AU2003249812A1 - Dihydrouracil compounds as anti-ictogenic or anti-epileptogenic agents - Google Patents
Dihydrouracil compounds as anti-ictogenic or anti-epileptogenic agentsInfo
- Publication number
- AU2003249812A1 AU2003249812A1 AU2003249812A AU2003249812A AU2003249812A1 AU 2003249812 A1 AU2003249812 A1 AU 2003249812A1 AU 2003249812 A AU2003249812 A AU 2003249812A AU 2003249812 A AU2003249812 A AU 2003249812A AU 2003249812 A1 AU2003249812 A1 AU 2003249812A1
- Authority
- AU
- Australia
- Prior art keywords
- ictogenic
- dihydrouracil
- compounds
- epileptogenic agents
- epileptogenic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- OIVLITBTBDPEFK-UHFFFAOYSA-N 5,6-dihydrouracil Chemical class O=C1CCNC(=O)N1 OIVLITBTBDPEFK-UHFFFAOYSA-N 0.000 title 1
- 230000002059 anti-epileptogenic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39715702P | 2002-07-18 | 2002-07-18 | |
| US60/397,157 | 2002-07-18 | ||
| PCT/CA2003/001082 WO2004009559A2 (en) | 2002-07-18 | 2003-07-18 | Dihydrouracil compounds as anti-ictogenic or anti-epileptogenic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2003249812A8 AU2003249812A8 (en) | 2004-02-09 |
| AU2003249812A1 true AU2003249812A1 (en) | 2004-02-09 |
Family
ID=30771012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003249812A Abandoned AU2003249812A1 (en) | 2002-07-18 | 2003-07-18 | Dihydrouracil compounds as anti-ictogenic or anti-epileptogenic agents |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU2003249812A1 (en) |
| WO (1) | WO2004009559A2 (en) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8835426B2 (en) | 2007-02-26 | 2014-09-16 | Vitae Pharmaceuticals, Inc. | Cyclic urea and carbamate inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| CL2008002199A1 (en) | 2007-07-26 | 2009-10-23 | Vitae Pharmaceuticals Inc | Compounds derived from 1,3-oxazin-2-one; pharmaceutical composition comprising said compounds; and use to treat a disease associated with the activity of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-hsd1) such as dyslipidemia, hyperlipidemia, hypertension, obesity and cardiovascular disease, among others. |
| AR069207A1 (en) | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | CYCLIC UREAS AS INHIBITORS OF THE 11 BETA - HIDROXI-ESTEROIDE DESHIDROGENASA 1 |
| CA2708303A1 (en) | 2007-12-11 | 2009-06-18 | Vitae Pharmaceuticals, Inc. | Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
| TW200934490A (en) | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
| US8592409B2 (en) | 2008-01-24 | 2013-11-26 | Vitae Pharmaceuticals, Inc. | Cyclic carbazate and semicarbazide inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| EP2252598A2 (en) | 2008-02-11 | 2010-11-24 | Vitae Pharmaceuticals, Inc. | 1,3-oxazepan-2-one and 1,3-diazepan-2-one inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| CA2715290A1 (en) | 2008-02-15 | 2009-08-20 | Vitae Pharmaceuticals, Inc. | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| JP5538365B2 (en) | 2008-05-01 | 2014-07-02 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | Cyclic inhibitor of 11β-hydroxysteroid dehydrogenase 1 |
| US8242111B2 (en) | 2008-05-01 | 2012-08-14 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| TW200946520A (en) | 2008-05-01 | 2009-11-16 | Vitae Pharmaceuticals Inc | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| EP2291371B1 (en) | 2008-05-01 | 2015-06-10 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| CN104327062A (en) | 2008-07-25 | 2015-02-04 | 贝林格尔·英格海姆国际有限公司 | Cyclic Inhibitors of 11Beta-Hydroxysteroid Dehydrogenase 1 |
| EP2324017B1 (en) | 2008-07-25 | 2014-12-31 | Boehringer Ingelheim International GmbH | INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1 |
| US8637505B2 (en) | 2009-02-04 | 2014-01-28 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| US8680093B2 (en) | 2009-04-30 | 2014-03-25 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| US8927539B2 (en) | 2009-06-11 | 2015-01-06 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure |
| US8883778B2 (en) | 2009-07-01 | 2014-11-11 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1 |
| US8933072B2 (en) | 2010-06-16 | 2015-01-13 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
| EP2585444B1 (en) | 2010-06-25 | 2014-10-22 | Boehringer Ingelheim International GmbH | Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders |
| CA2813671A1 (en) | 2010-11-02 | 2012-05-10 | Boehringer Ingelheim International Gmbh | Pharmaceutical combinations for the treatment of metabolic disorders |
| JP6450323B2 (en) | 2013-01-07 | 2019-01-09 | ユニバーシティ オブ サザン カリフォルニア | Deoxyuridine triphosphatase inhibitor |
| US10570100B2 (en) | 2015-07-08 | 2020-02-25 | University Of Southern California | Deoxyuridine triphosphatase inhibitors containing amino sulfonyl linkage |
| DK3319939T3 (en) | 2015-07-08 | 2025-02-24 | Cv6 Therapeutics Ni Ltd | HYDANTOIN-CONTAINING DEOXYURIDINE TRIPHOSPHATASE INHIBITORS |
| US10544105B2 (en) | 2015-07-08 | 2020-01-28 | Cv6 Therapeutics (Ni) Limited | Deoxyuridine triphosphatase inhibitors containing cyclopropano linkage |
| US10577321B2 (en) | 2015-07-08 | 2020-03-03 | University Of Southern California | Deoxyuridine triphosphatase inhibitors |
| US11014924B2 (en) | 2016-11-23 | 2021-05-25 | Cv6 Therapeutics (Ni) Limited | Hydantoin containing deoxyuridine triphosphatase inhibitors |
| WO2018098209A1 (en) | 2016-11-23 | 2018-05-31 | Cv6 Therapeutics (Ni) Limited | Amino sulfonyl compounds |
| US10858344B2 (en) | 2016-11-23 | 2020-12-08 | Cv6 Therapeutics (Ni) Limited | Hydantoin containing deoxyuridine triphosphatase inhibitors |
| US11174271B2 (en) | 2016-11-23 | 2021-11-16 | Cv6 Therapeutics (Ni) Limited | 6-membered uracil isosteres |
| US10829457B2 (en) | 2016-11-23 | 2020-11-10 | Cv6 Therapeutics (Ni) Limited | Nitrogen ring linked deoxyuridine triphosphatase inhibitors |
| WO2018128720A1 (en) * | 2017-01-05 | 2018-07-12 | Cv6 Therapeutics (Ni) Limited | Uracil containing compounds |
| WO2018220762A1 (en) * | 2017-05-31 | 2018-12-06 | 大塚製薬株式会社 | Pyrimidine compound |
| JP7539377B2 (en) | 2018-11-30 | 2024-08-23 | 大塚製薬株式会社 | Heterocyclic compounds for treating epilepsy |
| JP6870064B2 (en) * | 2018-11-30 | 2021-05-12 | 大塚製薬株式会社 | Pharmaceutical use of pyrimidine compounds |
| CN120965524B (en) * | 2025-10-21 | 2026-01-09 | 四川大学 | (N, N-dimethylamino) formic acid-4, 5-dimethoxy-2- [ (1E) -3-methoxy-propenyl ] phenyl ester compound and preparation method and application thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60243017A (en) * | 1984-05-16 | 1985-12-03 | Kyowa Hakko Kogyo Co Ltd | anticonvulsant composition |
| JPS61236724A (en) * | 1985-04-13 | 1986-10-22 | Kyowa Hakko Kogyo Co Ltd | Antispasmodic composition |
| WO2002083651A2 (en) * | 2001-04-11 | 2002-10-24 | Queen's University At Kingston | Pyrimidine compounds as anti-ictogenic and/or anti-epileptogenic agents |
-
2003
- 2003-07-18 AU AU2003249812A patent/AU2003249812A1/en not_active Abandoned
- 2003-07-18 WO PCT/CA2003/001082 patent/WO2004009559A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003249812A8 (en) | 2004-02-09 |
| WO2004009559A2 (en) | 2004-01-29 |
| WO2004009559A3 (en) | 2004-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |