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AU2003267581A1 - Drug delivery - Google Patents

Drug delivery

Info

Publication number
AU2003267581A1
AU2003267581A1 AU2003267581A AU2003267581A AU2003267581A1 AU 2003267581 A1 AU2003267581 A1 AU 2003267581A1 AU 2003267581 A AU2003267581 A AU 2003267581A AU 2003267581 A AU2003267581 A AU 2003267581A AU 2003267581 A1 AU2003267581 A1 AU 2003267581A1
Authority
AU
Australia
Prior art keywords
drug delivery
relates
delivery
drugs
solubilising
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003267581A
Other versions
AU2003267581A8 (en
Inventor
Woei Ping Cheng
Andreas Schatzlein
Ijeoma Uchegbu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Glasgow
University of Strathclyde
Original Assignee
University of Strathclyde
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Strathclyde filed Critical University of Strathclyde
Publication of AU2003267581A8 publication Critical patent/AU2003267581A8/en
Publication of AU2003267581A1 publication Critical patent/AU2003267581A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0206—Polyalkylene(poly)amines
    • C08G73/0213—Preparatory process
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0206—Polyalkylene(poly)amines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0206—Polyalkylene(poly)amines
    • C08G73/0213—Preparatory process
    • C08G73/0226—Quaternisation of polyalkylene(poly)amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

This invention relates to the delivery of drugs. In particular, this invention relates to the oral delivery of poorly soluble drugs using novel amphiphilic polymers with both solubilising and absorption enhancing properties.
AU2003267581A 2002-09-20 2003-09-22 Drug delivery Abandoned AU2003267581A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0221942.6 2002-09-20
GBGB0221942.6A GB0221942D0 (en) 2002-09-20 2002-09-20 Drug delivery
PCT/GB2003/004036 WO2004026941A1 (en) 2002-09-20 2003-09-22 Drug delivery

Publications (2)

Publication Number Publication Date
AU2003267581A8 AU2003267581A8 (en) 2004-04-08
AU2003267581A1 true AU2003267581A1 (en) 2004-04-08

Family

ID=9944516

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003267581A Abandoned AU2003267581A1 (en) 2002-09-20 2003-09-22 Drug delivery

Country Status (11)

Country Link
US (1) US20060148982A1 (en)
EP (1) EP1543063B1 (en)
JP (1) JP2006500437A (en)
AT (1) ATE426635T1 (en)
AU (1) AU2003267581A1 (en)
CA (1) CA2499681A1 (en)
DE (1) DE60326859D1 (en)
DK (1) DK1543063T3 (en)
GB (1) GB0221942D0 (en)
SI (1) SI1543063T1 (en)
WO (1) WO2004026941A1 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0422877D0 (en) * 2004-10-14 2004-11-17 Univ Glasgow Bioactive polymers
US8057821B2 (en) * 2004-11-03 2011-11-15 Egen, Inc. Biodegradable cross-linked cationic multi-block copolymers for gene delivery and methods of making thereof
CN101400730B (en) 2006-01-19 2012-10-17 阿列克斯塞尔公司 Solubilization and targeted delivery of drugs with self-assembling amphiphilic polymers
JP2009524719A (en) * 2006-01-27 2009-07-02 チバ ホールディング インコーポレーテッド Polymeric antibacterial agent
US20090263346A1 (en) * 2006-12-05 2009-10-22 David Taft Systems and methods for delivery of drugs
US20090246155A1 (en) * 2006-12-05 2009-10-01 Landec Corporation Compositions and methods for personal care
US8956602B2 (en) * 2006-12-05 2015-02-17 Landec, Inc. Delivery of drugs
US8399007B2 (en) * 2006-12-05 2013-03-19 Landec Corporation Method for formulating a controlled-release pharmaceutical formulation
US20100004124A1 (en) * 2006-12-05 2010-01-07 David Taft Systems and methods for delivery of materials for agriculture and aquaculture
US20100017973A1 (en) * 2006-12-22 2010-01-28 Basf Se Hydrophobically modified polyalkylenimines for use as dye transfer inhibitors
KR101470679B1 (en) * 2007-07-19 2014-12-08 올엑셀, 인크. Self-assembling amphiphilic polymers as anticancer agents
US8114883B2 (en) * 2007-12-04 2012-02-14 Landec Corporation Polymer formulations for delivery of bioactive materials
FR2928373B1 (en) 2008-03-05 2010-12-31 Centre Nat Rech Scient LINEAR POLYETHYLENIMINE DERIVATIVE POLYMER FOR GENE TRANSFER.
GB0903559D0 (en) 2009-03-02 2009-04-08 Univ London Pharmacy Oral delivery of hydrophilic drugs to the brain
SG175373A1 (en) 2009-04-28 2011-11-28 Surmodics Inc Devices and methods for delivery of bioactive agents
GB0915449D0 (en) 2009-09-04 2009-10-07 Univ Robert Gordon Composition
CA3000077A1 (en) 2010-04-28 2011-11-10 University Of Georgia Research Foundation, Inc. Photochemical cross-linkable polymers, methods of making photochemical cross-linkable polymers, methods of using photochemical cross-linkable polymers, and methods of making articles containing photochemical cross-linkable polymers
US8721936B2 (en) 2011-04-21 2014-05-13 University Of Georgia Research Foundation, Inc. Devices and methods for forming non-spherical particles
US10213529B2 (en) 2011-05-20 2019-02-26 Surmodics, Inc. Delivery of coated hydrophobic active agent particles
US9861727B2 (en) 2011-05-20 2018-01-09 Surmodics, Inc. Delivery of hydrophobic active agent particles
CA2841000C (en) 2011-07-15 2020-02-25 University Of Georgia Research Foundation, Inc. Permanent attachment of agents to surfaces containing c-h functionality
WO2013019918A2 (en) 2011-08-04 2013-02-07 The University Of Georgia Research Foundation, Inc. Permanent attachment of ammonium and guanidine-based antimicrobials to surfaces containing-oh functionality
WO2013056007A2 (en) 2011-10-14 2013-04-18 University Of Georgia Research Foundation, Inc. Photochemical cross-linkable polymers, methods of making photochemical cross-linkable plolymers, methods of using photochemical cross-linkable poloymers, and methods of making articles containing photochemical cross-linkable polymers
CA2890205C (en) 2012-11-05 2020-12-22 Surmodics, Inc. Composition and method for delivery of hydrophobic active agents
US11246963B2 (en) 2012-11-05 2022-02-15 Surmodics, Inc. Compositions and methods for delivery of hydrophobic active agents
US10898446B2 (en) 2016-12-20 2021-01-26 Surmodics, Inc. Delivery of hydrophobic active agents from hydrophilic polyether block amide copolymer surfaces
US12226552B2 (en) 2019-09-30 2025-02-18 Surmodics, Inc. Active agent depots formed in situ

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5879022A (en) * 1981-11-04 1983-05-12 Bitamin Kenkyusho:Kk Novel metal-crosslinked polymer compound containing quaternary nitrogen atom, its preparation, and remedy for hyperlipemia containing said polymer compound as active component
US5338532A (en) * 1986-08-18 1994-08-16 The Dow Chemical Company Starburst conjugates
US5681543A (en) * 1988-02-29 1997-10-28 Shering Aktiengesellschaft Polymer-bonded complexing agents and pharmaceutical agents containing them for MRI
JPH01236240A (en) * 1989-01-14 1989-09-21 Miyoshi Oil & Fat Co Ltd Novel polymer compound
DE3901527A1 (en) * 1989-01-20 1990-07-26 Hoechst Ag ALKYLATED POLYETHYLENE IMIN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS MEDICINAL PRODUCTS AND PHARMACEUTICAL PREPARATIONS
JP3406970B2 (en) * 1993-12-27 2003-05-19 ミヨシ油脂株式会社 Amphoteric surfactant
JP3526661B2 (en) * 1995-06-23 2004-05-17 ミヨシ油脂株式会社 Antibacterial agent, antibacterial resin and antibacterial paint
JPH11514024A (en) * 1996-06-19 1999-11-30 ザ、プロクター、エンド、ギャンブル、カンパニー Method for removing odor from modified polyamine
WO1999043752A1 (en) * 1998-02-27 1999-09-02 Dnavec Research Inc. Compositions for transporting negatively charged substances
JP3523821B2 (en) * 2000-02-09 2004-04-26 ナノキャリア株式会社 Method for producing polymer micelle in which drug is encapsulated and polymer micelle composition
US6696038B1 (en) * 2000-09-14 2004-02-24 Expression Genetics, Inc. Cationic lipopolymer as biocompatible gene delivery agent
CN1479632A (en) * 2000-10-09 2004-03-03 拜尔公司 Complexes for the introduction of nucleic acids into cells
DE10065710A1 (en) * 2000-12-29 2002-07-04 Bayer Ag Medicament containing a polyamine as an active substance
GB0221941D0 (en) * 2002-09-20 2002-10-30 Univ Strathclyde Polysoaps

Also Published As

Publication number Publication date
EP1543063B1 (en) 2009-03-25
SI1543063T1 (en) 2009-08-31
DE60326859D1 (en) 2009-05-07
US20060148982A1 (en) 2006-07-06
GB0221942D0 (en) 2002-10-30
EP1543063A1 (en) 2005-06-22
ATE426635T1 (en) 2009-04-15
WO2004026941A1 (en) 2004-04-01
CA2499681A1 (en) 2004-04-01
AU2003267581A8 (en) 2004-04-08
DK1543063T3 (en) 2009-05-18
JP2006500437A (en) 2006-01-05

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase