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AU2003235720A1 - Method for the production and purification of 1,7'-dimethyl-2'-propyl-2,5'-bi-1h-benzimidazole - Google Patents

Method for the production and purification of 1,7'-dimethyl-2'-propyl-2,5'-bi-1h-benzimidazole

Info

Publication number
AU2003235720A1
AU2003235720A1 AU2003235720A AU2003235720A AU2003235720A1 AU 2003235720 A1 AU2003235720 A1 AU 2003235720A1 AU 2003235720 A AU2003235720 A AU 2003235720A AU 2003235720 A AU2003235720 A AU 2003235720A AU 2003235720 A1 AU2003235720 A1 AU 2003235720A1
Authority
AU
Australia
Prior art keywords
benzimidazole
propyl
dimethyl
purification
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003235720A
Inventor
Werner Belzer
Rolf Dach
Volker Fachinger
Markus Heitzmann
Hartmut Schmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7712431&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2003235720(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Publication of AU2003235720A1 publication Critical patent/AU2003235720A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Purification of 1,7'-dimethyl-2'-propyl-2,5'-bi-1H-benzimidazole (I), obtained by reacting 2-propyl-4-methyl-1H-benzimidazole-6-carboxylic acid (II) (or its salt) with N-methyl-o-phenylene diamine (III) (or its salt), comprises treating the crude product with carbon. An independent claim is also included for the use of (I) as purified above in the preparation of telmisartan.
AU2003235720A 2002-01-18 2003-01-15 Method for the production and purification of 1,7'-dimethyl-2'-propyl-2,5'-bi-1h-benzimidazole Abandoned AU2003235720A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10201725A DE10201725A1 (en) 2002-01-18 2002-01-18 Process for the preparation and purification of 1,7'-dimethyl-2'-propyl-2,5'-bi-1H-benzimidazole
DE10201725.5 2002-01-18
PCT/EP2003/000319 WO2003059890A1 (en) 2002-01-18 2003-01-15 Method for the production and purification of 1,7'-dimethyl-2'-propyl-2,5'-bi-1h-benzimidazole

Publications (1)

Publication Number Publication Date
AU2003235720A1 true AU2003235720A1 (en) 2003-07-30

Family

ID=7712431

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003235720A Abandoned AU2003235720A1 (en) 2002-01-18 2003-01-15 Method for the production and purification of 1,7'-dimethyl-2'-propyl-2,5'-bi-1h-benzimidazole

Country Status (9)

Country Link
EP (2) EP1470111B1 (en)
JP (2) JP5129918B2 (en)
CN (1) CN100436426C (en)
AT (1) ATE465998T1 (en)
AU (1) AU2003235720A1 (en)
CA (1) CA2471730C (en)
DE (2) DE10201725A1 (en)
ES (1) ES2341235T3 (en)
WO (1) WO2003059890A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2414019A (en) * 2004-05-11 2005-11-16 Cipla Ltd One-step preparation of telmisartan by condensation and hydrolysis
WO2006044754A2 (en) 2004-10-18 2006-04-27 Dr. Reddy's Laboratories Ltd. Process for preparing telmisartan
DE102005034279A1 (en) 2005-07-22 2007-01-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Preparation of 1,7'-dimethyl-2'-propyl-2,5'-bi-1H-benzimidazole
CN101172968B (en) * 2006-11-01 2010-05-12 浙江天宇药业有限公司 2-propyl-4 methyl-6-(tolimidazole-2group) benzoglioxaline salt and method for producing the same
JP2011519840A (en) * 2008-05-02 2011-07-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Preparation of 1,7'-dimethyl-2'-propyl-2,5'-bi-1H-benzimidazole
CN101717370A (en) * 2009-11-30 2010-06-02 常州亚邦制药有限公司 New method for preparing 2-n-propyl-4-methyl-6-(1-methyl benzimidazole-2-yl) benzimidazole
JP6210599B2 (en) * 2014-02-26 2017-10-11 株式会社トクヤマ Process for producing 4-methyl-6 (1-methylbenzimidazol-2-yl) -2-n-propyl-1H-benzimidazole
CN104974096B (en) * 2015-07-07 2019-02-01 威海迪素制药有限公司 A kind of preparation method of telmisartan intermediate
CN107434786B (en) * 2016-05-27 2025-11-18 广东东阳光药业股份有限公司 Benzimidazole compound and process for producing the same
AU2018366253B2 (en) 2017-11-13 2024-05-02 Ecolab Usa Inc. A novel one-pot homogeneous process for the large scale manufacture of 2-substituted benzimidazoles
CN111808027A (en) * 2020-05-25 2020-10-23 重庆康刻尔制药有限公司 Purification method of telmisartan intermediate
CN114605333A (en) * 2020-12-04 2022-06-10 浙江华海药业股份有限公司 Method for preparing telmisartan intermediate
CN115466222B (en) * 2022-07-28 2024-06-04 江苏中邦制药有限公司 Preparation method of telmisartan intermediate

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1225318B (en) * 1959-09-05 1966-09-22 Bayer Ag Process for the production of azo dyes and their metal complex compounds
DE19917524C2 (en) 1999-04-17 2001-09-20 Boehringer Ingelheim Pharma Process for the nitration of aniline derivatives

Also Published As

Publication number Publication date
EP1470111B1 (en) 2010-04-28
ES2341235T3 (en) 2010-06-17
CA2471730A1 (en) 2003-07-24
JP2005529064A (en) 2005-09-29
WO2003059890A1 (en) 2003-07-24
JP2010241839A (en) 2010-10-28
HK1073844A1 (en) 2005-10-21
EP2199286A1 (en) 2010-06-23
CN100436426C (en) 2008-11-26
CN1620437A (en) 2005-05-25
EP1470111A1 (en) 2004-10-27
JP5129918B2 (en) 2013-01-30
ATE465998T1 (en) 2010-05-15
CA2471730C (en) 2011-03-29
DE10201725A1 (en) 2003-08-14
DE50312660D1 (en) 2010-06-10

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase