AU2002220684A1 - Fap-alpha-activated anti-tumor compounds - Google Patents
Fap-alpha-activated anti-tumor compoundsInfo
- Publication number
- AU2002220684A1 AU2002220684A1 AU2002220684A AU2068402A AU2002220684A1 AU 2002220684 A1 AU2002220684 A1 AU 2002220684A1 AU 2002220684 A AU2002220684 A AU 2002220684A AU 2068402 A AU2068402 A AU 2068402A AU 2002220684 A1 AU2002220684 A1 AU 2002220684A1
- Authority
- AU
- Australia
- Prior art keywords
- fap
- alpha
- activated anti
- tumor compounds
- tumor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0027552.9A GB0027552D0 (en) | 2000-11-10 | 2000-11-10 | Anti-tumor compounds |
| GB0027552 | 2000-11-10 | ||
| PCT/EP2001/012812 WO2002038590A1 (en) | 2000-11-10 | 2001-11-06 | Fap-alpha-activated anti-tumor compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2002220684A1 true AU2002220684A1 (en) | 2002-05-21 |
Family
ID=9902983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2002220684A Abandoned AU2002220684A1 (en) | 2000-11-10 | 2001-11-06 | Fap-alpha-activated anti-tumor compounds |
Country Status (5)
| Country | Link |
|---|---|
| AR (1) | AR031316A1 (en) |
| AU (1) | AU2002220684A1 (en) |
| GB (1) | GB0027552D0 (en) |
| UY (1) | UY27014A1 (en) |
| WO (1) | WO2002038590A1 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1963537A4 (en) * | 2005-12-14 | 2009-11-11 | Ludwig Inst For Cancer Res Ltd | METHOD FOR DIAGNOSING RHEUMATOID ARTHRITIS BY DETERMINING FIBROBLASTIC SYNOVIOCYTES FOR FIBROBLAST ACTIVATION PROTEIN |
| EP2525829A1 (en) | 2010-01-22 | 2012-11-28 | Ascendis Pharma A/S | Dipeptide-based prodrug linkers for aromatic amine-containing drugs |
| DK2525830T3 (en) | 2010-01-22 | 2016-08-15 | Ascendis Pharma As | DIPEPTID-BASED PRODRUG LINKERS TO ALIFATIC AMINE-CONTAINING MEDICINES |
| CN113476616A (en) * | 2012-12-28 | 2021-10-08 | 科比欧尔斯公司 | Minimally toxic prodrugs |
| JP6744826B2 (en) * | 2014-06-13 | 2020-08-19 | バック バイオサイエンシーズ, エルエルシーBach BioSciences, LLC | FAP activating therapeutic agent and related uses |
| WO2015192124A1 (en) | 2014-06-13 | 2015-12-17 | Trustees Of Tufts College | Fap-activated therapeutic agents, and uses related thereto |
| MA47215A (en) | 2017-01-09 | 2019-11-13 | Bioxcel Therapeutics Inc | PREDICTIVE AND DIAGNOSTIC PROCEDURES FOR PROSTATE CANCER |
| AU2021405744A1 (en) | 2020-12-22 | 2023-08-03 | Cobiores Nv | Compounds comprising a tetrapeptidic moiety |
| WO2022167664A1 (en) | 2021-02-07 | 2022-08-11 | Cobiores Nv | Compounds comprising a tetrapeptidic moiety |
| CN120590466A (en) * | 2025-08-06 | 2025-09-05 | 首都医科大学脑重大疾病研究中心(北京脑重大疾病研究院) | A compound targeting fibroblast activation protein and its application |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5866679A (en) * | 1994-06-28 | 1999-02-02 | Merck & Co., Inc. | Peptides |
| EP0855910A4 (en) * | 1995-10-18 | 2000-07-05 | Merck & Co Inc | CONJUGATES USEFUL FOR TREATING BENIN PROSTATIC ADENOMA |
| US6613879B1 (en) * | 1999-05-14 | 2003-09-02 | Boehringer Ingelheim Pharma Kg | FAP-activated anti-tumour compounds |
-
2000
- 2000-11-10 GB GBGB0027552.9A patent/GB0027552D0/en not_active Ceased
-
2001
- 2001-11-06 WO PCT/EP2001/012812 patent/WO2002038590A1/en not_active Ceased
- 2001-11-06 AU AU2002220684A patent/AU2002220684A1/en not_active Abandoned
- 2001-11-07 UY UY27014A patent/UY27014A1/en not_active Application Discontinuation
- 2001-11-09 AR ARP010105240A patent/AR031316A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| UY27014A1 (en) | 2002-07-31 |
| WO2002038590A1 (en) | 2002-05-16 |
| GB0027552D0 (en) | 2000-12-27 |
| AR031316A1 (en) | 2003-09-17 |
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