AU2004325005A1

AU2004325005A1 - Multifocal ophthalmic lenses

Info

Publication number: AU2004325005A1
Application number: AU2004325005A
Authority: AU
Inventors: James W. Haywood; Larry G. Jones; Jeffrey H. Roffman
Original assignee: Johnson and Johnson Vision Care Inc
Current assignee: Johnson and Johnson Vision Care Inc
Priority date: 2004-11-16
Filing date: 2004-11-16
Publication date: 2006-05-26
Also published as: WO2006054986A1; EP1812819A1; CA2587796A1

Description

WO 2006/054986 PCT/US2004/038436 1 MULTIFOCAL OPHTHALMIC LENSES 5 Field of the Invention The invention relates to ophthalmic lenses. In particular, the invention provides lenses that incorporate more than one optical power, or focal length, and that are useful in the correction of presbyopia. 10 Background of the Invention As an individual ages, the eye is less able to accommodate, or bend the natural lens, to focus on objects that are relatively near to the observer. This condition is known as presbyopia. Similarly, for persons who have had their natural lens removed and an intraocular lens inserted as a replacement, the ability to 15 accommodate is totally absent. Among the methods used to correct presbyopia is the mono-vision lens system in which a person is fitted with, and wears, two contact lenses; one lens for distance vision and one lens for near vision. The mono-vision system permits the 20 wearer to distinguish both distance and near objects, but is disadvantageous in that a substantial loss in depth perception results. Another method for presbyopia correction is the use of multifocal contact lenses. Each multifocal contact lens provides distance and near vision power or 25 distance, near and intermediate power. These lenses overcome the depth perception loss and typically use alternating concentric rings or alternating radial segments of distance and near power. However, multifocal contact lenses are problematic in that they expose the wearer's retina to two images at once, one in and one out of focus. The two images are not disadvantageous for near vision because the out of focus 30 distance objects being viewed in the near segments of the lens do not interfere, but rather contribute to the near vision resolution. The reason for this is that the out of WO 2006/054986 PCT/US2004/038436 2 focus distance objects are in an orientation that does not interfere with the near images. 5 However, such lenses are problematic for distance vision. As the wearer views distant objects through the lens, the near images also being viewed go through focus before the distant images. As a result, the out of focus near images are inverted and interfere with the image of the distant object. Thus, a need exists for 10 multifocal lenses that that overcome the disadvantages of known lenses. Brief Description of the Drawings Figure 1 is a plan view of a lens surface of one embodiment of the lens of the invention. 15 Detailed Description of the Invention and Preferred Embodiments The invention provides methods for correcting presbyopia, lenses for such correction, and methods for producing the lenses of the invention. Each of the lenses of the invention provide both distance and near vision correction by providing 20 both multifocal and monofocal regions within the same lens. In one embodiment, the invention provides an ophthalmic lens for a lens wearer comprising, consisting essentially of, and consisting of an optic zone having a first region that is a multifocal region, a second region that is a monofocal region, 25 and a third region of alternating distance optical power segments and near optical power segments wherein the near optical power segments are asymmetrical. By "ophthalmic lens" is meant a contact, intraocular lens, or the like, or combinations thereof. Preferably, the lenses of the invention are contact lenses. By 30 "multifocal region" is meant a region in which the power continuously increases from distance to near optical power or continuously decreases from near to distance WO 2006/054986 PCT/US2004/038436 3 optical power as one moves outwardly toward the lens edge from the center of the region. 5 By "distance optical power" is meant the amount of refractive power required to correct the wearer's distance vision acuity to the desired degree. By "near optical power" is meant the amount of refractive power required to correct the wearer's near vision acuity to the desired degree. By "asymmetrical" is meant that given any first point that is on a near optical power segment of the lens surface, any 10 second point on the surface that is at a corresponding location 180 degrees around the center of the lens from the first point is a point on a distance optical power segment of the surface. The near optical power segments in the asymmetrical portion of the lenses of the invention may be any distance from each other provided that the asymmetry requirement is met. 15 Figure 1 depicts a plan view of a surface of lens 10 of the invention. Lens 10 has an optic zone containing multifocal region 11, monofocal region 12, and region 15 which is a region of asymmetric, alternating, distance and near optical power segments. The optic zones is surrounded by non-optical zone 16. The multifocal 20 region of the lens of the invention preferably is located at the optical center of a surface of the lens. The multifocal region used in the lenses of the invention has at least distance and near vision power, and preferably distance, near, and intermediate vision power. By "intermediate vision power" is meant power that is suitable for viewing objects located at distances of about 46 to about 80 cm from the eye. 25 Intermediate vision power may be supplied as a consequence of the power progression between the peak of the power of the near and distance optical power within the multifocal zone. In a preferred embodiment, a pair of lenses according to the invention is provided, the lens to be worn on the eye dominant for distance vision having a multifocal region in which the power continuously increases from 30 distance to near optical power as one moves outwardly from the center of the lens and region to the periphery of the region.

WO 2006/054986 PCT/US2004/038436 4 The multifocal region may be designed by any convenient method. Preferably, the multifocal region is designed wherein a position, an amplitude, and a width for the region is determined by the following equation: [F 8a' s 5 Y = a3 ) . * Add = 4a' +P(x + k)j *Add (D) wherein: Y is the Add power at any point x on a surface within the multifocal region; x is a point on the lens surface; 10 ais 0.5; k is the point within the multifocal region at which the power peaks; P is the coefficient that controls the width of the multifocal region and is greater than about 0 and less than about 15; S is the coefficient that controls the amplitude and its decrease in the periphery of 15 the multifocal region and is greater than about 0 and less than about 30; and Add is a value that is equal to or less than the difference in power between the near vision power and distance vision power of the multifocal region. Alternatively, the multifocal region may be a region wherein a speed or 20 contour, meaning, the slope of the power change from near to distance power, for the zone is determined by the following equation: Add(x) = Addpeak * (1 /(a * (1 + (x Ix) 2 ")) (II) 25 wherein: Add(x) is actual instantaneous add power at any point x on a surface of the lens within the multifocal region; x is a point on the lens surface at a distance x from the center; a is a constant and preferably is 1; WO 2006/054986 PCT/US2004/038436 5 Addpeak is the full peak dioptric add power, or add power required for near vision correction; 5 xc is the cutoff semi-diameter or the midpoint in the power transition from distance to near power, or near to distance power within the multifocal region; n is a variable between 1 and 40, preferably between 1 and 20; and Add is a value that is equal to the difference in power between the near vision power and distance vision power of the multifocal region. 10 In Equation II, n is the variable that controls the slope of the progression from near to distance vision power and distance to near vision power in the multifocal region. The less the value of n, the more gradual the progression will be. 15 In another embodiment, the multifocal power region may be such that the a speed or contour for the zone is detennrmined by the following equation: Add(x) Addpeak * (I/(a * (1 + (x/x,) 2 ) * n) (III) 20 wherein: Add(x) is actual instantaneous add power at any point x on a surface of the lens within the multifocal region; x is a point on the lens surface at a distance x from the center; a is a constant and preferably is 1: 25 Addpeak is the full peak dioptric add power within the multifocal region; x. is the cutoff semi-diameter within the multifocal region; n is is a variable between 1 and 40, preferably between 1 and 20; and Add is a value that is equal to the difference in power between the near vision power and distance vision power of the multifocal region. 30 WO 2006/054986 PCT/US2004/038436 6 In a fourth embodiment, the multifocal power region is such that the speed and a contour for the region is determined by the following equation: 5 Add(x) = Addpeak * (1(a * (1 + (X x) ) * n) (IV) wherein: Add(,) is actual instantaneous add power at any point x on a surface of the lens within the multifocal region; 10 x is a point on the lens surface at a distance x from the center; a is a constant and preferably is 1; d is an arbitrary value between 1 and 40; Addpeak is the full peak dioptric add power within the multifocal region; x. is the cutoff semi-diameter within the multifocal region; 15 n is between 1 and 40, preferably between 1 and 20; and Add is a value that is equal to the difference in power between the near vision power and distance vision power of the multifocal region. The second region of the lens lies at the periphery, and preferably surrounds, 20 the multifocal region. The second region is a monofocal region that may be distance, intermediate, or near optical power. The power of the monofocal region preferably is the same power as the power at the extreme periphery of the multifocal region and which is immediately adjacent to the monofocal region. For example, if the multifocal region increases from near to distance vision power as one moves 25 from the center of the multifocal region to the its periphery, relative to the lens periphery, the monofocal region will be distance vision power. The third region of the lens is adjacent to and lies at the periphery of, and preferably substantially surrounds, the monofocal region. The third region contains 30 both distance and near optical power segments of any convenient shape that are WO 2006/054986 PCT/US2004/038436 7 asymmetrical. Preferably, the segments are radial segments. More preferably, the radial segments are triangular in shape. Any number of near and distance segments may be used. Preferaly however, the number of near optical power segments are 5 equal to or less than the areas for distance optical segments within the third region. The region may also include segments of intermediate vision optical power. However, if intermediate vision power segments are provided, they too preferably are asymmetrical in that, given any first point that is on an intermediate optical power segment of the lens surface, any second point on the surface that is at a 10 corresponding location 180 degrees around the center of the lens from the first point is a point on a distance or near optical power segment of the surface. As shown in Figure 1 region 15 has near optical power segments 13 alternating with distance optical power segments 14. As shown, the distance and 15 near segments are arc-shaped alternating as one moves circumferentially around the center of the lens. Any number of alternating distance and near segments may be used. Preferably, three segments each of distance and near optical power are used In the lenses of the invention, the distance, near, and intermediate optical 20 powers may be spherical, aspheric, or toric powers. Additionally, each of the three regions and the distance, near optical power zones or segments therein may be of any desired and practical dimensions. The multifocal, monofocal, and asymmetrical distance and near segment regions may be on the same surface of the lens. Alternatively, the multifocal and monofocal, multifocal and asymmetrical 25 segments, or asymmetrical segments and monofocal region may be on one surface and the remaining region may be on the opposite lens surface. Preferably, the multifocal, monofocal, and asymmetric regions are all on the same surface. More preferably, all three regions are on the front, or object side, surface of the lens. 30 WO 2006/054986 PCT/US2004/038436 8 The lens of the invention may, if desired, include a zone for rotationally stabilizing the lens on eye. Any number of rotational stabilization zones are known in the art and may be used in the lens of the invention. Typically, rotational 5 stabilization is categorized as static or dynamic stabilization. Examples of rotational stabilization includes, without limitation, ballast, prism ballast, thick zone, thin zone, protuberances on the lens surface, such as one or more bosses, and the like and combinations thereof. If the lens includes toric correction, or cylinder power, a stabilization zone will be required. 10 In still another embodiment of the invention, one surface of the lens provides each of the multifocal, monofocal and asymmetric segment regions and the other surface of the lens corrects the lens wearer's high order aberrations. By high order aberrations is meant aberration of third or higher order. In yet another embodiment, 15 on the front surface of the lens is each of the multifocal, monofocal and asymmetric segment regions and the back, or eye side, surface is matched to the wearer's corneal topography meaning that the back surface inversely corresponds to the wearer's corneal topography. Such lens incorporates an inverse topographic elevation map of the lens wearers' cornea. The inverse topographic elevation map may be derived 20 from the wearer's corneal topography, which corneal topography may be determined by any known method including, without limitation, by use of a corneal topographer. For soft contact lens manufacture, the elevational data initially is applied to a lens model in the unflexed state. Next, the data is transformed by taking into account the soft lens flexure, or wrap, when the lens 25 placed on the eye. Thus, the effects of both elevation of the cornea and wrap are accounted for when using the corneal topographic data. The flexure transformed data then may be mapped onto a CNC grid pattern and used to make the lenses or mold tool surface. 30 In yet another embodiment, cylinder power may be provided. In one such embodiment, on one surface of the lens is each of the multifocal, monofocal and WO 2006/054986 PCT/US2004/038436 9 asymmetric a segment regions and the opposite surface is a toric surface. As yet another embodiment, cylinder power may be combined with one or more of the asymmetric distance arid near optical power segments, the monofocal, and the 5 multifocal region. The lenses of the invention may be made by any convenient method. One such method uses a lathe to produce mold inserts. The mold inserts in turn are used to form molds. Subsequently, a suitable lens material is placed between the molds 10 followed by compression and curing of the resin to form the lenses of the invention. One ordinarily skilled in the art will recognize that any number of known methods may be used to produce the lenses of the invention. Contact lenses useful in the invention may be made of hard lens materials 15 orsoft lens materials, but the invention may provide particular utility when applied to the design and production of soft contact lenses. Thus, soft contact lenses, made of any material suitable for producing such lenses, preferably are used. Illustrative materials for formation of soft contact lenses include, without limitation silicone elastomers, silicone-containing macromers including, without limitation, those 20 disclosed in United States Patent Nos. 5,371,147, 5,314,960, and 5,057,578 incorporated in their entireties herein by reference, hydrogels, silicone-containing hydrogels, and the like and combinations thereof. More preferably, the surface is a siloxane, or contains a siloxane functionality, including, without limitation, polydimethyl siloxane macromers, methacryloxypropyl polyalkyl siloxanes, and 25 mixtures thereof, silicone hydrogel, such as galyfilcon, or a hydrogel, such as etafilcon A. A preferred lens material is a poly 2-hydroxyethyl methacrylate polymers, meaning, having a peak molecular weight between about 25,000 and about 80,000 30 and a polydispersity of less than about 1.5 to less than about 3.5 respectively and covalently bonded thereon, at least one cross-linkable functional WO 2006/054986 PCT/US2004/038436 10 group. This material is described in United States Serial No. 60/363,630 incorporated herein in its entirety by reference. Suitable materials for forming 5 intraocular lenses include, without limitation, polymethyl methacrylate, hydroxyethyl methacrylate, inert clear plastics, silicone-based polymers, and the like and combinations thereof. Curing of the lens material may be carried out by any means known 10 including, without limitation, thermal, irradiation, chemical, electromagnetic radiation curing and the like and combinations thereof. Preferably, the lens is molded which molding is carried out using ultraviolet light or using the full spectrum of visible light. More specifically, the precise conditions suitable for curing the lens material will depend on the material selected and the lens to be 15 formed. Polymerization processes for ophthalmic lenses including, without limitation, contact lenses are well known. Suitable processes are disclosed in U.S. Patent No. 5,540,410 incorporated herein in its entirety by reference.

Claims

1. A lens, comprising an optic zone having a first region that is a multifocal region, a second region that is a monofocal region, and a third region of alternating distance optical power segments and near optical power segments wherein the near optical power segments are asymmetrical. 10

2. The lens of claim 1, wherein the lens is a contact lens.

3. The lens of claim 2, wherein the first, second and third regions are located on a front surface of the lens. 15

4. The lens of claim 2, wherein the lens further comprises a cylinder power.

5. The lens of claim 3, wherein a back surface of the lens is a toric 20 surface.

6. The lens of claim 3, wherein a back surface of the lens inversely corresponds to an individual's corneal topography. 25

7. The lens of claim 2, wherein the first multifocal region is designed so that a position, an amplitude, and a width for the region is determined by the following equation: 30 8a'S Y =8a 3 I * Add 4a2 + P(x + k) s WO 2006/054986 PCT/US2004/038436 12 wherein: Y is an add power at any point x on a surface within the multifocal region; x is a point on the lens surface; 5 ais 0.5; k is a point within the multifocal region at which there is a power peak; P is greater than about 0 and less than about 15; S is greater than about 0 and less than about 30; and Add is a value that is equal to or less than a difference in power between the near 10 vision power and distance vision power of multifocal region.

8. The lens of claim 2, wherein the multifocal region is designed so that a speed or contour, meaning, the slope of the power change from near to distance power, for the zone is determined by the following equation: 15 Add(x) = Addpeak * (1(a * (1 + (xx) 2 n)) wherein: Add(x) is an actual instantaneous add power at any point x in the multifocal region; 20 x is a point in the multifocal region at a distance x from a center of the surface; a is a constant; Addpeak is an add power required for near vision correction; xc is a midpoint in a power transition from distance to near power in the multifocal region; 25 n is a variable between 1 and 40; and Add is a value that is equal to the difference the near vision power and distance vision power in the multifocal region. S30

9. The lens of claim 2, wherein the multifocal region is designed so that a speed or contour for the zone is determined by the following equation: WO 2006/054986 PCT/US2004/038436 13 Add(x) = Addpeak *(1 (a * (1 + (x/xc) 2 ) * n) (III) wherein: 5 Add(x) is actual instantaneous add power at any point x on a surface of the lens within the multifocal region; x is a point on the lens surface at a distance x from the center; a is a constant and preferably is 1: Addpeak is the full peak dioptric add power within the multifocal region; 10 x, is the cutoff semi-diameter within the multifocal region; n is is a variable between 1 and 40, preferably between 1 and 20; and Add is a value that is equal to the difference in power between the near vision power and distance vision power of the multifocal region. 15

10. The lens of claim 2, wherein the multifocal region is designed so that a speed and a contour for the region is determined by the following equation: Addx) = Addpeak * (1/ (a*(1 + (x / xc)d )n) (IV) 20 wherein: Add(x) is actual instantaneous add power at any point x on a surface of the lens within the multifocal region; x is a point on the lens surface at a distance x from the center; a is a constant and preferably is 1; 25 d is an arbitrary value between 1 and 40; Addpeak is the full peak dioptric add power within the multifocal region; xc is the cutoff semi-diameter within the multifocal region; n is between 1 and 40, preferably between 1 and 20; and Add is a value that is equal to the difference in power between the near vision power 30 and distance vision power of the multifocal region. WO 2006/054986 PCT/US2004/038436 14

11. A method of designing a lens, comprising the step of providing an optic zone having a first region that is a multifocal region, a second region that is a monofocal region, and a third region of alternating distance optical power segments 5 and near optical power segments wherein the near optical power segments are asymmetrical.

12. A method of correcting presbyopia, comprising the step of providing an optic zone having a first region that is a multifocal region, a second region that is 10 a monofocal region, and a third region of alternating distance optical power segments and near optical power segments wherein the near optical power segments are asymmetrical.