AU2005338050A8 - Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides - Google Patents

Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides

Info

Publication number: AU2005338050A8
Authority: AU; Australia
Prior art keywords: immunostimulatory; oligonucleotide; based compounds; dinucleotides; modified
Prior art date: 2005-11-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

AU2005338050A

Other versions

AU2005338050B2 (en

AU2005338050A1 (en

Inventor

Sudhir Agrawal

Ekambar R. Kandimalla

Dong Yu

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Aceragen Inc

Original Assignee

Idera Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-11-07

Filing date

2005-11-07

Publication date

2008-07-03

2005-11-07 Application filed by Idera Pharmaceuticals Inc filed Critical Idera Pharmaceuticals Inc

2007-05-18 Publication of AU2005338050A1 publication Critical patent/AU2005338050A1/en

2008-07-03 Publication of AU2005338050A8 publication Critical patent/AU2005338050A8/en

2008-08-21 Assigned to IDERA PHARMACEUTICALS, INC. reassignment IDERA PHARMACEUTICALS, INC. Alteration of Name(s) of Applicant(s) under S113 Assignors: IDERA PHARMACEUTICALS

2012-02-02 Application granted granted Critical

2012-02-02 Publication of AU2005338050B2 publication Critical patent/AU2005338050B2/en

2025-11-07 Anticipated expiration legal-status Critical

Status Ceased legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/17—Immunomodulatory nucleic acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Immunology (AREA)
Genetics & Genomics (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Molecular Biology (AREA)
Plant Pathology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Communicable Diseases (AREA)
Rheumatology (AREA)
Microbiology (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Biochemistry (AREA)
Dermatology (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AU2005338050A 2005-11-07 2005-11-07 Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides Ceased AU2005338050B2 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US2005/040215 WO2007055682A2 (en)	2005-11-07	2005-11-07	Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides

Publications (3)

Publication Number	Publication Date
AU2005338050A1 AU2005338050A1 (en)	2007-05-18
AU2005338050A8 true AU2005338050A8 (en)	2008-07-03
AU2005338050B2 AU2005338050B2 (en)	2012-02-02

Family

ID=38023708

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU2005338050A Ceased AU2005338050B2 (en)	2005-11-07	2005-11-07	Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides

Country Status (7)

Country	Link
EP (1)	EP1945653A4 (en)
JP (1)	JP2009514525A (en)
CN (1)	CN101351469A (en)
AU (1)	AU2005338050B2 (en)
CA (1)	CA2630118A1 (en)
MX (1)	MX2008006004A (en)
WO (1)	WO2007055682A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6207646B1 (en)	1994-07-15	2001-03-27	University Of Iowa Research Foundation	Immunostimulatory nucleic acid molecules
US7276489B2 (en) *	2002-10-24	2007-10-02	Idera Pharmaceuticals, Inc.	Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends
US7354907B2 (en) *	2003-02-07	2008-04-08	Idera Pharmaceuticals, Inc.	Short immunomodulatory oligonucleotides
US7470674B2 (en) *	2005-11-07	2008-12-30	Idera Pharmaceuticals, Inc.	Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides
AU2015269412B2 (en)	2014-06-04	2020-03-12	Exicure Operating Company	Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
CN107106493A (en)	2014-11-21	2017-08-29	西北大学	The sequence-specific cellular uptake of spherical nucleic acid nano particle conjugate
KR102617833B1 (en)	2016-05-06	2023-12-27	엑시큐어 오퍼레이팅 컴퍼니	Liposomal spherical nucleic acid (SNA) construct presenting antisense oligonucleotides (ASO) for specific knockdown of interleukin 17 receptor mRNA
WO2018039629A2 (en)	2016-08-25	2018-03-01	Northwestern University	Micellar spherical nucleic acids from thermoresponsive, traceless templates
WO2018201090A1 (en)	2017-04-28	2018-11-01	Exicure, Inc.	Synthesis of spherical nucleic acids using lipophilic moieties
WO2018209270A1 (en)	2017-05-11	2018-11-15	Northwestern University	Adoptive cell therapy using spherical nucleic acids (snas)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7785610B2 (en) *	2001-06-21	2010-08-31	Dynavax Technologies Corporation	Chimeric immunomodulatory compounds and methods of using the same—III
WO2003035836A2 (en) *	2001-10-24	2003-05-01	Hybridon Inc.	Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends
AU2004206820B2 (en) *	2003-01-16	2010-06-10	Idera Pharmaceuticals, Inc.	Modulation of immunostimulatory properties of oligonucleotide-based compounds by utilizing modified immunostimulatory dinucleotides
CN101094594B (en) *	2003-12-08	2012-08-15	海布里顿公司	Modulation of immunostimulatory properties by small oligonucleotide-based compounds

2005
- 2005-11-07 MX MX2008006004A patent/MX2008006004A/en active IP Right Grant
- 2005-11-07 AU AU2005338050A patent/AU2005338050B2/en not_active Ceased
- 2005-11-07 CA CA002630118A patent/CA2630118A1/en not_active Abandoned
- 2005-11-07 JP JP2008538854A patent/JP2009514525A/en active Pending
- 2005-11-07 EP EP05851389A patent/EP1945653A4/en not_active Withdrawn
- 2005-11-07 WO PCT/US2005/040215 patent/WO2007055682A2/en not_active Ceased
- 2005-11-07 CN CNA2005800524839A patent/CN101351469A/en active Pending

Also Published As

Publication number	Publication date
JP2009514525A (en)	2009-04-09
AU2005338050B2 (en)	2012-02-02
EP1945653A4 (en)	2012-03-14
WO2007055682A8 (en)	2007-08-02
MX2008006004A (en)	2008-10-01
WO2007055682A2 (en)	2007-05-18
EP1945653A2 (en)	2008-07-23
AU2005338050A1 (en)	2007-05-18
CN101351469A (en)	2009-01-21
CA2630118A1 (en)	2007-05-18

Publication	Publication Date	Title
EP1601789A4 (en)	2007-10-31	Modulation of immunostimulatory properties of oligonucleotide-based compounds by utilizing modified immunostimulatory dinucleotides
IL256157A (en)	2018-02-28	Method of preparing isolated modified uricase
AU2007308141A1 (en)	2008-04-17	Methods of treating oral mucositis
EP1874345A4 (en)	2008-12-24	Immunostimulatory compositions
GB0607634D0 (en)	2006-05-31	Set of connectors
AU2005338050A8 (en)	2008-07-03	Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides
EP1854467B8 (en)	2018-09-26	Immunostimulatory composition
ZA200805079B (en)	2009-08-26	Immunostimulatory compositions and methods
EP1834462A4 (en)	2012-07-04	Clipping of transmission signal
AU2005903848A0 (en)	2005-08-04	Modification of flavonoid biosynthesis
AU2005901939A0 (en)	2005-05-05	Treatment of Foodstuffs
HK1110796A (en)	2008-07-25	Treatment of tumors
HK1112919A (en)	2008-09-19	Methods of synthesizing 6-alkylaminoquinoline derivatives
AU2005906132A0 (en)	2005-11-17	Uses of Yin Yang-1
HK1108286A (en)	2008-05-02	Purification of oligonucleotides
AU2003905551A0 (en)	2003-10-23	Modulation of Hyaluronan Synthase
AU2003906658A0 (en)	2003-12-18	Modulation of Hyaluronan Synthase
AU2006901582A0 (en)	2006-04-13	Amplification of DNA fragments
AU2005906585A0 (en)	2005-12-15	Methods and Preparation of Uses of Xanthorrhoeaceae Compositions
AU2005906584A0 (en)	2005-12-15	Use of Inhibitors of Prolyl-4-Hydroxylases
AU2004905501A0 (en)	2004-10-07	Methods of dispersion
HK1113787A (en)	2008-10-17	Methods of purifying tigecycline
HK1121734A (en)	2009-04-30	SYNTHESIS OF 1α-FLUORO-25-HYDROXY-16-23E-DIENE-26,27-BISHOMO-20-EPI-CHOLECALCIFEROL
HK1139852A (en)	2010-09-30	Synthesis, methods of using , and compositions of cycloalkylmethylamines
AU2005901749A0 (en)	2005-04-21	Improved production of titana

Legal Events

Date	Code	Title	Description
2008-07-03	TH	Corrigenda	Free format text: IN VOL 22, NO 20, PAGE(S) 2413 UNDER THE HEADING PCT APPLICATIONS THAT HAVE ENTERED THE NATIONAL PHASE -NAME INDEX UNDER THE NAME IDERA PHARMACEUTICALS, INC., APPLICATION NO. 2005338050, UNDER INID (71), CORRECT THE NAME TO IDERA PHARMACEUTICALS.
2012-05-31	FGA	Letters patent sealed or granted (standard patent)
2013-05-30	MK14	Patent ceased section 143(a) (annual fees not paid) or expired