AU2003242860A8 - 2-aminopyrazine derivatives as inhibitors of cyclin dependent kinases for the treatment of proliferative disorders - Google Patents
2-aminopyrazine derivatives as inhibitors of cyclin dependent kinases for the treatment of proliferative disordersInfo
- Publication number
- AU2003242860A8 AU2003242860A8 AU2003242860A AU2003242860A AU2003242860A8 AU 2003242860 A8 AU2003242860 A8 AU 2003242860A8 AU 2003242860 A AU2003242860 A AU 2003242860A AU 2003242860 A AU2003242860 A AU 2003242860A AU 2003242860 A8 AU2003242860 A8 AU 2003242860A8
- Authority
- AU
- Australia
- Prior art keywords
- inhibitors
- treatment
- proliferative disorders
- cyclin dependent
- dependent kinases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108091007914 CDKs Proteins 0.000 title 1
- 102000003903 Cyclin-dependent kinases Human genes 0.000 title 1
- 108090000266 Cyclin-dependent kinases Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000002062 proliferating effect Effects 0.000 title 1
- XFTQRUTUGRCSGO-UHFFFAOYSA-N pyrazin-2-amine Chemical class NC1=CN=CC=N1 XFTQRUTUGRCSGO-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0215775A GB0215775D0 (en) | 2002-07-06 | 2002-07-06 | Pharmaceutical compounds |
| GB0215775.8 | 2002-07-06 | ||
| PCT/GB2003/002905 WO2004004730A2 (en) | 2002-07-06 | 2003-07-04 | 2-aminopyrazine derivatives as inhibitors of cyclin dependent kinases for the treatment of proliferative disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2003242860A8 true AU2003242860A8 (en) | 2004-01-23 |
| AU2003242860A1 AU2003242860A1 (en) | 2004-01-23 |
Family
ID=9940040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003242860A Abandoned AU2003242860A1 (en) | 2002-07-06 | 2003-07-04 | 2-aminopyrazine derivatives as inhibitors of cyclin dependent kinases for the treatment of proliferative disorders |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU2003242860A1 (en) |
| GB (1) | GB0215775D0 (en) |
| WO (1) | WO2004004730A2 (en) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1511742B1 (en) | 2002-05-23 | 2010-02-03 | Cytopia Research Pty Ltd | Kinase inhibitors |
| US20080194574A1 (en) * | 2003-12-16 | 2008-08-14 | Axxima Pharmaceuticals Ag | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases |
| AU2005230847B2 (en) * | 2004-03-31 | 2012-11-08 | Exelixis, Inc. | Anaplastic lymphoma kinase modulators and methods of use |
| AU2005252160A1 (en) | 2004-04-13 | 2005-12-22 | Astellas Pharma Inc. | Polycyclic pyrazines as potassium ion channel modulators |
| JP2008517061A (en) * | 2004-10-20 | 2008-05-22 | コンパス ファーマシューティカルズ リミティド ライアビリティ カンパニー | Compounds as antitumor agents and their use |
| GB0719644D0 (en) * | 2007-10-05 | 2007-11-14 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| DE102008022788A1 (en) * | 2008-05-08 | 2009-11-12 | Süd-Chemie AG | New 2,6-pyrazine bridged transition metal carbene complex useful as a catalyst for oxidation of hydrocarbons |
| JP5756457B2 (en) * | 2009-04-06 | 2015-07-29 | アジオス ファーマシューティカルズ， インコーポレイテッド | Pyruvate kinase M2 modulators, therapeutic compositions and related methods of use |
| PL2427441T3 (en) | 2009-05-04 | 2017-06-30 | Agios Pharmaceuticals, Inc. | Pkm2 activators for use in the treatment of cancer |
| JP5764555B2 (en) | 2009-06-29 | 2015-08-19 | アジオス ファーマシューティカルズ， インコーポレイテッド | Therapeutic compositions and related methods of use |
| NZ622505A (en) | 2009-06-29 | 2015-12-24 | Agios Pharmaceuticals Inc | Therapeutic compounds and compositions |
| JP5837091B2 (en) | 2010-12-17 | 2015-12-24 | アジオス ファーマシューティカルズ， インコーポレイテッド | Novel N- (4- (azetidine-1-carbonyl) phenyl)-(hetero-) arylsulfonamide derivatives as modulators of pyruvate kinase M2 (PKM2) |
| WO2012088314A1 (en) | 2010-12-21 | 2012-06-28 | Agios Pharmaceuticals, Inc. | Bicyclic pkm2 activators |
| TWI549947B (en) | 2010-12-29 | 2016-09-21 | 阿吉歐斯製藥公司 | Therapeutic compounds and compositions |
| WO2012151440A1 (en) | 2011-05-03 | 2012-11-08 | Agios Pharmaceuticals, Inc. | Pyruvate kinase activators for use for increasing lifetime of the red blood cells and treating anemia |
| PT2704721T (en) | 2011-05-03 | 2018-06-14 | Agios Pharmaceuticals Inc | Pyruvate kinase activators for use in therapy |
| JP2016506921A (en) | 2013-01-30 | 2016-03-07 | バイエル ファーマ アクチエンゲゼルシャフト | Amino-substituted isothiazole |
| WO2014139144A1 (en) | 2013-03-15 | 2014-09-18 | Agios Pharmaceuticals, Inc. | Therapeutic compounds and compositions |
| CN105985322A (en) * | 2015-03-03 | 2016-10-05 | 苏州翔实医药发展有限公司 | Amino pyrazine compound and application thereof |
| RS64777B1 (en) | 2015-06-11 | 2023-11-30 | Agios Pharmaceuticals Inc | Methods of using pyruvate kinase activators |
| CN112142716B (en) * | 2020-10-29 | 2021-08-31 | 山东新时代药业有限公司 | 5-membered heteroaryl substituted pyrazine derivative and application thereof |
| WO2024050374A2 (en) * | 2022-09-02 | 2024-03-07 | Miralogx Llc | Anti-inflammatory compounds, pharmaceutical compositions, and methods of treating hemochromatosis, and other disorders |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK377487A (en) * | 1986-07-21 | 1988-01-22 | Otsuka Pharma Co Ltd | P-aminophenol |
| GR900100380A (en) * | 1989-05-20 | 1991-10-10 | Fisons Plc | Method of preparation of anti-inflammatory derivatives of aminophenol. |
| JP2002516909A (en) * | 1998-06-05 | 2002-06-11 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | Substituted 1- (4-aminophenyl) pyrazoles and their use as anti-inflammatory agents |
| SE9903894D0 (en) * | 1999-10-28 | 1999-10-28 | New Pharma Research Ab | Novel compounds |
| SE9904108D0 (en) * | 1999-11-15 | 1999-11-15 | New Pharma Research Ab | New compounds |
| AU9458401A (en) * | 2000-09-20 | 2002-04-02 | Ortho Mcneil Pharm Inc | Pyrazine derivatives as modulators of tyrosine kinases |
| CA2448729A1 (en) * | 2000-11-20 | 2002-05-23 | Biovitrum Ab | Piperazinyl and piperidyl substituted heterocyclic compounds |
| CA2436487A1 (en) * | 2001-01-30 | 2002-08-08 | Cytopia Pty Ltd. | Methods of inhibiting kinases |
| CA2463563A1 (en) * | 2001-10-12 | 2003-04-17 | Irm Llc | Kinase inhibitor scaffolds and methods for their preparation |
| GB0124939D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
-
2002
- 2002-07-06 GB GB0215775A patent/GB0215775D0/en not_active Ceased
-
2003
- 2003-07-04 AU AU2003242860A patent/AU2003242860A1/en not_active Abandoned
- 2003-07-04 WO PCT/GB2003/002905 patent/WO2004004730A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004004730A2 (en) | 2004-01-15 |
| GB0215775D0 (en) | 2002-08-14 |
| WO2004004730A3 (en) | 2004-04-29 |
| AU2003242860A1 (en) | 2004-01-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |