AU2003223619A1 - Antiviral phosphorothioate oligonucleotides - Google Patents

Antiviral phosphorothioate oligonucleotides

Info

Publication number: AU2003223619A1
Authority: AU; Australia
Prior art keywords: antiviral; phosphorothioate oligonucleotides; phosphorothioate; oligonucleotides; antiviral phosphorothioate
Prior art date: 2002-05-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU2003223619A

Inventor

Zhidong Chen

Richard Koehn

Dinesh Patel

Duane Ruffner

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Salus Therapeutics Inc

Original Assignee

Salus Therapeutics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-05-13

Filing date

2003-04-16

Publication date

2003-12-02

2003-04-16 Application filed by Salus Therapeutics Inc filed Critical Salus Therapeutics Inc

2003-12-02 Publication of AU2003223619A1 publication Critical patent/AU2003223619A1/en

Status Abandoned legal-status Critical Current

Links

108091034117 Oligonucleotide Proteins 0.000 title 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
230000000840 anti-viral effect Effects 0.000 title 1
RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
- C12N15/1132—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses against retroviridae, e.g. HIV
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Virology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
AIDS & HIV (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AU2003223619A 2002-05-13 2003-04-16 Antiviral phosphorothioate oligonucleotides Abandoned AU2003223619A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US14436002A	2002-05-13	2002-05-13
US10/144,360		2002-05-13
PCT/US2003/011593 WO2003097661A2 (en)	2002-05-13	2003-04-16	Antiviral phosphorothioate oligonucleotides

Publications (1)

Publication Number	Publication Date
AU2003223619A1 true AU2003223619A1 (en)	2003-12-02

Family

ID=29548252

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU2003223619A Abandoned AU2003223619A1 (en)	2002-05-13	2003-04-16	Antiviral phosphorothioate oligonucleotides

Country Status (2)

Country	Link
AU (1)	AU2003223619A1 (en)
WO (1)	WO2003097661A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BR0314236A (en)	2002-09-13	2005-08-09	Replicor Inc	Oligonucleotide formulation, pharmaceutical composition, kit, antiviral compound, preparation of oligonucleotide and methods for selection of an antiviral oligonucleotide for use as an antiviral agent, for prophylaxis or treatment of a viral infection in a patient, for prophylactic treatment of cancer caused by oncoviruses. for identifying a compound that alters the binding of an oligonucleotide to at least one viral component, for purifying oligonucleotide binding to at least one viral component and for enriching oligonucleotides from an oligonucleotide cluster

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5276019A (en) *	1987-03-25	1994-01-04	The United States Of America As Represented By The Department Of Health And Human Services	Inhibitors for replication of retroviruses and for the expression of oncogene products

2003
- 2003-04-16 AU AU2003223619A patent/AU2003223619A1/en not_active Abandoned
- 2003-04-16 WO PCT/US2003/011593 patent/WO2003097661A2/en not_active Ceased

Also Published As

Publication number	Publication date
WO2003097661A3 (en)	2004-05-13
WO2003097661A2 (en)	2003-11-27

Publication	Publication Date	Title
AU2003237249A1 (en)	2003-12-12	Oligonucleotides having modified nucleoside units
AU2003241621A1 (en)	2003-12-12	Oligonucleotides having modified nucleoside units
AU2003295539A1 (en)	2004-06-15	Allele-targeted rna interference
AU2003295387A1 (en)	2004-06-03	Modified oligonucleotides for use in rna interference
EP1575980A4 (en)	2007-10-17	Rna interference
AU2002351077A1 (en)	2003-05-19	Oligonucleotides modified with novel alpha-l-rna analogues
AU2002313559A1 (en)	2003-03-10	Genes
AU2002358463A1 (en)	2003-06-30	Oligonucleotide analogues comprising intercalator pseudonucleotides
AU2003278857A1 (en)	2004-04-19	Oligonucleotide conjugates
GB0219143D0 (en)	2002-09-25	Modified tailed oligonucleotides
AU2003268055A1 (en)	2004-02-23	Distributed computations
AU2002350631A1 (en)	2003-05-06	Phosphorothioate-modified oligonucleotide as anti-restenosis agent
AU2002257446A1 (en)	2002-12-03	Antiviral nucleosides
AU2003242678A1 (en)	2003-12-31	Antisense oligonucleotides against pim1
AU2003281867A1 (en)	2004-02-23	Antisense nucleic acids
AU2003223619A1 (en)	2003-12-02	Antiviral phosphorothioate oligonucleotides
AU2003286495A1 (en)	2004-05-04	Rna-based inhibitory oligonucleotides
AU2003294705A8 (en)	2004-06-07	Ntsm gene
IL157805A0 (en)	2004-03-28	Immobilized oligonucleotides
AU2003241182A1 (en)	2003-12-22	Stat6 activation gene
AU2003267384A1 (en)	2004-04-19	Bhyd gene
AU2003238501A1 (en)	2003-12-31	Hybridization chamber
AUPR282501A0 (en)	2001-02-22	Expression facilitating nucleotides
AU2003241762A1 (en)	2004-02-25	Dna shuflling
ZA200502005B (en)	2006-05-31	Non-sequence complementary antiviral oligonucleotides

Legal Events

Date	Code	Title	Description
2005-01-27	MK6	Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase