compatibility is characterized by substituents whose physical bulk does not require confinement within volumes insufficient for the exercise of their normal behavior as discussed in D. J. Cram and G. Hammond, Organic Chemistry 2nd edition, McGraw-Hill Book Company, N.Y. page 215 (1964). The compounds of this invention are made using well known chemical procedures. The required starting materials are commercially available or are readily synthesized using standard procedures. Synthesis of Compounds of Formula (I-A) wherein X, is 0 WO 2011/025505 PCT/US2009/055522 9 Scheme 1 2 2 R H, 1J Y R b _R z I~3p Z R H 2 N N X Z I1I-A INT-A R=H f R = aryl or 4 L heteroaryl RNN N X N N1X II 2 2 Rn R mRn Rm 1 Y1 Y x c x

H

2 N N N R N 3 Z.Rp Z..- R p

H

2 N N X X N N X INT-B I-A The compounds of formula (I-A) wherein X is 0 can be made by condensing a compound of formula (II) L 4 R N X II 42 where R4, X2 and X3 are as defined as for compounds of formula (I-A); and L is a group such as F, Cl, Br, 1,2,3-triazol-1-yl, 1,2,4-triazol-1-yl, OH, arylthio, alkylthio, alkylsulfonyl, arylsulfonyl, alkoxy, alkylsulfinyl, or arylsulfinyl; with a compound of the formula (III-A) WO 2011/025505 PCT/US2009/055522 10 2 z'-- R III-A where R, R1, R , Y, Z, m, n, and p are as defined for compounds of formula (I-A) and X 1 is 0 as in step e of Scheme I. The reaction is preferably carried out in the presence of a base in a non-reactive solvent, such as dichloromethane (CH 2 Cl 2 , tetrahydrofuran (THF), dimethylsulfoxide (DMSO) or NN-dimethylformamide (DMF), at a temperature in the range of 0 0 C to reflux temperature. Alternatively, compounds of formula (I-A) can be made by reaction of a dicarbonyl or equivalent compound with a compound of formula (INT-B) 2 1

H

2 N N Nz' -Rp

H

2 N N X INT-B where R, R , R , X3, Y, Z. m, n, and p are as defined for compounds of formula (I-A) and X 1 is 0, as in step c of Scheme I. Representative dicarbonyl compounds include glyoxal, 2,3 butanedione and 1,4-dioxane-2,3-diol. The reaction is preferably carried out in an alcohol solvent, alternatively containing toluene, at a temperature in the range of 0 0 C to reflux temperature. Compounds of formula (INT-B) can be made by reaction of a 5,6-diaminopyrimidine compound L

H

2 N

H

2 N N X WO 2011/025505 PCT/US2009/055522 11 where X 3 and L are as defined as for compounds of formula (II); with a compound of formula (III-A) where R, R1, R 2, Y, Z, m, n, and p are as defined for compounds of formula (I-A) and X1 is 0 as in step d of Scheme I. The reaction is preferably carried out in the presence of a base in a non-reactive solvent, such as CH 2 Cl 2 , THF, DMSO or DMF, at a temperature in the range of 0 0 C to reflux temperature. Alternatively, compounds of formula (INT-B) can be synthesized by reduction of a 6-amino 5-nitropyrimidine compound of formula (INT-A) 2 O z' R 1 H2N NIX INT-A where R, R , R , X3, Y, Z, m, n, and p are as defined for compounds of formula (I-A) as in step b of Scheme I. Reduction can be achieved by hydrogenation in the presence of a palladium catalyst in an alcohol solvent. Compounds of formula (INT-A) can be synthesized by reaction of a 5-nitro-6 aminopyrimidine compound o L S-N

H

2 N N X where X 3 and L are as defined as for compounds of formula (II); with a compound of formula (III-A) where R, R1, R 2, Y, Z, m, n, and p are as defined for compounds of formula (I-A) as in step a of Scheme I. The reaction is preferably carried out in the presence of a base in a non reactive solvent, such as CH 2 Cl 2 , THF, DMSO or DMF, at a temperature in the range of 00 to reflux temperature. Compounds of formula (III-A), where R is a phenyl or heteroaryl, may be synthesized by reaction of compounds of formula (III-A) where R is H, with a compound of formula WO 2011/025505 PCT/US2009/055522 12 M-Het where M is a group such as F, Cl, Br, I, 1,2,3-triazol-1-yl, 1,2,4-triazol-1-yl, OH, arylthio, alkylthio, alkylsulfonyl, arylsulfonyl, alkoxy, alkylsulfinyl, or arylsulfinyl; and wherein Het is a phenyl or heterocycle, as in stepf of Scheme I. Het may be optionally substituted with one or more groups selected from H, halo, lower alkyl, lower alkoxy, benzyloxy, lower alkenyl, lower alkynyl, haloalkyl, haloalkoxy, NO 2 , CN, lower alkoxycarbonyl, lower alkylcarbonyl and lower alkyl-SOq. The reaction is preferably carried out in the presence of a base in a non-reactive solvent, such as CH 2 Cl 2 , THF, DMSO or DMF, at a temperature in the range of 0 0 C to reflux temperature. Synthesis of Compounds of Formula (I-A) wherein X 1 is NH or N-lower alkyl. 1 1 2 The compounds of formula (I-A) wherein X1 is NH or N-lower alkyl and R, R1, R2 R , X , X 3 Y, Z, m, n and p are as defined for compounds of formula (I-A), can be made in the same manner as described for Scheme I, from compounds of the formulas (II), (III-A), 1 2 4 2 3 (INT-A), (INT-B) wherein R, R , R , R4, X , X , Y, Z, m, n and p are as defined for formula (I-A), and X 1 is NH or N-lower alkyl. Scheme II 2 2 R n1 R N L 1 Rm N N X Z R N -- z - Rp X N N< X II III-A I-A Preferably, the compounds of formula (I-A) wherein X 1 is NH or N-lower alkyl and Z is as defined for compounds of formula (I-A), can be made by condensing a compound of formula (II) L 4 R N

II

WO 2011/025505 PCT/US2009/055522 13 where R4, X2 , and X3 are as defined as for compounds of formula (I-A); and L is a group, such as F, Cl, Br, 1,2,3-triazol-1-yl, 1,2,4-triazol-1-yl, OH, arylthio, alkylthio, alkylsulfonyl, arylsulfonyl, alkoxy, alkylsulfinyl, or arylsulfinyl; with a compound of the formula (III-A) 2 RR H, 1 ' -" *0 Y _ Z..- R III-A where R, R1, R2, Y, Z, m, n, and p are as defined for compounds of formula (I-A) and X, is NH or N-lower alkyl, optionally as a salt (e.g., HCl), as in Scheme II. The reaction is preferably carried out in the presence of base, such as triethylamine, in a non-reactive solvent, such as CH 2 Cl 2 , THF or DMF. Alternatively, the reaction may be carried out in hexamethyldisilazane in the presence of ammonium sulfate. SCHEME Ill 2 R N 1m Y X a b R N NX c~< RN N IV I-A 22 2 3 Xj N N VI I- WO 2011/025505 PCT/US2009/055522 14 1 1 2 The compounds of formula (I-A) wherein X1 is NH or N-lower alkyl and R, R1, R, R 3, R 4, X 2, X 3, and Z are as defined for compounds of formula (I-A) where R is a phenyl or heterocycle optionally substituted with one or more groups selected from halo, lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, haloalkyl, haloalkoxy, NO 2 , CN, lower alkoxycarbonyl, lower alkylcarbonyl and lower alkyl-SOq, when q is an integer from 0 to 2; alternatively are prepared by treatment of a compound of formula (IV) 2 x R R N R~ ~ ..-- H '-" X N N 3 IV wherein R1, R 2, R4, X2, X3, Y, Z, m and n are as defined for compounds of formula (I-A) and

X

1 is NH or N-lower alkyl; with a compound of formula M-Het where M is a group such as F, Cl, Br, I, 1,2,3-triazol-1-yl, 1,2,4-triazol-1-yl, OH, arylthio, alkylthio, alkylsulfonyl, arylsulfonyl, alkoxy, alkylsulfinyl, or arylsulfinyl; and wherein Het is a phenyl or heterocycle, as in step c of Scheme III. Het may be optionally substituted with one or more groups selected from H, halo, lower alkyl, lower alkoxy, benzyloxy, lower alkenyl, lower alkynyl, haloalkyl, haloalkoxy, NO 2 , CN, lower alkoxycarbonyl, lower alkylcarbonyl and lower alkyl-SOq. The reaction is preferably carried out in the presence of a base in a non-reactive solvent, such as CH 2 Cl 2 , THF, DMSO or DMF, at a temperature in the range of 0 0 C to reflux temperature. Certain compounds of formula (I-A) are prepared by modifications of other compounds of formula (I-A), by methods described in the experimental procedures of the Preparations and Examples section. The compounds of formula (IV) where Z is oxygen can be prepared by treatment of compounds of formula (V) WO 2011/025505 PCT/US2009/055522 15 2 R R R N 6 'N .--- R V where R', R 2, R3, R4, Y, m and n are as defined for compounds of formula (I-A), X1 is NH or N-lower alkyl, Z is oxygen, and R6 is lower alkyl; with a reagent such as BBr 3 in a nonreactive organic solvent, such as CH 2 Cl 2 . The compounds of formula (IV) alternatively may be prepared by treatment of compounds of formula (VI) wherein R4 , X2 and X3 are as described for compound of formula (I-A), R4 N0:N X N N3 VI with a compound of formula (VII), optionally as a salt (e.g., HCl), 2 R Y N H OH VII where R , R , Y, m and n are as defined for compounds of formula (I-A), and R3 is H; in the presence of acetic acid, optionally as a solution in an appropriate solvent such as ethanol; with heating at temperatures from 250 to reflux.

WO 2011/025505 PCT/US2009/055522 16 The compounds of formula (IV) alternatively may be prepared by treatment of compounds of formula (II) L 4 R N X:_ 'N N N~X II where R4, X2 and X3 are as defined for compounds of formula (I-A); and L is a leaving group, such as F, Cl, Br, I, NO 2 , 1,2,3-triazol-1-yl, 1,2,4-triazol-1-yl, OSiMe 3 , arylthio, alkylthio, alkylsulfonyl, arylsulfonyl, alkoxy, alkylsulfinyl or arylsulfinyl; with a compound of formula (VII), optionally as a salt (e.g., HCl), 2 R' Y N H OH VII where R , R 2, R 3, Y, m and n are as defined for compounds of formula (I-A); optionally in the presence of a base, in a solvent such as acetonitrile, THF or DMF. Compounds of formula (V) are prepared by the treatment of compounds of formula (VI) wherein R 4 , X 2 , and X 3 are as described for compound of formula (I-A); with a compound of formula (VIII-A), optionally as a salt (e.g., HCl), 2 SY Rm N H O'R VIII-A where R1, R2, Y, m and n are as defined for compounds of formula (I-A), R 3 is H, and R 6 is lower alkyl as defined for compounds of formula (I-A); in the presence of acetic acid, WO 2011/025505 PCT/US2009/055522 17 optionally as a solution in an appropriate solvent such as ethanol; with heating at temperatures from 25 'C to reflux. 1 2 3 Amines of formula (VIII-A) where R , R , R , Y, m and n are as defined for compounds of formula (I-A) and R 6 is lower alkyl as defined for compounds of formula (I A); are commercially available or may be prepared by well-known methods. For example, 1 2 compounds of formula (VIII-A), where R1, R , m and n are as defined for compounds of formula (I-A), R 6 is lower alkyl, R 3 is H, and Y is R 5 n are prepared as their hydrochloride salts by treatment of appropriately substituted (4-alkoxyphenyl)-acetonitriles with hydrogen in the presence of hydrochloric acid, a catalyst such as palladium on carbon, and an appropriate solvent such as ethanol. 1 2 Alternatively, compounds of formula (VIII-A), where R , R , m and n are as defined for compounds of formula (I-A), R 6 is lower alkyl, R 3 is H, Y is R 5 n are prepared by treatment of appropriately substituted (4-alkoxyphenyl)-acetonitriles with borane-dimethyl sulfide complex or lithium aluminum hydride in an appropriate solvent such as tetrahydrofuran at temperatures from 20 0 C to reflux. 1 2 Alternatively, compounds of formula (VIII-A), where R1, R , m and n are as defined for compounds of formula (I-A), R 6 is lower alkyl, R 3 is H, and Y is R 5 n are prepared as their hydrochloride salts by treatment of appropriately substituted 1-alkoxy-4-((E)-2-nitrovinyl) benzenes with hydrogen in the presence of hydrochloric acid, a catalyst such as palladium on carbon, and an appropriate solvent such as ethanol. 1 2 Alternatively, compounds of formula (VIII-A), where R , R , m and n are as defined for compounds of formula (I-A), R 6 is alkyl or benzyl, R 3 is H, and Y is R 5 n are prepared by treatment of the appropriately substituted 1 -alkoxy-4-((E)-2-nitrovinyl)-benzenes with lithium aluminum hydride in an appropriate solvent such as tetrahydrofuran. The 1 -alkoxy-4-((E)-2-nitrovinyl)-benzenes are prepared by treatment of the appropriately substituted benzaldehyde with nitromethane in the presence of ammonium acetate.

WO 2011/025505 PCT/US2009/055522 18 The compounds of formula (I-A) wherein X is NH alternatively are prepared by treatment of a compound of formula (VI), as defined above, with a compound of formula (III 12 A), optionally as a salt (e.g., HCl), where R, R1, R , Y, Z, m, n and p are as defined for compounds of formula (I-A) and X is NH; in the presence of acetic acid, optionally as a solution in an appropriate solvent such as ethanol; with heating at temperatures from 25' to reflux. Similarly, compounds of formula (I-B), wherein X1 is NH can be prepared by treatment of a compound of formula (VI), as defined above, with a compound of formula (III B) 2 1 2 optionally as a salt (e.g., HC), where R, R , R , Y, Z, m, n and p are as defined for compounds of formula (I-B) and X is NH; in the presence of acetic acid, optionally as a solution in an appropriate solvent such as ethanol; with heating at temperatures from 250 to reflux. Compounds of formula (III-B) can be prepared by the methods in the Preparations and Examples section. Compounds of formula (VI) 4 ,N R N ';X X N N N VI where R4, X2 and X3 are as described for compound of formula (I-A) were prepared by treatment of a compound of formula (IX) WO 2011/025505 PCT/US2009/055522 19 4 N R N X N

NH

2 Ix where R 4 and X 2 are as described for compound of formula (I-A), with N,N dimethylformamide dimethyl acetal in an appropriate solvent such as toluene, with heating at temperature from 25 C up to the reflux temperature. Compounds of formula (IX) 4 'N R N X N

NH

2 Ix where R4 and X2 are as defined for compounds of formula (I-A) are commercially available or were prepared by well known synthetic procedures. Synthesis of Compounds of Formula (I-A) wherein X, is S. Scheme IV 2 x H R2 R1 R m 44 M N R R p X XI I-A The compounds of formula (I-A) wherein R, R1, R , R 4, X2, X3, Y, Z, m, n, and p are as defined for compounds of formula (I-A), and X 1 is S, can be made as in Scheme IV by condensing a compound of formula (X) WO 2011/025505 PCT/US2009/055522 20 1 H 4 Rl N X~< x where R4, X2 , and X3 are as defined as for compounds of formula (I-A); and X 1 is S; with a compound of the formula (XI) 2 M Rm z p XI where R, R1, R 2, Y, Z, m, n, and p are as defined for formula (I-A); and M is as defined in the reacting partner M-Het in Scheme III, step c. In compounds of formula (XI), M is preferably chlorine or bromine. The reaction is preferably carried out in the presence of base, such as triethylamine, in a non-reactive solvent, such as CH 2 Cl 2 , THF or DMF. The compounds of the present invention may be pesticides that have fungitoxic activity against harmful fungi including, but not limited to, fungi that are pathogens of plants, animals, and humans. They are active against fungi of a number of classes including Oomycetes, Deuteromycetes (Fungi Imperfecti), Basidiomycetes, and Ascomycetes. More particularly, one embodiment of a method of the present invention provides for activity against phytopathogenic organisms including, but not limited to, Pyricularia oryzae, Colletotrichum species, Erysiphe species, Puccinia species, Cochliobolus species, Alternaria species, Septoria species, Rhynchosporium secalis, Cercospora and Cercosporella species, and Pyrenophora species. Additional diseases controlled include powdery mildews incited by Sphaerothecafulignea (cucurbit powdery mildew) and Uncinula necator (grape powdery mildew), soybean rust incited by Phakopsora pachyrhizi, downy mildews such as cucumber downy mildew (Pseudoperonospora cubensis), grape downy mildew (Plasmopara viticola), WO 2011/025505 PCT/US2009/055522 21 apple scab incited by Venturia inaequalis, late blight incited by Phytophthora infestans, and Maize smut (Ustilago maydis). The compounds of the present invention may have insecticidal activity against harmful insects and mites including, but not limited to, insects that are pests or parasites of plants, animals, and humans. In other embodiments, the invention disclosed in this document may be used to control pests of Phylum Nematoda, the Phylum Arthropoda, the Subphylum Chelicerata, the Class Arachnida, the Subphylum Myriapoda, the Class Symphyla, the Subphylum Hexapoda, the Class Insecta. Within the Class Insecta, the invention disclosed in this document may be use to control Coleoptera (beetles). A non-exhaustive list of these such pests includes, but is not limited to, Acanthoscelides spp. (weevils), Acanthoscelides obtectus (common bean weevil), Agrilus planipennis (emerald ash borer), Agriotes spp. (wireworms), Anoplophora glabripennis (Asian longhorned beetle), Anthonomus spp. (weevils), Anthonomus grandis (boll weevil), Aphidius spp., Apion spp. (weevils), Apogonia spp. (grubs), Ataenius spretulus (Black Turfgrass Ataenius), Atomaria linearis (pygmy mangold beetle), Aulacophore spp., Bothynoderes punctiventris (beet root weevil), Bruchus spp. (weevils), Bruchus pisorum (pea weevil), Cacoesia spp., Callosobruchus maculatus (southern cow pea weevil), Carpophilus hemipteras (dried fruit beetle), Cassida vittata, Cerosterna spp., Cerotoma spp. (chrysomeids), Cerotoma trifurcata (bean leaf beetle), Ceutorhynchus spp. (weevils), Ceutorhynchus assimilis (cabbage seedpod weevil), Ceutorhynchus napi (cabbage curculio), Chaetocnema spp. (chrysomelids), Colaspis spp. (soil beetles), Conoderus scalaris, Conoderus stigmosus, Conotrachelus nenuphar (plum curculio), Cotinus nitidis (Green June beetle), Crioceris asparagi (asparagus beetle), Cryptolestesferrugineus (rusty grain beetle), Cryptolestes pusillus (flat grain beetle), Cryptolestes turcicus (Turkish grain beetle), Ctenicera spp. (wireworms), Curculio spp. (weevils), Cyclocephala spp. (grubs), Cylindrocpturus adspersus (sunflower stem weevil), Deporaus marginatus (mango leaf cutting weevil), Dermestes lardarius (larder beetle), Dermestes maculates (hide beetle), Diabrotica spp. (chrysolemids), Epilachna varivestis (Mexican bean beetle), Faustinus cubae, Hylobius pales (pales weevil), Hypera spp. (weevils), Hypera postica (alfalfa weevil), Hyperdoes spp. (Hyperodes weevil), Hypothenemus hampei (coffee berry beetle), Ips spp. (engravers), Lasioderma serricorne (cigarette beetle), Leptinotarsa decemlineata (Colorado potato beetle), Liogenysfuscus, Liogenys suturalis, Lissorhoptrus oryzophilus (rice water weevil), Lyctus spp. (wood beetles/powder post beetles), Maecolaspis joliveti, Megascelis WO 2011/025505 PCT/US2009/055522 22 spp., Melanotus communis, Meligethes spp., Meligethes aeneus (blossom beetle), Melolontha melolontha (common European cockchafer), Oberea brevis, Oberea linearis, Oryctes rhinoceros (date palm beetle), Oryzaephilus mercator (merchant grain beetle), Oryzaephilus surinamensis (sawtoothed grain beetle), Otiorhynchus spp. (weevils), Oulema melanopus (cereal leaf beetle), Oulema oryzae, Pantomorus spp. (weevils), Phyllophaga spp. (May/June beetle), Phyllophaga cuyabana, Phyllotreta spp. (chrysomelids), Phynchites spp., Popillia japonica (Japanese beetle), Prostephanus truncates (larger grain borer), Rhizopertha dominica (lesser grain borer), Rhizotrogus spp. (European chafer), Rhynchophorus spp. (weevils), Scolytus spp. (wood beetles), Shenophorus spp. (Billbug), Sitona lineatus (pea leaf weevil), Sitophilus spp. (grain weevils), Sitophilus granaries (granary weevil), Sitophilus oryzae (rice weevil), Stegobium paniceum (drugstore beetle), Tribolium spp. (flour beetles), Tribolium castaneum (red flour beetle), Tribolium confusum (confused flour beetle), Trogoderma variabile (warehouse beetle), and Zabrus tenebioides. In another embodiment, the invention disclosed in this document may be used to control Dermaptera (earwigs). In another embodiment, the invention disclosed in this document may be used to control Dictyoptera (cockroaches). A non-exhaustive list of such pests includes, but is not limited to, Blattella germanica (German cockroach), Blatta orientalis (oriental cockroach), Parcoblatta pennsylvanica, Periplaneta americana (American cockroach), Periplaneta australoasiae (Australian cockroach), Periplaneta brunnea (brown cockroach), Periplaneta fuliginosa (smokybrown cockroach), Pycnoselus surinamensis (Surinam cockroach), and Supella longipalpa (brownbanded cockroach). In another embodiment, the invention disclosed in this document may be used to control Diptera (true flies). A non-exhaustive list of such pests includes, but is not limited to, Aedes spp. (mosquitoes), Agromyzafrontella (alfalfa blotch leafminer), Agromyza spp. (leaf miner flies), Anastrepha spp. (fruit flies), Anastrepha suspensa (Caribbean fruit fly), Anopheles spp. (mosquitoes), Batrocera spp. (fruit flies), Bactrocera cucurbitae (melon fly), Bactrocera dorsalis (oriental fruit fly), Ceratitis spp. (fruit flies), Ceratitis capitata (Mediterranean fruit fly), Chrysops spp. (deer flies), Cochliomyia spp. (screwworms), Contarinia spp. (Gall midges), Culex spp. (mosquitoes), Dasineura spp. (gall midges), Dasineura brassicae (cabbage gall midge), Delia spp., Delia platura (seedcorn maggot), Drosophila spp. (vinegar flies), Fannia spp. (filth flies), Fannia canicularis (little house fly), Fannia scalaris (latrine fly), Gasterophilus intestinalis (horse bot fly), Gracillia perseae, WO 2011/025505 PCT/US2009/055522 23 Haematobia irritans (horn fly), Hylemyia spp. (root maggots), Hypoderma lineatum (common cattle grub), Liriomyza spp. (leafminer flies), Liriomyza brassica (serpentine leafminer), Melophagus ovinus (sheep ked), Musca spp. (muscid flies), Musca autumnalis (face fly), Musca domestica (house fly), Oestrus ovis (sheep bot fly), Oscinellafrit (frit fly), Pegomyia betae (beet leafminer), Phorbia spp., Psila rosae (carrot rust fly), Rhagoletis cerasi (cherry fruit fly), Rhagoletis pomonella (apple maggot), Sitodiplosis mosellana (orange wheat blossom midge), Stomoxys calcitrans (stable fly), Tabanus spp. (horse flies), and Tipula spp. (crane flies). In another embodiment, the invention disclosed in this document may be used to control Hemiptera (true bugs). A non-exhaustive list of such pests includes, but is not limited to, Acrosternum hilare (green stink bug), Blissus leucopterus (chinch bug), Calocoris norvegicus (potato mirid), Cimex hemipterus (tropical bed bug), Cimex lectularius (bed bug), Dagbertusfasciatus, Dichelopsfurcatus, Dysdercus suturellus (cotton stainer), Edessa meditabunda, Eurygaster maura (cereal bug), Euschistus heros, Euschistus servus (brown stink bug), Helopeltis antonii, Helopeltis theivora (tea blight plantbug), Lagynotomus spp. (stink bugs), Leptocorisa oratorius, Leptocorisa varicornis, Lygus spp. (plant bugs), Lygus hesperus (western tarnished plant bug), Maconellicoccus hirsutus, Neurocolpus longirostris, Nezara viridula (southern green stink bug), Phytocoris spp. (plant bugs), Phytocoris californicus, Phytocoris relativus, Piezodorus guildingi, Poecilocapsus lineatus (fourlined plant bug), Psallus vaccinicola, Pseudacysta perseae, Scaptocoris castanea, and Triatoma spp. (bloodsucking conenose bugs/kissing bugs). In another embodiment, the invention disclosed in this document may be used to control Homoptera (aphids, scales, whiteflies, leafhoppers). A non-exhaustive list of such pests includes, but is not limited to, Acrythosiphon pisum (pea aphid), Adelges spp. (adelgids), Aleurodes proletella (cabbage whitefly), Aleurodicus disperses, Aleurothrixus floccosus (woolly whitefly), Aluacaspis spp., Amrasca bigutella bigutella, Aphrophora spp. (leafhoppers), Aonidiella aurantii (California red scale), Aphis spp. (aphids), Aphis gossypii (cotton aphid), Aphis pomi (apple aphid), Aulacorthum solani (foxglove aphid), Bemisia spp. (whiteflies), Bemisia argentifolii, Bemisia tabaci (sweetpotato whitefly), Brachycolus noxius (Russian aphid), Brachycorynella asparagi (asparagus aphid), Brevennia rehi, Brevicoryne brassicae (cabbage aphid), Ceroplastes spp. (scales), Ceroplastes rubens (red wax scale), Chionaspis spp. (scales), Chrysomphalus spp. (scales), Coccus spp. (scales), Dysaphis plantaginea (rosy apple aphid), Empoasca spp. (leafhoppers), Eriosoma lanigerum (woolly WO 2011/025505 PCT/US2009/055522 24 apple aphid), Icerya purchasi (cottony cushion scale), Idioscopus nitidulus (mango leafhopper), Laodelphax striatellus (smaller brown planthopper), Lepidosaphes spp., Macrosiphum spp., Macrosiphum euphorbiae (potato aphid), Macrosiphum granarium (English grain aphid), Macrosiphum rosae (rose aphid), Macrosteles quadrilineatus (aster leafhopper), Mahanarva frimbiolata, Metopolophium dirhodum (rose grain aphid), Mictis longicornis, Myzus persicae (green peach aphid), Nephotettix spp. (leafhoppers), Nephotettix cinctipes (green leafhopper), Nilaparvata lugens (brown planthopper), Parlatoria pergandii (chaff scale), Parlatoria ziziphi (ebony scale), Peregrinus maidis (corn delphacid), Philaenus spp. (spittlebugs), Phylloxera vitifoliae (grape phylloxera), Physokermes piceae (spruce bud scale), Planococcus spp. (mealybugs), Pseudococcus spp. (mealybugs), Pseudococcus brevipes (pine apple mealybug), Quadraspidiotus perniciosus (San Jose scale), Rhapalosiphum spp. (aphids), Rhapalosiphum maida (corn leaf aphid), Rhapalosiphum padi (oat bird-cherry aphid), Saissetia spp. (scales), Saissetia oleae (black scale), Schizaphis graminum (greenbug), Sitobion avenae (English grain aphid), Sogatellafurcifera (white backed planthopper), Therioaphis spp. (aphids), Toumeyella spp. (scales), Toxoptera spp. (aphids), Trialeurodes spp. (whiteflies), Trialeurodes vaporariorum (greenhouse whitefly), Trialeurodes abutiloneus (bandedwing whitefly), Unaspis spp. (scales), Unaspis yanonensis (arrowhead scale), and Zulia entreriana. In another embodiment, the invention disclosed in this document may be used to control Hymenoptera (ants, wasps, and bees). A non-exhaustive list of such pests includes, but is not limited to, Acromyrrmex spp., Athalia rosae, Atta spp. (leafcutting ants), Camponotus spp. (carpenter ants), Diprion spp. (sawflies), Formica spp. (ants), Iridomyrmex humilis (Argentine ant), Monomorium spp., Monomorium minumum (little black ant), Monomorium pharaonis (Pharaoh ant), Neodiprion spp. (sawflies), Pogonomyrmex spp. (harvester ants), Polistes spp. (paper wasps), Solenopsis spp. (fire ants), Tapoinoma sessile (odorous house ant), Tetranomorium spp. (pavement ants), Vespula spp. (yellow jackets), and Xylocopa spp. (carpenter bees). In another embodiment, the invention disclosed in this document may be used to control Isoptera (termites). A non-exhaustive list of such pests includes, but is not limited to, Coptotermes spp., Coptotermes curvignathus, Coptotermes frenchii, Coptotermes formosanus (Formosan subterranean termite), Cornitermes spp. (nasute termites), Cryptotermes spp. (drywood termites), Heterotermes spp. (desert subterranean termites), Heterotermes aureus, Kalotermes spp. (drywood termites), Incistitermes spp. (drywood termites), Macrotermes WO 2011/025505 PCT/US2009/055522 25 spp. (fungus growing termites), Marginitermes spp. (drywood termites), Microcerotermes spp. (harvester termites), Microtermes obesi, Procornitermes spp., Reticulitermes spp. (subterranean termites), Reticulitermes banyulensis, Reticulitermes grassei, Reticulitermes flavipes (eastern subterranean termite), Reticulitermes hageni, Reticulitermes hesperus (western subterranean termite), Reticulitermes santonensis, Reticulitermes speratus, Reticulitermes tibialis, Reticulitermes virginicus, Schedorhinotermes spp., and Zootermopsis spp. (rotten-wood termites). In another embodiment, the invention disclosed in this document may be used to control Lepidoptera (moths and butterflies). A non-exhaustive list of such pests includes, but is not limited to, Achoea janata, Adoxophyes spp., Adoxophyes orana, Agrotis spp. (cutworms), Agrotis ipsilon (black cutworm), Alabama argillacea (cotton leafworm), Amorbia cuneana, Amyelosis transitella (navel orangeworm), Anacamptodes defectaria, Anarsia lineatella (peach twig borer), Anomis sabulifera (jute looper), Anticarsia gemmatalis (velvetbean caterpillar), Archips argyrospila (fruittree leafroller), Archips rosana (rose leaf roller), Argyrotaenia spp. (tortricid moths), Argyrotaenia citrana (orange tortrix), Autographa gamma, Bonagota cranaodes, Borbo cinnara (rice leaf folder), Bucculatrix thurberiella (cotton leafperforator), Caloptilia spp. (leafminers), Capua reticulana, Carposina niponensis (peach fruit moth), Chilo spp., Chlumetia transversa (mango shoot borer), Choristoneura rosaceana (obliquebanded leafroller), Chrysodeixis spp., Cnaphalocerus medinalis (grass leafroller), Colias spp., Conpomorpha cramerella, Cossus cossus (carpenter moth), Crambus spp. (Sod webworms), Cydiafunebrana (plum fruit moth), Cydia molesta (oriental fruit moth), Cydia nignicana (pea moth), Cydia pomonella (codling moth), Darna diducta, Diaphania spp. (stem borers), Diatraea spp. (stalk borers), Diatraea saccharalis (sugarcane borer), Diatraea graniosella (southwestern corn borer), Earias spp. (bollworms), Earias insulata (Egyptian bollworm), Earias vitella (rough northern bollworm), Ecdytopopha aurantianum, Elasmopalpus lignosellus (lesser cornstalk borer), Epiphysias postruttana (light brown apple moth), Ephestia spp. (flour moths), Ephestia cautella (almond moth), Ephestia elutella (tobacco moth), Ephestia kuehniella (Mediterranean flour moth), Epimeces spp., Epinotia aporema, Erionota thrax (banana skipper), Eupoecilia ambiguella (grape berry moth), Euxoa auxiliaris (army cutworm), Feltia spp. (cutworms), Gortyna spp. (stemborers), Grapholita molesta (oriental fruit moth), Hedylepta indicata (bean leaf webber), Helicoverpa spp. (noctuid moths), Helicoverpa armigera (cotton bollworm), Helicoverpa zea (bollworm/corn earworm), Heliothis spp. (noctuid moths), Heliothis WO 2011/025505 PCT/US2009/055522 26 virescens (tobacco budworm), Hellula undalis (cabbage webworm), Indarbela spp. (root borers), Keiferia lycopersicella (tomato pinworm), Leucinodes orbonalis (eggplant fruit borer), Leucoptera malifoliella, Lithocollectis spp., Lobesia botrana (grape fruit moth), Loxagrotis spp. (noctuid moths), Loxagrotis albicosta (western bean cutworm), Lymantria dispar (gypsy moth), Lyonetia clerkella (apple leaf miner), Mahasena corbetti (oil palm bagworm), Malacosoma spp. (tent caterpillars), Mamestra brassicae (cabbage armyworm), Maruca testulalis (bean pod borer), Metisa plana (bagworm), Mythimna unipuncta (true armyworm), Neoleucinodes elegantalis (small tomato borer), Nymphula depunctalis (rice caseworm), Operophthera brumata (winter moth), Ostrinia nubilalis (European corn borer), Oxydia vesulia, Pandemis cerasana (common currant tortrix), Pandemis heparana (brown apple tortrix), Papilio demodocus, Pectinophora gossypiella (pink bollworm), Peridroma spp. (cutworms), Peridroma saucia (variegated cutworm), Perileucoptera coffeella (white coffee leafminer), Phthorimaea operculella (potato tuber moth), Phyllocnisitis citrella, Phyllonorycter spp. (leafminers), Pieris rapae (imported cabbageworm), Plathypena scabra, Plodia interpunctella (Indian meal moth), Plutella xylostella (diamondback moth), Polychrosis viteana (grape berry moth), Prays endocarpa, Prays oleae (olive moth), Pseudaletia spp. (noctuid moths), Pseudaletia unipunctata (armyworm), Pseudoplusia includens (soybean looper), Rachiplusia nu, Scirpophaga incertulas, Sesamia spp. (stemborers), Sesamia inferens (pink rice stem borer), Sesamia nonagrioides, Setora nitens, Sitotroga cerealella (Angoumois grain moth), Sparganothis pilleriana, Spodoptera spp. (armyworms), Spodoptera exigua (beet armyworm), Spodoptera frugiperda (fall armyworm), Spodoptera oridania (southern armyworm), Synanthedon spp. (root borers), Thecla basilides, Thermisia gemmatalis, Tineola bisselliella (webbing clothes moth), Trichoplusia ni (cabbage looper), Tuta absoluta, Yponomeuta spp., Zeuzera coffeae (red branch borer), and Zeuzera pyrina (leopard moth). In another embodiment, the invention disclosed in this document may be used to control Mallophaga (chewing lice). A non-exhaustive list of such pests includes, but is not limited to, Bovicola ovis (sheep biting louse), Menacanthus stramineus (chicken body louse), and Menopon gallinea (common hen louse). In another embodiment, the invention disclosed in this document may be used to control Orthoptera (grasshoppers, locusts, and crickets). A non-exhaustive list of such pests includes, but is not limited to, Anabrus simplex (Mormon cricket), Gryllotalpidae (mole crickets), Locusta migratoria, Melanoplus spp. (grasshoppers), Microcentrum retinerve WO 2011/025505 PCT/US2009/055522 27 (angularwinged katydid), Pterophylla spp. (katydids), Schistocerca gregaria, Scudderia furcata (forktailed bush katydid), and Valanga nigricornis (short homed grasshopper). In another embodiment, the invention disclosed in this document may be used to control Phthiraptera (sucking lice). A non-exhaustive list of such pests includes, but is not limited to, Haematopinus spp. (cattle and hog lice), Linognathus ovillus (sheep louse), Pediculus humanus capitis (human body louse), Pediculus humanus humanus (human body lice), and Pthirus pubis (crab louse). In another embodiment, the invention disclosed in this document may be used to control Siphonaptera (fleas). A non-exhaustive list of such pests includes, but is not limited to, Ctenocephalides canis (dog flea), Ctenocephalidesfelis (cat flea), and Pulex irritans (human flea). In another embodiment, the invention disclosed in this document may be used to control Thysanoptera (thrips). A non-exhaustive list of such pests includes, but is not limited to, Frankliniellafusca (tobacco thrips), Frankliniella occidentalis (western flower thrips), Frankliniella shultzei, Frankliniella williamsi (corn thrips), Heliothrips haemorrhaidalis (greenhouse thrips), Riphiphorothrips cruentatus, Scirtothrips spp., Scirtothrips citri (citrus thrips), Scirtothrips dorsalis (yellow tea thrips), Taeniothrips rhopalantennalis, and Thrips spp. In another embodiment, the invention disclosed in this document may be used to control Thysanura (bristletails). A non-exhaustive list of such pests includes, but is not limited to, Lepisma spp. (silverfish) and Thermobia spp. (firebrats). In another embodiment, the invention disclosed in this document may be used to control Acarina (mites and ticks). A non-exhaustive list of such pests includes, but is not limited to, Acarapsis woodi (tracheal mite of honeybees), Acarus spp. (food mites), Acarus siro (grain mite), Aceria mangiferae (mango bud mite), Aculops spp., Aculops lycopersici (tomato russet mite), Aculops pelekasi, Aculus pelekassi, Aculus schlechtendali (apple rust mite), Amblyomma americanum (lone star tick), Boophilus spp. (ticks), Brevipalpus obovatus (privet mite), Brevipalpus phoenicis (red and black flat mite), Demodex spp. (mange mites), Dermacentor spp. (hard ticks), Dermacentor variabilis (American dog tick), Dermatophagoides pteronyssinus (house dust mite), Eotetranycus spp., Eotetranychus carpini (yellow spider mite), Epitimerus spp., Eriophyes spp., Ixodes spp. (ticks), Metatetranycus spp., Notoedres cati, Oligonychus spp., Oligonychus coffee, Oligonychus ilicus (southern red mite), Panonychus spp., Panonychus citri (citrus red mite), Panonychus WO 2011/025505 PCT/US2009/055522 28 ulmi (European red mite), Phyllocoptruta oleivora (citrus rust mite), Polyphagotarsonemun latus (broad mite), Rhipicephalus sanguineus (brown dog tick), Rhizoglyphus spp. (bulb mites), Sarcoptes scabiei (itch mite), Tegolophus perseaflorae, Tetranychus spp., Tetranychus urticae (two-spotted spider mite), and Varroa destructor (honey bee mite). In another embodiment, the invention disclosed in this document may be used to control Nematoda (nematodes). A non-exhaustive list of such pests includes, but is not limited to, Aphelenchoides spp. (bud and leaf & pine wood nematodes), Belonolaimus spp. (sting nematodes), Criconemella spp. (ring nematodes), Dirofilaria immitis (dog heartworm), Ditylenchus spp. (stem and bulb nematodes), Heterodera spp. (cyst nematodes), Heterodera zeae (corn cyst nematode), Hirschmanniella spp. (root nematodes), Hoplolaimus spp. (lance nematodes), Meloidogyne spp. (root knot nematodes), Meloidogyne incognita (root knot nematode), Onchocerca volvulus (hook-tail worm), Pratylenchus spp. (lesion nematodes), Radopholus spp. (burrowing nematodes), and Rotylenchus reniformis (kidney-shaped nematode). In another embodiment, the invention disclosed in this document may be used to control Symphyla (symphylans). A non-exhaustive list of such pests includes, but is not limited to, Scutigerella immaculata. In another embodiment, the invention disclosed in this document may be used to control animal and human parasites. A non-exhaustive list of such pests includes, but is not limited to, arthropods such as mites (e.g., mesostigmatids, itch, mange, scabies, chiggers), ticks (e.g., soft-bodied and hard-bodied), lice (e.g., sucking, biting), fleas (e.g., dog flea, cat flea, oriental rat flea, human flea), true bugs (e.g., bed bugs, Triatomid bugs), bloodsucking adult flies (e.g., horn fly, horse fly, stable fly, black fly, deer fly, louse fly, tsetse fly, mosquitoes), and parasitic fly maggots (e.g, bot fly, blow fly, screwworm, cattle grub, fleeceworm); helminths such as nematodes (e.g., threadworm, lungworm, hookworm, whipworm, nodular worm, stomach worm, round worm, pinworm, heartworm), cestodes (e.g., tapeworms) and trematodes (e.g., liver fluke, blood fluke); protozoa such as coccidia, trypanosomes, trichomonads, amoebas and plasmodia; acanthocephalans such as thorny headed worms (e.g., lingulatulida); and pentastomids such as tongueworms. Detailed information regarding pests may be found in the "Handbook of Pest Control - The Behavior, Life History, and Control of Household Pests" by Arnold Mallis, 9th Edition, copyright 2004 by GIE Media Inc, which is expressly incorporated by reference herein.

WO 2011/025505 PCT/US2009/055522 29 The present invention contemplates all vehicles by which the composition of the present invention can be formulated for delivery and use as a pesticide composition, including solutions, suspensions, emulsions, wettable powders and water dispersible granules, emulsifiable concentrates, granules, dusts, baits, and the like. Compositions suitable for administration to vertebrates or man include preparations suitable for oral, parenteral, percutaneous, e.g. pour-on, or topical administration. Compositions for oral administration comprise one or more of the compounds of general formula (I-A) or (I-B) in association with pharmaceutically acceptable carriers or coatings and include, for example, tablets, pills, capsules, pastes, gels, drenches, medicated feeds, medicated drinking water, medicated dietary supplements, slow-release boluses or other slow-release devices intended to be retained within the gastrointestinal tract. Any of these may incorporate active ingredient contained within microcapsules or coated with acid labile or alkali-labile or other pharmaceutically acceptable enteric coatings. Feed premixes and concentrates containing compounds of the present invention for use in preparation of medicated diets, drinking water or other materials for consumption by animals may also be used. Compositions for parenteral administration include solutions, emulsions or suspensions in any suitable pharmaceutically acceptable vehicle and solid or semisolid subcutaneous implants or pellets designed to release active ingredient over a protracted period and may be prepared and made sterile in any appropriate manner known to the art. Compositions for percutaneous and topical administration include sprays, dusts, baths, dips, showers, jets, greases, shampoos, creams, wax-smears, or pour-on preparations and devices (e.g. ear tags) attached externally to animals in such a way as to provide local or systemic arthropod control. Typically, formulations for application to plants, seeds, or soil are applied following dilution of the concentrated formulation with water as aqueous solutions, suspensions or emulsions, or combinations thereof. Such solutions, suspensions or emulsions are produced from water-soluble, water-suspended or water-suspendable, water-emulsified or water emulsifiable formulations or combinations thereof which are solids, including and usually known as wettable powders or water dispersible granules; or liquids including and usually known as emulsifiable concentrates, aqueous suspensions or suspension concentrates, and aqueous emulsions or emulsions in water, or mixtures thereof such as suspension-emulsions.

WO 2011/025505 PCT/US2009/055522 30 As will be readily appreciated, any materials to which this composition can be added may be used, provided they yield the desired utility without significant interference with the desired activity of the pesticidally active ingredients as pesticidal agents. Wettable powders, which may be compacted to form water dispersible granules, comprise an intimate mixture of one or more of the pesticidally active ingredients, an inert carrier and surfactants. The concentration of the pesticidally active ingredient in the wettable powder is usually from about 10 percent to about 90 percent by weight based on the total weight of the wettable powder, more preferably about 25 weight percent to about 75 weight percent. In the preparation of wettable powder formulations, the pesticidally active ingredients can be compounded with any finely divided solid, such as prophyllite, talc, chalk, gypsum, Fuller's earth, bentonite, attapulgite, starch, casein, gluten, montmorillonite clays, diatomaceous earths, purified silicates or the like. In such operations, the finely divided carrier and surfactants are typically blended with the compound(s) and milled. Emulsifiable concentrates of the pesticidally active ingredient comprise a convenient concentration, such as from about 10 weight percent to about 50 weight percent of the pesticidally active ingredient, in a suitable liquid, based on the total weight of the concentrate. The pesticidally active ingredients are dissolved in an inert carrier, which is either a water miscible solvent or a mixture of water-immiscible organic solvents, and emulsifiers. The concentrates may be diluted with water and oil to form spray mixtures in the form of oil-in-water emulsions. Useful organic solvents include aromatics, especially the high-boiling naphthalenic and olefinic portions of petroleum such as heavy aromatic naphtha. Other organic solvents may also be used, such as, for example, terpenic solvents, including rosin derivatives, aliphatic ketones, such as cyclohexanone, and complex alcohols, such as 2 ethoxyethanol. Emulsifiers which can be advantageously employed herein can be readily determined by those skilled in the art and include various nonionic, anionic, cationic and amphoteric emulsifiers, or a blend of two or more emulsifiers. Examples of nonionic emulsifiers useful in preparing the emulsifiable concentrates include the polyalkylene glycol ethers and condensation products of alkyl and aryl phenols, aliphatic alcohols, aliphatic amines or fatty acids with ethylene oxide, propylene oxides such as the ethoxylated alkyl phenols and carboxylic esters esterified with the polyol or polyoxyalkylene. Cationic emulsifiers include quaternary ammonium compounds and fatty amine salts. Anionic emulsifiers include the WO 2011/025505 PCT/US2009/055522 31 oil-soluble salts (e.g., calcium) of alkylaryl sulfonic acids, oil-soluble salts of sulfated polyglycol ethers and appropriate salts of phosphated polyglycol ether. Representative organic liquids which can be employed in preparing emulsifiable concentrates are the aromatic liquids such as xylene, propyl benzene fractions; or mixed naphthalene fractions, mineral oils, substituted aromatic organic liquids such as dioctyl phthalate; kerosene; dialkyl amides of various fatty acids, particularly the dimethyl amides; and glycol ethers such as the n-butyl ether, ethyl ether or methyl ether of diethylene glycol, and the methyl ether of triethylene glycol and the like. Mixtures of two or more organic liquids may also be employed in the preparation of the emulsifiable concentrate. Surface active emulsifying agents are typically employed in liquid formulations and in an amount of from 0.1 to 20 percent by weight based on the combined weight of the emulsifying agents. The formulations can also contain other compatible additives, for example, plant growth regulators and other biologically active compounds used in agriculture. Aqueous suspensions comprise suspensions of one or more water-insoluble pesticidally active ingredients dispersed in an aqueous vehicle at a concentration in the range from about 5 to about 70 weight percent, based on the total weight of the aqueous suspension. Suspensions are prepared by finely grinding one or more of the pesticidally active ingredients, and vigorously mixing the ground material into a vehicle comprised of water and surfactants chosen from the same types discussed above. Other components, such as inorganic salts and synthetic or natural gums, may also be added to increase the density and viscosity of the aqueous vehicle. It is often most effective to grind and mix at the same time by preparing the aqueous mixture and homogenizing it in an implement such as a sand mill, ball mill, or piston-type homogenizer. Aqueous emulsions comprise emulsions of one or more water-insoluble pesticidally active ingredients emulsified in an aqueous vehicle at a concentration typically in the range from about 5 to about 70 weight percent, based on the total weight of the aqueous emulsion. If the pesticidally active ingredient is a solid it must be dissolved in a suitable water immiscible solvent prior to the preparation of the aqueous emulsion. Emulsions are prepared by emulsifying the liquid pesticidally active ingredient or water-immiscible solution thereof into an aqueous medium typically with inclusion of surfactants that aid in the formation and stabilization of the emulsion as described above. This is often accomplished with the aid of vigorous mixing provided by high shear mixers or homogenizers.

WO 2011/025505 PCT/US2009/055522 32 The compositions of the present invention can also be granular formulations, which are particularly useful for applications to the soil. Granular formulations usually contain from about 0.5 to about 10 weight percent, based on the total weight of the granular formulation of the pesticidally active ingredient(s), dispersed in an inert carrier which consists entirely or in large part of coarsely divided inert material such as attapulgite, bentonite, diatomite, clay or a similar inexpensive substance. Such formulations are usually prepared by dissolving the pesticidally active ingredients in a suitable solvent and applying it to a granular carrier which has been preformed to the appropriate particle size, in the range of from about 0.5 to about 3 mm. A suitable solvent is a solvent in which the compound is substantially or completely soluble. Such formulations may also be prepared by making a dough or paste of the carrier and the compound and solvent, and crushing and drying to obtain the desired granular particle. Dusts can be prepared by intimately mixing one or more of the pesticidally active ingredients in powdered form with a suitable dusty agricultural carrier, such as, for example, kaolin clay, ground volcanic rock, and the like. Dusts can suitably contain from about 1 to about 10 weight percent of the compounds, based on the total weight of the dust. The formulations may additionally contain adjuvant surfactants to enhance deposition, wetting and penetration of the pesticidally active ingredients onto the target site such as a crop or organism. These adjuvant surfactants may optionally be employed as a component of the formulation or as a tank mix. The amount of adjuvant surfactant will typically vary from 0.01 to 1.0 percent by volume, based on a spray-volume of water, preferably 0.05 to 0.5 volume percent. Suitable adjuvant surfactants include, but are not limited to ethoxylated nonyl phenols, ethoxylated synthetic or natural alcohols, salts of the esters of sulfosuccinic acids, ethoxylated organosilicones, ethoxylated fatty amines and blends of surfactants with mineral or vegetable oils. The formulations may optionally include combinations that contain one or more other pesticidal compounds. Such additional pesticidal compounds may be fungicides, insecticides, nematicides, miticides, arthropodicides, bactericides, plant growth stimulators or regulators, nitrification inhibitors, nutrients, or combinations thereof that are compatible with the compounds of the present invention in the medium selected for application, and not antagonistic to the activity of the present compounds. The compounds of the present invention, and the pesticidal compound in the combination can generally be present in a weight ratio of from 1:100 to100:1.

WO 2011/025505 PCT/US2009/055522 33 The compounds disclosed in this invention can be in the form of pesticidally acceptable acid addition salts. By way of non-limiting example, an amine function can form salts with hydrochloric, hydrobromic, sulfuric, phosphoric, acetic, benzoic, citric, malonic, salicylic, malic, fumaric, oxalic, succinic, tartaric, lactic, gluconic, ascorbic, maleic, aspartic, benzenesulfonic, methanesulfonic, ethanesulfonic, hydroxymethanesulfonic, and hydroxyethanesulfonic acids. Additionally, by way of non-limiting example, an acid function can form salts including those derived from alkali or alkaline earth metals and those derived from ammonia and amines. Examples of preferred cations include sodium, potassium, magnesium, and aminium cations. The salts are prepared by contacting the free base form with a sufficient amount of the desired acid to produce a salt. The free base forms may be regenerated by treating the salt with a suitable dilute aqueous base solution such as dilute aqueous NaOH, potassium carbonate, ammonia, and sodium bicarbonate. As an example, in many cases, a pesticide is modified to a more water soluble form e.g. 2,4-dichlorophenoxy acetic acid dimethyl amine salt is a more water soluble form of 2,4-dichlorophenoxy acetic acid, a well known herbicide. The compounds disclosed in this invention can also form stable complexes with solvent molecules that remain intact after the non-complexed solvent molecules are removed from the compounds. These complexes are often referred to as "solvates". Certain compounds disclosed in this document can exist as one or more stereoisomers. The various stereoisomers include geometric isomers, diastereomers, and enantiomers. Thus, the compounds disclosed in this invention include racemic mixtures, individual stereoisomers, and optically active mixtures. It will be appreciated by those skilled in the art that one stereoisomer may be more active than the others. Individual stereoisomers and optically active mixtures may be obtained by selective synthetic procedures, by conventional synthetic procedures using resolved starting materials, or by conventional resolution procedures. The compounds of the present invention can also be combined with other agricultural fungicides to form fungicidal mixtures and synergistic mixtures thereof. The fungicidal compounds of the present invention are often applied in conjunction with one or more other fungicides to control a wider variety of undesirable diseases. When used in conjunction with WO 2011/025505 PCT/US2009/055522 34 other fungicide(s), the presently claimed compounds can be formulated with the other fungicide(s), tank mixed with the other fungicide(s) or applied sequentially with the other fungicide(s). Such other fungicides include but are not limited to 2-(thiocyanatomethylthio) benzothiazole, 2-phenylphenol, 8-hydroxyquinoline sulfate, ametoctradin, amisulbrom, antimycin, Ampelomyces quisqualis, azaconazole, azoxystrobin, Bacillus subtilis, benalaxyl, benomyl, benthiavalicarb-isopropyl, benzylaminobenzene-sulfonate (BABS) salt, bicarbonates, biphenyl, bismerthiazol, bitertanol, bixafen, blasticidin-S, borax, Bordeaux mixture, boscalid, bromuconazole, bupirimate, BYF 1047, calcium polysulfide, captafol, captan, carbendazim, carboxin, carpropamid, carvone, chloroneb, chlorothalonil, chlozolinate, Coniothyrium minitans, copper hydroxide, copper octanoate, copper oxychloride, copper sulfate, copper sulfate (tribasic), cuprous oxide, cyazofamid, cyflufenamid, cymoxanil, cyproconazole, cyprodinil, coumarin, dazomet, debacarb, diammonium ethylenebis-(dithiocarbamate), dichlofluanid, dichlorophen, diclocymet, diclomezine, dichloran, diethofencarb, difenoconazole, difenzoquat ion, diflumetorim, dimethomorph, dimoxystrobin, diniconazole, diniconazole-M,dinobuton, dinocap, diphenylamine, dithianon, dodemorph, dodemorph acetate, dodine, dodine free base, edifenphos, enestrobin, epoxiconazole, ethaboxam, ethoxyquin, etridiazole, famoxadone, fenamidone, fenarimol, fenbuconazole, fenfuram, fenhexamid, fenoxanil, fenpiclonil, fenpropidin, fenpropimorph, fentin, fentin acetate, fentin hydroxide, ferbam, ferimzone, fluazinam, fludioxonil, flumorph, fluopicolide, fluopyram, fluoroimide, fluoxastrobin, fluquinconazole, flusilazole, flusulfamide, flutianil, flutolanil, flutriafol, folpet, formaldehyde, fosetyl, fosetyl-aluminium, fuberidazole, furalaxyl, furametpyr, guazatine, guazatine acetates, GY-81, hexachlorobenzene, hexaconazole, hymexazol, imazalil, imazalil sulfate, imibenconazole, iminoctadine, iminoctadine triacetate, iminoctadine tris(albesilate), ipconazole, iprobenfos, iprodione, iprovalicarb, isoprothiolane, isopyrazam, isotianil, kasugamycin, kasugamycin hydrochloride hydrate, kresoxim-methyl, mancopper, mancozeb, mandipropamid, maneb, mepanipyrim, mepronil, mercuric chloride, mercuric oxide, mercurous chloride, metalaxyl, mefenoxam, metalaxyl-M, metam, metam-ammonium, metam-potassium, metam-sodium, metconazole, methasulfocarb, methyl iodide, methyl isothiocyanate, metiram, metominostrobin, metrafenone, mildiomycin, myclobutanil, nabam, nitrothal-isopropyl, nuarimol, octhilinone, ofurace, oleic acid (fatty acids), orysastrobin, oxadixyl, oxine-copper, oxpoconazole fumarate, oxycarboxin, pefurazoate, penconazole, pencycuron, pentachlorophenol, pentachlorophenyl laurate, penthiopyrad, phenylmercury WO 2011/025505 PCT/US2009/055522 35 acetate, phosphonic acid, phthalide, picoxystrobin, polyoxin B, polyoxins, polyoxorim, potassium bicarbonate, potassium hydroxyquinoline sulfate, probenazole, prochloraz, procymidone, propamocarb, propamocarb hydrochloride, propiconazole, propineb, proquinazid, prothioconazole, pyraclostrobin, pyrametostrobin, pyraoxystrobin, pyrazophos, pyribencarb, pyributicarb, pyrifenox, pyrimethanil, pyroquilon, quinoclamine, quinoxyfen, quintozene, Reynoutria sachalinensis extract, sedaxane, silthiofam, simeconazole, sodium 2 phenylphenoxide, sodium bicarbonate, sodium pentachlorophenoxide, spiroxamine, sulfur, SYP-Z071, SYP-Z048, tar oils, tebuconazole, tebufloquin, tecnazene, tetraconazole, thiabendazole, thifluzamide, thiophanate-methyl, thiram, tiadinil, tolclofos-methyl, tolylfluanid, triadimefon, triadimenol, triazoxide, tricyclazole, tridemorph, trifloxystrobin, triflumizole, triforine, triticonazole, validamycin, valifenalate, valiphenal, vinclozolin, zineb, ziram, zoxamide, Candida oleophila, Fusarium oxysporum, Gliocladium spp., Phlebiopsis gigantea, Streptomyces griseoviridis, Trichoderma spp., (RS)-N-(3,5-dichlorophenyl)-2 (methoxymethyl)-succinimide, 1,2-dichloropropane, 1,3-dichloro-1,1,3,3-tetrafluoroacetone hydrate, 1-chloro-2,4-dinitronaphthalene, 1-chloro-2-nitropropane, 2-(2-heptadecyl-2 imidazolin-1-yl)ethanol, 2,3-dihydro-5-phenyl-1,4-dithi-ine 1,1,4,4-tetraoxide, 2 methoxyethylmercury acetate, 2-methoxyethylmercury chloride, 2-methoxyethylmercury silicate, 3-(4-chloro-phenyl)-5-methylrhodanine, 4-(2-nitroprop-1-enyl)phenyl thiocyanateme, ampropylfos, anilazine, azithiram, barium polysulfide, Bayer 32394, benodanil, benquinox, bentaluron, benzamacril; benzamacril-isobutyl, benzamorf, binapacryl, bis(methylmercury) sulfate, bis(tributyltin) oxide, buthiobate, cadmium calcium copper zinc chromate sulfate, carbamorph, CECA, chlobenthiazone, chloraniformethan, chlorfenazole, chlorquinox, climbazole, copper bis(3-phenylsalicylate), copper zinc chromate, cufraneb, cupric hydrazinium sulfate, cuprobam, cyclafuramid, cypendazole, cyprofuram, decafentin, dichlone, dichlozoline, diclobutrazol, dimethirimol, dinocton, dinosulfon, dinoterbon, dipyrithione, ditalimfos, dodicin, drazoxolon, EBP, ESBP, etaconazole, etem, ethirim, fenaminosulf, fenapanil, fenitropan, fluotrimazole, furcarbanil, furconazole, furconazole-cis, furmecyclox, furophanate, glyodine, griseofulvin, halacrinate, Hercules 3944, hexylthiofos, ICIA0858, isopamphos, isovaledione, mebenil, mecarbinzid, metazoxolon, methfuroxam, methylmercury dicyandiamide, metsulfovax, milneb, mucochloric anhydride, myclozolin, N 3,5-dichlorophenyl-succinimide, N-3-nitrophenyl-itaconimide, natamycin, N-ethylmercurio 4-toluenesulfonanilide, nickel bis(dimethyldithiocarbamate), OCH, phenylmercury dimethyldithiocarbamate, phenylmercury nitrate, phosdiphen, prothiocarb; prothiocarb WO 2011/025505 PCT/US2009/055522 36 hydrochloride, pyracarbolid, pyridinitril, pyroxychlor, pyroxyfur, quinacetol; quinacetol sulfate, quinazamid, quinconazole, rabenzazole, salicylanilide, SSF-109, sultropen, tecoram, thiadifluor, thicyofen, thiochlorfenphim, thiophanate, thioquinox, tioxymid, triamiphos, triarimol, triazbutil, trichlamide, urbacid, XRD-563, and zarilamid, IK-1 140, and any combinations thereof. Additionally, the compounds of the present invention can be combined with other pesticides, including insecticides, nematicides, miticides, arthropodicides, bactericides or combinations thereof that are compatible with the compounds of the present invention in the medium selected for application, and not antagonistic to the activity of the present compounds to form pesticidal mixtures and synergistic mixtures thereof. The pesticidal compounds of the present invention are often applied in conjunction with one or more other insecticides, miticides, or other pesticides to control a wider variety of undesirable pests. When used in conjunction with other pesticides, the presently claimed compounds can be formulated with the other pesticide(s), tank mixed with the other pesticide(s) or applied sequentially with the other pesticide(s). Typical insecticides include, but are not limited to: antibiotic insecticides such as allosamidin and thuringiensin; macrocyclic lactone insecticides such as spinosad and spinetoram; avermectin insecticides such as abamectin, doramectin, emamectin, eprinomectin, ivermectin and selamectin; milbemycin insecticides such as lepimectin, milbemectin, milbemycin oxime and moxidectin; arsenical insecticides such as calcium arsenate, copper acetoarsenite, copper arsenate, lead arsenate, potassium arsenite and sodium arsenite; botanical insecticides such as anabasine, azadirachtin, d-limonene, nicotine, pyrethrins, cinerins, cinerin I, cinerin II, jasmolin I, jasmolin II, pyrethrin I, pyrethrin II, quassia, rotenone, ryania and sabadilla; carbamate insecticides such as bendiocarb and carbaryl; benzofuranyl methylcarbamate insecticides such as benfuracarb, carbofuran, carbosulfan, decarbofuran and furathiocarb; dimethylcarbamate insecticides dimitan, dimetilan, hyquincarb and pirimicarb; oxime carbamate insecticides such as alanycarb, aldicarb, aldoxycarb, butocarboxim, butoxycarboxim, methomyl, nitrilacarb, oxamyl, tazimcarb, thiocarboxime, thiodicarb and thiofanox; phenyl methylcarbamate insecticides such as allyxycarb, aminocarb, bufencarb, butacarb, carbanolate, cloethocarb, dicresyl, dioxacarb, EMPC, ethiofencarb, fenethacarb, fenobucarb, isoprocarb, methiocarb, metolcarb, mexacarbate, promacyl, promecarb, propoxur, trimethacarb, XMC and xylylcarb; diamide insecticides such as chlorantraniliprole, cyantraniliprole and flubendiamide; dinitrophenol insecticides such as dinex, dinoprop, dinosam and DNOC;fluorine insecticides such as WO 2011/025505 PCT/US2009/055522 37 barium hexafluorosilicate, cryolite, sodium fluoride, sodium hexafluorosilicate and sulfluramid;formamidine insecticides such as amitraz, chlordimeform, formetanate and formparanate; fumigant insecticides such as acrylonitrile, carbon disulfide, carbon tetrachloride, chloroform, chloropicrin, para-dichlorobenzene, 1,2-dichloropropane, ethyl formate, ethylene dibromide, ethylene dichloride, ethylene oxide, hydrogen cyanide, iodomethane, methyl bromide, methylchloroform, methylene chloride, naphthalene, phosphine, sulfuryl fluoride and tetrachloroethane; inorganic insecticides such as borax, calcium polysulfide, copper oleate, mercurous chloride, potassium thiocyanate and sodium thiocyanate; chitin synthesis inhibitors such as bistrifluron, buprofezin, chlorfluazuron, cyromazine, diflubenzuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, penfluron, teflubenzuron and triflumuron; juvenile hormone mimics such as epofenonane, fenoxycarb, hydroprene, kinoprene, methoprene, pyriproxyfen and triprene; juvenile hormones such as juvenile hormone I, juvenile hormone II and juvenile hormone III; moulting hormone agonists such as chromafenozide, halofenozide, methoxyfenozide and tebufenozide; moulting hormones such as a-ecdysone and ecdysterone; moulting inhibitors such as diofenolan; precocenes such as precocene I, precocene II and precocene III; unclassified insect growth regulators such as dicyclanil; nereistoxin analogue insecticides such as bensultap, cartap, thiocyclam and thiosultap; nicotinoid insecticides such as flonicamid; nitroguanidine insecticides such as clothianidin, dinotefuran, imidacloprid and thiamethoxam; nitromethylene insecticides such as nitenpyram and nithiazine; pyridylmethyl amine insecticides such as acetamiprid, imidacloprid, nitenpyram and thiacloprid; organochlorine insecticides such as bromo-DDT, camphechlor, DDT, pp'-DDT, ethyl-DDD, HCH, gamma-HCH, lindane, methoxychlor, pentachlorophenol and TDE; cyclodiene insecticides such as aldrin, bromocyclen, chlorbicyclen, chlordane, chlordecone, dieldrin, dilor, endosulfan, endrin, HEOD, heptachlor, HHDN, isobenzan, isodrin, kelevan and mirex; organophosphate insecticides such as bromfenvinfos, chlorfenvinphos, crotoxyphos, dichlorvos, dicrotophos, dimethylvinphos, fospirate, heptenophos, methocrotophos, mevinphos, monocrotophos, naled, naftalofos, phosphamidon, propaphos, TEPP and tetrachlorvinphos; organothiophosphate insecticides such as dioxabenzofos, fosmethilan and phenthoate; aliphatic organothiophosphate insecticides such as acethion, amiton, cadusafos, chlorethoxyfos, chlormephos, demephion, demephion-O, demephion-S, demeton, demeton 0, demeton-S, demeton-methyl, demeton-O-methyl, demeton-S-methyl, demeton-S methylsulphon, disulfoton, ethion, ethoprophos, IPSP, isothioate, malathion, methacrifos, WO 2011/025505 PCT/US2009/055522 38 oxydemeton-methyl, oxydeprofos, oxydisulfoton, phorate, sulfotep, terbufos and thiometon; aliphatic amide organothiophosphate insecticides such as amidithion, cyanthoate, dimethoate, ethoate-methyl, formothion, mecarbam, omethoate, prothoate, sophamide and vamidothion; oxime organothiophosphate insecticides such as chlorphoxim, phoxim and phoxim-methyl; heterocyclic organothiophosphate insecticides such as azamethiphos, coumaphos, coumithoate, dioxathion, endothion, menazon, morphothion, phosalone, pyraclofos, pyridaphenthion and quinothion; benzothiopyran organothiophosphate insecticides such as dithicrofos and thicrofos; benzotriazine organothiophosphate insecticides such as azinphos-ethyl and azinphos-methyl; isoindole organothiophosphate insecticides such as dialifos and phosmet; isoxazole organothiophosphate insecticides such as isoxathion and zolaprofos; pyrazolopyrimidine organothiophosphate insecticides such as chlorprazophos and pyrazophos; pyridine organothiophosphate insecticides such as chlorpyrifos and chlorpyrifos-methyl; pyrimidine organothiophosphate insecticides such as butathiofos, diazinon, etrimfos, lirimfos, pirimiphos-ethyl, pirimiphos-methyl, primidophos, pyrimitate and tebupirimfos; quinoxaline organothiophosphate insecticides such as quinalphos and quinalphos-methyl; thiadiazole organothiophosphate insecticides such as athidathion, lythidathion, methidathion and prothidathion; triazole organothiophosphate insecticides such as isazofos and triazophos; phenyl organothiophosphate insecticides such as azothoate, bromophos, bromophos-ethyl, carbophenothion, chlorthiophos, cyanophos, cythioate, dicapthon, dichlofenthion, etaphos, famphur, fenchlorphos, fenitrothion fensulfothion, fenthion, fenthion-ethyl, heterophos, jodfenphos, mesulfenfos, parathion, parathion-methyl, phenkapton, phosnichlor, profenofos, prothiofos, sulprofos, temephos, trichlormetaphos-3 and trifenofos; phosphonate insecticides such as butonate and trichlorfon; phosphonothioate insecticides such as mecarphon; phenyl ethylphosphonothioate insecticides such as fonofos and trichloronat; phenyl phenylphosphonothioate insecticides such as cyanofenphos, EPN and leptophos; phosphoramidate insecticides such as crufomate, fenamiphos, fosthietan, mephosfolan, phosfolan and pirimetaphos; phosphoramidothioate insecticides such as acephate, isocarbophos, isofenphos, methamidophos and propetamphos; phosphorodiamide insecticides such as dimefox, mazidox, mipafox and schradan; oxadiazine insecticides such as indoxacarb; oxadiazolone insecticides such as metoxadiazone; phthalimide insecticides such as dialifos, phosmet and tetramethrin; pyrazole insecticides such as acetoprole, cyenopyrafen, ethiprole, fipronil, pyrafluprole, pyriprole, tebufenpyrad, tolfenpyrad and vaniliprole; pyrethroid ester insecticides such as acrinathrin, allethrin, bioallethrin, barthrin, WO 2011/025505 PCT/US2009/055522 39 bifenthrin, bioethanomethrin, cyclethrin, cycloprothrin, cyfluthrin, beta-cyfluthrin, cyhalothrin, gamma-cyhalothrin, lambda-cyhalothrin, cypermethrin, alpha-cypermethrin, beta-cypermethrin, theta-cypermethrin, zeta-cypermethrin, cyphenothrin, deltamethrin, dimefluthrin, dimethrin, empenthrin, fenfluthrin, fenpirithrin, fenpropathrin, fenvalerate, esfenvalerate, flucythrinate, fluvalinate, tau-fluvalinate, furethrin, imiprothrin, metofluthrin, permethrin, biopermethrin, transpermethrin, phenothrin, prallethrin, profluthrin, pyresmethrin, resmethrin, bioresmethrin, cismethrin, tefluthrin, terallethrin, tetramethrin, tralomethrin and transfluthrin; pyrethroid ether insecticides such as etofenprox, flufenprox, halfenprox, protrifenbute and silafluofen; pyrimidinamine insecticides such as flufenerim and pyrimidifen; pyrrole insecticides such as chlorfenapyr; tetramic acid insecticides such as spirotetramat; tetronic acid insecticides such as spiromesifen; thiourea insecticides such as diafenthiuron; urea insecticides such as flucofuron and sulcofuron; and unclassified insecticides such as closantel, copper naphthenate, crotamiton, EXD, fenazaflor, fenoxacrim, hydramethylnon, isoprothiolane, malonoben, metaflumizone, nifluridide, plifenate, pyridaben, pyridalyl, pyrifluquinazon, rafoxanide, sulfoxaflor, triarathene, triazamate, and any combinations thereof. Additionally, the compounds of the present invention may be combined with herbicides that are compatible with the compounds of the present invention in the medium selected for application, and not antagonistic to the activity of the present compounds to form pesticidal mixtures and synergistic mixtures thereof. The pesticidal compounds of the present disclosure may be applied in conjunction with one or more herbicides to control a wide variety of undesirable plants, diseases, and pests. When used in conjunction with herbicides, the presently claimed compounds may be formulated with the herbicide(s), tank mixed with the herbicide(s) or applied sequentially with the herbicide(s). Typical herbicides include, but are not limited to: amide herbicides such as allidochlor, beflubutamid, benzadox, benzipram, bromobutide, cafenstrole, CDEA, cyprazole, dimethenamid, dimethenamid-P, diphenamid, epronaz, etnipromid, fentrazamide, flupoxam, fomesafen, halosafen, isocarbamid, isoxaben, napropamide, naptalam, pethoxamid, propyzamide, quinonamid and tebutam; anilide herbicides such as chloranocryl, cisanilide, clomeprop, cypromid, diflufenican, etobenzanid, fenasulam, flufenacet, flufenican, mefenacet, mefluidide, metamifop, monalide, naproanilide, pentanochlor, picolinafen and propanil; arylalanine herbicides such as benzoylprop, flamprop and flamprop-M; chloroacetanilide herbicides such as acetochlor, alachlor, butachlor, butenachlor, delachlor, diethatyl, WO 2011/025505 PCT/US2009/055522 40 dimethachlor, metazachlor, metolachlor, S-metolachlor, pretilachlor, propachlor, propisochlor, prynachlor, terbuchlor, thenylchlor and xylachlor; sulfonanilide herbicides such as benzofluor, perfluidone, pyrimisulfan and profluazol; sulfonamide herbicides such as asulam, carbasulam, fenasulam and oryzalin; thioamide herbicides such as chlorthiamid; antibiotic herbicides such as bilanafos; benzoic acid herbicides such as chloramben, dicamba, 2,3,6-TBA and tricamba; pyrimidinyloxybenzoic acid herbicides such as bispyribac and pyriminobac; pyrimidinylthiobenzoic acid herbicides such as pyrithiobac; phthalic acid herbicides such as chlorthal; picolinic acid herbicides such as aminopyralid, clopyralid and picloram; quinolinecarboxylic acid herbicides such as quinclorac and quinmerac; arsenical herbicides such as cacodylic acid, CMA, DSMA, hexaflurate, MAA, MAMA, MSMA, potassium arsenite and sodium arsenite; benzoylcyclohexanedione herbicides such as mesotrione, sulcotrione, tefuryltrione and tembotrione; benzofuranyl alkylsulfonate herbicides such as benfuresate and ethofumesate; benzothiazole herbicides such as benzazolin; carbamate herbicides such as asulam, carboxazole chlorprocarb, dichlormate, fenasulam, karbutilate and terbucarb; carbanilate herbicides such as barban, BCPC, carbasulam, carbetamide, CEPC, chlorbufam, chlorpropham, CPPC, desmedipham, phenisopham, phenmedipham, phenmedipham-ethyl, propham and swep; cyclohexene oxime herbicides such as alloxydim, butroxydim, clethodim, cloproxydim, cycloxydim, profoxydim, sethoxydim, tepraloxydim and tralkoxydim; cyclopropylisoxazole herbicides such as isoxachlortole and isoxaflutole; dicarboximide herbicides such as cinidon-ethyl, flumezin, flumiclorac, flumioxazin and flumipropyn; dinitroaniline herbicides such as benfluralin, butralin, dinitramine, ethalfluralin, fluchloralin, isopropalin, methalpropalin, nitralin, oryzalin, pendimethalin, prodiamine, profluralin and trifluralin; dinitrophenol herbicides such as dinofenate, dinoprop, dinosam, dinoseb, dinoterb, DNOC, etinofen and medinoterb; diphenyl ether herbicides such as ethoxyfen; nitrophenyl ether herbicides such as acifluorfen, aclonifen, bifenox, chlomethoxyfen, chlornitrofen, etnipromid, fluorodifen, fluoroglycofen, fluoronitrofen, fomesafen, furyloxyfen, halosafen, lactofen, nitrofen, nitrofluorfen and oxyfluorfen; dithiocarbamate herbicides such as dazomet and metam; halogenated aliphatic herbicides such as alorac, chloropon, dalapon, flupropanate, hexachloroacetone, iodomethane, methyl bromide, monochloroacetic acid, SMA and TCA; imidazolinone herbicides such as imazamethabenz, imazamox, imazapic, imazapyr, imazaquin and imazethapyr; inorganic herbicides such as ammonium sulfamate, borax, calcium chlorate, copper sulfate, ferrous sulfate, potassium azide, potassium cyanate, sodium azide, sodium WO 2011/025505 PCT/US2009/055522 41 chlorate and sulfuric acid; nitrile herbicides such as bromobonil, bromoxynil, chloroxynil, dichlobenil, iodobonil, ioxynil and pyraclonil; organophosphorus herbicides such as amiprofos-methyl, anilofos, bensulide, bilanafos, butamifos, 2,4-DEP, DMPA, EBEP, fosamine, glufosinate, glufosinate-P, glyphosate and piperophos; phenoxy herbicides such as bromofenoxim, clomeprop, 2,4-DEB, 2,4-DEP, difenopenten, disul, erbon, etnipromid, fenteracol and trifopsime; oxadiazoline herbicides such as methazole, oxadiargyl, oxadiazon; oxazole herbicides such as fenoxasulfone; phenoxyacetic herbicides such as 4-CPA, 2,4-D, 3,4-DA, MCPA, MCPA-thioethyl and 2,4,5-T; phenoxybutyric herbicides such as 4-CPB, 2,4-DB, 3,4-DB, MCPB and 2,4,5-TB; phenoxypropionic herbicides such as cloprop, 4-CPP, dichlorprop, dichlorprop-P, 3,4-DP, fenoprop, mecoprop and mecoprop-P; aryloxyphenoxypropionic herbicides such as chlorazifop, clodinafop, clofop, cyhalofop, diclofop, fenoxaprop, fenoxaprop-P, fenthiaprop, fluazifop, fluazifop-P, haloxyfop, haloxyfop-P, isoxapyrifop, metamifop, propaquizafop, quizalofop, quizalofop-P and trifop; phenylenediamine herbicides such as dinitramine and prodiamine; pyrazole herbicides such as pyroxasulfone; benzoylpyrazole herbicides such as benzofenap, pyrasulfotole, pyrazolynate, pyrazoxyfen, and topramezone; phenylpyrazole herbicides such as fluazolate, nipyraclofen, pioxaden and pyraflufen; pyridazine herbicides such as credazine, pyridafol and pyridate; pyridazinone herbicides such as brompyrazon, chloridazon, dimidazon, flufenpyr, metflurazon, norflurazon, oxapyrazon and pydanon; pyridine herbicides such as aminopyralid, cliodinate, clopyralid, dithiopyr, fluroxypyr, haloxydine, picloram, picolinafen, pyriclor, thiazopyr and triclopyr; pyrimidinediamine herbicides such as iprymidam and tioclorim; quaternary ammonium herbicides such as cyperquat, diethamquat, difenzoquat, diquat, morfamquat and paraquat; thiocarbamate herbicides such as butylate, cycloate, di allate, EPTC, esprocarb, ethiolate, isopolinate, methiobencarb, molinate, orbencarb, pebulate, prosulfocarb, pyributicarb, sulfallate, thiobencarb, tiocarbazil, tri-allate and vernolate; thiocarbonate herbicides such as dimexano, EXD and proxan; thiourea herbicides such as methiuron; triazine herbicides such as dipropetryn, indaziflam, triaziflam and trihydroxytriazine; chlorotriazine herbicides such as atrazine, chlorazine, cyanazine, cyprazine, eglinazine, ipazine, mesoprazine, procyazine, proglinazine, propazine, sebuthylazine, simazine, terbuthylazine and trietazine; methoxytriazine herbicides such as atraton, methometon, prometon, secbumeton, simeton and terbumeton; methylthiotriazine herbicides such as ametryn, aziprotryne, cyanatryn, desmetryn, dimethametryn, methoprotryne, prometryn, simetryn and terbutryn; triazinone herbicides such as ametridione, WO 2011/025505 PCT/US2009/055522 42 amibuzin, hexazinone, isomethiozin, metamitron and metribuzin; triazole herbicides such as amitrole, cafenstrole, epronaz and flupoxam; triazolone herbicides such as amicarbazone, bencarbazone, carfentrazone, flucarbazone, ipfencarbazone, propoxycarbazone, sulfentrazone and thiencarbazone-methyl; triazolopyrimidine herbicides such as cloransulam, diclosulam, florasulam, flumetsulam, metosulam, penoxsulam and pyroxsulam; uracil herbicides such as benzfendizone, bromacil, butafenacil, flupropacil, isocil, lenacil, saflufenacil and terbacil; urea herbicides such as benzthiazuron, cumyluron, cycluron, dichloralurea, diflufenzopyr, isonoruron, isouron, methabenzthiazuron, monisouron and noruron; phenylurea herbicides such as anisuron, buturon, chlorbromuron, chloreturon, chlorotoluron, chloroxuron, daimuron, difenoxuron, dimefuron, diuron, fenuron, fluometuron, fluothiuron, isoproturon, linuron, methiuron, methyldymron, metobenzuron, metobromuron, metoxuron, monolinuron, monuron, neburon, parafluron, phenobenzuron, siduron, tetrafluron and thidiazuron; pyrimidinylsulfonylurea herbicides such as amidosulfuron, azimsulfuron, bensulfuron, chlorimuron, cyclosulfamuron, ethoxysulfuron, flazasulfuron, flucetosulfuron, flupyrsulfuron, foramsulfuron, halosulfuron, imazosulfuron, mesosulfuron, metazosulfuron, nicosulfuron, orthosulfamuron, oxasulfuron, primisulfuron, propyrisulfuron, pyrazosulfuron, rimsulfuron, sulfometuron, sulfosulfuron and trifloxysulfuron; triazinylsulfonylurea herbicides such as chlorsulfuron, cinosulfuron, ethametsulfuron, iodosulfuron, metsulfuron, prosulfuron, thifensulfuron, triasulfuron, tribenuron, triflusulfuron and tritosulfuron; thiadiazolylurea herbicides such as buthiuron, ethidimuron, tebuthiuron, thiazafluron and thidiazuron; and unclassified herbicides such as acrolein, allyl alcohol, aminocyclopyrachlor, azafenidin, bentazone, benzobicyclon, bicyclopyrone, buthidazole, calcium cyanamide, cambendichlor, chlorfenac, chlorfenprop, chlorflurazole, chlorflurenol, cinmethylin, clomazone, CPMF, cresol, cyanamide, ortho-dichlorobenzene, dimepiperate, endothal, fluoromidine, fluridone, flurochloridone, flurtamone, fluthiacet, indanofan, methyl isothiocyanate, OCH, oxaziclomefone, pentachlorophenol, pentoxazone, phenylmercury acetate, prosulfalin, pyribenzoxim, pyriftalid, quinoclamine, rhodethanil, sulglycapin, thidiazimin, tridiphane, trimeturon, tripropindan and tritac. The compounds of the present invention may have broad ranges of efficacy as pesticides. The exact amount of the active material to be applied is dependent not only on the specific active material being applied, but also on the particular action desired, the pathogen or pest to be controlled, and the stage of growth thereof, as well as the part of the plant, animal or other medium to be contacted with the compound. Thus, all the compounds, and WO 2011/025505 PCT/US2009/055522 43 formulations containing the same, may not be equally effective at similar concentrations or against the same pathogen and pest species. The compounds are effective in use with plants in a phytologically acceptable amount. The term "phytologically acceptable amount" refers to an amount of a compound that kills or inhibits the pest or plant disease for which control is desired, but is not significantly toxic to the plant. This amount will generally be from about 0.1 to about 1000 parts per million (ppm), with 1 to 500 ppm being preferred. The exact concentration of compound required varies with the pest or disease to be controlled, the type of formulation employed, the method of application, the particular plant or animal species, climate conditions, and the like. For fungicides, dilution and rate of application will depend upon the type of equipment employed, the method and frequency of application desired and diseases to be controlled, but the effective amount is usually from about 0.01 kilogram (kg) to about 20 kg of active ingredient (a.i.) per hectare (ha). As a foliar fungicide, a compound of the present invention is usually applied to growing plants at a rate of about 0.1 to about 5 and preferably from about 0.125 to about 0.5 kg per hectare. As a seed-applied fungicide, the amount of toxicant coated on the seed is usually at a dosage rate of about 0.1 to about 250 grams (g) and preferably from about 1 to about 60 g per 100 kg of seed. As a soil fungicide, the chemical can be incorporated in the soil or applied to the surface of the soil or a rice nursery box usually at a rate of about 0.1 to about 5 kg per hectare. The actual amount of insecticide or miticide to be applied to loci of pests is generally not critical and can readily be determined by those skilled in the art. In general, concentrations from about 10 g of pesticide per hectare to about 5000 g of pesticide per hectare are expected to provide good control. The locus to which a pesticide is applied can be any locus inhabited by a pest, for example, vegetable crops, fruit and nut trees, grape vines, ornamental plants, domesticated animals, the interior or exterior surfaces of buildings, and the soil around buildings. Controlling pests generally means that pest populations, activity, or both, are reduced in a locus. This can come about when: pest populations are repulsed from a locus; when pests are incapacitated, partially or completely, temporarily or permanently, in or around a locus; or pests are exterminated, in whole or in part, in or around a locus. Of course a combination of these results can occur. Generally, pest populations, activity, or both are desirably reduced more than fifty percent, preferably more than 90 percent, even more preferably 99 percent.

WO 2011/025505 PCT/US2009/055522 44 Generally, with baits, the baits are placed in the ground where, for example, termites can come into contact with the bait. Baits can also be applied to a surface of a building, (horizontal, vertical, or slant, surface) where, for example, ants, termites, cockroaches, and flies, can come into contact with the bait. Because of the unique ability of the eggs of some pests to resist pesticides repeated applications may be desirable to control newly emerged larvae. Systemic movement of pesticides in plants may be utilized to control pests on one portion of the plant by applying the pesticides to a different portion of the plant, or to a location where the root system of a plant can uptake pesticides. For example, control of foliar-feeding insects can be controlled by drip irrigation or furrow application, or by treating the seed before planting. Seed treatment can be applied to all types of seeds, including those from which plants genetically transformed to express specialized traits will germinate. Representative examples include those expressing proteins toxic to invertebrate pests, such as Bacillus thuringiensis or other insecticidal toxins, those expressing herbicide resistance, such as "Roundup Ready" seed, or those with "stacked" foreign genes expressing insecticidal toxins, herbicide resistance, nutrition-enhancement or any other beneficial traits. Furthermore, such seed treatments with the invention disclosed in this document can further enhance the ability of a plant to better withstand stressful growing conditions. This results in a healthier, more vigorous plant, which can lead to higher yields at harvest time. It should be readily apparent that the invention may be used with plants genetically transformed to express specialized traits, such as Bacillus thuringiensis or other insecticidal toxins, or those expressing herbicide resistance, or those with "stacked" foreign genes expressing insecticidal toxins, herbicide resistance, nutrition-enhancement or any other beneficial traits. An example of such a use is spraying such plants with the invention disclosed in this document. The invention disclosed in this document may be suitable for controlling endoparasites and ectoparasites in the veterinary medicine sector or in the field of animal keeping. Compounds according to the invention are applied here in a known manner, such as by oral administration in the form of, for example, tablets, capsules, drinks, granules, by dermal application in the form of, for example, dipping, spraying, pouring on, spotting on, and dusting, and by parenteral administration in the form of, for example, an injection. The invention disclosed in this document may also be employed advantageously in livestock keeping, for example, cattle, sheep, pigs, chickens, and geese. Suitable formulations WO 2011/025505 PCT/US2009/055522 45 may be administered orally to the animals with the drinking water or feed. The dosages and formulations that are suitable depend on the species. It will be understood by those in the art that the efficacy of the compound on the foregoing fungi and insects establishes the general utility of the compounds as fungicides and insecticides. Chromatography Definitions Prep RP-HPLC (preparative reverse-phase high-performance liquid chromatography): 20 mm x 250 mm S5pm 120A YMC-AQ, or 50 mm x 250 mm S10pm 120A YMC-AQ column, using 0.1% v/v H 3

PO

4 mixtures with MeCN (acetonitrile) as eluent; HPLC (high performance liquid chromatography): acetonitrile/water solvent system over C8 C18 on silica gel support) TLC (thin layer chromatography): SiO 2 / glass plates, eluted with hexane, Et 2 0 (diethyl ether), CH 2 Cl 2 (dichloromethane), EtOAc (ethyl acetate), MeOH (methanol), or any useful mixture of these; GC (gas chromatography); GC-MS (gas chromatography-mass spectrometry) LC-MS (liquid chromatography-mass spectrometry) H N OH Br HON H N Preparation 1. 2-(4-Benzyloxyphenyl)-ethylamine. To a suspension of potassium carbonate (K 2

CO

3 ; 1.4 grams (g), 10.11 millimole (mmol)) in acetone (40 milliliters (mL)) was added bromomethylbenzene (1.73 g, 10.11 mmol) and tert-butyl 2-(4 hydroxyphenyl)ethylcarbamate (2 g, 8.4 mmol). The reaction mixture was heated at reflux for 15 hours (h) and then concentrated in vacuo. The residue was partitioned between diethyl ether (Et 2 0) and water (H 2 0), and the organic fraction was washed with brine, dried over sodium sulfate (Na 2 SO4), suction filtered, and concentrated in vacuo. The residue was purified by silica gel (SiO 2 ) flash chromatography with 25% Et 2 0 in hexane to afford [2-(4 benzyloxyphenyl)-ethyl]-carbamic acid tert-butyl ester as a white solid (2.4 g). This was dissolved in CH 2 Cl 2 (50 mL) and trifluoroacetic acid (5 mL) was added. After stirring 16 h, the solvent was removed in vacuo, and the residue was redissolved in CH 2 Cl 2 , washed with 1 M sodium hydroxide (NaOH), dried (Na 2

SO

4 ) and filtered. The solvent was removed in WO 2011/025505 PCT/US2009/055522 46 vacuo to yield 2-(4-benzyloxyphenyl)-ethylamine (1.5 g). This was used without purification in the next step. OH 0N HN + HN N N +) Q6 N N Example 1. [2-(4-Benzyloxyphenyl)-ethyll-pteridin-4-yl-amine. To a mixture of pteridin-4 ol (282 mg, 1.9 mmol) and 2-(4-benzyloxyphenyl)-ethylamine (476 mg, 2.1 mmol) and hexamethyldisilazane (5 mL) in a 25 mL round bottom flask, equipped with reflux condenser, drying tube and magnetic stir bar, was added ammonium sulfate (100 mg, 0.76 mmol). The mixture was heated to 114 'C overnight and then the solvent was removed in vacuo. The residue was suspended in H 2 0 and filtered. The filter cake was dissolved in CH 2 Cl 2 , dried with Na 2

SO

4 , filtered, and concentrated in vacuo to provide [2-(4-benzyloxyphenyl)-ethyl] pteridin-4-yl-amine as a white solid (501 mg): 'H NMR (300 MHz) 6 9.01 (d, J = 1.9 Hz, 1H), 8.81 (s, 1H), 8.61 (d, J= 1.9 Hz, 1H), 7.49-7.29 (m, 6H), 7.25-7.15 (m, 3H), 6.96 (dd, J = 6.8, 4.8 Hz, 2H), 5.06 (s, 2H), 3.93 (dd, J= 13.2, 6.9 Hz, 2H), 3.00 (t, J= 7.0 Hz, 2H); ESIMS m/z 358.1 ([M+H]*). OH N N OH HN (N N N Example 2. 4-[2-(Pteridin-4-ylamino)-ethyl -phenol. To a solution of N-(3-cyanopyrazin-2 yl)-N,N-dimethylformamidine (prepared as in Albert and Ohta, J. Chem. Soc. C 1971, 3727 3730, which is expressly incorporated by reference herein; 2.0 g, 11.4 mmol) in ethyl alcohol (EtOH; 50 mL) was added 4-(2-aminoethyl)-phenol (4.7 g, 34 mmol) and acetic acid (3.9 mL, 4.1 g, 68 mmol). The solution was heated to reflux for 19 h, concentrated in vacuo, and the residue was slurried with H 2 0 and suction filtered. The filter cake was washed with H 2 0 and dried in a vacuum oven (80 0 C, 0.5 torr) to yield 4- [2-(pteridin-4-ylamino)-ethyl]-phenol (2.7 g) as a white solid: mp >210 0 C; 1H NMR (DMSO-d 6 ) 8 9.20 (s, 1H), 9.08 (s, 1H), 8.94 (s, 1H), 8.95 (t, J = 6.0 Hz, 1H), 8.82 (s, 1H), 8.64(s, 1H), 7.06 (d, J = 8.5 Hz, 2H), 6.69 (d, J = 8.2 Hz, 2H), 3.75 (t, J = 6.2 Hz, 2H), 2.85 (t, J = 7.6 Hz, 2H); ESIMS m/z 268 (M+).

WO 2011/025505 PCT/US2009/055522 47 OH 0 ci F F F N + ~- F -N F F C I N N N~ N N Example 3. Pteridin-4-yl- { 2- [4-(5-trifluoromethylpyridin-2-yloxy)-phenyl -ethyl } -amine. To a solution of 4- [2-(pteridin-4-ylamino)ethyl]phenol (270 mg, 1.0 mmol) and dry DMSO (5 mL) was added 2-chloro-5-trifluoromethylpyridine (155 mg, 0.85 mmol) and K 2

CO

3 (280 mg, 2.0 mmol). This mixture was heated to 80 'C for 3 h, cooled to ambient temperature, poured into H 2 0 (20 mL) and extracted with CH 2 Cl 2 (20 mL). The CH 2 Cl 2 solution was washed with H 2 0 (2 x 10 mL), dried with Na 2

SO

4 , and the solution was filtered. The solution was concentrated in vacuo, redissolved in a minimum volume of CH 2 Cl 2 and treated with hexane to precipitate a solid. The solid was collected by filtration and dried under vacuum to afford pteridin-4-yl- {2-[4-(5-trifluoromethylpyridin-2-yloxy)-phenyl] -ethyl } amine (310 mg) as an off-white solid: mp 147-150 0 C; 1H NMR (300 MHz, CDCl 3 ) 6 9.04 (d, J= 1.9 Hz, 1H), 8.85 (s, 1H), 8.64 (d, J= 1.9 Hz, 1H), 8.35 (d, J= 5.2 Hz, 1H), 7.40-7.29 (m, 3H), 7.22 (dd, J= 5.2, 0.8 Hz, 1H), 7.19-7.05 (m, 3H), 4.01 (dd, J= 13.3, 7.0 Hz, 2H), 3.10 (t, J= 7.1 Hz, 2H); ESIMS m/z 413 ([M+H]*). F OH FN ~ F - -' HN O+ F F HN F N N F N N N Example 3 Alt. Pteridin-4-yl- {2-[4-(4-trifluoromethylpyridin-2-yloxy)-phenyl -ethyl } amine. To a solution of 4- [2-(pteridin-4-ylamino)ethyl]phenol (2.5 g, 9.3 mmol) and DMSO (20 mL) in a 100 mL round bottom flask, equipped with reflux condenser, drying tube and magnetic stir bar, was added 2-fluoro-4-(trifluoromethyl)pyridine (prepared as in U.S. Patent 4,775,762, which is expressly incorporated by reference herein; 1.7 g, 10 mmol) and cesium carbonate (Cs 2

CO

3 ; 3.7 g, 11.5 mmol). This mixture was heated to 57 'C for 16 h, then cooled to ambient temperature and poured into ice H 2 0 (150 mL), precipitating an off-white solid. This was collected by suction filtration and the filter cake was washed with H 2 0 and then pentane. The cake was then dissolved in CH 2 Cl 2 , dried with Na 2

SO

4 , and the solution was filtered. The solution was concentrated in vacuo to afford pteridin-4-yl-{2-[4-(4 trifluoromethylpyridin-2-yloxy)-phenyl]-ethyl}-amine (3.0 g) as an off-white solid: mp 147- WO 2011/025505 PCT/US2009/055522 48 149 'C; I H NMR (300 MHz, CDCl 3 ) 6 9.04 (d, J = 1.9 Hz, 1H), 8.85 (s, 1H), 8.64 (d, J = 1.9 Hz, 1H), 8.35 (d, J= 5.2 Hz, 1H), 7.40-7.29 (m, 3H), 7.22 (dd, J= 5.2, 0.8 Hz, 1H), 7.19 7.05 (m, 3H), 4.01 (dd, J= 13.3, 7.0 Hz, 2H), 3.10 (t, J= 7.1 Hz, 2H); ESIMS m/z 413 ([M+H]*). OH N ,, HN OH CI N HN O N (N ; N ± "N N N t N Example 4. Pteridin-4-yl-12-[4-(pyrazin-2-yloxy)-phenyll-ethyl}-amine. To a solution of 4 [2-(pteridin-4-ylamino)ethyl]phenol (0.267 g, 1.0 mmol) and 2-chloropyrazine (0.114 g, 1.0 mmol) in anhydrous DMF (7 mL) was added 60% sodium hydride (NaH) in mineral oil (0.060 g, 1.5 mmol) portionwise. The mixture was stirred at 55 0 C overnight and then at 70 0 C for a total reaction time of 32 h. The solvent was removed in vacuo and the residue was suspended in H 2 0. The solid was collected by suction filtration, washed with H 2 0 and Et 2 0, dried in a vacuum oven at 55 0 C overnight to afford pteridin-4-yl-{2-[4-(pyrazin-2-yloxy) phenyl]-ethyl}-amine (0.291 g, 84%) as a light brown solid: 'HNMR (300 MHz, CDCl 3 ) 6 9.02 (d, J= 1.9 Hz, 1H), 8.82 (s, 1H), 8.63 (d, J= 1.9 Hz, 1H), 8.43 (d, J= 1.5 Hz, 1H), 8.26 (d, J= 2.4 Hz, 1 H), 8.10 (dd, J= 2.4, 1.5 Hz, 1H), 7.33 (d, J= 8.4 Hz, 2H), 7.13 (d, J= 8.4 Hz, 2H), 3.99 (dd, J= 13.6, 6.9 Hz, 2H), 3.08 (t, J= 6.9 Hz, 2H); ESIMS m/z 346.24 ([M+H]*). N 0" HN HN (N' F O N N N N Example 5. 12- [4-(6-Methoxypyridin-2-yloxy)-phenyl -ethyl I -pteridin-4-yl-amine. {2-[4 (6-Fluoropyridin-2-yloxy)-phenyl] -ethyl I -pteridin-4-ylamine (200 mg, 0.55 mmol) was dissolved in 4 mL dry DMSO and treated with sodium methoxide (300 mg, 5.5 mmol, 10 eq) and stirred for 20 h at 25 0 C. The mixture was poured into H 2 0 (15 mL) and extracted with

CH

2 Cl 2 (2 x 25 ml). The pooled CH 2 Cl 2 extracts were washed with H 2 0 and brine, dried (Na 2 SO4), filtered, and evaporated. The gummy residue was dissolved in a minimum quantity of CH 2 Cl 2 and treated with hexane to precipitate the product as a solid that was collected by suction filtration, washed with hexane and dried in vacuo to afford {2-[4-(6 methoxypyridin-2-yloxy)-phenyl]-ethyl}-pteridin-4-yl-amine (139 mg) as a tan solid: mp 152-153 0 C; 1H NMR (DMSO-d 6 ) 8 9.09 (s, 1H), 9.00 (t, J = 5.9 Hz, 1H), 8.82 (s, 1H), 8.63 WO 2011/025505 PCT/US2009/055522 49 (s, 1H), 7.70 (t, J= 8.0 Hz, 1H), 7.30 (d, J= 8.3 Hz, 2H), 7.05 (d, J= 8.4 Hz, 2H), 6.51 (d, J = 8.0 Hz, 2H), 6.36 (d, J = 7.7 Hz, 2H), 3.83 (m, 2H), 3.65 (s, 3H), 3.00 (m, 2H); ESIMS m/z 375 ([M+H]*). Also prepared by Example 5. Pteridin-4-yl-(2- { 4- [6-(2,2,2-trifluoroethoxy)-pyridin-2-yloxy -phenyl I -ethyl)-amine, from sodium 2,2,2-trifluoroethoxide, prepared by treatment of 2,2,2-trifluoroethanol with sodium hydride. {2- [4-(6-Ethoxypyridin-2-yloxy)-phenyl -ethyl } -pteridin-4-yl-amine, from sodium ethoxide, prepared by treatment of ethanol with sodium hydride. CI CI H,Ne H N NH 2 N CI N- 2N Preparation 2. 6-Chloro-4,5-diamino-2-methylpyrimidine. A 200 mL stainless steel Parr vessel was loaded with 5-amino-4,6-dichloro-2-methylpyrimidine (7.2 g, 40 mmol) and 2 M ammonia in isopropanol (100 mL), and then was sealed and heated at 150 0 C for 16 h. HPLC analysis indicated complete conversion. The mixture was concentrated in vacuo, and the residue was suspended in a mixture of H 2 0 (10 mL) and isopropanol (35 mL). This was stirred at 50 0 C for 1 h and then was cooled to room temperature. The precipitate was collected by suction filtration, washed sparingly with isopropanol, then air dried on the filter to afford 6-chloro-4,5-diamino-2-methylpyrimidine (5.8 g, 91%) as a brown powder, which was used without further purification in the next step. CI CI H N .. ____ HN N ~- :N 0 H 2 N N N N KNN N I Example 6. [1-(4-Methoxyphenyl)ethyll-2-methylpteridin-4-yl-amine. A mixture of 6 chloro-4,5-diamino-2-methylpyrimidine (317 mg, 2.0 mmol) and 1,4-dioxane-2,3-diol (240 mg, 2.0 mmol) in EtOH (15 mL) was stirred at 25 OC for 1 h. TLC analysis (1:1 hexane/EtOAc on SiO 2 ) indicated complete consumption of starting material. 1-(4 Methoxyphenyl)-ethylamine (332 mg, 2.2 mmol) and triethylamine (Et 3 N; 0.3 mL, 2.2 mmol) were added, and the reaction was stirred overnight. The majority of solvent was removed in vacuo and the residue was partitioned between EtOAc and H 2 0. The organic layer was WO 2011/025505 PCT/US2009/055522 50 concentrated in vacuo to leave a brown residue that was purified by column chromatography over SiO 2 , eluting with 2:1 EtOAc/hexane, then 100% EtOAc to afford [1-(4 methoxyphenyl)ethyl]-2-methylpteridin-4-yl-amine (126 mg) as a brown oil. SyN S N S, N yN N 6' N CN F F F2-F FF Preparation 3. 1. 2-Methylthio-4-(2,2,2)-trifluoroethoxypyrimidine. To a suspension of 60% NaH (524 mg, 130.1 mmol) in DMSO (30 mL) was added 2,2,2-trifluoroethanol (1.31 g, 130.1 mmol). The reaction mixture was stirred 0.5 h at 25 0 C and then 4-chloro-2-(methylthio)pyrimidine (2.0 g, 12.5 mmol) was added and stirred for 16 h. The reaction was diluted with H 2 0 and extracted with Et 2 0. The Et 2 0 layer was washed with brine, concentrated in vacuo, and filtered through SiO 2 to yield 2.16 g of yellow oil which appeared to be 60% pure by HPLC and was used without further purification in the following step. 2. 2-Methylsulfonyl-4-(2,2,2)-trifluoroethoxypyrimidine. To a solution of 1.0 g, (4.46 mmol) of the product from Preparation 3, Step 1, in CH 2 Cl 2 (5 mL), was added meta chloroperoxybenzoic acid (MCPBA; 1.6 g, 6.7 mmol) in CH 2 Cl 2 (6 mL). After 3 h, the reaction mixture was diluted with CH 2 Cl 2 (20 mL) and washed with saturated aqueous sodium bicarbonate (NaHCO 3 ) solution. The organic layer was dried (Na 2 SO4), filtered and concentrated in vacuo to yield 2-methylsulfonyl-4-(2,2,2)-trifluoroethoxypyrimidine (1.3 g, 70% pure by LC). This was used without further purification. 0 F F CI N CIN Preparation 4. 2-Chloro-4-(1.1-difluoroethyl)-pyridine. To a solution of 2-chloro-4 acetylpyridine (2.6 g, 17.2 mmol) in CH 2 Cl 2 (50 mL) was added diethylamino sulfurtrifluoride (8 mL, 60 mmol) at 25 C and the mixture was stirred for 16 h. The reaction was quenched by addition of saturated aqueous NaHCO 3 dropwise at 0 0 C. After separation of the two phases, the organic phase was dried over Na 2

SO

4 , filtered, and concentrated in vacuo. The residue was purified by column chromatography over SiO 2 with 10% EtOAc in WO 2011/025505 PCT/US2009/055522 51 hexane to yield 2-chloro-4-(1,1-difluoroethyl)pyridine (1.72 g) as a light brown oil: EIMS m/z 177 ([M]+). Also prepared by this method: 2-Bromo-6-(1,1-difluoroethyl)-pyridine, from 1-(6-bromo-pyridin-2-yl)-ethanone. EIMS m/z 222 ([M]+). 2-Chloro-4-difluoromethylpyridine, from 2-chloropyridine-4-carbaldehyde. EIMS m/z 163 ([M]+). F 0" F 0F 0, HN H 0 .HCI Preparation 5. 1. 2-Fluoro-4-methoxy-1-((E)-2-nitrovinyl)benzene. A solution of 2-fluoro-4 methoxybenzaldehyde (5.0 g, 33 mmol) and ammonium acetate (1.0 g, 13 mmol) in nitromethane (40 mL) was heated on a steam bath for 2.5 h. The reaction mixture was concentrated under reduced pressure, and the sticky residue was partitioned between CH 2 Cl 2 and H 2 0. The organic layer was washed with half-saturated brine, dried (MgSO4), filtered, and concentrated. The residue was triturated in hexane and the solid was filtered and washed with hexane and dried to give 2-fluoro-4-methoxy-1-((E)-2-nitrovinyl)benzene (5.57 g) as an orange solid: mp 80-82 0 C; 1H NMR (CDCl 3 ): 8 8.02 (d, J = 13.5 Hz, 1H), 7.66 (d, J = 13.5 Hz, 1H), 7.43 (m, 1H), 6.68-6.80 (m, 2H), 3.87 (s, 3H); EIMS m/z 197 ([M]+). This material was used in the next step without additional purification. 2. 2-(2-Fluoro-4-methoxyphenyl)ethylamine hydrochloride. Under a nitrogen atmosphere, 2 fluoro-4-methoxy-1-((E)-2-nitrovinyl)benzene (26.5 g, 134.5 mmol) was added in portions to a suspension of LiAlH 4 (16 g, 195 mmol) in THF (1 L) at 0 0 C. The mixture then was heated at reflux, and after 3.5 h, the reaction mixture was cooled to 0 0 C and quenched carefully with

H

2 0 (34.6 mL) and 10% aqueous NaOH (28 mL). After removal of green precipitates by suction filtration, the filtrate was dried over MgSO 4 , filtered and evaporated under reduced pressure. The oily residue was dissolved in EtOAc (150 mL) and then conc. HCl was added to adjust the pH to approximately 1. Et 2 0 (1 L) was added with stirring and the solid was collected by suction filtration and washed with a small amount of acetone, then dried under WO 2011/025505 PCT/US2009/055522 52 vacuum to give 12.3 g of 2-(2-fluoro-4-methoxyphenyl)ethylamine hydrochloride as a white solid, mp 162-165 'C. The filtrate was concentrated under reduced pressure, and the residue was dried azeotropically by suspending in toluene and concentrating in vacuo. The residue was dissolved in methanol, and the solution was diluted with EtOAc to precipitate additional product. The second crop was collected by suction filtration and washed with ethyl acetate, affording another 7.3 g of product. The total yield was 19.6 g (72%). 1H NMR (CDCl 3 ): 6 8.29 (br, 3H), 7.24 (t, J= 8.7 Hz, 1H), 6.73-6.84 (m, 2H), 3.74 (s, 3H), 2.83-2.99 (m, 4H); ESIMS m/z 169.9 ([M]* -HCl). CI N CI N Preparation 6. 2-Chloro-4-methoximinoacetylpyridine. To a solution of methoxylamine hydrochloride (0.37 g, 4.5 mmol) and sodium acetate (NaOAc; 0.37 g, 4.5 mmol) in H 2 0 (0.6 mL) and MeOH (5 mL) was added 2-chloro-4-acetylpyridine (0.47 g, 3 mmol), and the reaction was stirred overnight. The MeOH was evaporated, H 2 0 added, and the solution was extracted with CH 2 Cl 2 . The organic layer was dried (Na 2 SO4), filtered, and concentrated in vacuo to provide 0.50 g of crude product. EIMS m/z 184 ([M]+). C0N HN HN HN 0 NI , N 0 Nj OH OH-NNOH HN N ) LL -1 J HN N OH N N N Preparation 7. 1. 4-[i-(6-Amino-5-nitropyrimidin-4-ylamino)-ethyl -phenol. 4-Amino-5 -nitro-6 chloropyrimidine (5.0 g, 29 mmol), 4-(1-aminoethyl)phenol (4.3 g, 32 mmol) and Et 3 N (4.5 mL, 3.2 g, 32 mmol) were combined in anhydrous DMF (30 mL). After stirring 2 h at 25 0 C, the mixture was poured into dilute citric acid (150 mL; pH ca. 3) and the precipitated product was collected by suction filtration and washed with H 2 0. The solid was recrystallized from a refluxing mixture of H 2 0 (100 mL) and EtOH (50 mL) to yield 6.6 g (84%). 2. 4-[i-(5,6-Diaminopyrimidin-4-ylamino)-ethyll]-phenol. The product from Preparation 7, Step 1, was dissolved in hot EtOH (200 mL), the solution cooled and sparged with nitrogen for 15 minutes (min), treated with Raney nickel (10 g), and hydrogenated for 2 h in a Parr shaker. The catalyst was removed by suction filtration and the solvent removed in vacuo to yield 3.8 g (98%).

WO 2011/025505 PCT/US2009/055522 53 Example 7. 4-[1-(Pteridin-4-ylamino)-ethyll-phenol. The product from Preparation 7, Step 2 (1.1 g, 4.5 mmol) was dissolved in EtOH (5 mL) and treated with 40 wt. % aqueous glyoxal solution (1.3 g, 9.0 mmol) plus H20 (10 mL) and heated at 75 0 C for 40 min. After cooling, the mixture was diluted with H20 (20 mL), and the precipitated product was collected by suction filtration, washed with H20 and dried in vacuo at 80 0 C to give 4- [1-(pteridin-4 ylamino)-ethyl]-phenol (900 mg, 75%): '1H NMR (300 MHz, CDCl 3 ) 6 9.33 (s, 111), 9.06 (s,1H), 8.99 (s, 111), 8.85 (s,1H), 8.63 (s, 111), 7.32 (d, J= 9Hz, 211), 6.73 (d, J= 9Hz, 211), 5.52 (t, J= 9 Hz, 1H), 1.60 (d, J= 9 Hz, 311). '0 HO N '* OHCI Preparation 8._ 4-(2-aminoethoxy)-phenol. 1. (4-Benzyloxyphenoxy)-acetonitrile. A mixture of 4-benzyloxyphenol (9.4 g, 47 mmol), bromoacetonitrile (6.8 g, 56.7 mmol) in acetone (50 mL) with K 2

CO

3 (2 g, 14. 5 mmol) was heated to reflux 1 min, then at 40 0 C for 1 h with stirring. The reaction mixture was filtered, the solids washed with acetone, and the filtrate concentrated in vacuo to afford a tan oil which crystallized on standing, providing 10.70 g of (4-benzyloxyphenoxy)-acetonitrile. 2. 4-(2-Aminoethyloxy)-phenol. In a Parr bottle the product from Preparation 8, Step 1. (10.7 g, 44.7 mmol) was dissolved in absolute EtOH (100 mL). The solution was treated with 37% HCl (9 g) and 10% Pd/C (1.8 g). The reaction mixture was de-aerated, then charged with hydrogen (initial pressure: 50 pso 112) and shaken for 16 h. The mixture was filtered and the filtrate was concentrated in vacuo to afford 4-(2-aminoethoxy)-phenol hydrochloride salt (7.22 g, 85%) as a beige solid. This material was used without further purification. Also prepared by Preparation 8: 3-(2-Aminoethyloxy)-phenol hydrochloride salt, from 3 benzyloxyphenol. Also prepared by Preparation 8, Step 2. 2-(4-Methoxy-2,5-dimethylphenyl)-ethylamine hydrochloride, from (4-methoxy-2,5 dimethylphenyl)-acetonitrile. 2-(4-Methoxy-2-methylphenyl)-ethylamine hydrochloride, from (4-methoxy-2 methylphenyl)-acetonitrile. 2-(4-Methoxy-2,3-dimethylphenyl)-ethylamine hydrochloride, from (4-methoxy-2,3 dimethylphenyl)-acetonitrile.

WO 2011/025505 PCT/US2009/055522 54 F F F F HN : HN N CI N N-) N N Example 8. (2-14-[6-(2-Methoxyethoxy)-4-trifluoromethyl-pyridin-2-yloxyl-phenyl}-ethyl) pteridin-4-yl-amine. To a solution of {2-[4-(6-chloro-4-trifluoromethylpyridin-2-yloxy) phenyl]-ethyl}-pteridin-4-yl-amine (320 mg, 0.7 mmol) in anhydrous methoxyethanol (5 mL) was added NaH (50 mg, 60% dispersion in oil). This was heated at 100 0 C until TLC indicated completion. The reaction was evaporated under N 2 , and the residue was taken up in

H

2 0 (125 mL) and treated with dilute HCl to adjust the pH to 7. The aqueous mixture was washed with EtOAc, the layers were separated, and the organic layer was concentrated in vacuo to provide 0.22 g of a gum. This was dissolved in Et 2 0, hexane was added, and the Et 2 0 boiled off to precipitate a solid. The product was collected by suction filtration to afford (2-{4-[6-(2-methoxyethoxy)-4-trifluoromethyl-pyridin-2-yloxy]-phenyl} -ethyl) pteridin-4-yl-amine (97 mg) as a beige powder: mp 101-104 0 C; 1H NMR (CDCl 3 ) 8 9.03 (d, J= 2.0 Hz, 1H), 8.84 (s, 1H), 8.63 (d, J= 1.8 Hz, 1H), 7.31-7.29 (m, 2H), 7.27-7.23 (m, 1H), 7.13-7.09 (m, 2H), 6.73 (s, 1H), 6.55 (s, 1H), 4.30-4.28 (m, 2H), 4.01-3.96 (m, 2H), 3.63 3.61 (m, 2H), 3.38 (s, 3H), 3.10-3.07 (m, 2H); EIMS m/z 487.3 ([M]+). F 0 Y 1I HN~f HN . N-, , N N HN Example 9. Pteridin-4-yl-(2-{4-[4-(2,2,2-trifluoroethoxy)-pyridin-2-yloxyl]-phenyl}-ethyl) amine. To a solution of N-(2-{4-[(4-iodopyridin-2-yl)oxy]phenyl}ethyl)pteridin-4-amine (300 mg, 0.64 mmol) and 2,2,2-trifluoroethanol (5 mL, 1.27 mmol) in a 45 mL Parr Bomb was added Cs 2

CO

3 (412 mg, 1.27 mmol), 1,10-phenanthroline (22 mg, 0.127 mmol), and Cul (12 mg, 0.064 mmol). The reaction was held at 1100 C for 72 h, diluted with CH 2 Cl 2 , and washed with H 2 0. The organic layer was concentrated in vacuo and the residue was purified by preparative HPLC to afford pteridin-4-yl-(2-{4-[4-(2,2,2-trifluoroethoxy)-pyridin-2- WO 2011/025505 PCT/US2009/055522 55 yloxy]-phenyl}-ethyl)-amine (74 mg, 26%) as a yellow solid: mp 166 'C; EIMS m/z 442 ([M]+). F HN HNN N N BN F C-N NN Example 10. 12-[4-(6-Fluoropyridin-3-yl)-phenyl -ethyl I -pteridin-4-yl-amine. To a round bottom flask was added [2-(4-bromophenyl)-ethyl]-pteridin-4-yl-amine (200 mg, 0.61 mmol), 2-fluoro-5-pyridineboronic acid (102 mg, 0.73 mmol), NaHCO 3 (102 mg, 1.21 mmol), PdCl 2 (PPh 3

)

2 (213 mg) and 50% aqueous ethylene glycol dimethyl ether (DME; 3.0 mL). The reaction was heated to reflux for 4.5 h, after which the reaction was cooled and the resulting orange precipitate filtered. The filtered material was washed with EtOAc and the filtrate washed with H 2 0. The organic fractions were pooled and concentrated in vacuo. The residue (229 mg) was purified by preparative RP-HPLC to afford {2-[4-(6-fluoropyridin-3 yl)-phenyl]-ethyl}-pteridin-4-yl-amine (20 mg) as an orange solid: mp 184-186 0 C; EIMS m/z 346 ([M]+). 0 0 0 F F F F HO I 0 0 F -CI -I F N CI N CI N 0 N 0 F FF N! j e F F N 0 N 0 Preparation 9. 2-[6-(4-Trifluoromethylphenoxy)-pyridin-3-yll-ethylamine. 1. 6-Chloronicotinic acid, methyl ester. To a solution of 6-chloronicotinic acid (20.0 g, 0.127 mol) in CH 2 Cl 2 (250 mL) was added oxalyl chloride (123.3 mL, 0.15 mol) with 1-5 drops of DMF. The solution was stirred 18 h and concentrated in vacuo. The residue was dissolved in CH 2 Cl 2 (100 mL) and cooled in an ice bath. To this was added MeOH (20 mL) and the solution was stirred for 15 min while maintaining a temp below 40 0 C. The solvent was removed in vacuo, and the residue was dissolved in Et 2 0, washed with H 2 0 and brine, dried with Na 2

SO

4 , and filtered through SiO 2 . The solvent was removed in vacuo to yield 6 chloronicotinic acid, methyl ester (21 g) as an off-white solid: 'H-NMR (300 MHz, CDCl 3 ) 6 9.02 (d, J= 13.8 Hz, 1H), 8.51-8.06 (m, 1H), 7.76-7.30 (m, 1H), 4.01 (s, 3H); EIMS m/z 171 ([M]+), which was used in Step 2 without further purification.

WO 2011/025505 PCT/US2009/055522 56 2. 6-(4-Trifluoromethylphenoxy)-nicotinic acid methyl ester. To a suspension of NaH (60% dispersion in oil; 1.2 g, 30 mmol) in 30 mL of DMSO was added a solution of 4 (trifluoromethyl)phenol (1.86 g, 30 mmol) in 20 mL of DMSO and the mixture was stirred for 30 min. To this was added methyl 6-chloronicotinate (5.13 g, 30 mmol) and the solution was heated overnight at 70 0 C. The reaction was cooled to room temperature and then diluted with Et 2 0. The solution was washed with H 2 0, brine, dried with Na 2

SO

4 , suction filtered, and the solvent removed in vacuo. The residue was purified via normal phase column chromatography over SiO 2 using 15% Et 2 0/pentane to yield 6-(4-trifluoromethylphenoxy) nicotinic acid methyl ester (4.5 g) as a colorless solid: 'H-NMR (300 MHz, CDCl 3 ) 6 8.81 (dd, J = 2.5, 0.6 Hz, 1H), 8.33 (dd, J = 8.6, 2.4 Hz, 1H), 7.69 (d, J = 8.5 Hz, 2H), 7.31 - 7.24 (m, 2H), 7.02 (dd, J = 8.5, 0.6 Hz, 1H), 3.93 (s, 3H); EIMS m/z 297 ([M]'). 3. 5-Chloromethyl-2-(4-trifluoromethylphenoxy)-pyridine. To a suspension of LiAlH 4 (0.051 g, 13.5 mmol) in THF (20 mL) was added dropwise a solution of 6-(4 trifluoromethylphenoxy)-nicotinic acid methyl ester (4.0 g, 13.5 mmol) in THF (10 mL). After the mixture was stirred 1 h, the reaction was quenched by the addition of 4M NaOH (3 mL) followed by H 2 0 (3 mL). A precipitate formed and the THF was decanted. The precipitate was washed with hot THF 2 times. The organic fractions were combined and the solvent removed in vacuo to yield 3.5 g of yellow oil which was dissolved in toluene (15 mL) and cooled in an ice bath. To this solution was added SOC1 2 (3.9 mL) dropwise. The solution was allowed to warm to RT and stirred 2 h, at which point the reaction was concentrated in vacuo. The residue was dissolved in Et 2 0 and washed with IM NaOH. The Et 2 0 phase was dried with Na 2

SO

4 and suction filtered through SiO 2 . The solvent was removed in vacuo yielding 5-chloromethyl-2-(4-trifluoromethylphenoxy)-pyridine (1.8 g) as a yellow solid: 'H NMR (300 MHz, CDCl 3 ) 6 8.17 (d, J = 2.5 Hz, 1H), 7.80 (dd, J = 8.5, 2.5 Hz, 1H), 7.66 (dd, J = 5.5, 3.5 Hz, 2H), 7.30 - 7.17 (m, 2H), 7.00 (d, J = 8.4 Hz, 1H), 4.57 (s, 2H); EIMS m/z 287 ([M]'). 4. [6-(4-Trifluoromethylphenoxy)-pyridin-3-yll-acetonitrile. To a solution of 5 chloromethyl-2-(4-trifluoromethylphenoxy)-pyridine (1.8 g, 6.27 mmol) in EtOH (12 mL) was added NaCN (1.23 g, 25 mmol). The reaction mixture was heated to 50 0 C for 16 h. More ethanol (6 mL) was added, and the reaction mixture clarified. After an additional 3 h, the solvent was removed in vacuo, the residue taken up in Et 2 0 and washed with H 2 0,. The organic layer was dried with Na 2

SO

4 , suction filtered and concentrated in vacuo. The residue was purified by flash chromatography (50% Et 2 0 in petroleum ether over SiO 2 ) to yield [6- WO 2011/025505 PCT/US2009/055522 57 (4-trifluoromethylphenoxy)-pyridin-3-yl]-acetonitrile (1.3 g) as a pink solid; '1H NMR (300 MHz, CDCl 3 ) 6 8.17 - 8.09 (m, 1H), 7.81 - 7.71 (m, 1H), 7.70 - 7.61 (m, 2H), 7.29 - 7.19 (m, 2H), 7.04 (d, J = 8.4 Hz, 1H), 3.73 (s, 2H); EIMS m/z 278 ([M]'). 5. 2-{6-[4-(Trifluoromethyl)phenoxylpyridin-3-yllethylamine. To a solution of AlCl 3 (268 mg, 1.8 mmol) in Et 2 0 cooled to 0 0 C in an ice bath was added LiAlH 4 (66 mg, 1.8 mmol) in one portion, under N 2 . After stirring 15 min, a solution of [6-(4-trifluoromethylphenoxy) pyridin-3-yl]-acetonitrile (500 mg, 1.8 mmol) in Et 2 0 (2 mL) and THF (1 mL) was added dropwise resulting in an exotherm. The reaction was allowed to cool to room temperature, and after 2 h, the reaction was quenched by careful addition of 5 mL of saturated aqueous ammonium chloride. The resulting mixture was made alkaline by addition of 2M NaOH solution. The precipitate which formed was removed by filtration through Celite. The filtrate phases were separated, and the aqueous phase was extracted 3 times with Et 2 0. The pooled organic fractions were dried with Na 2

SO

4 and suction filtered. The solvent was removed in vacuo to yield 2-[6-(4-trifluoromethylphenoxy)-pyridin-3-yl]-ethylamine (200 mg), as a brown oil. Also prepared by Preparation 9, Steps 4 and 5. 2-(4-Methoxy-3-trifluoromethylphenyl) ethylamine hydrochloride, from (4-methoxy-3-trifluoromethylphenyl)-methanol. Also prepared by Preparation 9, Step 5. 2-(3-Fluoro-4-methoxyphenyl)-ethylamine hydrochloride, from (3-fluoro-4-methoxyphenyl) acetonitrile. 2-(4-Methoxy-3-methylphenyl)-ethylamine hydrochloride, from (4-methoxy-3 methylphenyl)-acetonitrile. CI OH HN N_ H 2 N N N N Preparation 10. 6,7-Dimethyl-pteridin-4-ol. A mixture of 6-chloropyrimidine-4,5-diamine (1.4 g, 10 mmol) and 2,3-butanedione (2.0 g, 23 mmol) in toluene (35 mL) and methanol (10 mL) was stirred at reflux for 1 h. Upon cooling, the product precipitated and was collected by suction filtration and rinsed with a MeOH/ Et 2 0 mixture (ca. 1:2), then air dried to afford 6,7-dimethylpteridin-4-ol (1.4 g, 72%) as a gold powder.

WO 2011/025505 PCT/US2009/055522 58 OH 0 HN HN N N N N Example 11. { 2- [4-(4-Isopropylphenoxy)-phenyl -ethyl } -pteridin-4-yl-amine. 4-[2 (Pteridin-4-ylamino)-ethyl]-phenol (500 mg, 1.9 mmol), 4-isopropylphenylboronic acid (400 mg, 2.4 mmol), anh. Cu(OAc) 2 (360 mg, 2.0 mmol) and powdered, freshly activated 4A molecular sieves (approximately 1 g) were combined in CH 2 Cl 2 (15 mL), treated with pyridine (920 pL, 900 mg, 11.4 mmol) and sealed and stirred for 20 h with a moisture trap. The reaction was suction filtered and the filtrate shaken with dilute aqueous NH 4 0H. The organic phase was washed with H 2 0 and brine and concentrated in vacuo. The residue was purified by preparative RP-HPLC using 80% MeCN/ H 2 0 to yield {2-[4-(4 isopropylphenoxy)-phenyl]-ethyl}-pteridin-4-yl-amine (78 mg, 11%) as a tan solid: mp 105 106.5 C. OH Oj >K OH HNIJ HN ' S t N N N N N N N N Example 12. { 2- [4-(tert-Butyldimethylsilanyloxy)-phenyl -ethyl } -pteridin-4-yl-amine. 4 [2-(Pteridin-4-ylamino)-ethyl]-phenol (1.0 g, 3.7 mmol) was partially dissolved in dry DMF (75 mL), treated with imidazole (630 mg, 9.3 mmol), cooled to 0-5 0 C and treated dropwise with a solution of t-butyldimethylsilyl chloride (680 mg, 4.5 mmol) in DMF (15 mL). After warming to 25 0 C the mixture was stirred for 20 h, diluted with H 2 0 (75 mL) and extracted with EtOAc. The extracts were washed with H 2 0, brine, dried (Na 2 SO4), filtered and concentrated in vacuo to give {2- [4-(tert-butyldimethylsilanyloxy)-phenyl] -ethyl I -pteridin-4 yl-amine (1.3 g) as a white solid: mp 164-165 0 C; 1H NMR (300 MHz, CDCl 3 ) 6 8.99 (s, 1H), 8.61 (s, 1H), 8.59 (s, 1H), 8.26 (d, J = 5.9 Hz, 1H), 6.8-7.2 (m, 5H), 3.98 (t, J = 6.2 Hz, 2H), 2.99 (t, 6.3 Hz, 2H), 1.02 (s, 6H), 0.18 (s, 9H). Example 13. { 2-[4-(tert-Butyldimethylsilanyloxy)-phenyl -ethyl } -pteridin-4-yl-carbamic acid tert-butyl ester. {2-[4-(tert-Butyldimethylsilanyloxy)-phenyl] -ethyl } -pteridin-4-yl amine (10.15 g, 3.0 mmol) was dissolved in dry DMF (50 mL), treated with di-tert butyldicarbonate (730 mg, 3.3 mmol) plus approximately DMAP (N,N-dimethyl-4 aminopyridine; 25 mg) and stirred at 25 0 C for 22 h. The mixture was diluted with H 2 0 and WO 2011/025505 PCT/US2009/055522 59 extracted with EtOAc. The EtOAc extracts were washed with H 2 0, dried (Na 2 SO4), suction filtered and concentrated in vacuo to give {2-[4-(tert-butyldimethylsilanyloxy)-phenyl] ethyl}-pteridin-4-yl-carbamic acid tert-butyl ester (1.2 g; 83%), as a yellow gum; ESIMS m/z 482 ([M+H]*). Example 14. [2-(4-Hydroxyphenyl)-ethyll-pteridin-4-yl-carbamic acid tert-butyl ester {2- [4-(tert-Butyldimethylsilanyloxy)-phenyl] -ethyl I -pteridin-4-yl-carbamic acid tert-butyl ester (680 mg, 1.4 mmol) was dissolved in 5 mL CH 2 Cl 2 and treated with tetrabutylammonium fluoride 3H 2 0 in 10 mL THF. After stirring for 18 h, the solution was washed with H 2 0, dried (Na 2 SO4), suction filtered, and concentrated in vacuo to give [2-(4 hydroxyphenyl)-ethyl]-pteridin-4-yl-carbamic acid tert-butyl ester as a tan solid, mp 132 134 0 C (dec.); ESIMS m/z ([M+H]*) 368. Br F 0 0 - 0N F F HN N. HN OHN N NN N Example 15. 5- [2-(Pteridin-4-ylamino)-ethyl -2-(4-trifluoromethyl-pyridin-2-yloxy)-benzoic acid, methyl ester. To a solution of {2-[3-bromo-4-(4-trifluoromethylpyridin-2-yloxy) phenyl]-ethyl}-pteridin-4-yl-amine (243 mg, 0.5 mmol), in methanol in a 45 mL Parr bomb was added Pd(OAc) 2 (5.6 mg, 0.25 mmol), DPPB (21 mg, 0.5 mmol), and K 2 C0 3 (138 mg, 1 mmol). The reactor was sealed and charged with 300 psi of CO. The reaction was heated to 1 10 0 C for 15 h, cooled to ambient temperature, filtered through Celite, and concentrated in vacuo. The residue was dissolved in CH 2 Cl 2 , washed with H 2 0, brine, dried over Na 2

SO

4 , suction filtered and concentrated in vacuo. The residue was slurried in Et 2 0 and pentane. The solvent was decanted to leave 5-[2-(pteridin-4-ylamino)-ethyl]-2-(4 trifluoromethylpyridin-2-yloxy)-benzoic acid, methyl ester (55 mg; 23% yield) as a light yellow solid: mp 171-172 0 C; 1H NMR (300 MHz, CDCl 3 ) 6 9.04 (d, J = 2.0 Hz, 1H), 8.84 (s, 1H), 8.64 (d, J = 1.9 Hz, 1H), 8.23 (d, J = 5.0 Hz, 1H), 7.94 (d, J = 2.3 Hz, 1H), 7.52 (dd, J = 8.2, 2.2 Hz, 1H), 7.26 - 7.12 (m, 4H), 4.02 (dd, J = 13.7, 6.9 Hz, 2H), 3.67 (s, 3H), 3.13 (t, J = 7.3 Hz, 2H); ESIMS m/z 471.

WO 2011/025505 PCT/US2009/055522 60 OH F F HN OH 7 HN O N N Example 16. Pteridin-4-yl- 12- [4-(3,5,6-trifluoro-4-trifluoromethyl-pyridin-2-yloxy)-phenyll -ethyl } amine. 4- [2-(Pteridin-4-ylamino)-ethyl] -phenol (0.27 g, 1.0 mmol), 2,3,5,6-tetrafluoro-4 trifluoromethylpyridine (0.24 g, 1.0 mmol) and DMF (5 mL) were added to a 25 mL round bottom flask equipped with magnetic stirring bar and dry nitrogen line. To the reaction mixture was added Et 3 N (0.12 g, 1.2 mmol). After stirring 24 h at room temperature, the reaction mixture was concentrated in vacuo, and the residue was partitioned between H 2 0 and EtOAc. The organic layer was concentrated in vacuo and the residue was purified by column chromatography (EtOAc/hexane over SiO 2 ) to afford pteridin-4-yl-{2-[4-(3,5,6-trifluoro-4-trifluoromethyl-pyridin-2-yloxy)-phenyl] ethyll-amine (110 mg) as a beige solid: mp 103-108 0 C. 1 OH 0 HN HN~f (N N N N N N Example 17. (2-14- [2-(4-Benzyloxy-phenyl)-ethoxyl -phenyl I -ethyl)-pteridin-4-yl-amine. 4- [2-(Pteridin-4-ylamino)-ethyl]-phenol (300 mg, 10.1 mmol), triphenylphosphine (790 mg, 3.0 mmol) and 2-(4-benzyloxyphenyl)ethanol (700 mg, 3.0 mmol) were combined in 10 mL anh. dioxane, treated with diisopropylazodicarboxylate (590 P L, 610 mg, 3.0 mmol) and stirred for 18 h. The volatiles were removed in vacuo and the residue was chromatographed on SiO 2 with EtOAc (10% to 40%) in CH 2 Cl 2 to obtain (2-{4-[2-(4-benzyloxyphenyl) ethoxy]-phenyl}-ethyl)-pteridin-4-ylamine (105 mg; 20%) as a white solid: mp 120-122 0 C; ESIMS m/z 478 ([M+H]*); 1H NMR (300 MHz, CDCl 3 ) 6 9.23 (s,1H), 8.96 (s, 1H), 8.80 (s, 1H), 6.8-7.5 (m, 13H), 4.1 (m, 2H), 3.90 (m, 2H), 3.01 (m, 4H). 0 F OH F F S Nx HN HN (N N_ Example 18: 2-[4-(1.1-Difluoroethyl)-pyridin-2-yloxyl-5-[2-(pteridin-4-ylamino)-ethyll phenol. To a solution of (2-{4- [4-(1,1 -difluoroethyl)-pyridin-2-yloxy] -3-methoxyphenyl } ethyl)-pteridin-4-yl-amine (1.37 g, 3.13 mmol) in CH 2 Cl 2 (15 mL) cooled to 0 0 C, was added WO 2011/025505 PCT/US2009/055522 61 IM BBr 3 /hexane (9.4 mL, 9.4 mmol). The solution was allowed to warm to room temperature and stirred overnight. The reaction was quenched with methanol and concentrated in vacuo. The residue was dissolved in small amount of methanol and poured into aqueous NaHCO 3 . The hydroxyaryl product precipitated and was collected by suction filtration and washed with H 2 0. The filter cake was air dried on the filter to yield 2- [4-(1,1 difluoroethyl)-pyridin-2-yloxy] -5- [2-(pteridin-4-ylamino)-ethyl] -phenol (0.76 g), as a light brown solid: I H NMR (300 MHz, d 6 -DMSO) 6 9.53 (br s, 1H), 9.45 (s, 1H), 9.12 (s, 1H), 8.91 (d, J= 1.5 Hz, 1H), 8.78 (br, 1H), 8.20 (d, J= 5.3 Hz, 1H), 7.22 (d, J= 5.3 Hz, 1H), 7.08 (s, 1H), 6.98 (d, J= 8.1 Hz, 1H), 6.85 (d, J= 1.8 Hz, 1H), 6.72 (dd, J= 8.1, 1.8 Hz, 1H), 3.84 (dd, J= 14.7, 7.4 Hz, 2H), 2.93 (t, J= 7.4 Hz, 2H), 1.98 (t, J= 19.2 Hz, 3H); ESIMS m/z 425 ([M+H]*). F FF N; F C, F )C < N F ci , Preparation 11. 2-Methoxy-6-chloro-4-trifluoromethylpyridine. To a solution of 2,6 dichloro-4-trifluoromethylpyridine (10 g , 46.3 mmol) in methanol (200 mL) was added 25% NaOH/MeOH (12.5 g, 13.2 mL, 231 mmol), which was then stirred at 50 0 C for 2 h and then at room temperature overnight. The reaction mixture was extracted with pentane, and the extract was concentrated in vacuo to afford 2-methoxy-6-chloro-4-trifluoromethylpyridine (9.79 g), used without further purification. CI N CI N 0 Preparation 12. 2-Chloro-4-t-butylpyridine-N-oxide. 2-Chloro-4-t-butylpyridine (5.0 g, 30 mmol) was dissolved in chloroform (75 mL), treated with MCPBA, ca. 75% (8.3 g, 36 mmol, 1.2 equivalents) and heated to reflux for 19 h. The mixture was stirred with sodium bisulfite solution until testing with starch-iodide paper indicated consumption of oxidant. The pH was adjusted to 7 with saturated aqueous NaHCO 3 solution, the phases separated and the aqueous phase extracted once with CH 2 Cl 2 . The organic phases were pooled and washed twice with

H

2 0, once with brine, dried (Na 2

SO

4 ) and concentrated in vacuo to afford 2-chloro-4-t butylpyridine-N-oxide (5.0 g, 90%), which crystallized to long white needles on standing.

WO 2011/025505 PCT/US2009/055522 62 OH F H 1 ' F 0 F I F - N' N F N HN'' NN I F, N N NNN Example 19. 12-[3-(Isopropoxy)-4-(4-trifluoromethy-pyridin-2-yloxy)-phenyl -ethyl } pteridin-4-ylamine. To a solution of 5-[2-(pteridin-4-ylamino)-ethyl]-2-(4 trifluoromethylpyridin-2-yloxy)-phenol (200 mg, 0.47 mmol) in 2 mL of DMSO was added 2-iodopropane (62 mg, 0.5 mmol), and K 2

CO

3 (97 mg, 0.7 mmol). The solution was heated 2 h at 50 0 C, after which TLC analysis indicated absence of starting material. The mixture was poured onto ice. The product precipitated and was collected by suction filtration, washed with H 2 0, and air dried, yielding {2-[3-(isopropoxy)-4-(4-trifluoromethylpyridin-2-yloxy) phenyl]-ethyl}-pteridin-4-ylamine (180 mg; 81% yield) as a light brown solid: ESIMS m/z: 471 ([M+H]*). 0 OH O OJ< ,:I, N C' N CIICN Preparation 13. 2-Chloroisonicotinic acid, 2,2-dimethyl-propyl ester. 2-Chloroisonicotinic acid (2.0 g, 13 mmol) was suspended in 50 mL dry CH 2 Cl 2 and treated with oxalyl chloride (3.5 mL, 5.0 g, 39 mmol) plus 3 drops DMF. The mixture was stirred for 4 h, the volatiles removed in vacuo and the residue taken up in 50 mL CH 2 Cl 2 . After cooling to 0 0 C and treating with neopentyl alcohol (1.7 ml, 1.4 g, 16 mmol), Et 3 N (2.5 mL, 1.8 g, 18 mmol) was added in portions. The mixture was warmed to 25 0 C, stirred for 15 h, washed sequentially with 15 mL H 2 0, 15 mL saturated aqueous NaHCO 3 , and 15 mL brine, then dried (Na 2 SO4), filtered, and concentrated in vacuo to give 2.4 g (80%) of 2-chloroisonicotinic acid, 2,2 dimethyl-propyl ester as an oil, used without additional purification: 'H NMR (300 MHz, CDCl 3 ) 6 8.56 (d, J= 5.6 Hz, 1H), 7.88 (s, 1H), 7.78 (d J= 5.0 Hz, 1H), 4.06 (s, 2H), 1.05 (s, 9H). Also prepared by Preparation 13. 2-Chloroisonicotinic acid, tert-butyl ester, from tert butanol.

WO 2011/025505 PCT/US2009/055522 63 CI N 0 F F F F Preparation 14. 2-chloro-4-( 1,1 -difluoro)ethylpyridine-N-oxide. To a solution of 1.27 g (7 mmol) 2-chloro-4-(1,1-difluoro)ethylpyridine (Preparation 4) in TFA was added 30% hydrogen peroxide (6 mL) and the solution was heated at reflux for 2.5 h. The TFA was removed in vacuo and the residue poured into ice-cold H 2 0. The mixture was neutralized with Na 2

CO

3 and extracted with EtOAc and CH 2 Cl 2 . The pooled organic layers were dried (Na 2 SO4), filtered and concentrated in vacuo to give 2-chloro-4-(1,1-difluoroethyl)-pyridine 1-oxide (1.00 g) as a brown oil: 1H NMR (CDCl 3 ): 8 8.39 (d, J= 6.6 Hz, 1H), 7.63 (d, J= 2.4 Hz, 1H), 7.33 (dd, J= 6.6, 2.4 Hz, 1H), 1.94 (t, J= 18 Hz, 3H); EIMS m/z 193 ([M]'). 0 OH F ( N HN N- I N HN N N N N Example 20. Acetic acid 5-[2-(pteridin-4-ylamino)-ethyll-2-(4-trifluoromethylpyridin-2 yloxy)-phenyl ester. To 4 mL of acetic anhydride was added 5-[2-(Pteridin-4-ylamino) ethyl]-2-(4-trifluoromethylpyridin-2-yloxy)-phenol (330 mg, 0.7 mmol), pyridine (0.5 mL), and 5 mg DMAP. The solution was stirred at ambient temperature for 15 h, then diluted with

CH

2 Cl 2 and washed sequentially with H 2 0 and saturated aqueous NaHCO 3 solution. The organic fraction was dried with Na 2

SO

4 , suction filtered, and concentrated in vacuo. The residue was diluted with 1:1 Et 2 0/pentane. The product precipitated, was collected by filtration, and the cake washed with cool 1:1 Et 2 0/pentane. This afforded 184 mg (56% yield) of acetic acid 5- [2-(pteridin-4-ylamino)-ethyl] -2-(4-trifluoromethylpyridin-2-yloxy) phenyl ester, an off-white solid: ESIMS n/z: 471 ([M]'). F F F F 0 0 -N N HN 0 ,. HN (N N rN _ N N N N Example 21. (2- { 4-[4-(1,1 -Difluoroethyl)-6-methoxypyridin-2-yloxyl]-phenyl} -ethyl) pteridin-4-yl-amine. A round bottom flask was charged with (2-{4-[4-(1,1-difluoroethyl)-1 oxy-pyridin-2-yloxy] -phenyl I -ethyl)-pteridin-4-yl-amine (0.52 g, 1.13 mmol), ethyl WO 2011/025505 PCT/US2009/055522 64 chloroformate (0.43 mL, 4.5 mmol), Et 3 N (0.95 mL, 6.81 mmol) and MeOH (10 mL), and heated at reflux for 2 days. The solvent was removed and the residue dissolved in CH 2 Cl 2 . The solution was washed with brine, dried over Na 2

SO

4 , filtered, concentrated in vacuo and purified by preparative RP-HPLC to give (2-{4-[4-(1,1-difluoroethyl)-6-methoxypyridin-2 yloxy]-phenyl}-ethyl)-pteridin-4-yl-amine (0.130 g, 24% yield) as a pale yellow solid: 'H NMR (300 MHz, CDCl 3 ) 6 9.02 (d, J= 1.9 Hz, 1H), 883 (s, 1H), 8.62 (d, J= 1.9 Hz, 1H), 7.29 (d, J= 8.1 Hz, 2H), 7.12 (d, J= 8.1 Hz, 2H), 6.54 (s, 1H), 6.44 (s, 1H), 3.98 (dd, J= 13.2, 6.9 Hz, 2H), 3.79 (s, 3H), 3.08 (t, J= 6.9 Hz, 2H), 1.86 (t, J= 18.3 Hz, 3H); ESIMS m/z 439.2 ([M+H]*). N F 0 F F CI FF N:) N- N, Preparation 15. 4-(1,1-Difluoroethyl)-2-fluoropyridine. 1. 2-Fluoroisonicotinonitrile. Cesium fluoride (30 g, 0.22 mmol) was slurried in dry sulfolane (150 mL) and concentrated via vacuum distillation at 0.5 mm Hg. After removal of 20% of the solvent, the suspension was cooled and 2-chloroisonicotinonitrile (15 g, 0.11 mmol) was added, then stirred and heated at 100 0 C for 20 h. It was cooled to 25 0 C, poured into H 2 0 (200 mL) and extracted with Et 2 0. The Et 2 0 phase was washed with H 2 0, then brine, dried over Na 2

SO

4 , filtered and concentrated in vacuo. The residue was purified by column chromatography over SiO 2 with CH 2 Cl 2 to give 2-fluoroisonicotinonitrile (12.0 g) as a low melting colorless solid: EIMS m/z: 122 ([M]+); 'H NMR (CDCl 3 ): 8 8.45 (dd, 1H), 7.47 (dd,1H), 7.24 (m, 1H). 2. 1-(2-Fluoropyridin-4-yl)-ethanone. To a solution of 2-fluoroisonicotinonitrile (10 g, 82 mmol) in anhydrous Et 2 0 (250 mL) cooled in an ice-H 2 0 bath was slowly added 3M methyl magnesium bromide in hexane (40 mL, 120 mmol). The mixture was stirred at 25 0 C overnight. The reaction was quenched slowly with IN aq. citric acid solution at 0 0 C until all solids dissolved. Brine was added and the two phases were separated. The organic phase was dried over Na 2

SO

4 , filtered, and concentrated in vacuo to give 1-(2-fluoropyridin-4-yl) ethanone (6.2 g) as a brown oil. The aqueous phase was stirred at 25 0 C for 3h, then extracted with CH 2 Cl 2 . The CH 2 Cl 2 layer was dried over Na 2

SO

4 , filtered, and concentrated in vacuo to give an additional 1.1 g of the product, for a total of 7.3 g, used in the next step without further purification: EIMS m/z 139 ([M]+). 1H NMR (CDCl 3 ): 8 8.25 (dd, 1H), 7.47 (d, 1H), 7.21 (m, 1H).

WO 2011/025505 PCT/US2009/055522 65 3. 2-Fluoro-4-(1,1-difluoroethyl)pyridine. 1-(2-Fluoropyridin-4-yl)-ethanone (6.2 g, 44.6 mmol) from the previous reaction was treated with diethylamino-sulfurtrifluoride (17 mL, 130 mmol), as in Preparation 4, to yield 3.5 g of 2-fluoro-4-(1,1-difluoroethyl)pyridine (45% yield), as a light yellow oil: EIMS m/z 161 ([M]+). HO O HO O + + OH O

O

O H O H O H -HCI OH Preparation 16. 4-(2-Aminoethoxy)-3-methylphenol hydrochloride. 1. 4-Benzyloxy-2-methylphenol. 2-Methylbenzene-1,4-diol (12.4 g, 0.1 mol) was dissolved in acetone (200 mL) in a 500 mL round bottom flask equipped with magnetic stirrer, reflux condenser and dry nitrogen line. To the solution was added K 2

CO

3 (20.5 g), followed by benzyl bromide (12.2 mL, 0.1 mol) with vigorous stirring. After stirring at room temperature for 72 h, the reaction mixture was filtered and concentrated in vacuo. The residue was partitioned between slightly acidic H 2 0 (pH adjusted to 5 with 0.1 N HCl) and a 1:1 mixture of Et 2 0 and pentane. The organic layer was filtered and concentrated in vacuo to provide a black oil (20.66 g). The oil was extracted with isopentane (3 x 150 mL) and the pooled isopentane fractions were concentrated in vacuo to provide an orange oil (10 g); the dark insoluble residue was set aside. The orange oil was passed over a SiO 2 column with Et 2 0/pentane (1:1) eluent. The appropriate fractions were pooled and concentrated in vacuo to provide 7.0 g of 1,4-bisbenzyloxy-2-methylbenzene as a pale yellow oil, which solidified on standing. The dark insoluble residue from above was passed over a SiO 2 column with Et 2 0 /pentane (1:2) eluent. The appropriate fractions were pooled and concentrated in vacuo to provide 7.2 g 4-benzyloxy-2-methylphenol and 4-benzyloxy-3-methylphenol (approximately 1:1 mixture of monobenzylated isomers) as an orange solid, used in the next step without further purification. 2. (4-Benzyloxy-2-methylphenoxy)-acetonitrile. 4-Benzyloxy-2-methylphenol and 4 benzyloxy-3-methylphenol product from step 1 ( 5.76 g, 27 mmol) and bromoacetonitrile (3.24 g, 27 mmol) were dissolved in tetrahydrofuran (100 mL) in a 500 mL round bottom WO 2011/025505 PCT/US2009/055522 66 flask equipped with magnetic stir bar, reflux condenser and dry nitrogen line. The solution was treated with NaH (60% dispersion in oil; 1.4 g, 35 mmol) and stirred at room temperature overnight. The reaction mixture was diluted with dimethyl formamide (20 mL), and then stirred another 2 h at room temperature. The reaction mixture was concentrated in vacuo, then taken up in H 2 0 (200 mL). After adjusting pH to 4 with 2N HCl, the aqueous layer was washed with an equivolume of Et 2 0 /pentane (1:1). The organic layer was concentrated in vacuo to provide a yellow-brown oil (6.45 g). The oil was subjected to preparative HPLC to provide a slightly purified product, after pooling appropriate fractions. This product was extracted with boiling isopentane (3 x 100 mL) and the pooled isopentane fractions were concentrated in vacuo to provide 2.25 g of (4-benzyloxy-2-methylphenoxy)-acetonitrile (isomer A) and (4-benzyloxy-3-methylphenoxy)-acetonitrile (isomer B), approximately 2:1 mixture of A:B (determined by 'H-NMR integrations), as a pale yellow oil. The insoluble residue was digested in boiling pentane, decanted, and cooled to room temperature. After 24 hours, crystals had formed. The supernatant was decanted, and concentrated in vacuo to provide 750 mg of isomers A and B in 1:3 ratio ('H-NMR analysis). The crystals were found to be the desired isomer A. Successive pentane digestions of the crude residues and crystallization eventually led to the recovery of 1.95 g of the highly enriched (4-benzyloxy-2 methylphenoxy)-acetonitrile (isomer A). 3. 4-(2-Aminoethoxy)-3-methylphenol hydrochloride. (4-Benzyloxy-2-methylphenoxy) acetonitrile (isomer A from Step 2; 1.95 g, 7.7 mmol) was dissolved in absolute ethanol (100 mL) in a Parr bottle. The solution was treated with con. aq. HCl (1.55 g) and 10%Pd-C (0.3 g), degassed, charged with hydrogen (55 psig), and shaken for 72 h. The suspension was filtered and concentrated in vacuo to afford 1.92 g 4-(2-aminoethoxy)-3-methylphenol hydrochloride as a beige solid, used without further purification: EIMS m/z 167 ([M]+). H00 N O0H F0- 01N 0 N N + - HO - -N HO -a 0 ON F F F FFFFF F F F F F HN N 0 - N 0 N NFF FF FF HN N N N Example 22. 4- {2- r4-(4-Trifluoromethylp2yridin-2-yloxy)-p2henyl] -ethoxy I-p2teridine.

WO 2011/025505 PCT/US2009/055522 67 1. 2-[4-(4-Trifluoromethylpyridin-2-yloxy)-phenyl -ethanol. 2-(4-Hydroxyphenyl)ethanol (4.0 g, 29 mmol), K 2 C0 3 (8.0 g, 58 mmol) and 2-fluoro-4-trifluoromethylpyridine (3.6 g, 22 mmol) were combined in DMSO (30 mL) and stirred at 25 0 C for 20 h. The mixture was poured into H 2 0 and extracted twice with Et 2 0. The combined Et 2 0 extracts were washed with IM NaOH, H 2 0, brine, and concentrated in vacuo to give 2-[4-(4 trifluoromethylpyridin-2-yloxy)-phenyl]-ethanol (4.7 g ; 57%), mp 78-79 0 C; EIMS m/z 283; 1H NMR (300 MHz, DMSO-d 6 ) 6 8.38 (d, J = 5.3 Hz, 1H), 7.0-7.5 (m, 8H), 4.67 (t, J = 5.0 Hz, 2H), 2.74 (t, J = 5.2 Hz, 2H). 2. 4-Nitro-6-{2-[4-(4-trifluoromethylpyridin-2-yloxy)-phenyll-ethoxy}-pyrimidin-5-ylamine. 2-[4-(4-Trifluoromethylpyridin-2-yloxy)-phenyl]-ethanol (product from Step 1; 400 mg, 1.4 mmol) was dissolved in DMSO (10 mL), treated with 95% NaH (36 mg, 1.5 mmol) and the mixture was warmed to 50-60 0 C to produce a clear solution. Upon cooling the mixture was treated with 4-amino-5-nitro-6-chloropyrimidine (260 mg, 1.5 mmol) and heated at 45 0 C for 6 h. After cooling the mixture was poured into H 2 0 (60 mL) and the precipitate was collected by suction filtration, washed with H 2 0 and air-dried on the filter: 1H NMR (300 MHz, CDCl 3 ) 6 8.39 (s, 1H), 8.33 (s, 1H), 8.18 (s, 1H), 7.38 (m, 2H), 7.15 (m, 4H), 4.69(t, J= 6.8 Hz, 2H), 3.15 (t, 6.6 Hz, 2H). This material was used in the next step without further purification. 3. 6-{2-[4-(4-Trifluoromethylpyridin-2-yloxy)-phenyll-ethoxy} -pyrimidine-4,5-diamine. 4 Nitro-6-{2- [4-(4-trifluoromethylpyridin-2-yloxy)-phenyl] -ethoxy I -pyrimidin-5 -ylamine was taken up in 75 mL absolute ethanol, treated with 100 mg 5% Pd/C and shaken under 50 psi hydrogen for 20 h. After removal of the catalyst by filtration, the crude diamino ether (6-{2 [4-(4-trifluoromethylpyridin-2-yloxy)-phenyl]-ethoxy}-pyrimidine-4,5-diamine) was obtained by removal of the solvent in vacuo to provide 6-{2-[4-(4-trifluoromethylpyridin-2 yloxy)-phenyl]-ethoxy}-pyrimidine-4,5-diamine, which was used in the next step without further purification. 4. 4-12-[4-(4-Trifluoromethylpyridin-2-yloxy)-phenyll-ethoxy }-pteridine. 6-{2-[4-(4 Trifluoromethylpyridin-2-yloxy)-phenyl]-ethoxy}-pyrimidine-4,5-diamine (75 mg, 0.19 mmol) was combined with 50% aqueous glyoxal solution (1 mL) in EtOH (5 mL) and stirred overnight at 25 0 C. The solution was evaporated and the residue extracted with CH 2 Cl 2 . The

CH

2 Cl 2 layer was washed with H 2 0 and concentrated in vacuo. The residue was recrystallized from hot MeCN to give 4-{2-[4-(4-trifluoromethyl-pyridin-2-yloxy)-phenyl] ethoxy}-pteridine (16 mg, 20%): mp 172-173 C; EIMS m/z 413; 'H NMR (300 MHz, WO 2011/025505 PCT/US2009/055522 68 CDCl 3 ) 6 9.24 (s, 1H), 9.07 (s, 1H), 9.02 (s, 1H), 8.30 (s, 1H), 7.43 (d, J= 9.5 Hz, 2H), 7.28(d, J= 9.0 Hz, 2H), 4.63 (t, 6.8 Hz, 2H), 3.17(t, J= 7.0 Hz, 2H). 0 I I HN N HN N (NN N N N N Example 23. {2-[4-(4-tert-Butylpyridin-2-yloxy)-phenyl -ethyl } -pteridin-4-ylamine. {2-[4 (4-tert-Butyl- 1 -oxypyridin-2-yloxy)-phenyl] -ethyl I -pteridin-4-ylamine (500 mg, 1.2 mmol) and triphenylphosphine (310 mg,1.2 mmol) were dissolved in dry THF (15 mL) and treated with rhenium bis-thiolate catalyst (5 mg; prepared according to Y. Wang and J.H. Espenson, Org. Lett., 2000, 2(22), 3525-26; expressly incorporated by reference herein). The mixture was stirred for 1.5 h, evaporated, and the residue purified by preparative RP-HPLC using 85% MeCN to give {2- [4-(4-tert-butylpyridin-2-yloxy)-phenyl] -ethyl I -pteridin-4-ylamine as a tan solid (155 mg, 32%): mp: 156-157 0 C; ESIMS m/z 400 ([M+H]*); . 1H NMR (300 MHz, CDCl 3 ) 6 9.02 (s, 1H), 8.82 (s, 1H), 8.62 (s, 1H), 8.08 (d, J = 5.9 Hz, 1H), 6.9-7.3 (m, 7H), 3.99(t, J= 7.0 Hz, 2H), 3.055 (t, 7.0 Hz, 2H). C OHO H 2 NNN HN HN Example 24. [2-(4-Methoxyphenyl)-ethyl] -(2,6,7-trimethylpteridin-4-yl)-amine. 1. 2,6,7-Trimethylpteridin-4(1H)-one: A mixture of 6-chloro-2-methylpyrimidine-4,5 diamine (3.2 g, 20 mmol) and 2,3-butanedione (3.6 g, 42 mmol) in n-butanol (40 mL) was stirred at 75-80 0 C for 1 h. After cooling, the reaction was diluted with Et 2 0 (50 mL) and the solid collected by suction filtration. This was dried in vacuo affording, 2,6,7 trimethylpteridin-4(1H)-one (3.9 g), as a gold powder which was used in the next step without further purification. 2. [2-(4-Methoxyphenyl)-ethyl] -(2,6,7-trimethylpteridin-4-yl)-amine. A mixture of 2,6,7 trimethylpteridin-4(1H)-one (1.1 g, 6.0 mmol), 4-methoxyphenethylamine (1.6 g, 11 mmol) and ammonium sulfate (0.56 g, 4.2 mmol) in hexamethyldisilazane (16 mL) was heated at 115 0 C for 6 h. After cooling, the majority of solids were dissolved by addition of CH 2 Cl 2 and H 2 0 and the solvents removed in vacuo. The residue was slurried in a mixture of MeOH (5 mL) and H 2 0 (50 mL) and stirred for 45 min. The bronze solid was collected by suction WO 2011/025505 PCT/US2009/055522 69 filtration and dried in vacuo at 500 C. The residue was dissolved in MeOH/CH 2 Cl 2 and diluted with Et 2 0, causing crystallization. All solvent was allowed to evaporate, and the remaining solid dried in vacuo to afford [2-(4-methoxyphenyl)-ethyl]-(2,6,7 trimethylpteridin-4-yl)-amine as a brown powder (1.3 g; 67%): 'H NMR (300 MHz, CDCl 3 ) 6 7.22 - 7.14 (m, 2H), 6.95 (t, J= 6.3 Hz, 1H), 6.90 - 6.83 (m, 2H), 3.87 (dd, J= 13.5, 6.8 Hz, 2H), 3.80 (s, 3H), 2.97 (t, J= 7.2 Hz, 2H), 2.69 (s, 3H), 2.66 (s, 3H), 2.61 (s, 3H). TABLE 1. Examples of compounds of formula (I-A) and (I-B) including synthesis parameters.12 Electrophile or Other Amine or Other Preparative ID Structure Naectrutureor Reactant (Cmpd Name, (Example , Structure Structure or Number) example Number) Numbers) 00 HN N N) Preparation 1 F 6I HN O F 2N J 3 Alt. N N Knox, I. L.; Rogers, R. B U.S. Patent 4,775,762, 1988. 4 F 3 HN OF Cl N CF NN N 4 O H N H H N N N H2N 4 ~ 2 2 N N Albert, A.; Ohta, K. J. Chem. Soc. C 1971, 3727-3730. 0 N .- CF( <N 5 HFF N C1 3 N N 4 WO 2011/025505 PCT/US2009/055522 70 Electrophile or Other Preparative ID Structure NReacStrut ure or Reactant (Cmpd Name, example Name Strctur or Structure or Number) (xml Number) Numbers) HN CI N

CF

3 6 N N I _ N N N\J~ N F F N'N N N 4 HN C N 89 H N N. NN N N 4 let . ha .J HN 10N5 H N 9N 7 2 N N N Chem So.3 HN N) F HN 1 3N n 5 N N 7 methanol HN O cl 13 N CN" H N N 12~Chm Noc CC si x N N N 1HN 7 3ehao N N N 4 WO 2011/025505 PCT/US2009/055522 71 Electrophile or Other Preparative ID Structure NReactStrut ure or Reactant (Cmpd Name, (eampl Name Strctur or Structure or Number) (xml Number) Numbers) - 0" ckr 14 HN O - N I CN 3 N N N 4 15 N CI N HN N 16 3 N N 4 OHN N 17 N N 2 KN C~H 3 Albert, A.; Ohta, K. J. Chem. Soc. C 1971, 3727-3730. SHN NC 4 N N 4

CH

3 HN OH N N OH 1 N 0 N- Albert, A.; Ohta, K. J. Chem. Soc. C 1971, 3727-3730.

WO 2011/025505 PCT/US2009/055522 72 Electrophile or Other Preparative ID Structure NReacStrut ure or Reactant (Cmpd Name, example Name Strctur or Structure or Number) (xml Number) Numbers) HN S-N CH 3 CI 21 4 N N Leung-Toung, R. et al., Bioorg. Med. Chem. 2003, 11, 5529-5537. 4 HN O S-NC -' 22 N N N Leung-Toung, R. et al., Bioorg. Med. Chem. 2003, 11, 5529-5537. 4 23 HN N C N N N 4 H ON111 G>.. N CI 25r N 24 HN O N.NN N N 4 0 NFEF HN NF 27 Yadav L.s D. S.eNl F Preparation 2 4 26 H:N HC 4 CH N N' 4 HN S I- GA1X0 27 04.D .e l N N Yadav, L .S ta. Pest. Sci. 1989, 25, 219-225. 4 WO 2011/025505 PCT/US2009/055522 73 Electrophile or Other Amine or Other Preparative ID Structure Naectrutureor Reactant (Cmpd Name, (Example NaeStrueure or Structure or Number) example Number) Numbers) N C 28 N N N4 HN O N C4 29 N4 N N Mixan, C.E.; Pews, R.G. J. Org. Chem. 1977, 42, 1869-1871. 4 H N OCI' HN' -'a N- Nz:. 30 1N 0 0 4 N NJ Wang, X.-J. et al., Org. Lett. 2005, 7, 5593-5595. 4 0OyN HN O CI 31 N N C 2 CHO 4 N N 4 HN' ' F C C, N N-3 32 N 4 N N Smith, R. et al., WO 2006044775 A2, 2006. 4 33 HN Br CI r 4 N 0 N' N HN O IF C F'N 34 (N, F N Goodman, A. J. et al., Tetrahedron 1999, 55, 15067-15070. 4 N C N II"C N.G HN CI 35 HN)' N"N-C 3 N N5_ _ 4_ _ WO 2011/025505 PCT/US2009/055522 74 Electrophile or Other Preparative ID Structure NReactStrut ure or Reactant (Cmpd Name, (eampl Name Strctur or Structure or Number) (xml Number) Numbers) F I HN N 36 N 3 N N 4 0,CH N '-N 0 HN OH NOH NN N HN 37 ( 2 N N Albert, A.; Ohta, K. J. Chem. Soc. C 1971, 3727-3730. OH N HOH HN N'I. ~H, HGC, N N" N N 38 H2 N Taylor, E. C.; LaMattina J. L. J. Org. Chem. 1977, 42, 1523-1527. HN N 39 (NCH, N N N 4 40 HN -N N N 4 0 N CF 3 SH3CN F F 41 F N N ' 38 42 HN O CF4 N N N N 4 43 HN N 4 CN:N N NY 4 WO 2011/025505 PCT/US2009/055522 75 Electrophile or Other Preparative ID Structure Reactant (Cmpd Reactant (Cmpd Name, Mehd Name, Structure or r n (Example Number) Numbers) F C F HN'-a N N 44 N CI N N N Preparation 4 4 HN CN H2 45 'N 2 N N Albert, A.; Ohta, K. J. Chem. Soc. C 1971, 3727-3730. 46 N F CI N N 2 N- 20 F 47 HN O CI CN N N N 20 HN Br N 48 HN c 3 (N N N 4 49 HN H N- F 3 5 N CN N NN 37 CH3 C F 51 H 50 HN N-, N C (NN N- N) 37 0'CH3 F CF, I0- FF 51 HN' N N-C N 3 ~N, N- N) 37 WO 2011/025505 PCT/US2009/055522 76 Electrophile or Other Preparative ID Structure Naectrutureor Reactant (Cmpd Name, (eample NaeStrueure or Structure or Number) example Number) Numbers) 0 N C HN N N N 38 HN F F CF 53 H3C N N N 38 10 N F y CF 54 FF 3 N F 3 N N 4 FCF 5 H F N-0 57 HN CI N 3 HGC N -N 8 N38 FFF F CI,,: : CF 3 56 HN N N 4 4 0'CH3 NC -0 rCNI 57 HN NN-3 r, NY37 58 HNJ2' , 4 59 HN NH N N_ _ _ 4 _ WO 2011/025505 PCT/US2009/055522 77 Electrophile or Other Preparative ID Structure NReacStrut ure or Reactant (Cmpd Name, example Name Strctur or Structure or Number) (xml Number) Numbers) F F CF 60 H-a0N 4 N C N NI'O 4 H NC

H

3 H 2NO I

H

2 NN 62 N*HCl NN Albert, A.; Ohta, K. J. Chem. Soc. C 1971, 3727-3730. Preparation 5 HNCH N3 N N N5 Preparation 6 4 F 0 HN"O C 64 NNN 4 N Wang, X.-J. et al., Org. N N Lett. 2005, 7, 5593-5595. 4 H1N 3H 2 N72-33Preparation 7 65 N N . OHH and Example HN N 66 NCH, / 4 6 (N N 41 N N N 67No NJF I CF 6 WO 2011/025505 PCT/US2009/055522 78 Electrophile or Other Preparative ID Structure NReacStrut ure or Reactant (Cmpd Name, example Name Strctur or Structure or Number) (xml Number) Numbers) CH 3 F F 7 CI YN. CF 3 68 N C O C 3 N N) 65 FF CI CF, SF Ny-) 69 HN ON CI CF 4 C-:)t- 4 N 9N HN 0 CI C N 20 HN F CF3 71 F F Scovell, E. G.; N N) Watson, D. J. EP 63872 Al, 1982. 20 FF F F F- F HN F CF3 72 N4 'N SCOVell, E. G.; N N Watson, D. J. EP 63872 A1, 1982. 4 OH,-N CI NN H2 H HN 2 '7 CI.1 NN N N N 2 N N Cragoe, E. J., Jr.; Holden, J. H. U.S. Patent 3,299,063, 1967. 74 HN OAN N F 4 N N 20 0 N N CF 2 H N N~ 75 CI ,N HN CI N3 N F FF N N 73 WO 2011/025505 PCT/US2009/055522 79 Electrophile or Other Preparative ID Structure Reactant (Cmpd Reactant (Cmpd Name, Mehd Name, Structure N a uure Remie(Example Number) Numbers) 0 N CF HN 76 HC N F F F N 3 NFF Knox, I. L.; Rogers, N N R. B. U.S. Patent 4,775,762, 1988. 38 HO N CF, 77 NN NF F F N N 20

OH

3 H S C I N 78 N 3 N N Brimm, E. O. et al., J. Chem. Soc. 1954, 3832-3839.

CH

3 F CF 3 H 79FSF Br 79 ' N N 3 Brimm, E. O. et al., J. Chem. Soc. 1954, 3832-3839. (N_: I H N N" H 2 % _ ''I r H 80 NNOH 2 N N Albert, A.; Ohta, K. J. Chem. Soc. C 1971, 3727-3730. Preparation 8 H N O H2HN N 81 N 2 Ny OH Albert, A.; Ohta, K. J. N N Chem. Soc. C 1971, 3727-3730. Preparation 8 FF CF H N 82 N N N F Knox, I. L.; Rogers, R. B. U.S. Patent 4,775,762, 1988. 65 WO 2011/025505 PCT/US2009/055522 80 Electrophile or Other Preparative ID Structure NReacStrut ure or Reactant (Cmpd Name, example Name Strctur or Structure or Number) (xml Number) Numbers) N'-"" 0CF 83 N N N F N 3 F, Knox, I. L.; Rogers, F R. B. U.S. Patent 4,775,762, 1988. 80 84 N CF, 3 H N OCI CN N N O 85N N N( HCF 86 F N F Knox, I. L.; Rogers, F F R. B. U.S. Patent 4,775,762, 1988. 81 87 N CF0 F F -i HN CI CN N N 88 N N - 3 N 81 N FKWegr, F.. J.grs NF F U.. atent9 3 4,7,,19. 41 HN O F I 90 N N N FuS PA 4,910,351, 4,90,1. 4 F UF HN . F I( I 90 ~NJN N 3 N ~ ' NNug A US.Ptn 4,590SPte ,29,3 98., WO 2011/025505 PCT/US2009/055522 81 Electrophile or Other Preparative ID Structure Reactant (Cmpd Reactant (Cmpd Name, Mehd Name, Structure or r (Example Number) Numbers) FF _1 F 91 HN 8 N ~~ 0,C0H, N N) 90 2-methoxyethanol -0 N 11 C N HN CI CI 92 N F F3 N N JP 58206563 A, 1983. 4 93 HN' O F F Cl FHN O FNF [ NN-II 93 HN 4 N N NY 177 F 0 F F 94 HN F,,a FjF 3 C:_ NF F N 1N 4 N NN 36 methanol F 96 H N 9V~ NN36 2,2,2-trifluoroethanol 0' CH3 F CF, 0N N Y1 N- CI N 97 HNN N N) 37 CH, F 98 HN GIP N~ N4 N NY 4 WO 2011/025505 PCT/US2009/055522 82 Electrophile or Other Preparative ID Structure NReacStrut ure or Reactant (Cmpd Name, example Name Strctur or Structure or Number) (xml Number) Numbers) F F 0 , CH 3 Cl 99 HN " N Na 4 N NY 4 0 F 100 HN FC CHO 4 F H H F ClF H N N.~ 101 N N N Cartwright, D. Brit. GB Pat. Apple. 2002368 4 0 C' C CHO 102 N N N Bayer A.-G. DE 4429465 A1, 1994. 4 F CF Fy Iy0 FF HN O CICN 103 HN C N 3 N N220 HN O N,.F 104 3 N N 220 F 0 CF3 HN F N 105 N: F 3 NN 220 F F 0 N F 106 HN 'N F ~NN N N 4 WO 2011/025505 PCT/US2009/055522 83 Electrophile or Other Preparative ID Structure Naectrutureor Reactant (Cmpd Name, (Example NaeStrueure or Structure or Number) example Number) Numbers) 107 HN O F- F 3 N N 4 108 HN O F F 3 N N N N 4 4 NH F CF 108 HN O F F 4 1 4 110 HN O N BCF 3 N N4 F , 110 3 N NY 4 F F F F3 N N4 FFF 112 H N F 0 i F F3 F F

C

3 114 HN )'l o F F N3 N N) 224_____ WO 2011/025505 PCT/US2009/055522 84 Electrophile or Other Amine or Other Preparative ID Structure Naectrutureor Reactant (Cmpd Name, (eample NaeStrueure or Structure or Number) example Number) Numbers) F CI~r CF, 11 F 115 HN O CF, 4 (N F F N NH 4 N CH NN 116 2 N N Taylor, E. C.; LaMattina, J. L. J. Org. Chem. 1977, 42, 1523-1527. F F F I -", II, HN F F CF3 117 CIN)N 3 N NY Scovell, E. G.; Watson, N N D. J. EP 63872 Al, 1982. 73 0 N F F HN F F 118 C3 F C 3 N N 73 N C 119 HN N N 3 CI N: C N73 120 HN "' O CI CI C 3 H3C F N N N _N_ N N 382 F N. N 121 HN F 10 (N 6-fluoropyridine-3 N Y222 boronic acid 'NF 122 HN N FF10 N N3-trifluoromethyl N N 222 benzene boronic acid WO 2011/025505 PCT/US2009/055522 85 Electrophile or Other Preparative ID Structure Reactant (Cmpd Reactant (Cmpd Name, Mehd Name, Structure or r n (Example Number) Numbers) - 0 HNN HN 'NB r f N) 123 H F B F 4 N N Preparation 4 4 0fN

CF

3 HNF F 124 CI N( F 3 F N N) 73 125 HN10 (NN N NY 222 benzene boronic acid 0.. ... N HN N - F N N N'H 2 126 N HF H N O C 2 N jAlbert, A.; Ohta, K. J. N N- Chem. Soc. C 1971, 3727-3730. Preparation 9 HN NCN 127 N N N) Wright, T. L. US4540786 A, 1985. 4 H O FF F CI 128 HN N N 4 129 HN F C1 4 N F F N 224 H3C,0 F F n CF 130 HN N. N6 F F N 3 N N 37 WO 2011/025505 PCT/US2009/055522 86 Electrophile or Other Preparative ID Structure Reactant (Cmpd Reactant (Cmpd Name, Mehd Name, Structure or r n (Example Number) Numbers) N 0 'CH OH HN OMe H N N' 'N 131 H C N N N N H3C N N Preparation 10 0 0 HN CH O 132 CH Si- H, 133 HN 12 N N NY C4 I C kH 134 O- N CH 3 13 (NX~ N NY 133 HN 1a 135 N15 N 0 0 N N 36 methanol r- 0 N ~ (N ~N HN CH, N H2N O CH 136 2 N N Albert, A.; Ohta, K. J. Chem. Soc. C 1971, 3727-3730. CO 2 Et 137 N HN N N 4 F F O F

-

r N F 138 HN O N-F 16 F N N 4 WO 2011/025505 PCT/US2009/055522 87 Electrophile or Other Preparative ID Structure Reactant (Cmpd Reactant (Cmpd Name, Mehd Name, Structure or r n (Example Number) Numbers) 0 CH, 139 O N Example 11 N CHN 4-ethylphenylboronic N N acid 217 HNO HO 140 0 0 17 N N CH, C CF3 HN 141 HNF 174 4 N: NF 1 N H O N 1C N I 142 F 174 4 CN NY

H

3 F F, 143 HN F'& 0N6CF 3 174 4 N NN CHN

F

3 HC ,. 01 144 HN M L 4 NE79 210 175 CH, F F HC . 0- -- F 145 HN' No, NN 175 O N 146 NHN CI NIN CH3 N N Mills, L.; Previdoli, F. EP370391 A2, 1990. 4 WO 2011/025505 PCT/US2009/055522 88 Electrophile or Other Preparative ID Structure NReacStrut ure or Reactant (Cmpd Name, example Name Strctur or Structure or Number) (xml Number) Numbers) N 11C N HC-0 C 147 HN H 175 1H 3 F F CF

H

3 G 0 'fCF 3 NN- F 148 HN' 4 N 175

CH

3 F F F

H

3 G F 0 N HN F F CF 3 149 N 9 I 4 Scovell, E. G.; N N Watson, D. J. EP 63872 Al, 1982. 175 F N' 150 HN O FF4 44 N N) 4

GH

3 N HN O CHO 151 N H H 2 N2 NIN) Albert, A.; Ohta, K. J. Chem. Soc. C As in 1971, 3727-3730. Preparation 8, Step 2

GH

3 F CF, 0~ F 152 HN C N 3 CH N 229 CHa CF ZO F "( -- N. F 153 HN C N 3 N 219 154

NHHCO

2 -t-But 154 N4 4 N N) 4 WO 2011/025505 PCT/US2009/055522 89 Electrophile or Other Preparative ID Structure NReacStrut ure or Reactant (Cmpd Name, example Name Strctur or Structure or Number) (xml Number) Numbers) 155 HN O /C 4 N N 174 CH 3CF 156 HN 3 FF N N CH 3 F NY 229 H C O CF 3 FCF 15NN, F F N ~NN N NF 220 CI HN O'CH N Me 158 N HI H 2 Albert, A.; Ohta, K. J. N N Chem. Soc. C 1971, 3727-3730. HN'- F '- 1r F 159 'N O N F 4 N N) 80 N HN r 0 N F 1 13 ) N N F F 80 OH 161 H3 N 18 HOC N 131 0 N CF3 HN O 162HCN N F F F N 162 FNFNF Knox, I. L.; Rogers, HC N N) R. B. U.S. Patent 4,775,762, 1988 161 WO 2011/025505 PCT/US2009/055522 90 Electrophile or Other Preparative ID Structure NReactStrut ure or Reactant (Cmpd Name, (eampl Name Strctur or Structure or Number) (xml Number) Numbers) 0 N F CF, I I N 163H CN H Aj)-' F F I HN F_ F F3 H3C N N 161 CI CO i-Pr 0I N HN C OyCH3 l 164 N 0 CH 3 N N 4 CORt-Bu OHN ON CH 165 NHO CH 3 N N 4

GH

3 I F F 'NF HN FF CF3 166 N N SCOVell, E. G.: N N Watson, D. J. EP 63872 Al, 1982. 174 CH, 4F3 0~ 167 HN C Me3 F F Preparation 11 174 FF F C OMe 168 N H N:) 0 0N O CH N N C Preparation 11 80 CH, F H N0 N 169 (N Hii 3 N F F N N P7 Preparation 4 174 WO 2011/025505 PCT/US2009/055522 91 Electrophile or Other Preparative ID Structure NReacStrut ure or Reactant (Cmpd Name, example Name Strctur or Structure or Number) (xml Number) Numbers) O, CH F F F HN H CHi HN CI x I _ 170 HN CZ 3 N N Preparation 4 37 F F 4 F3 0 F HN O C OMe 171 N HC 0 3 N N) Preparation 11 4 0 -r 0 N HN O 172 N0 3 FN N CH3 Preparation 12 4 HNH N CH 173 N C O 15 N 36 2-propanol OH 174 HN 18 r4'NN 221 H,

H

3 G OH 175 HN 18 N' N 228 F .- N F HNO'HN N N 176 N I HN 2 N N Albert, A.; Ohta, K. J. Chem. Soc. C As in Preparation 9, 1971, 3727-3730. Step 5 WO 2011/025505 PCT/US2009/055522 92 Electrophile or Other Preparative ID Structure NReacStrut ure or Reactant (Cmpd Name, example Name Strctur or Structure or Number) (xml Number) Numbers) F OH 177 HN O 18 N' N 176 O CH, F F HN F FOMe 178 HN 3 C, N N 179 N CH3HCO Preparation 11 37 OH F N8 H F HN H CH2Me 179 NX CN N H,3 N N Preparation 11 229 oXCH 3 F -N"F F 180 FN-, 0 19 HN O N CI 183 N 4p2 N 4 N- N- Albert, A.; Ohta, K. J. Chem. Soc. C 1971, 3727-3730. N0 N 18 HN

.

4 82 N ~ H 3 0!"" 00 N " N 4 __ _ __ __ _ WO 2011/025505 PCT/US2009/055522 93 Electrophile or Other Preparative ID Structure NReacStrut ure or Reactant (Cmpd Name, example Name Strctur or Structure or Number) (xml Number) Numbers) F F HN CH, Cl F HN' a I, F 184 (N N 0 4 N N Preparation 14 4 HN N O' H NI C ~Me 185 ( N F 4 N N) Preparation 11 177 0'CH3 186 HN C| CY 181 C F F F 187 HN CN 3 1N-Nb 230 H CHN N F O CH- F 188 HN & F 19 N eN 1-bromopropane 218 O- CH3 F F F

-

CH3 191 HN C, C 189 NC 4 N N Preparation 4 219 0 )CH~ F N- 'I F 190 HN F 20 (N N Nj acetic anhydride 218 F F ( N ~ - H HC NYN 184 WO 2011/025505 PCT/US2009/055522 94 Electrophile or Other Preparative ID Structure Reactant (Cmpd Reactant (Cmpd Name, Mehd Name, Structure or r n (Example Number) Numbers) 01N 0 0 HN HC O >r 192 N H3 C O' N CI 192N CI N N from tert-butanol, as in Preparation 13 4 F F 193~ ~ ~~ NJ~ F?. ~ GN H N 193 N N F CH,C Preparation 4 177 CH, F F F 194 (N HN , O CH F NI N N Preparation 15 229 Ha 0 "C3F F 195 HN 19 197 N 197 O F F 197 HN N 18 7170 HN CH, 198 H NFF CI N OMe Pre N t 11 16 ___ ________________Preparation 11 161 _ ____ WO 2011/025505 PCT/US2009/055522 95 Electrophile or Other Preparative ID Structure NReacStrut ure or Reactant (Cmpd Name, example Name Strctur or Structure or Number) (xml Number) Numbers) - - F O CH 199 HN No CH 19 N NN 1 -bromopropane 197 200 HN F N 3 H3C N T H3C Nr N 161 CH F CF HN N 201 4 N O 0N N Knox, I. L.; Rogers, N N R. B. U.S. Patent 4,775,762, 1988 225 F C F F - _ F O 0CH 3 202 HN 'C N CH3 CI O 4 N HN 4 O N 0,C 203 HN F N 4 H3C

CH

3 N N4 20 N 4HFI O CHG O N 205 HN F 4 HC CH. 219 0 N 206 N N F F 22 N J Knox, I. L.; Rogers, NN R. B. U.S. Patent 4,775,762, 1988 WO 2011/025505 PCT/US2009/055522 96 Electrophile or Other Amine or Other Preparative ID Structure Naectrutureor Reactant (Cmpd Name, (eample NaeStrueure or Structure or Number) example Number) Numbers) HN1 207 H 23 (N N 17 N H 3C CH. SN N) 172 HN CHI3 O 208 HC N N H 2 N 24 HC N NOCH 3 OH HN N 209 HC N 18 HC N N CH, 208 HN O-CH, Me N N2 210 N N N' Albert, A.; Ohta, K. J. Chem. Soc. C 1971, 3727-3730. Br OH 211 H N 18 (N)N N NY 210 Br F CF3 HN O F 212 N) 3 N Knox, I. L.; Rogers, N N R. B. U.S. Patent 4,775,762, 1988 211

CH

3 No'IF F 213 HN F 15 N N5 212 methanol HN F F CF, 214 H3CN N F H3C N N CH 3 209 WO 2011/025505 PCT/US2009/055522 97 Electrophile or Other Amine or Other Preparative ID Structure Reactant (Cmpd Reactant (Cmpd Name, Mehd Name, Structure N a ur or e a (Example Number) Numbers) O N CF I I 215 HCIN F N F F F Knox, I. L.; Rogers, HC N N CH, R. B. U.S. Patent 4,775,762, 1988 209 F 216 H N O~ F FTF 4

CH

3 21H OH A A N N 34 OH F O~ F 218 H N 18 N N 51 ON OH 1N NO

-

" HNC 219 HN OH N N Albert, A.; Ohta, K. J. H 2 N2 Chem. Soc. C 1971, 3727-3730. F OH 220 N H62 18 NN N N 221 H2 221-'Albert, A.; Ohta, K. J. H 2 N 2 Chem. Soc. C As in Preparation 9, 1971, 3727-3730. Step 5 WO 2011/025505 PCT/US2009/055522 98 Electrophile or Other Amine or Other Preparative ID Structure Reactant (Cmpd Reactant (Cmpd Name, Mehd Name, Structure or a (Example Number) Numbers) Br N HN N N N" Br 222 N N H 2 N 2 N N Albert, A.; Ohta, K. J. Chem. Soc. C 1971, 3727-3730. HN ON NH NO 223 N2 N N Albert, A.; Ohta, K. J. Chem. Soc. C As in Preparation 8, 1971, 3727-3730. Step 2 H3C OH 224 N HN 223 18 NN N N N CH H2N O 225 OH -HCI OH 2 N N Albert, A.; Ohta, K. J. Chem. Soc. C 1971, 3727-3730. Preparation 16 0 N 226 HN N: N' 209 F F F F 0 N 227 HN H N ON 43 FF N N-HCI NYN ,NN HN :1 N NONI 228 N H 2 N 2 N N Albert, A.; Ohta, K. J. Chem. Soc. C As in Preparation 8, 1971, 3727-3730. Step 2 WO 2011/025505 PCT/US2009/055522 99 Electrophile or Other Amine or Other Preparative ID Structure Naectrutureor Reactant (Cmpd Name, (Example , Structure Structure or Number) example Number) Numbers) OH 229 HN 151 18 N_ N N N CI OH 230 HN 158 18 (N NY 4 (by product from HN S preparation N " _of NIN 1Compound 231 59) F HN HN HN N2, ,C N N Dreikorn, B. A. et al., 232 WO 9404527 Al, 1994. 1 Footnotes to Table 1. 'All literature references to compounds used in the Preparations and Examples listed in Table 1 are expressly incorporated by reference herein. 2 All compounds used for chemical synthesis which are depicted in Table 1 and are listed with no specified literature reference or Preparation were purchased from commercial sources. 3 The synthesis of compound 227 began with transformation of (4-methoxy-3-trifluoromethylphenyl) methanol to 2-(4-methoxy-3-trifluoromethyl-phenyl)-ethylamine hydrochloride, in the same manner as described in Preparation 9, Steps 4 and 5. 2-(4-Methoxy-3-trifluoromethyl-phenyl)-ethylamine hydrochloride then was sequentially elaborated by the similar chemical transformations as in Examples 2, 18 and 4 (the other reactant was 2-chloro-4-trifluoromethylpyridine) to provide Compound 227. BIOLOGICAL TESTING WO 2011/025505 PCT/US2009/055522 100 The following Table 2 shows characterizing mass spectrometry and biological activity of representative compounds of formula (I-A) and (I-B). TABLE 2: Examples of compounds of formula (I-A) and (I-B) including mass spectrometry data and biological activity against representative fungal diseases and insects. >80% mortality ID MS COCHSA COLLLA LEPTNO PSPECU PUCCRT PYRIOR on any [M + H]+ insect species @ 4000 ppm 1 358 ** 2 413 ** + 3 414 * ** ** *** *** 4 268 * * * * * ** 5 413 * *** *** *** *** *** + 6 413 * * *** *** *** *** + 7 363 * * * *** *** *** + 8 370 * *** * *** *** *** + 9 252 * * * *** *** 10 375 * * ** *** *** *** + 11 443 * * ** ** *** *** + 12 389 * * *** *** *** *** + 13 370 * * * *** *** *** + 14 370 * * * *** *** ** + 15 346 * * * *** *** *** + 16 376 * * * *** *** 17 282 * ** ** *** *** 18 371 * * * *** *** 19 296 * * * * * 20 268 * * * * * ** 21 382 * ** ** ** *** 22 428 * ** ** ** *** 23 429 * * * * *** ** 24 380 * ** * *** *** 25 444 * * *** *** *** *** + 26 408 * * * *** *** 27 458 * * * * *** 28 346 * * * *** *** *** + 29 362 * * * *** ** ** 30 413 * * *** ** *** *** + 31 385 NT NT *a NT **b ***b NT 32 470 NT NT *a NT **b **b NT 33 430 * * ** * *** ** 34 414 * * ** *** *** *** + 35 404 * * * *** *** WO 2011/025505 PCT/US2009/055522 101 >80% mortality ID MS COCHSA COLLLA LEPTNO PSPECU PUCCRT PYRIOR on any [M + H]+ insect species @ 4000 ppm 36 471 ** ** ** + 37 * * * * *** ** 38 282 * * * * * ** 39 359 * * *** *** *** *** + 40 359 * ** *** *** *** *** + 41 427 * ** *** *** *** *** + 42 359 * *** *** *** *** *** + 43 359 * * *** *** *** *** + 44 409 * ** *** *** *** *** + 45 282 NT NT *a NT **b ***b NT 46 413 * *** *** *** *** 47 413 * ** *** *** *** 48 351 * * * *** *** *** + 49 443 ** ** ** *** *** *** + 50 400 * * * *** + 51 443 * ** ** *** *** *** + 52 384 * * *** *** *** *** + 53 445 * *** *** *** *** *** + 54 431 * *** *** *** *** *** + 55 428 * ** *** *** *** *** + 56 447 * * ** ** *** * 57 -- 2 58 427 * * ** ** *** *** + 59 366 * * * * ** + 60 413 * ** *** *** *** *** + 61 403 * * ** *** *** 62 -- 3* * ** *** *** 63 416 * * * *** *** 64 413 * * * *** *** 65 268 * * ** ** ** * 66 365 ** *** ** *** *** *** + 67 413 * * *** *** *** *** + 68 414 * * * *** *** *** + 69 427 * *** ** *** *** 70 404 NT NT *a NT **b **b 71 449 * * ** * *** 72 449 * ** ** *** *** 73 302 * * * * *** ** 74 471 * * ** *** *** 75 448 * * ** * *** *** + 76 427 * * ** *** *** *** + 77 413 * * *** *** *** 78 294 * * ** * ** * 79 337 * * * * ** * + WO 2011/025505 PCT/US2009/055522 102 >80% mortality ID MS COCHSA COLLLA LEPTNO PSPECU PUCCRT PYRIOR on any [M + H]+ insect species @ 4000 ppm 80 284 * * * * * * 81 284 * * * *** * * 82 413 * * ** *** *** *** + 83 429 * *** *** *** *** 84 429 * *** *** *** *** *** + 85 386 * * * *** *** 86 429 * * * *** *** 87 429 * * ** *** *** 88 386 * * ** *** *** ** 89 467 * * ** *** *** 90 447 * * *** *** *** *** + 91 487 * * ** *** *** *** + 92 447 * * ** *** *** *** + 93 431 ** + 94 417 * ** ** ** *** 95 375 * *** *** *** *** *** + 96 443 * * *** *** *** *** + 97 444 * * ** *** *** *** + 98 393 NT NT *a NT **b **b NT 99 377 NT NT **a NT b b NT 100 440 * * ** *** *** 101 395 * *** *** *** *** *** + 102 407 * * * *** *** 103 431 * * *** *** *** *** + 104 389 * * *** *** *** *** + 105 431 NT NT ***a NT ***b ***b NT 106 449 * * ** *** *** *** + 107 381 * * ** *** *** *** + 108 381 * * ** *** *** *** + 109 427 * ** ** *** *** *** + 110 423 * * *** *** *** *** + 111 413 * ** *** *** *** *** + 112 484 * * *** *** *** *** + 113 430 * * *** *** *** *** + 114 449 * * *** *** *** *** + 115 481 * * * *** *** 116 308 NT NT *a NT *b **b + 117 483 NT NT **a NT **b ***b + 118 465 * * ** * *** ** + 119 439 * * ** * ** ** 120 418 * * ** * ** + 121 347 * * *** *** *** *** NT 122 396 * * ** ** *** *** + 123 409 NT NT NT NT NT NT NT WO 2011/025505 PCT/US2009/055522 103 >80% mortality ID MS COCHSA COLLLA LEPTNO PSPECU PUCCRT PYRIOR on any [M + H]+ insect species @ 4000 ppm 124 447 * * *** *** *** ** NT 125 328 * ** *** *** *** *** + 126 413 * *** *** *** *** *** + 127 420 * * ** ** *** 128 453 * * ** *** *** *** + 129 427 ** ** *** *** *** *** + 130 461 * * ** *** *** *** + 131 310 * * * *** *** *** + 132 386 * * ** *** *** * + 133 382 * * * *** *** * 134 482 * * * * *** * 135 403 * * ** *** *** ** 136 358 * ** ** *** *** *** + 137 417 * * ** * *** *** + 138 467 * *** ** *** *** *** + 139 472 * * * * *** * 140 478 * ** * *** *** *** + 141 427 * ** *** *** *** *** + 142 418 * * ** *** *** *** + 143 445 * * *** *** *** *** + 144 441 * * *** *** *** *** + 145 441 * ** *** *** *** *** + 146 408 * ** ** *** *** *** + 147 432 * * ** *** *** 148 459 * * ** *** *** *** + 149 477 * * ** *** *** 150 399 * * *** *** *** *** + 151 310 * * * *** *** 152 441 * * *** *** *** *** + 153 457 * * *** *** *** *** + 154 444 NT NT ***a NT ***b ***b NT 155 384 * ** ** *** *** *** + 156 441 * * *** *** *** *** + 157 457 * * ** *** *** *** + 158 316 * * ** * *** 159 379 * * * *** *** 160 429 * * ** *** *** 161 296 * * * * ** ** 162 441 * * *** *** *** *** + 163 459 * *** *** *** *** *** + 164 465 * * ** * *** *** + 165 445 * * *** *** *** *** + 166 463 * ** *** *** *** *** + 167 457 * * ** *** *** WO 2011/025505 PCT/US2009/055522 104 >80% mortality ID MS COCHSA COLLLA LEPTNO PSPECU PUCCRT PYRIOR on any [M + H]+ insect species @ 4000 ppm 168 459 * * ** * *** 169 423 * ** *** *** *** *** + 170 439 * * ** *** *** *** + 171 443 * * ** *** *** 172 417 * * * *** *** 173 431 * * * *** *** 174 282 * * ** * ** 175 296 * * * * *** 176 300 * * * * *** 177 286 * * * * * ** 178 473 * * ** * *** 179 -- 4* * * * * * 180 -- * ** ** *** *** 181 328 * * * * ** 182 459 * * * *** *** * 183 417 * * ** *** *** 184 425 * ** ** *** *** 185 461 * * ** *** *** 186 473 * * ** *** *** 187 -- * *** *** *** *** *** + 188 -- 7* *** * *** *** *** + 189 451 * ** ** *** *** 190 471 * * * * + 191 439 * ** ** *** *** 192 445 * *** ** *** *** *** + 193 427 * * ** *** *** 194 437 * *** ** *** *** *** + 195 467 * ** * *** *** 196 467 * * * *** *** ** 197 425 * * * *** *** 198 471 * * ** * *** *** + 199 467 * * ** *** *** *** + 200 441 * * ** * *** *** + 201 443 * * ** *** *** 202 471 * * *** *** *** *** + 203 387 * ** ** *** *** *** + 204 417 * * * *** *** ** + 205 431 * * ** *** *** ** 206 414 NT NT *a NT *b NT NT 207 401 * * * *** *** 208 324 * * * ** *** 209 310 * * ** * ** * 210 362 * * * *** *** 211 348 * * * * ** ** WO 2011/025505 PCT/US2009/055522 105 >80% mortality ID MS COCHSA COLLLA LEPTNO PSPECU PUCCRT PYRIOR on any [M + H]+insect species @ 4000 ppm 212 493 ** ** + 213 471 * * * *** *** *** + 214 473 * * *** * ** ** + 215 455 * * ** *** *** *** + 216 430 * * *** *** *** *** + 217 368 ** * NT ** * * 218 - NT NT NT NT NT NT NT 219 312 NT NT NT NT NT NT NT 220 286 NT NT NT NT NT NT NT 221 -- NT NT NT NT NT NT NT 222 -- NT NT NT NT NT NT NT 223 -- NT NT NT NT NT NT NT 224 -- NT NT NT NT NT NT NT 225 -- NT NT NT NT NT NT NT 226 -- 9 NT NT *a NT *b *b + 227 481 NT NT *** a NT *** b NT NT 228 -- NT NT NT NT NT NT NT 229 297 NT NT NT NT NT NT NT 230 303 NT NT NT NT NT NT NT 231 338 * * *** * *** ** + 232 352 * ** * *** *** *** + *= 0-49 percent control; ** = 50-79 percent control; = 80-100 percent control += 80% active on at least one insect species - = Not 80% active on insect species tested a indicates that compound was tested at 75 ppm b indicates that compound was tested at 8.3 ppm NT indicates not tested Additional footnotes to Table 2. For compounds 37, 57, 62, 179, 180, 187, 188, 218, and 226, the following descriptive data are presented. 1Compound 37: mp 131-132 C; 1H NMR (300 MHz, DMSO-d 6 ) 6 9.06 (d, J = 2.0 Hz, 1H), 8.88 (d, J = 5.9 Hz, 1H), 8.80 (d, J = 1.9 Hz, 1H), 8.71 (s, 1H), 8.62 (s, 1H), 7.31 (s, OH), 6.79 (d, J = 1.6 Hz, 1H), 3.75 (dd, J = 14.6, 6.4 Hz, 2H), 3.70 (s, 3H), 2.91 - 2.80 (m, 2H). 2 Compound 57: mp 215 'C; 1H NMR (300 MHz) 6 9.03 (d, J = 1.9 Hz, 1H), 8.84 (s, 1H), 8.63 (d, J= 1.9 Hz, 1H), 8.29 (dd, J= 5.0, 0.9 Hz, 1H), 7.17 (dd, J= 6.0, 1.0 Hz, 2H), 7.13 - WO 2011/025505 PCT/US2009/055522 106 7.06 (m, 1H), 6.92 (dt, J= 4.0, 2.0 Hz, 3H), 4.01 (dd, J= 13.3, 6.9 Hz, 3H), 3.08 (t, J= 7.1 Hz, 3H). 3 Compound 62: 'H NMR (300 MHz, CDC1 3 ) 6 9.02 (d, J = 2.0 Hz, 1H), 8.80 (s, 1H), 8.63 (d, J= 1.9 Hz, 1H), 7.24 (s, OH), 7.13 (t, J= 8.8 Hz, 1H), 6.63 (ddd, J= 8.5, 6.7, 2.6 Hz, 2H), 3.92 (dd, J= 13.1, 6.8 Hz, 2H), 3.79 (s, 3H), 3.03 (t, J= 6.9 Hz, 2H). 4 Compound 179: 'H NMR (300 MHz, CDCl 3 ) 6 9.04 (d, J = 2.0 Hz, 1H), 8.84 (s, 1H), 8.63 (d, J= 1.9 Hz, 1H), 7.10 (s, 1H), 6.91 (s, 1H), 6.63 (s, 1H), 6.40 (s, 1H), 3.94 (dd, J= 14.6, 6.3 Hz, 2H), 3.81 (s, 3H), 3.11 - 2.92 (m, 2H), 2.35 (s, 3H), 2.12 (s, 3H). 5 Compound 180: 'H NMR (300 MHz, CDC1 3 ) 6 9.04 (d, J = 2.0 Hz, 1H), 8.84 (s, 1H), 8.63 (d, J= 1.9 Hz, 1H), 7.10 (s, 1H), 6.91 (s, 1H), 6.63 (s, 1H), 6.40 (s, 1H), 3.94 (dd, J= 14.6, 6.3 Hz, 3H), 3.81 (s, 3H), 3.11 - 2.92 (m, 2H), 2.35 (s, 3H), 2.12 (s, 3H). 6 Compound 187: 1H NMR (300 MHz, DMSO) 6 9.17 (s, 1H), 9.10 (d, J= 1.9 Hz, 1H), 8.86 (d, J= 2.0 Hz, 1H), 8.67 (s, 1H), 8.36 (d, J= 5.1 Hz, 1H), 7.57 - 7.44 (m, 3H), 7.36 - 7.21 (m, 2H), 3.88 (dd, J = 13.4, 6.9 Hz, 2H), 3.05 (t, J = 7.2 Hz, 2H). 7 Compound 188: 'H NMR (300 MHz, CDC1 3 ) 6 9.02 (dd, J= 4.8, 1.9 Hz, 1H), 8.82 (d, J= 6.4 Hz, 1H), 8.61 (dd, J= 6.5, 1.9 Hz, 1H), 8.28 (d, J= 5.4 Hz, 1H), 8.28 (d, J= 5.4 Hz, 1H), 7.13 (dd, J= 12.9, 5.7 Hz, 4H), 6.99 - 6.82 (m, 2H), 4.07 - 3.91 (m, 2H), 3.84 (dd, J= 12.0, 5.7 Hz, 2H), 3.05 (dd, J= 11.8, 4.7 Hz, 2H), 1.52 (dd, J= 13.8, 6.4 Hz, 2H), 1.52 (dd, J= 13.8, 6.4 Hz, 2H), 0.68 (td, J= 7.4, 1.8 Hz, 3H). 8 Compound 218: 1H NMR (300 MHz,DMSO ) 6 9.21 (d, J = 2.2 Hz, 1H), 9.11 (d, J = 2.1 Hz, 1H), 9.03 (s, 1H), 8.35 (d, J = 5.2 Hz, 1H), 7.42 (d, J = 5.3 Hz, 1H), 7.33 (s, 1H), 7.02 (d, J= 8.1 Hz, 1H), 6.91 (d, J= 2.0 Hz, 1H), 6.75 (dd, J= 8.1, 2.0 Hz, 1H), 4.13 - 3.84 (m, 2H), 2.97 (t, J = 7.4 Hz, 2H). 9 Compound 226: 1H NMR (300 MHz, CDC1 3 ) 6 8.30 (dd, J = 4.7, 1.5 Hz, 1H), 7.99 (dd, J = 7.6, 1.8 Hz, 1H), 7.37 - 7.29 (m, 2H), 7.17 - 7.11 (m, 2H), 7.09 (dd, J = 7.5, 4.9 Hz, 1H), 7.01 (t, J = 5.9 Hz, 1H), 3.93 (dd, J = 13.4, 6.9 Hz, 2H), 3.05 (t, J = 7.1 Hz, 2H), 2.69 (s, 3H), 2.68 (s, 3H), 2.62 (s, 3H). FUNGICIDAL ACTIVITY The compounds of the present invention have been found to have significant fungicidal effect, particularly for agricultural use. Many of the compounds are particularly effective for use with agricultural crops and horticultural plants. In particular, the compounds WO 2011/025505 PCT/US2009/055522 107 effectively control a variety of undesirable fungi that infect useful plant crops. Activity has been demonstrated for a variety of fungi, including for example the following representative fungi species: Anthracnose of Cucumber (Collatotrichum lagenarium - COLLLA); Spot Blotch of Wheat (Cochiobolus sativus-COCHSA), Downy Mildew of Cucumber (Pseudoperonospora cubensis - PSPECU), Rice Blast (Magnaporthe grisea-PYRIOR), Brown Rust of Wheat (Puccinia recondita tritici - PUCCRT), and Glume Blotch of Wheat (Leptosphaeria nodorum - LEPTNO). It will be understood by those in the art that the efficacy of the compounds against the foregoing fungi establishes the general utility of the compounds as fungicides. The activity of the compounds as effective fungicides was determined by applying the compounds to plants and observing control of fungal disease. The compounds were formulated at 200 ppm in 10 vol.% acetone plus 90 vol.% Triton X water (deionized water 99.99 wt% + 0.01 wt% Triton X100), giving a "formulated test compound." In a few cases, compounds were formulated at 75 or 8.3 ppm rather than 200 ppm in 10 vol. % acetone plus 90 vol. % Triton X water (deionized water 99.99 wt. % + 0.01 wt. % Triton X100), giving a "formulated test compound." Formulated test compounds were applied to plants using a turn table sprayer fitted with two opposing air atomization nozzles which delivered approximately 1500 L/ha of spray volume. All plants were inoculated with spores of the fungus the day after treatment, then incubated in an environment conducive to disease development. Disease severity was evaluated 4 to 15 days later, depending on the disease and the speed of disease development. The following experiments were performed in the laboratory to determine the fungicidal efficacy of the compounds of the invention. Leaf Rust of Wheat (causal agent Puccinia recondita tritici = Puccinia triticina; Bayer code PUCCRT): Wheat plants (variety Yuma) were grown from seed in a soil-less peat-based potting mixture (Metromix) until the seedlings had a fully expanded first leaf. Each pot contained 3-8 seedlings. These plants were sprayed until wet with the formulated test compounds. On the following day, the leaves were inoculated with an aqueous spore suspension of Puccinia recondita tritici and the plants were kept in high humidity overnight WO 2011/025505 PCT/US2009/055522 108 to permit spores to germinate and infect the leaf. The plants were then transferred to a greenhouse until disease developed on untreated control plants. Cucumber Anthracnose (causal agent Colletotricum lagenarium; Bayer code COLLLA): Cucumber plants (variety Bush Champion) were grown from seed in a soil-less peat-based potting mixture (Metromix) until the first true leaf was 20-80% expanded. Each pot contained 1 seedling. These plants were sprayed until wet with the formulated test compound. On the following day, the leaves were inoculated with an aqueous spore suspension of Colletotricum lagenarium and the plants were kept in high humidity for one day to permit spores to germinate and infect the leaf. The plants were then transferred to a growth chamber until disease developed on untreated control plants. Cucumber Downy Mildew (causal agent Pseudoperonospora cubensis; Bayer code PSPECU): Cucumber plants (variety Bush Champion) were grown from seed in a soil-less peat-based potting mixture (Metromix) until the first true leaf was 20-80% expanded. Each pot contained 1 seedling. These plants were sprayed until wet with the formulated test compound. On the following day, the leaves were inoculated with an aqueous suspension of downy mildew sporangia and the plants were kept in high humidity for one day to permit sporangia to germinate and infect the leaf. The plants were then incubated in a growth chamber until disease developed on untreated control plants. Glume Blotch of Wheat (causal agent Leptosphaeria nodorum = Stagnospora nodorum; Bayer code LEPTNO): Wheat plants (variety Yuma) were grown from seed in a 50% pasteurized soil/50% soil-less mix until the seedlings had a fully expanded first leaf. Each pot contained 3-20 seedlings. These plants were sprayed until wet with the formulated test compound. On the following day, the leaves were inoculated with an aqueous spore suspension of Leptosphaeria nodorum and the plants were kept in high humidity (one day in a dark dew chamber followed by four days in a lighted dew chamber) to permit spores to germinate and infect the leaf. The plants were then transferred to a greenhouse until disease developed on untreated control plants. Rice Blast (causal agent Magnaporthe grisea = Pyricularia orvzae; Bayer code PYRIOR): Rice plants (variety M202) were grown from seed in a soil-less peat-based WO 2011/025505 PCT/US2009/055522 109 potting mixture (Metromix) until the seedlings had a partly to fully expanded second leaf. Each pot contained 5-20 seedlings. These plants were sprayed until wet with the formulated test compound. On the following day, the leaves were inoculated with an aqueous spore suspension of Pyricularia oryzae and the plants were kept in high humidity overnight to permit spores to germinate and infect the leaf. The plants were then transferred to a growth chamber until disease developed on untreated control plants. Table 2 presents the activity of typical compounds of the present invention when evaluated in these experiments. The effectiveness of the test compounds at controlling disease when sprayed on leaves was determined by assessing the severity of disease on treated plants, then converting the severity to percent control based on the level of disease on untreated, inoculated plants. Data are the level (in percent) at which the given disease was controlled when the given compound was applied to the foliage of the plants at 200 ppm. In a few cases (noted in the table) the compound was applied to the plants at 75 ppm or 8.3 ppm. INSECTICIDAL ACTIVITY The compounds of the present invention have been found to have insecticidal activity. Activity may be demonstrated for a variety of insects, including for example the following representative insect species: Beet Armyworm (Spodoptera exigua -LAPHEG) or Tobacco Budworm (Heliothus virescens- HELIVI); Mosquito (Aedes aegypti - AEDSAE), Fruit Fly (Drosophila melanogaster - DROSME). It will be understood by those skilled in the art that the efficacy of the compounds against the foregoing insects establishes the general utility of the compounds as insecticides. The activity of the compounds as effective insecticides was determined by applying the compounds to diet or water, placing insects in the water or on the diet, and observing mortality after an appropriate incubation time. The compounds were formulated at 4000 ppm or 400 ppm in dimethyl sulfoxide (DMSO) giving a "formulated test compound." Formulated test compounds were diluted in 96-well plates with acetone:water solutions and applied to species-specific diet or water. The plates were infested and evaluated as described below. Results were averaged over 2-6 replications.

WO 2011/025505 PCT/US2009/055522 110 DROSME: Formulated test compounds were applied to microtiter plates containing fruit fly agar (10% sugar-water) to give a dose of 80 pg test compound per well. Plates were infested by placing at least three flies in each well and sealing the plate. Mortality was evaluated after incubation for two days at room temperature. AEDSAE: Plates containing formulated test compounds at 6 pg per well were diluted with water containing mosquito larvae. Each well contained at least two larvae. Mortality was evaluated after incubation for three days at room temperature. LAPHEG or HELIVI: Formulated test compounds were applied to 96-well plates containing Lepidoptera diet at 12 pg per well (one-tenth the rate was used for HELIVI). Plates were infested by placing at least four fresh armyworm or budworm eggs in each well and sealing the plate with cotton batting and plastic. Mortality was evaluated after incubation for seven days at 28 0 C. Table 2 presents the activity of typical compounds of the present invention when evaluated in these experiments. The effectiveness of the test compounds at controlling insects was determined by assessing the mortality in treated test plates, then converting the average mortality to percent control. Each compound was tested on at least two species. If any of the species DROSME, AEDSAE, LAPHEG, or HELIVI was controlled at 80% or more, the compound was considered active (shown as "+" in Table 2). If no species was controlled at 80% or more, the compound was considered inactive (shown as "-" in Table 2). ANIMAL HEALTH ACTIVITY The compounds of the present invention have been found to have significant potential as anti-parasitics for animal health. Table 3, shown below, presents the activity of typical compounds of the present invention when evaluated in these experiments. Activity has been demonstrated by four out of five compounds screened against Caenorhabditis elegans, a free living nematode that is an indicator species for animal parasites. It will be understood by those in the art that the efficacy of four compounds against Caenorhabditis elegans, which at 10 pg/mL was equivalent to the commercial anti-parastitic product ivermectin, establishes the potential utility of these compounds to control parasites that attack animals.

WO 2011/025505 PCT/US2009/055522 111 The activity of the compounds against Caenorhabditis elegans was determined by dissolving compounds in DMSO, then applying them to petri dishes containing Nematode Growth Medium agar to a final concentration of 10 pg compound per milliliter agar. Escherichia coli bacteria were grown on the plates to provide a food source for the larvae of Caenorhabditis elegans. The bacteria were heat-killed at 65 0 C before compounds were added to the plates. The plates with compound and heat-killed bacteria were infested with 10 microliter drops containing eggs from wild-type Caenorhabditis elegans worms. Adult worms were dissolved in KOH and bleach and washed in Ringers solution to generate the egg suspension. Each compound was screened with approximately 400 eggs, divided between two petri dishes. Egg hatching was evaluated after 24 h at 20 0 C. Mortality was averaged over the two plates. TABLE 3: Activity of compounds of the formula (I-A) against Caenorhabditis elegans. Application rate is 10 micrograms per milliliter agar. Structure Percent Mortality 1F 100 N N 100 N) N O. CH N NF 100 N N' O N F 97 N N Ivermectin 95

Claims (2)

1. A compound of Formula (I-A): 2 1 Y NX R NR X N N X I-A wherein: R is H, CH 3 , phenyl, or a heterocycle comprising a 5 or 6 membered single ring or a fused ring system comprising at least one 5 or 6 membered heterocycle optionally substituted with H, halo, lower alkyl, lower alkoxy, benzyloxy, lower alkenyl, lower alkynyl, haloalkyl, haloalkoxy, NO 2 , CN, lower alkoxycarbonyl, lower alkylcarbonyl, lower alkyl-SOq, and aldoximes and lower alkyloximes, optionally substituted on oxygen by lower alkyl. Z is H, a C-C single bond, CH 2 , NH, 0, S, CN, CH 2 0, OCH 2 , CH 2 CH 2 0, or OCH 2 CH 2 ; m is 4; p is 0 or 1; q is an integer from 0 to 2; R1 is independently H, halo, lower alkyl, lower alkenyl, lower alkynyl, hydroxy, lower alkoxy, haloalkyl, haloalkoxy, NO 2 , CN, lower alkylcarbonyl, lower alkoxycarbonyl, mercapto, lower alkylthio, aldoximes and lower alkyloximes, optionally substituted on oxygen by lower alkyl; Y is a C-C single bond, C(R 5 )O or CR5n); WO 2011/025505 PCT/US2009/055522 113 n is 2; alternatively Rm, Z, and R, may be taken together to form a fused 5 or 6 membered heterocycle optionally substituted with H, halo, lower alkyl, lower alkoxy, benzyloxy, lower alkenyl, lower alkynyl, haloalkyl, haloalkoxy, NO 2 , CN, lower alkylcarbonyl, lower alkoxycarbonyl and lower alkyl-SOq; R2 are independently H or lower alkyl; R 4 is H, halogen, lower alkyl, lower alkoxy or lower haloalkyl; R are independently H or lower alkyl; X 1 is NR 3 , 0, and S, where R 3 is selected from H, lower alkyl, lower alkylcarbonyl, lower alkoxycarbonyl, hydroxy, lower alkoxy, lower alkyl-SOq, phenyl-SOq or substituted phenyl-SOq; X2 is H, halogen or lower alkyl; and X3 is H, halogen or lower alkyl; with the proviso that when Y is C(R 5) , R 2n and Rlm may be taken together to form 1 Rm R 4 N Z..--R R>N ,' z -- RP X N N X

2. A compound of Formula (I-B): 2 Rm 1n R m-1 SNN Xz p I-B WO 2011/025505 PCT/US2009/055522 114 wherein: R is H, CH 3 , haloalkyl, phenyl, or a heterocycle comprising a 5 or 6 membered single ring or a fused ring system comprising at least one 5 or 6 membered heterocycle optionally substituted with H, halo, lower alkyl, lower alkoxy, benzyloxy, lower alkenyl, lower alkynyl, haloalkyl, haloalkoxy, NO 2 , CN, lower alkoxycarbonyl, lower alkylcarbonyl, lower alkyl SOq, aldoximes and lower alkyloximes, optionally substituted on oxygen by lower alkyl; Z is H, a C-C single bond, CH 2 , NH, 0, S, CN, CH 2 0, OCH 2 , CH 2 CH 2 0, or OCH 2 CH 2 ; m is 4; p is 0 or 1; q is an integer from 0 to 2; R1 is independently H, halo, lower alkyl, lower alkenyl, lower alkynyl, hydroxy, lower alkoxy, haloalkyl, haloalkoxy, NO 2 , CN, lower alkylcarbonyl, lower alkoxycarbonyl, mercapto, lower alkylthio, aldoximes and lower alkyloximes, optionally substituted on oxygen by lower alkyl; Y is a C-C single bond, C(R 5 )O or CR5n); n is 2; alternatively R,, Z, and R, may be taken together to form a fused 5 or 6 membered heterocycle optionally substituted with H, halo, lower alkyl, lower alkoxy, benzyloxy, lower alkenyl, lower alkynyl, haloalkyl, haloalkoxy, NO 2 , CN, lower alkylcarbonyl, lower alkoxycarbonyl and lower alkyl-SOq; R2 are independently H or lower alkyl; R 4 is H, halogen, lower alkyl, lower alkoxy or lower haloalkyl; R are independently H or lower alkyl; WO 2011/025505 PCT/US2009/055522 115 X 1 is NR 3 , 0, and S, where R 3 is selected from H, lower alkyl, lower alkylcarbonyl, lower alkoxycarbonyl, hydroxy, lower alkoxy, lower alkyl-SOq, phenyl-SOq or substituted phenyl-SOq; X2 is H, halogen or lower alkyl; and X3 is H, halogen or lower alkyl; with the proviso that when Y is C(R 5 ) , R 2 . and Rm may be taken together to form R SN N X