[go: up one dir, main page]

AU2002312348A1 - Non-peptide gnrh agents, pharmaceutical compositions and methods for their uses, and processes for preparing them - Google Patents

Non-peptide gnrh agents, pharmaceutical compositions and methods for their uses, and processes for preparing them

Info

Publication number
AU2002312348A1
AU2002312348A1 AU2002312348A AU2002312348A AU2002312348A1 AU 2002312348 A1 AU2002312348 A1 AU 2002312348A1 AU 2002312348 A AU2002312348 A AU 2002312348A AU 2002312348 A AU2002312348 A AU 2002312348A AU 2002312348 A1 AU2002312348 A1 AU 2002312348A1
Authority
AU
Australia
Prior art keywords
preparing
processes
methods
pharmaceutical compositions
peptide gnrh
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002312348A
Inventor
Kenna L. Anderes
Mark B. Anderson
Lance C. Christie
Quyen-Quyen T. Do
Jun Feng
Thomas Goetzen
Yufeng Hong
Eugenia A. Iatsimirskaia
Haitao Li
David R. Luthin
Genevieve D. Paderes
Ved P. Pathak
Ranjan Jagath Rajapakse
Scott Shackelford
Eric T. Sun
Eileen Valenzuela Tompkins
Larry K. Truesdale
Haresh Vazir
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agouron Pharmaceuticals LLC
Original Assignee
Agouron Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharmaceuticals LLC filed Critical Agouron Pharmaceuticals LLC
Publication of AU2002312348A1 publication Critical patent/AU2002312348A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AU2002312348A 2001-06-06 2002-06-05 Non-peptide gnrh agents, pharmaceutical compositions and methods for their uses, and processes for preparing them Abandoned AU2002312348A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US29581201P 2001-06-06 2001-06-06
US60/295,812 2001-06-06
US30186801P 2001-06-29 2001-06-29
US60/301,868 2001-06-29
PCT/US2002/017846 WO2002098363A2 (en) 2001-06-06 2002-06-05 NON-PEPTIDE GnRH AGENTS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR USES, AND PROCESSES FOR PREPARING THEM

Publications (1)

Publication Number Publication Date
AU2002312348A1 true AU2002312348A1 (en) 2002-12-16

Family

ID=26969346

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002312348A Abandoned AU2002312348A1 (en) 2001-06-06 2002-06-05 Non-peptide gnrh agents, pharmaceutical compositions and methods for their uses, and processes for preparing them

Country Status (7)

Country Link
EP (1) EP1401427A4 (en)
JP (1) JP2005501006A (en)
AU (1) AU2002312348A1 (en)
BR (1) BR0210191A (en)
CA (1) CA2449843A1 (en)
MX (1) MXPA03011002A (en)
WO (1) WO2002098363A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0130341D0 (en) 2001-12-19 2002-02-06 Smithkline Beecham Plc Compounds
US7205307B2 (en) * 2002-02-14 2007-04-17 Icagen, Inc. Pyrimidines as novel openers of potassium ion channels
AU2003233127A1 (en) 2002-06-13 2003-12-31 Pfizer Inc. Non-peptide gnrh agents, pharmaceutical compositions and methods for their use
US7332521B2 (en) 2003-09-25 2008-02-19 Wyeth Substituted indoles
EP1541549A1 (en) * 2003-12-12 2005-06-15 Exonhit Therapeutics S.A. Tricyclic hydroxamate and benzaminde derivatives, compositions and methods
US7888361B2 (en) 2006-09-11 2011-02-15 Curis, Inc. Tyrosine kinase inhibitors containing a zinc binding moiety
UA103319C2 (en) 2008-05-06 2013-10-10 Глаксосмитклайн Ллк Thiazole- and oxazole-benzene sulfonamide compounds
CN102329234B (en) * 2011-06-24 2013-11-06 灌南伊斯特化工有限公司 Production process of m-nitrobenzaldehyde
EP2712862A1 (en) * 2012-09-28 2014-04-02 Splicos New anti-invasive compounds
US20160058895A1 (en) * 2013-04-19 2016-03-03 Oslo Universitetssykehus Hf Radiolabeled gnrh antagonists as pet imaging agents
CN108905641B (en) * 2018-08-01 2020-04-28 湖南七纬科技有限公司 Nanofiltration membrane and preparation method thereof
JP2024521450A (en) * 2021-06-09 2024-05-31 ラディオネティクス オンコロジー，インク． Non-peptide targeted therapy and uses thereof
CN114105775A (en) * 2021-11-30 2022-03-01 武汉工程大学 Preparation method of substituted iodobenzene with terminal double bond
EP4634174A1 (en) * 2022-12-13 2025-10-22 Radionetics Oncology, Inc. Gonadotropin-releasing hormone receptor (gnrhr) targeted therapeutics and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU751139B2 (en) * 1997-10-13 2002-08-08 Astellas Pharma Inc. Amide derivative
KR20010041656A (en) * 1998-03-05 2001-05-25 개리 이. 프라이드만 Non-peptide GnRH Agents
CA2341346A1 (en) * 1998-08-20 2000-04-13 Agouron Pharmaceuticals, Inc. Non-peptide gnrh agents, methods and intermediates for their preparation

Also Published As

Publication number Publication date
EP1401427A2 (en) 2004-03-31
JP2005501006A (en) 2005-01-13
BR0210191A (en) 2004-04-06
WO2002098363A3 (en) 2003-03-20
WO2002098363A2 (en) 2002-12-12
CA2449843A1 (en) 2002-12-12
MXPA03011002A (en) 2004-10-28
EP1401427A4 (en) 2004-12-01

Similar Documents

Publication Publication Date Title
HUP0402560A3 (en) N-adamantylmethyl derivates, processes for their preparation, pharmaceutical compositions thereof and intermediates
MXPA03006884A (en) Pharmaceutical formulation.
AU2002341205A1 (en) Pharmaceutical compositions comprising cyclosporin
MXPA03007641A (en) Pharmaceutical formulation.
HUP0402225A3 (en) Macrolide-compounds, process for their preparation and pharmaceutical compositions containing them
AU2002257582A1 (en) Pharmaceutical formulation
AU2002302147A1 (en) Pharmaceutical composition
AU2002312348A1 (en) Non-peptide gnrh agents, pharmaceutical compositions and methods for their uses, and processes for preparing them
AU2003233127A1 (en) Non-peptide gnrh agents, pharmaceutical compositions and methods for their use
HUP0401018A3 (en) 2h-1-benzopyran derivatives, processes for their preparation and pharmaceutical compositions thereof
ZA200404807B (en) Imidazoquinoline derivatives.
AU2002333276A1 (en) Drugs for vasculopaties
IL162497A0 (en) Benzhydryl derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
HUP0401038A3 (en) Piperazinylcarbonylquinolines and -isoquinolines, process for their preparation and pharmaceutical compositions containing them
AUPR529701A0 (en) Pharmaceutical composition
AU2002365643A1 (en) Substituted aryl-cycloalkanes, and use thereof as anticancer agents
AU2002351637A1 (en) Compositions, methods and systems for discovery of lipopeptides
HUP0401597A3 (en) Methylene-4-azasteroids, process for their preparation and pharmaceutical compositions containing them
ZA200402731B (en) Pharmaceutical formulation.
HUP0402424A3 (en) Imidazoquinoline derivatives, process for their preparation and pharmaceutical compositions containing the same
AU2002332747A1 (en) Oxadiazolyl-phenoxyalkylthiadiazoles, compositions thereof and methods for their use as anti-picornaviral agents
AU2002323481A1 (en) Oxadiazolyl-phenoxyalkylisoxazoles, compositions thereof and methods for their use as anti-picornaviral agents
AU2002323480A1 (en) Oxadiazolyl-phenoxyalkylisoxazoles, compositions thereof and methods for their use as anti-picornaviral agents
HK1061812A (en) Pharmaceutical combinations
AU2002100921A4 (en) Pharmaceutical composition

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase