AU2006202171B2

AU2006202171B2 - Nutritional composition

Info

Publication number: AU2006202171B2
Application number: AU2006202171A
Authority: AU
Inventors: Blake Norris
Original assignee: Individual
Current assignee: Individual
Priority date: 2005-05-23
Filing date: 2006-05-23
Publication date: 2008-12-11
Anticipated expiration: 2026-05-23
Also published as: AU2006202171A1

Description

NUTRITIONAL COMPOSITION This invention relates to nutritional compositions.

This invention has particular but not exclusive application to nutritional compositions for weight reduction, and for illustrative purposes reference will be made to such application. However, it is to be understood that this invention could be used in other applications, such as dietary supplementation generally.

The natural "feast or famine" response of the human body is to store excess calorific intake as fat and to call on this calorific reserve in times of low dietary intake. The basal metabolic rate is the rate at which the body utilizes energy to maintain function at rest. A set point could be regarded as the combination of intake and BMR at which the body starts to store fat. Over time as a body both loses and gains weight, the set point shifts in favour of a lower basal metabolic rate which increases the size and number of fat cells for a given intake. The set point also lowers in response to starvation to conserve energy. When the body is subjected to highs and lows of calorific intake, this tends to lower the BMR thus increasing the fat cell size.

It is recognized that nutritional supplements will in cases where dietary intakes are insufficient, have a profound effect on metabolic rate and calorific utilization. In particular, Vitamins B1, B2, B3, B5, B6 and B12, minerals such as manganese, potassium, chromium and magnesium, amino acids such as leucine, isoleucine, tyrosine and valine, lipid metabolism-active compounds and compositions such as choline bitartrate, inositol, lecithins, biotin and chitosan, cofactors such as the coenzyme Q family, are administered as a supplement where diagnosis indicates that insufficiency is leading to metabolic disorder.

The applicant has surprisingly determined that supplementation with a specific group of known constituents produces a metabolic result favouring weight loss.

This invention in one aspect resides broadly in a nutritional supplement composition comprising Vitamin B3, lecithin and co-enzyme Q10, wherein the composition comprises, based upon the total amount of Vitamin B3, lecithin, preferably having a phosphatidyl content of about 35%) and co-enzyme from about 13 3000 parts by weight Vitamin B3, about 10 5000 parts by weight of lecithin and from about 10 250 parts by weight of coenzyme In addition there may be administered one or more other nutritional supplements such as vitamins B1 (preferably 2mg 300mg), B2 (10 100 mg), B5 (preferably 2 200 mg), B6 (preferably 2 200mg) and B12 (3 1000 mg), minerals such as manganese (2.5 500 mg), potassium (preferably 2 6 mg) and magnesium (preferably 300 350 mg), amino acids such as leucine 100 mg), isoleucine (preferably 10 100 mg), tyrosine (preferably 500 mg 2000mg) and valine (preferably 10 100 mg), lipid metabolism-active compounds and compositions such as choline bitartrate (preferably 10 mg 500 mg), inositol (preferably 1 mg 500 mg), biotin (preferably 150 mcg 400 mcg) and chitosan, or cofactors, administered as a supplement where diagnosis indicates that insufficiency is leading to metabolic disorder.

The invention also relates to nutritional supplementation method comprising the daily administration of a composition comprising from about 13 mg to about 3000 mg preferably from about 50 mg to about 500 mg Vitamin B3, from about 10 mg to about 5000 mg preferably about 1000 mg to about 3000 mg of a lecithin preferably having a phosphatidyl choline content of about 35% and about 10 mg to about 250 mg preferably about 50 mg to about 150 mg coenzyme This composition may be administered in any suitable form such as a powder, tablet, capsule or the like. The composition may also be in the form of a food stuff such as a food bar, drink or the like. The food stuff may be in the form of a meal replacement. Suitable administration forms are known to those skilled in the art.

In order that this invention may be more readily understood and put into practical effect, reference will now be made to the accompanying comparative and inventive Examples which illustrate a preferred embodiment of the invention.

COMPARATIVE EXAMPLE 1 Vitamin B6 (pyridoxine HCI) 50 mg Vitamin B12 (cyanocobalamin) 50 pg Manganese amino acid chelate 200 mg Chromium 50 pg Choline bitartrate 100 mg Inositol 100 mg COMPARATIVE EXAMPLE 2 Vitamin B6 (pyridoxine HCI) 50 mg Vitamin B12 (cyanocobalamin) 50 pg Manganese amino acid chelate 200 mg Chromium 50 pg Choline bitartrate 250 mg Inositol 150 mg Vitamin C (ascorbic acid) 500 mg COMPARATIVE EXAMPLE 3 Vitamin B6 (pyridoxine HCI) 50 mg Vitamin B12 (cyanocobalamin) 50 pg Manganese amino acid chelate 200 mg Chromium 100 pg Choline bitartrate 250 mg Inositol 250 mg Vitamin C (ascorbic acid) 500 mg COMPARATIVE EXAMPLE 4 Vitamin B6 (pyridoxine HCI) 50 mg Vitamin B12 (cyanocobalamin) 50 pg Manganese amino acid chelate 200 mg Chromium 100 pg Choline bitartrate 250 mg Inositol 250 mg Vitamin C (ascorbic acid) 500 mg Vitamin B1 (thiamine nitrate) 50 mg Vitamin B2 (riboflavin) 50 mg Vitamin B5 (pantothenic acid) 50 mg INVENTIVE EXAMPLE Vitamin B6 (pyridoxine HCI) 100 mg Vitamin B12 (cyanocobalamin) 100 pg Manganese amino acid chelate 200 mg Chromium 100 pg Choline bitartrate 250 mg Inositol 250 mg Vitamin C (ascorbic acid) 500 mg Vitamin B1 (thiamine nitrate) 100 mg Vitamin B2 (ribiflavin) 100 mg Vitamin B3 (niacin) 100 mg Vitamin B5 (pantothenic acid) 100 mg Coenzyme Q10 (ubiquinone) 90 mg Lecithin (35% phosphatidyl choline) 2000 mg The five compositions were administered daily to respective adult female subjects A to E, according to the following Table I.

TABLE I SUBJECT SUBJECT& WEIGHT

FORMULA

AGE

A, 42 75 kg Comparative Example 1 B, 49 67 kg Comparative Example 2 C, 50 85 kg Comparative Example 3 D, 50 83 kg Comparative Example 4 E, 53 80 kg Inventive Example The results are summarized in Table 2.

SUBJEC Weight Waist Chest Hips Le Arm

T

A

Week 1 75 90 105 99 46 33 Week 2 75 90 105 99 46 33 Week 3 75 90 105 99 46 33 Week 4 74.5 89 105 98.5 45.5 33

B

Week 1 67 97 99 100.5 44 Week 2 67 97 99 100.5 44 Week 3 67 97 99 100.5 44 Week 4 66.5 96 98.5 95 44

C

Week 1 85 86 99 112 54 34 Week 2 85 86 99 112 54 34 Week 3 84 85.5 99 112 54 34 Week 4 84 85.5 99 112 54 34

D

Week 1 83 98 99.5 119 55 38 Week 2 83 98 99.5 119 55 38 Week 3 83 98 99.5 119 55 38 Week 4 82.5 97 99 119 54 37.5

E

Week 1 80 89 100 111 59 30.5 Week 2 78 87 99 110 52 29.5 Week 3 78 87 99 109 50 27 Week 4 75 86 99 109 46 It may be seen that the subject subjected to the method and composition of the invention experienced a reduction for all measurements.

In the specification the term "comprising" shall be understood to have a broad meaning similar to the term "including" and will be understood to imply the inclusion of a stated integer or step or group of integers or steps but not the exclusion of any other integer or step or group of integers or steps. This definition also applies to variations on the term "comprising" such as "comprise" and "comprises".

It will of course be realised that while the above has been given by way of illustrative example of this invention, all such and other modifications and variations thereto as would be apparent to persons skilled in the art are, deemed to fall within the broad scope and ambit of this invention as is herein set forth.

Claims

1. A nutritional supplement comprising Vitamin B3, lecithin and co- enzyme Q10, wherein the composition comprises, based upon the total amount of Vitamin B3, lecithin, and co-enzyme Q10 from about 13 to about 3000 parts by weight Vitamin B3, from about 10 to about 5000 parts by weight of lecithin and from about 10 to about 250 parts by weight of coenzyme

2. The composition of Claim 1 comprising from about 50 to about 500 parts by weight Vitamin B3.

3. The composition of claim 1 or claim 2, wherein the lecithin comprises about 35% phosphatidyl choline.

4. The composition of any one of the preceding claims comprising from about 1000 to 3000 parts by weight of lecithin.

The composition according to any one of the preceding Claims having a coenzyme Q10 content of about 50 parts by weight to 150 parts by weight.

6. The composition of any one of the preceding claims further comprising at least one other nutritional supplement selected form the group comprising vitamins B1, B2, B5, B6 and B12 ,essential minerals, amino acids and lipid metabolism-active compounds and compositions.

7. The composition of claim 6, wherein the at least one essential mineral is potassium, manganese or magnesium.

8. The composition of claim 6 or claim 7, wherein the at least one amino acid is leucine, isoleucine, tyrosine and valine.

9. The composition of any one of claims 6 to 8, wherein the at least one lipid-metabolism active compound or composition is choline bitartate, insotol, biotin or chitosan.

The composition of claim 6 in a preparation form to provide a daily dose of from about 2mg to about 300mg vitamin B1, from about 10 to about 100mg vitamin B2, from about 2 to about 200mg vitamin B5, from about 2 to about 200mg vitamin B6, from about 3to about 1000mg vitamin B12, about 2.5 to about 500 mg manganese, from about 2 to about 6mg potassium, from about 300 to about 350mg magnesium, from about 10 to about 100mg leucine, from about 10 to about 100mg isoleucine, from about 500 to about 2000mg tyrosine, from about 10 to about 100mg valine, from about 10mg to about 500mg choline bitartrate, from about 1 to about 500mg inositol, from about 150 to about 400mcg biotin and from about 250 to about 1000mg chitosan.

11. A composition according to any one of the preceding claims in a preparation form to provide a daily, dosage from about 13 to about 3000 mg Vitamin B3, from about 10 to about 5000 mg of lecithin and about 10 to about 250 mg of coenzyme

12. The composition of claim 11 comprising from about 50 to about 500 mg Vitamin B3, from about 1000 to about 3000 mg lecithin and from about to about 150 mg coenzyme

13. A nutritional composition substantially as hereinbefore described with reference to Example

14. A nutritional supplementation method comprising the daily administration of a composition of claim 11 or claim 12. A nutritional supplementation method substantially as hereinbefore described with reference to inventive Example DATED THIS TWENTY-THIRD DAY OF MAY 2006 BLAKE NORRIS BY PIZZEYS PATENT AND TRADEMARK ATTORNEYS