AU2003219947A1 - Compositions and methods for hydroxylating epothilones - Google Patents
Compositions and methods for hydroxylating epothilonesInfo
- Publication number
- AU2003219947A1 AU2003219947A1 AU2003219947A AU2003219947A AU2003219947A1 AU 2003219947 A1 AU2003219947 A1 AU 2003219947A1 AU 2003219947 A AU2003219947 A AU 2003219947A AU 2003219947 A AU2003219947 A AU 2003219947A AU 2003219947 A1 AU2003219947 A1 AU 2003219947A1
- Authority
- AU
- Australia
- Prior art keywords
- hydroxylating
- epothilones
- compositions
- methods
- hydroxylating epothilones
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 229930013356 epothilone Natural products 0.000 title 1
- HESCAJZNRMSMJG-KKQRBIROSA-N epothilone A Chemical class C/C([C@@H]1C[C@@H]2O[C@@H]2CCC[C@@H]([C@@H]([C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)O)C)=C\C1=CSC(C)=N1 HESCAJZNRMSMJG-KKQRBIROSA-N 0.000 title 1
- 230000000640 hydroxylating effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2003/006108 WO2004078978A1 (en) | 2003-02-26 | 2003-02-26 | Compositions and methods for hydroxylating epothilones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2003219947A1 true AU2003219947A1 (en) | 2004-09-28 |
Family
ID=32961093
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003219947A Abandoned AU2003219947A1 (en) | 2003-02-26 | 2003-02-26 | Compositions and methods for hydroxylating epothilones |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU2003219947A1 (en) |
| WO (1) | WO2004078978A1 (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| ATE450534T1 (en) | 2002-08-23 | 2009-12-15 | Sloan Kettering Inst Cancer | SYNTHESIS OF EPOTHILONES, INTERMEDIATE PRODUCTS THEREOF, ANALOGUE AND USE THEREOF |
| DK2094841T3 (en) * | 2006-12-13 | 2012-05-29 | Dsm Sinochem Pharm Nl Bv | Process for the preparation of pravastatin |
| JP5881254B2 (en) | 2010-05-18 | 2016-03-09 | セルリアン・ファーマ・インコーポレイテッド | Compositions and methods for the treatment of autoimmune and other diseases |
| JP7142813B2 (en) * | 2016-11-15 | 2022-09-28 | ハイファ ディスカバリー リミテッド | Hydroxylation of Branched Aliphatic or Aromatic Substrates Using Cytochrome P450s from Amycolatopsis lurida |
| GB201807815D0 (en) * | 2018-05-14 | 2018-06-27 | Hypha Discovery Ltd | Hydroxylation techniques |
| GB201819209D0 (en) | 2018-11-26 | 2019-01-09 | Hypha Discovery Ltd | Biocatalytic techniques |
| GB201917077D0 (en) | 2019-11-22 | 2020-01-08 | Hypha Discovery Ltd | Biocatalytic techniques |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6211412B1 (en) * | 1999-03-29 | 2001-04-03 | The University Of Kansas | Synthesis of epothilones |
| US6294374B1 (en) * | 1999-10-08 | 2001-09-25 | The Scripps Research Institute | Use of catalytic antibodies for synthesizing epothilone |
-
2003
- 2003-02-26 WO PCT/US2003/006108 patent/WO2004078978A1/en not_active Ceased
- 2003-02-26 AU AU2003219947A patent/AU2003219947A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004078978A1 (en) | 2004-09-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |