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AU2003250014A1 - Method for producing substituted thiazol-2-yl methyl esters - Google Patents

Method for producing substituted thiazol-2-yl methyl esters

Info

Publication number
AU2003250014A1
AU2003250014A1 AU2003250014A AU2003250014A AU2003250014A1 AU 2003250014 A1 AU2003250014 A1 AU 2003250014A1 AU 2003250014 A AU2003250014 A AU 2003250014A AU 2003250014 A AU2003250014 A AU 2003250014A AU 2003250014 A1 AU2003250014 A1 AU 2003250014A1
Authority
AU
Australia
Prior art keywords
methyl esters
producing substituted
substituted thiazol
thiazol
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003250014A
Inventor
Barbara Beck
Alexander Doemling
Bernd Henkel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Morphochem GmbH
Original Assignee
Morphochem AG fuer Kombinatorische Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphochem AG fuer Kombinatorische Chemie filed Critical Morphochem AG fuer Kombinatorische Chemie
Publication of AU2003250014A1 publication Critical patent/AU2003250014A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2003250014A 2002-07-09 2003-07-09 Method for producing substituted thiazol-2-yl methyl esters Abandoned AU2003250014A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10230872.1 2002-07-09
DE2002130872 DE10230872A1 (en) 2002-07-09 2002-07-09 Process for the preparation of substituted thiazol-2-ylmethyl esters
PCT/EP2003/007414 WO2004005269A1 (en) 2002-07-09 2003-07-09 Method for producing substituted thiazol-2-yl methyl esters

Publications (1)

Publication Number Publication Date
AU2003250014A1 true AU2003250014A1 (en) 2004-01-23

Family

ID=29761787

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003250014A Abandoned AU2003250014A1 (en) 2002-07-09 2003-07-09 Method for producing substituted thiazol-2-yl methyl esters

Country Status (3)

Country Link
AU (1) AU2003250014A1 (en)
DE (1) DE10230872A1 (en)
WO (1) WO2004005269A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2409983A1 (en) 2010-07-19 2012-01-25 Leibniz-Institut für Pflanzenbiochemie (IPB) Tubulysin analogues
TWI603741B (en) 2011-06-10 2017-11-01 梅爾莎納醫療公司 Protein-polymer-drug conjugates
PL2872157T3 (en) 2012-07-12 2020-07-13 Hangzhou Dac Biotech Co., Ltd Conjugates of cell binding molecules with cytotoxic agents
CA2891280C (en) 2012-11-24 2018-03-20 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
WO2014093394A1 (en) 2012-12-10 2014-06-19 Mersana Therapeutics, Inc. Protein-polymer-drug conjugates
WO2014093640A1 (en) 2012-12-12 2014-06-19 Mersana Therapeutics,Inc. Hydroxy-polmer-drug-protein conjugates
CN103333133B (en) * 2013-06-13 2016-06-08 西北师范大学 The synthetic method of a kind of Tubulysin family compound key intermediate TUV
US10464955B2 (en) 2014-02-28 2019-11-05 Hangzhou Dac Biotech Co., Ltd. Charged linkers and their uses for conjugation
EP4678240A2 (en) 2015-07-12 2026-01-14 Hangzhou Dac Biotech Co., Ltd. Bridge linkers for conjugation of cell-binding molecules
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
US11793880B2 (en) 2015-12-04 2023-10-24 Seagen Inc. Conjugates of quaternized tubulysin compounds
CN108367043A (en) 2015-12-04 2018-08-03 西雅图基因公司 The conjugate of quaternized tubulysin compound
MX2019005583A (en) 2016-11-14 2019-10-21 Hangzhou Dac Biotech Co Ltd Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers.
JP2020533308A (en) * 2017-09-08 2020-11-19 シアトル ジェネティックス， インコーポレイテッド Process for the preparation of tube ricin and their intermediates
CN109912683B (en) * 2017-12-13 2023-01-06 杭州多禧生物科技有限公司 Cytotoxin molecule, conjugate, preparation method and application thereof
US20230025327A1 (en) 2019-06-29 2023-01-26 Hangzhou Dac Biotech Co., Ltd. Conjugates of tubulysin derivatives and cell binding molecules and methods of making
EP4426727A2 (en) 2021-11-03 2024-09-11 Hangzhou Dac Biotech Co., Ltd. Specific conjugation of an antibody

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10162134A1 (en) * 2001-12-18 2003-07-10 Morphochem Ag Ag Fuer Kombinat Resin-bound isonitriles

Also Published As

Publication number Publication date
DE10230872A1 (en) 2004-01-22
WO2004005269A1 (en) 2004-01-15

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase