AU2002231049A1 - Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents - Google Patents

Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents

Info

Publication number: AU2002231049A1
Authority: AU; Australia
Prior art keywords: sugar; substituted; hypocholesterolemic agents; azetidinones useful; azetidinones
Prior art date: 2000-12-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

AU2002231049A

Other versions

AU2002231049B2 (en

Inventor

Kevin B. Alton

Swapan K Chowdhury

Harry R Davis

Wenqing Feng

Anima Ghosal

Robert M. Iannucci

James E Patrick

Shmuel Zbaida

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck Sharp and Dohme LLC

Original Assignee

Merck Sharp and Dohme LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-20

Filing date

2001-12-17

Publication date

2002-09-05

2001-12-17 Application filed by Merck Sharp and Dohme LLC filed Critical Merck Sharp and Dohme LLC

2001-12-17 Priority claimed from PCT/US2001/049127 external-priority patent/WO2002050090A1/en

2002-09-05 Publication of AU2002231049A1 publication Critical patent/AU2002231049A1/en

2006-07-20 Application granted granted Critical

2006-07-20 Publication of AU2002231049B2 publication Critical patent/AU2002231049B2/en

2013-01-31 Assigned to MERCK SHARP & DOHME CORP. reassignment MERCK SHARP & DOHME CORP. Request to Amend Deed and Register Assignors: SCHERING CORPORATION

2021-12-17 Anticipated expiration legal-status Critical

Status Ceased legal-status Critical Current

Links

AU2002231049A 2000-12-20 2001-12-17 Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents Ceased AU2002231049B2 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US25687500P	2000-12-20	2000-12-20
US60/256,875		2000-12-20
PCT/US2001/049127 WO2002050090A1 (en)	2000-12-20	2001-12-17	Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents

Publications (2)

Publication Number	Publication Date
AU2002231049A1 true AU2002231049A1 (en)	2002-09-05
AU2002231049B2 AU2002231049B2 (en)	2006-07-20

Family

ID=22973953

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AU2002231049A Ceased AU2002231049B2 (en)	2000-12-20	2001-12-17	Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
AU3104902A Pending AU3104902A (en)	2000-12-20	2001-12-17	Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AU3104902A Pending AU3104902A (en)	2000-12-20	2001-12-17	Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents

Country Status (34)

Country	Link
US (1)	US20020137690A1 (en)
EP (1)	EP1347987B1 (en)
JP (2)	JP4351842B2 (en)
KR (1)	KR100883461B1 (en)
CN (1)	CN100475829C (en)
AR (1)	AR035611A1 (en)
AT (2)	ATE279425T1 (en)
AU (2)	AU2002231049B2 (en)
BR (1)	BR0116212A (en)
CA (1)	CA2432798C (en)
CY (1)	CY1106912T1 (en)
CZ (1)	CZ302193B6 (en)
DE (2)	DE60129863T2 (en)
DK (2)	DK1347987T3 (en)
EC (1)	ECSP034659A (en)
ES (2)	ES2287826T3 (en)
GE (1)	GEP20053548B (en)
HU (1)	HUP0302269A3 (en)
IL (1)	IL155771A0 (en)
MA (1)	MA26975A1 (en)
MX (1)	MXPA03005671A (en)
MY (1)	MY129148A (en)
NO (2)	NO326981B1 (en)
NZ (1)	NZ525722A (en)
PE (1)	PE20020718A1 (en)
PL (1)	PL208242B1 (en)
PT (2)	PT1593670E (en)
RU (1)	RU2297422C2 (en)
SI (2)	SI1347987T1 (en)
SK (1)	SK286703B6 (en)
TR (1)	TR200402758T4 (en)
TW (1)	TWI316942B (en)
WO (1)	WO2002050090A1 (en)
ZA (1)	ZA200303694B (en)

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US6982251B2 (en)	2000-12-20	2006-01-03	Schering Corporation	Substituted 2-azetidinones useful as hypocholesterolemic agents
US7071181B2 (en)	2001-01-26	2006-07-04	Schering Corporation	Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
SI1413331T1 (en)	2001-01-26	2008-02-29	Schering Corp	Combinations of the peroxisome proliferator-activated receptor (PPAR) activator fenofibrate with sterol absorption inhibitor ezetimibe for vascular indications
RS50406B (en)	2001-01-26	2009-12-31	Schering Corporation,	USE OF SUBSTITUTED AZETIDINONE UNITS FOR TREATMENT OF SITOSTEROLEMIA
UA75644C2 (en)	2001-03-28	2006-05-15	Schering Corp	Enantioselective synthesis of azetidinone intermediate compounds
US7053080B2 (en)	2001-09-21	2006-05-30	Schering Corporation	Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
MXPA04002573A (en)	2001-09-21	2004-06-18	Schering Corp	Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors.
US7056906B2 (en)	2001-09-21	2006-06-06	Schering Corporation	Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
GB0215579D0 (en)	2002-07-05	2002-08-14	Astrazeneca Ab	Chemical compounds
AR040588A1 (en)	2002-07-26	2005-04-13	Schering Corp	PHARMACEUTICAL FORMULATION INCLUDING AN INHIBITOR OF CHOLESTEROL ABSORPTION AND AN INHIBITOR OF A HMGCO TO REDUCTASE
EP1562582A1 (en)	2002-11-06	2005-08-17	Schering Corporation	Cholesterol absorption inhibitors for the treatment of demyelination
US7459442B2 (en)	2003-03-07	2008-12-02	Schering Corporation	Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
JP4589919B2 (en)	2003-03-07	2010-12-01	シェーリングコーポレイション	Substituted azetidinone compounds, their formulations and uses for the treatment of hypercholesterolemia
ES2311806T3 (en)	2003-03-07	2009-02-16	Schering Corporation	AZETIDINONA COMPOSITE SUBSTITUTED, FORNULATIONS AND USES OF THE SAME FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA.
US7192944B2 (en)	2003-03-07	2007-03-20	Schering Corp.	Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
JP2005015434A (en)	2003-06-27	2005-01-20	Kotobuki Seiyaku Kk	Serum cholesterol-lowering agent or prophylactic or therapeutic agent for atherosclerosis
EP1522541A1 (en) *	2003-10-07	2005-04-13	Lipideon Biotechnology AG	Novel hypocholesterolemic compounds
EP1918000A2 (en)	2003-11-05	2008-05-07	Schering Corporation	Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions
ATE485267T1 (en) *	2003-12-23	2010-11-15	Astrazeneca Ab	DIPHENYLAZETIDINONE DERIVATIVES WITH CHOLESTERINE ABSORPTION INHIBITING EFFECT
JP2007516287A (en)	2003-12-23	2007-06-21	メルク　エンド　カムパニー　インコーポレーテッド	Anti-hypercholesterolemic compound
GB0329778D0 (en) *	2003-12-23	2004-01-28	Astrazeneca Ab	Chemical compounds
MX2007003732A (en) *	2004-09-29	2007-04-23	Schering Corp	Combinations of substituted azetidonones and cb1 antagonists.
US7737155B2 (en)	2005-05-17	2010-06-15	Schering Corporation	Nitrogen-containing heterocyclic compounds and methods of use thereof
AR054482A1 (en) *	2005-06-22	2007-06-27	Astrazeneca Ab	DERIVATIVES OF AZETIDINONE FOR THE TREATMENT OF HYPERLIPIDEMIAS
SA06270191B1 (en)	2005-06-22	2010-03-29	استرازينيكا ايه بي	Novel 2-Azetidinone Derivatives as Cholesterol Absorption Inhibitors for the Treatment of Hyperlipidaemic Conditions
RU2008136765A (en) *	2006-03-06	2010-04-20	Тева Фармасьютикл Индастриес Лтд. (Il)	EZETIMIBE COMPOSITIONS
AR060623A1 (en)	2006-04-27	2008-07-02	Astrazeneca Ab	COMPOUNDS DERIVED FROM 2-AZETIDINONE AND A PREPARATION METHOD
CN101652377A (en) *	2007-04-02	2010-02-17	泰拉科斯有限公司	Benzylated glycoside derivatives and methods of use thereof
WO2010075068A1 (en)	2008-12-16	2010-07-01	Schering Corporation	Pyridopyrimidine derivatives and methods of use thereof
EP2379562A1 (en)	2008-12-16	2011-10-26	Schering Corporation	Bicyclic pyranone derivatives as nicotinic acid receptor agonists
ES2487540T3 (en) *	2009-02-11	2014-08-21	Dow Agrosciences Llc	Pesticide Compositions
WO2010100255A1 (en)	2009-03-06	2010-09-10	Lipideon Biotechnology Ag	Pharmaceutical hypocholesterolemic compositions
EP2414529A2 (en)	2009-04-01	2012-02-08	Matrix Laboratories Ltd	Enzymatic process for the preparation of (s)-5-(4-fluoro-phenyl)-5-hydroxy- 1morpholin-4-yl-pentan-1-one, an intermediate of ezetimibe and further conversion to ezetimibe
CN101993403B (en)	2009-08-11	2012-07-11	浙江海正药业股份有限公司	Azetidinone compound and medical applications thereof
KR101102749B1 (en) *	2009-11-30	2012-01-05	최길용	Multiplication learner
KR20150079373A (en)	2013-12-30	2015-07-08	한미약품 주식회사	Composite formulation for oral administration comprising ezetimibe and rosuvastatin
CN105055404B (en) *	2015-08-19	2017-07-18	四川大学	Purposes of the HMGCS2 inhibitor in the medicine for preparing treatment cocaine habituation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
LT3595B (en) *	1993-01-21	1995-12-27	Schering Corp	Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents
US5631365A (en) *	1993-09-21	1997-05-20	Schering Corporation	Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
US5627176A (en) *	1994-03-25	1997-05-06	Schering Corporation	Substituted azetidinone compounds useful as hypocholesterolemic agents
US5633246A (en) *	1994-11-18	1997-05-27	Schering Corporation	Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
MY114803A (en) *	1995-10-31	2003-01-31	Schering Corp	Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
US5756470A (en) *	1996-10-29	1998-05-26	Schering Corporation	Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
AUPQ342599A0 (en) *	1999-10-14	1999-11-04	University Of Melbourne, The	Conjugates and uses thereof

2001
- 2001-12-17 CZ CZ20031674A patent/CZ302193B6/en not_active IP Right Cessation
- 2001-12-17 CA CA002432798A patent/CA2432798C/en not_active Expired - Fee Related
- 2001-12-17 SI SI200130228T patent/SI1347987T1/en unknown
- 2001-12-17 ES ES05004699T patent/ES2287826T3/en not_active Expired - Lifetime
- 2001-12-17 SK SK770-2003A patent/SK286703B6/en not_active IP Right Cessation
- 2001-12-17 EP EP01991315A patent/EP1347987B1/en not_active Expired - Lifetime
- 2001-12-17 BR BR0116212-8A patent/BR0116212A/en active Search and Examination
- 2001-12-17 WO PCT/US2001/049127 patent/WO2002050090A1/en not_active Ceased
- 2001-12-17 DK DK01991315T patent/DK1347987T3/en active
- 2001-12-17 PL PL363237A patent/PL208242B1/en not_active IP Right Cessation
- 2001-12-17 PT PT05004699T patent/PT1593670E/en unknown
- 2001-12-17 DE DE60129863T patent/DE60129863T2/en not_active Expired - Lifetime
- 2001-12-17 AT AT01991315T patent/ATE279425T1/en active
- 2001-12-17 KR KR1020037007778A patent/KR100883461B1/en not_active Expired - Fee Related
- 2001-12-17 AU AU2002231049A patent/AU2002231049B2/en not_active Ceased
- 2001-12-17 AR ARP010105837A patent/AR035611A1/en not_active Application Discontinuation
- 2001-12-17 NZ NZ525722A patent/NZ525722A/en not_active IP Right Cessation
- 2001-12-17 AT AT05004699T patent/ATE369334T1/en active
- 2001-12-17 US US10/023,295 patent/US20020137690A1/en not_active Abandoned
- 2001-12-17 HU HU0302269A patent/HUP0302269A3/en unknown
- 2001-12-17 RU RU2003122520/04A patent/RU2297422C2/en not_active IP Right Cessation
- 2001-12-17 AU AU3104902A patent/AU3104902A/en active Pending
- 2001-12-17 PT PT01991315T patent/PT1347987E/en unknown
- 2001-12-17 MX MXPA03005671A patent/MXPA03005671A/en active IP Right Grant
- 2001-12-17 PE PE2001001260A patent/PE20020718A1/en not_active Application Discontinuation
- 2001-12-17 TR TR2004/02758T patent/TR200402758T4/en unknown
- 2001-12-17 CN CNB01821133XA patent/CN100475829C/en not_active Expired - Fee Related
- 2001-12-17 DK DK05004699T patent/DK1593670T3/en active
- 2001-12-17 ES ES01991315T patent/ES2230385T3/en not_active Expired - Lifetime
- 2001-12-17 JP JP2002551983A patent/JP4351842B2/en not_active Expired - Fee Related
- 2001-12-17 IL IL15577101A patent/IL155771A0/en not_active IP Right Cessation
- 2001-12-17 SI SI200130760T patent/SI1593670T1/en unknown
- 2001-12-17 DE DE60106489T patent/DE60106489T2/en not_active Expired - Lifetime
- 2001-12-18 TW TW090131349A patent/TWI316942B/en not_active IP Right Cessation
- 2001-12-19 MY MYPI20015742A patent/MY129148A/en unknown
2003
- 2003-05-13 ZA ZA200303694A patent/ZA200303694B/en unknown
- 2003-06-19 NO NO20032806A patent/NO326981B1/en not_active IP Right Cessation
- 2003-06-19 MA MA27205A patent/MA26975A1/en unknown
- 2003-06-19 EC EC2003004659A patent/ECSP034659A/en unknown
2004
- 2004-11-19 GE GEAP8505A patent/GEP20053548B/en unknown
2007
- 2007-10-08 CY CY20071101279T patent/CY1106912T1/en unknown
2008
- 2008-08-29 NO NO20083737A patent/NO20083737L/en not_active Application Discontinuation
2009
- 2009-03-25 JP JP2009075266A patent/JP2009132745A/en active Pending

Publication	Publication Date	Title
AU2002231049A1 (en)	2002-09-05	Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
IL155771A0 (en)	2003-12-23	Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
AU2002218266A1 (en)	2002-07-25	Novel indanylidene compounds
AU2002333547A1 (en)	2003-04-07	Exterior panel
AU2001292518A1 (en)	2002-04-08	Novel compounds
AU2002223503A1 (en)	2002-06-03	Decondenser unit
AU2001239765A1 (en)	2001-08-27	Novel compounds
AU4277601A (en)	2001-10-03	Microscope unit
AU2001253362A1 (en)	2001-10-30	Novel compounds
AU2000255762A1 (en)	2001-12-03	Air-conditioner
AU2001256964A1 (en)	2001-10-08	Novel compounds
AU4089601A (en)	2001-09-24	Panel
AU2001230689A1 (en)	2001-08-07	Novel compounds
AU2001278360A1 (en)	2002-01-02	Wood-duroplastic composites
AU2002216060A1 (en)	2002-06-11	Novel compounds
AU2002221923A1 (en)	2002-06-11	Novel compounds
AU2001276890A1 (en)	2002-01-21	Novel compounds
AUPQ484599A0 (en)	2000-02-03	Reciprocating mechanism
AU2001275800A1 (en)	2002-02-13	Working vehicle
AU2001237533A1 (en)	2001-08-27	Novel p-gp-inhibiting compounds
AU2002240841A1 (en)	2002-07-08	Cytostatic-glycoconjugates having specifically cleavable peptidiclinking units
AU2001232568A1 (en)	2001-08-20	Novel compounds
AUPR471801A0 (en)	2001-05-24	Polymeric structural panel
AU5052701A (en)	2001-11-07	Block construction
AU2002218529A1 (en)	2002-06-24	Antilipemic agents