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AU2003245752A1 - Process for promoting graft acceptance by depletion of hematopoietic stem cells - Google Patents

Process for promoting graft acceptance by depletion of hematopoietic stem cells

Info

Publication number
AU2003245752A1
AU2003245752A1 AU2003245752A AU2003245752A AU2003245752A1 AU 2003245752 A1 AU2003245752 A1 AU 2003245752A1 AU 2003245752 A AU2003245752 A AU 2003245752A AU 2003245752 A AU2003245752 A AU 2003245752A AU 2003245752 A1 AU2003245752 A1 AU 2003245752A1
Authority
AU
Australia
Prior art keywords
depletion
stem cells
hematopoietic stem
graft acceptance
promoting graft
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003245752A
Other versions
AU2003245752A8 (en
Inventor
Julian D. Down
Mary E. White-Scharf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biotransplant Inc
Original Assignee
BIO TRANSPLANT Inc
Biotransplant Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BIO TRANSPLANT Inc, Biotransplant Inc filed Critical BIO TRANSPLANT Inc
Publication of AU2003245752A8 publication Critical patent/AU2003245752A8/en
Publication of AU2003245752A1 publication Critical patent/AU2003245752A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2003245752A 2002-06-28 2003-06-27 Process for promoting graft acceptance by depletion of hematopoietic stem cells Abandoned AU2003245752A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US39259002P 2002-06-28 2002-06-28
US60/392,590 2002-06-28
US35770603A 2003-02-04 2003-02-04
US10/357,706 2003-02-04
PCT/US2003/020520 WO2004002425A2 (en) 2002-06-28 2003-06-27 Process for promoting graft acceptance by depletion of hematopoietic stem cells

Publications (2)

Publication Number Publication Date
AU2003245752A8 AU2003245752A8 (en) 2004-01-19
AU2003245752A1 true AU2003245752A1 (en) 2004-01-19

Family

ID=30002887

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003245752A Abandoned AU2003245752A1 (en) 2002-06-28 2003-06-27 Process for promoting graft acceptance by depletion of hematopoietic stem cells

Country Status (2)

Country Link
AU (1) AU2003245752A1 (en)
WO (1) WO2004002425A2 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE034583T2 (en) 2006-11-03 2018-02-28 Univ Leland Stanford Junior Selective immune depletion of endogenous stem cell for implantation
US9155708B2 (en) 2008-10-10 2015-10-13 Probelte Pharma, S.A. Orally administrable immunostimulant product for aquaculture
BRPI0923422A2 (en) * 2008-12-12 2016-06-21 Univ Tokyo immune reconstitution promoter or prophylactic agent for infections each of which maintains the graft-versus-tumor effect "
DK2668210T3 (en) 2011-01-26 2020-08-24 Celldex Therapeutics Inc ANTI-KIT ANTIBODIES AND USES THEREOF
WO2014018625A1 (en) 2012-07-25 2014-01-30 Kolltan Pharmaceuticals, Inc. Anti-kit antibodies and uses thereof
WO2015050959A1 (en) * 2013-10-01 2015-04-09 Yale University Anti-kit antibodies and methods of use thereof
CN113975386A (en) 2014-05-23 2022-01-28 塞尔德克斯医疗公司 Treatment of eosinophil or mast cell related disorders
EP3177294B1 (en) * 2014-08-07 2022-03-23 Laevoroc Immunology AG Compositions comprising a pnp inhibitor for use in the treatment of the relapse of malignancy following hematopoietic stem cell transplant
PT3656869T (en) 2014-08-26 2021-01-13 Univ Leland Stanford Junior Engraftment of stem cells with a combination of an agent that targets stem cells and modulation of immunoregulatory signaling
BR112017021536A2 (en) 2015-04-06 2018-07-03 President And Fellows Of Harvard College compositions and methods for nonmyeloablative conditioning
PL3341015T5 (en) 2015-08-26 2024-04-08 The Board Of Trustees Of The Leland Stanford Junior University Enhanced depletion of targeted cells with cd47 blockade and an immune costimulatory agonist
AU2017204125B1 (en) 2016-06-17 2017-10-26 Crispr Therapeutics Ag Compositions and methods for the depletion of cd117+ cells
JOP20190155A1 (en) * 2016-12-21 2019-06-23 Novartis Ag Antibody drug conjugates for ablating hematopoietic stem cells
IL267912B2 (en) 2017-01-30 2023-09-01 Univ Leland Stanford Junior A non-genotoxic conditioning regimen for stem cell transplantation
US12485186B2 (en) 2017-03-31 2025-12-02 The Children's Medical Center Corporation Antibody-mediated conditioning with immunosuppression to enable allogeneic transplantation
JP7642531B2 (en) 2018-05-11 2025-03-10 ビーム セラピューティクス インク． Methods for replacing pathogenic amino acids using a programmable base editor system
AR115571A1 (en) * 2018-06-20 2021-02-03 Novartis Ag DRUG ANTIBODY CONJUGATES FOR HEMATOPOIETIC STEM CELL ABLATION
EP3886869A4 (en) 2018-11-28 2022-07-06 Forty Seven, Inc. GENETICALLY MODIFIED CSPH RESISTANT TO ABLATIVE TREATMENT
WO2020219861A1 (en) * 2019-04-25 2020-10-29 Actinium Pharmaceuticals, Inc. Compositions and methods of immunodepletion for the treatment of malignant and non-malignant hematological diseases
EP4611807A1 (en) * 2022-11-04 2025-09-10 The Board of Trustees of the Leland Stanford Junior University Rebalancing the immune system through depletion of myeloid-biased hematopoietic stem cells

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE432080T1 (en) * 1996-08-16 2009-06-15 Biotransplant Inc LO-CD2A ANTIBODIES AND THEIR USE FOR INHIBITING T-CELL ACTIVATION AND PROLIFERATION
CA2385750A1 (en) * 1999-10-01 2001-04-12 Biotransplant Incorporated Process for inducing functional tolerance to gene transfer products
WO2001030369A1 (en) * 1999-10-22 2001-05-03 Biotransplant, Inc. Process for inducing immunological tolerance for xenogeneic transplants
WO2001087310A1 (en) * 2000-05-18 2001-11-22 Biotransplant, Inc. Process for reducing antibody response against xenografts
WO2002033043A2 (en) * 2000-10-18 2002-04-25 Coriell Institute For Medical Research Method and marker for the isolation of human multipotent hematopoietic stem cells

Also Published As

Publication number Publication date
AU2003245752A8 (en) 2004-01-19
WO2004002425A2 (en) 2004-01-08
WO2004002425A3 (en) 2004-08-26

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase