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AU2003263301A8 - Alternative processes for the preparation of d- (+) -morphine, and d- (+) - morphine tartrate - Google Patents

Alternative processes for the preparation of d- (+) -morphine, and d- (+) - morphine tartrate

Info

Publication number
AU2003263301A8
AU2003263301A8 AU2003263301A AU2003263301A AU2003263301A8 AU 2003263301 A8 AU2003263301 A8 AU 2003263301A8 AU 2003263301 A AU2003263301 A AU 2003263301A AU 2003263301 A AU2003263301 A AU 2003263301A AU 2003263301 A8 AU2003263301 A8 AU 2003263301A8
Authority
AU
Australia
Prior art keywords
morphine
preparation
tartrate
alternative processes
alternative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003263301A
Other versions
AU2003263301A1 (en
Inventor
John Whittall
Paul Mather
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stylacats Ltd
Original Assignee
Stylacats Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stylacats Ltd filed Critical Stylacats Ltd
Publication of AU2003263301A8 publication Critical patent/AU2003263301A8/en
Publication of AU2003263301A1 publication Critical patent/AU2003263301A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2003263301A 2002-09-03 2003-09-03 Alternative processes for the preparation of d- (+) -morphine, and d- (+) - morphine tartrate Abandoned AU2003263301A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0220385A GB2392670A (en) 2002-09-03 2002-09-03 (+)-Morphine production
GB0220385.9 2002-09-03
PCT/GB2003/003805 WO2004022564A2 (en) 2002-09-03 2003-09-03 Alternative processes for the preparation of d- (+) -morphine, and d- (+) - morphine tartrate

Publications (2)

Publication Number Publication Date
AU2003263301A8 true AU2003263301A8 (en) 2004-03-29
AU2003263301A1 AU2003263301A1 (en) 2004-03-29

Family

ID=9943367

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003263301A Abandoned AU2003263301A1 (en) 2002-09-03 2003-09-03 Alternative processes for the preparation of d- (+) -morphine, and d- (+) - morphine tartrate

Country Status (3)

Country Link
AU (1) AU2003263301A1 (en)
GB (1) GB2392670A (en)
WO (1) WO2004022564A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2357216T3 (en) 2005-06-16 2011-04-20 Mallinckrodt, Inc. A SYNTHESIS ROUTE OF 14-HYDROXYL-OPIACES THROUGH 1-HALO-THEBAINE OR ANALOGS.
AU2008276385B2 (en) * 2007-07-17 2013-07-18 SpecGx LLC Preparation of N-alkylated opiates by reductive amination
US8252928B2 (en) 2008-09-16 2012-08-28 Mallinckrodt LLC. Processes for the synthesis of five and six membered heterocyclic rings
AU2009322622B2 (en) * 2008-12-02 2015-03-12 Mallinckrodt Llc Process for preparing hydrocodone using a super acid
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
JP2012518652A (en) * 2009-02-23 2012-08-16 マリンクロッド インコーポレイテッド (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
EP2398806A1 (en) * 2009-02-23 2011-12-28 Mallinckrodt LLC (+)-morphinanium n-oxides and processes for their production
US10363251B2 (en) 2009-07-16 2019-07-30 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
TR201809739T4 (en) * 2009-07-16 2018-07-23 Mallinckrodt Llc (+) - morphinans as toll-like receptor 9 antagonists and their therapeutic use.
ES2728701T3 (en) 2010-07-16 2019-10-28 Mallinckrodt Llc (+) - Morphinans as antagonists of the Toll-type receptor 9 and therapeutic applications thereof
CN104672142B (en) * 2015-02-13 2017-08-04 江苏大学 Preparation and medical application of binary structure sinomenine derivatives
CN109666030B (en) * 2018-11-19 2021-04-27 兰州大学 A method for catalyzing asymmetric synthesis of codeine and morphine
JP2023518875A (en) * 2020-03-24 2023-05-08 ユニバーシティ オブ パドヴァ Morphinan isomers and their structural modifications as NMDAR antagonists and neuroplastogens

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1495271A (en) * 1974-04-10 1977-12-14 Macfarlan Smith Ltd Dehydrohalogenation of codeinone derivatives
CA2063607C (en) * 1989-08-17 2001-08-07 Patricia A. Broderick Microelectrodes and their use in cathodic electrochemical current arrangement with telemetric application

Also Published As

Publication number Publication date
WO2004022564A2 (en) 2004-03-18
WO2004022564A3 (en) 2004-07-01
GB2392670A (en) 2004-03-10
GB0220385D0 (en) 2002-10-09
AU2003263301A1 (en) 2004-03-29

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase