AU2002360413A1 - Biosynthetic gene cluster for the maytansinoid antitumor agent ansamitocin - Google Patents

Biosynthetic gene cluster for the maytansinoid antitumor agent ansamitocin

Info

Publication number: AU2002360413A1
Authority: AU; Australia
Prior art keywords: gene cluster; antitumor agent; biosynthetic gene; maytansinoid; ansamitocin
Prior art date: 2001-11-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU2002360413A

Other versions

AU2002360413A8 (en

Inventor

Heinz G. Floss

Eckhard Leistner

Tin-Wein Yu

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

University of Washington

Original Assignee

University of Washington

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-11-21

Filing date

2002-11-21

Publication date

2003-06-10

2002-11-21 Application filed by University of Washington filed Critical University of Washington

2003-06-10 Publication of AU2002360413A8 publication Critical patent/AU2002360413A8/en

2003-06-10 Publication of AU2002360413A1 publication Critical patent/AU2002360413A1/en

Status Abandoned legal-status Critical Current

Links

PVNFMCBFDPTNQI-UIBOPQHZSA-N [(1S,2R,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] acetate [(1S,2R,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] 3-methylbutanoate [(1S,2R,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] 2-methylpropanoate [(1S,2R,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] propanoate Chemical compound CO[C@@H]1\C=C\C=C(C)\Cc2cc(OC)c(Cl)c(c2)N(C)C(=O)C[C@H](OC(C)=O)[C@]2(C)OC2[C@H](C)[C@@H]2C[C@@]1(O)NC(=O)O2.CCC(=O)O[C@H]1CC(=O)N(C)c2cc(C\C(C)=C\C=C\[C@@H](OC)[C@@]3(O)C[C@H](OC(=O)N3)[C@@H](C)C3O[C@@]13C)cc(OC)c2Cl.CO[C@@H]1\C=C\C=C(C)\Cc2cc(OC)c(Cl)c(c2)N(C)C(=O)C[C@H](OC(=O)C(C)C)[C@]2(C)OC2[C@H](C)[C@@H]2C[C@@]1(O)NC(=O)O2.CO[C@@H]1\C=C\C=C(C)\Cc2cc(OC)c(Cl)c(c2)N(C)C(=O)C[C@H](OC(=O)CC(C)C)[C@]2(C)OC2[C@H](C)[C@@H]2C[C@@]1(O)NC(=O)O2 PVNFMCBFDPTNQI-UIBOPQHZSA-N 0.000 title 1
239000002246 antineoplastic agent Substances 0.000 title 1
230000001851 biosynthetic effect Effects 0.000 title 1
108091008053 gene clusters Proteins 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Microbiology (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Gastroenterology & Hepatology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AU2002360413A 2001-11-21 2002-11-21 Biosynthetic gene cluster for the maytansinoid antitumor agent ansamitocin Abandoned AU2002360413A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US33215801P	2001-11-21	2001-11-21
US60/332,158		2001-11-21
PCT/US2002/037547 WO2003045312A2 (en)	2001-11-21	2002-11-21	Biosynthetic gene cluster for the maytansinoid antitumor agent ansamitocin

Publications (2)

Publication Number	Publication Date
AU2002360413A8 AU2002360413A8 (en)	2003-06-10
AU2002360413A1 true AU2002360413A1 (en)	2003-06-10

Family

ID=23296960

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU2002360413A Abandoned AU2002360413A1 (en)	2001-11-21	2002-11-21	Biosynthetic gene cluster for the maytansinoid antitumor agent ansamitocin

Country Status (5)

Country	Link
US (1)	US20060084141A1 (en)
EP (1)	EP1458737A4 (en)
JP (1)	JP2005510226A (en)
AU (1)	AU2002360413A1 (en)
WO (1)	WO2003045312A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20100056762A1 (en)	2001-05-11	2010-03-04	Old Lloyd J	Specific binding proteins and uses thereof
CA2447139C (en)	2001-05-11	2013-11-19	Ludwig Institute For Cancer Research	Specific binding proteins and uses thereof
US7189549B2 (en) *	2002-06-14	2007-03-13	Kosan Biosciences, Inc.	Recombinant polynucleotides encoding pro-geldanamycin producing polyketide synthase and accessory proteins, and uses thereof
US7799904B2 (en) *	2003-06-13	2010-09-21	University Of Kentucky Research Foundation	Gilvocarcin gene cluster, recombinant production and use thereof
WO2008091701A2 (en)	2007-01-25	2008-07-31	Dana-Farber Cancer Institute	Use of anti-egfr antibodies in treatment of egfr mutant mediated disease
MX2009009782A (en)	2007-03-15	2010-09-10	Ludwig Inst Cancer Res	Treatment method using egfr antibodies and src inhibitors and related formulations.
CN108424454B (en)	2007-08-14	2022-05-31	路德维格癌症研究所有限公司	Monoclonal antibody 175 targeting EGF receptor, and derivatives and uses thereof
EP2103618A1 (en)	2008-03-20	2009-09-23	Leibniz Universität Hannover	Novel ansamitocin derivatives
BR112012020102A2 (en)	2010-02-10	2016-11-29	Immunogen Inc	cd20 antibodies and uses thereof.
CN104817514B (en) *	2015-04-02	2017-10-27	重庆大学	The method for preparing the tricyclic ring heart molecular skeleton of rubradirin
CN107913410B (en) *	2016-10-08	2021-02-02	浙江大学	Amphiphilic copolymer-maytansine covalent coupling drug, preparation method and application
CN107881137A (en) *	2017-09-25	2018-04-06	辽宁斯韦尔生物科技有限公司	Strengthen high yield ansamitocin bacterial strain of transcriptional level and preparation method thereof
CN107881138A (en) *	2017-09-25	2018-04-06	辽宁斯韦尔生物科技有限公司	Interrupt high yield ansamitocin bacterial strain of missing and preparation method thereof
CN107881139A (en) *	2017-09-25	2018-04-06	辽宁斯韦尔生物科技有限公司	Strengthen high yield ansamitocin bacterial strain of polyketide synthase gene transcriptional level and preparation method thereof
CN108048503B (en) *	2018-01-23	2022-03-08	上海交通大学	Method for improving ansamitocin P-3production
CN110484592B (en) *	2019-05-15	2023-04-07	中国医学科学院医药生物技术研究所	Bioassay plate for detecting ansamitocin concentration and fermentation titer, and preparation and application thereof

2002
- 2002-11-21 EP EP02795666A patent/EP1458737A4/en not_active Withdrawn
- 2002-11-21 AU AU2002360413A patent/AU2002360413A1/en not_active Abandoned
- 2002-11-21 WO PCT/US2002/037547 patent/WO2003045312A2/en not_active Ceased
- 2002-11-21 JP JP2003546817A patent/JP2005510226A/en not_active Withdrawn
- 2002-11-21 US US10/496,351 patent/US20060084141A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20060084141A1 (en)	2006-04-20
AU2002360413A8 (en)	2003-06-10
WO2003045312A2 (en)	2003-06-05
JP2005510226A (en)	2005-04-21
WO2003045312A3 (en)	2004-07-15
EP1458737A4 (en)	2006-03-29
EP1458737A2 (en)	2004-09-22

Publication	Publication Date	Title
AU2001294209A1 (en)	2003-03-20	Vehicle seat
AU2001294209A2 (en)	2003-09-18	Vehicle seat
AU2002360413A1 (en)	2003-06-10	Biosynthetic gene cluster for the maytansinoid antitumor agent ansamitocin
AU2002258913A1 (en)	2002-11-05	Bifunctional-modified hydrogels
AU2002334833A1 (en)	2003-04-14	Urethral support for incontinence
WO2001077360A3 (en)	2002-09-12	Methods for ansamitocin production
AU3876300A (en)	2000-09-28	Mitomycin biosynthetic gene cluster
AU2001283672A1 (en)	2002-03-26	Installation carriage
AU2002351489A1 (en)	2003-04-28	Vehicle guidance-maintaining horizontal laser
AU2002352346A1 (en)	2003-06-10	Amphibious vehicle
AU2002248692A1 (en)	2002-10-08	Leinamycin biosynthesis gene cluster and its components and their uses
AU2002255120A1 (en)	2002-11-11	Amphibious vehicle
AU3457300A (en)	2000-10-16	Substrates for thioredoxin reductase
AU2002336336A1 (en)	2003-05-12	Drilling vehicle with support bearing
AU2001231457A1 (en)	2001-08-07	Genetic locus for everninomicin biosynthesis
EP1188588B8 (en)	2003-01-02	Supplementing suspension for armoured vehicle
AU2002366761A1 (en)	2003-07-09	Mobile support for children
AU2002355045A1 (en)	2003-06-17	Movable dashboard
AU3744101A (en)	2001-09-12	Mobile seat for vehicles
HK1053331A (en)	2003-10-17	Methods for ansamitocin production
AUPR389701A0 (en)	2001-04-12	An improved vehicle
AU2002308699A1 (en)	2002-11-25	Automotive differential
AU2002316117A1 (en)	2002-11-25	Automotive differential
AU2001236093A1 (en)	2002-09-19	Seat for vehicle
AUPR390701A0 (en)	2001-04-12	Swivel seat for vehicle

Legal Events

Date	Code	Title	Description
2004-08-05	MK6	Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase