AU2002220069B2 - Methods and instruments for treating pseudoarthrosis - Google Patents

Methods and instruments for treating pseudoarthrosis Download PDF

Info

Publication number: AU2002220069B2
Authority: AU; Australia
Prior art keywords: mass; elongated member; bone; pseudoarthrosis; bmp
Prior art date: 2000-10-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

AU2002220069A

Other languages

English (en)

Other versions

AU2002220069A1 (en

Inventor

William F. Mckay

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Warsaw Orthopedic Inc

Original Assignee

Warsaw Orthopedic Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-24

Filing date

2001-10-24

Publication date

2005-12-15

2001-10-24 Application filed by Warsaw Orthopedic Inc filed Critical Warsaw Orthopedic Inc

2002-07-11 Publication of AU2002220069A1 publication Critical patent/AU2002220069A1/en

2005-12-15 Application granted granted Critical

2005-12-15 Publication of AU2002220069B2 publication Critical patent/AU2002220069B2/en

2007-02-15 Assigned to WARSAW ORTHOPEDIC, INC. reassignment WARSAW ORTHOPEDIC, INC. Request for Assignment Assignors: SDGI HOLDINGS, INC.

2021-10-24 Anticipated expiration legal-status Critical

Status Ceased legal-status Critical Current

Links

238000000034 method Methods 0.000 title claims description 80
208000002607 Pseudarthrosis Diseases 0.000 title claims description 67
210000000988 bone and bone Anatomy 0.000 claims description 63
230000002138 osteoinductive effect Effects 0.000 claims description 61
239000000203 mixture Substances 0.000 claims description 57
230000004927 fusion Effects 0.000 claims description 34
210000001519 tissue Anatomy 0.000 claims description 24
102100026632 Mimecan Human genes 0.000 claims description 12
101800002327 Osteoinductive factor Proteins 0.000 claims description 12
108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims description 11
102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims description 11
229940112869 bone morphogenetic protein Drugs 0.000 claims description 11
230000008569 process Effects 0.000 claims description 10
239000003937 drug carrier Substances 0.000 claims description 9
239000001506 calcium phosphate Substances 0.000 claims description 7
229910000389 calcium phosphate Inorganic materials 0.000 claims description 7
235000011010 calcium phosphates Nutrition 0.000 claims description 7
230000001737 promoting effect Effects 0.000 claims description 7
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical group [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 7
-1 BMP-12 Proteins 0.000 claims description 6
230000008468 bone growth Effects 0.000 claims description 6
239000004568 cement Substances 0.000 claims description 6
102100033337 PDZ and LIM domain protein 7 Human genes 0.000 claims description 5
101710121660 PDZ and LIM domain protein 7 Proteins 0.000 claims description 5
229920000954 Polyglycolide Polymers 0.000 claims description 4
229920000747 poly(lactic acid) Polymers 0.000 claims description 4
239000004633 polyglycolic acid Substances 0.000 claims description 4
239000004626 polylactic acid Substances 0.000 claims description 4
102000007056 Recombinant Fusion Proteins Human genes 0.000 claims description 3
108010008281 Recombinant Fusion Proteins Proteins 0.000 claims description 3
238000001727 in vivo Methods 0.000 claims description 3
KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 2
108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 claims description 2
102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims description 2
229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 2
229920002683 Glycosaminoglycan Polymers 0.000 claims description 2
229920005603 alternating copolymer Polymers 0.000 claims description 2
239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 2
239000008112 carboxymethyl-cellulose Substances 0.000 claims description 2
229920002674 hyaluronan Polymers 0.000 claims description 2
229960003160 hyaluronic acid Drugs 0.000 claims description 2
230000003834 intracellular effect Effects 0.000 claims description 2
238000004519 manufacturing process Methods 0.000 claims description 2
241000701161 unidentified adenovirus Species 0.000 claims description 2
208000010392 Bone Fractures Diseases 0.000 claims 2
239000000833 heterodimer Substances 0.000 claims 2
239000002773 nucleotide Substances 0.000 claims 2
125000003729 nucleotide group Chemical group 0.000 claims 2
108010049951 Bone Morphogenetic Protein 3 Proteins 0.000 claims 1
108010049955 Bone Morphogenetic Protein 4 Proteins 0.000 claims 1
108010049976 Bone Morphogenetic Protein 5 Proteins 0.000 claims 1
108010049974 Bone Morphogenetic Protein 6 Proteins 0.000 claims 1
108010049870 Bone Morphogenetic Protein 7 Proteins 0.000 claims 1
102100028726 Bone morphogenetic protein 10 Human genes 0.000 claims 1
101710118482 Bone morphogenetic protein 10 Proteins 0.000 claims 1
102000003928 Bone morphogenetic protein 15 Human genes 0.000 claims 1
108090000349 Bone morphogenetic protein 15 Proteins 0.000 claims 1
102100024504 Bone morphogenetic protein 3 Human genes 0.000 claims 1
102100024505 Bone morphogenetic protein 4 Human genes 0.000 claims 1
102100022526 Bone morphogenetic protein 5 Human genes 0.000 claims 1
102100022525 Bone morphogenetic protein 6 Human genes 0.000 claims 1
102100022544 Bone morphogenetic protein 7 Human genes 0.000 claims 1
102100022545 Bone morphogenetic protein 8B Human genes 0.000 claims 1
108010090290 Growth Differentiation Factor 2 Proteins 0.000 claims 1
102100040898 Growth/differentiation factor 11 Human genes 0.000 claims 1
101710194452 Growth/differentiation factor 11 Proteins 0.000 claims 1
102100040892 Growth/differentiation factor 2 Human genes 0.000 claims 1
102100035379 Growth/differentiation factor 5 Human genes 0.000 claims 1
101710204282 Growth/differentiation factor 5 Proteins 0.000 claims 1
102100035368 Growth/differentiation factor 6 Human genes 0.000 claims 1
101710204281 Growth/differentiation factor 6 Proteins 0.000 claims 1
101000899368 Homo sapiens Bone morphogenetic protein 8B Proteins 0.000 claims 1
101710192602 Latent membrane protein 1 Proteins 0.000 claims 1
239000000463 material Substances 0.000 description 17
239000007943 implant Substances 0.000 description 10
238000000429 assembly Methods 0.000 description 8
230000000712 assembly Effects 0.000 description 8
108091028043 Nucleic acid sequence Proteins 0.000 description 7
125000006850 spacer group Chemical group 0.000 description 6
210000004027 cell Anatomy 0.000 description 5
238000002591 computed tomography Methods 0.000 description 5
230000007547 defect Effects 0.000 description 4
239000003102 growth factor Substances 0.000 description 4
230000000921 morphogenic effect Effects 0.000 description 4
102000004169 proteins and genes Human genes 0.000 description 4
108090000623 proteins and genes Proteins 0.000 description 4
238000001356 surgical procedure Methods 0.000 description 4
102000014015 Growth Differentiation Factors Human genes 0.000 description 3
108010050777 Growth Differentiation Factors Proteins 0.000 description 3
239000000560 biocompatible material Substances 0.000 description 3
239000000969 carrier Substances 0.000 description 3
238000004891 communication Methods 0.000 description 3
238000005553 drilling Methods 0.000 description 3
238000002347 injection Methods 0.000 description 3
239000007924 injection Substances 0.000 description 3
238000003780 insertion Methods 0.000 description 3
230000037431 insertion Effects 0.000 description 3
230000007246 mechanism Effects 0.000 description 3
150000007523 nucleic acids Chemical group 0.000 description 3
230000011164 ossification Effects 0.000 description 3
208000008035 Back Pain Diseases 0.000 description 2
102000008186 Collagen Human genes 0.000 description 2
108010035532 Collagen Proteins 0.000 description 2
239000006144 Dulbecco’s modiﬁed Eagle's medium Substances 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
229920001436 collagen Polymers 0.000 description 2
239000012530 fluid Substances 0.000 description 2
238000002594 fluoroscopy Methods 0.000 description 2
239000012634 fragment Substances 0.000 description 2
229910052751 metal Inorganic materials 0.000 description 2
239000002184 metal Substances 0.000 description 2
238000012986 modification Methods 0.000 description 2
230000004048 modification Effects 0.000 description 2
210000005009 osteogenic cell Anatomy 0.000 description 2
230000002188 osteogenic effect Effects 0.000 description 2
238000011084 recovery Methods 0.000 description 2
239000007787 solid Substances 0.000 description 2
239000000243 solution Substances 0.000 description 2
208000024891 symptom Diseases 0.000 description 2
108091003079 Bovine Serum Albumin Proteins 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
102000018386 EGF Family of Proteins Human genes 0.000 description 1
108010066486 EGF Family of Proteins Proteins 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
102000012966 Growth Differentiation Factor 5 Human genes 0.000 description 1
108010090254 Growth Differentiation Factor 5 Proteins 0.000 description 1
241000282412 Homo Species 0.000 description 1
102000003839 Human Proteins Human genes 0.000 description 1
108090000144 Human Proteins Proteins 0.000 description 1
108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
239000004698 Polyethylene Substances 0.000 description 1
239000004743 Polypropylene Substances 0.000 description 1
239000012980 RPMI-1640 medium Substances 0.000 description 1
102000013275 Somatomedins Human genes 0.000 description 1
RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
102000009618 Transforming Growth Factors Human genes 0.000 description 1
108010009583 Transforming Growth Factors Proteins 0.000 description 1
241001447056 Uristes Species 0.000 description 1
241000700605 Viruses Species 0.000 description 1
239000000853 adhesive Substances 0.000 description 1
230000001070 adhesive effect Effects 0.000 description 1
229910045601 alloy Inorganic materials 0.000 description 1
239000000956 alloy Substances 0.000 description 1
230000004075 alteration Effects 0.000 description 1
210000004102 animal cell Anatomy 0.000 description 1
229910052586 apatite Inorganic materials 0.000 description 1
238000013459 approach Methods 0.000 description 1
239000012062 aqueous buffer Substances 0.000 description 1
208000037873 arthrodesis Diseases 0.000 description 1
230000008901 benefit Effects 0.000 description 1
230000000740 bleeding effect Effects 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
239000011575 calcium Substances 0.000 description 1
210000000845 cartilage Anatomy 0.000 description 1
238000004113 cell culture Methods 0.000 description 1
239000006143 cell culture medium Substances 0.000 description 1
230000001413 cellular effect Effects 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
230000007850 degeneration Effects 0.000 description 1
230000000994 depressogenic effect Effects 0.000 description 1
238000011161 development Methods 0.000 description 1
230000018109 developmental process Effects 0.000 description 1
208000016097 disease of metabolism Diseases 0.000 description 1
230000007613 environmental effect Effects 0.000 description 1
210000003527 eukaryotic cell Anatomy 0.000 description 1
230000001747 exhibiting effect Effects 0.000 description 1
239000012091 fetal bovine serum Substances 0.000 description 1
230000009969 flowable effect Effects 0.000 description 1
238000009472 formulation Methods 0.000 description 1
238000007499 fusion processing Methods 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
239000011521 glass Substances 0.000 description 1
230000012010 growth Effects 0.000 description 1
229910052588 hydroxylapatite Inorganic materials 0.000 description 1
230000001939 inductive effect Effects 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
230000001788 irregular Effects 0.000 description 1
238000011694 lewis rat Methods 0.000 description 1
230000013011 mating Effects 0.000 description 1
208000030159 metabolic disease Diseases 0.000 description 1
239000007769 metal material Substances 0.000 description 1
238000003801 milling Methods 0.000 description 1
239000011707 mineral Substances 0.000 description 1
238000012978 minimally invasive surgical procedure Methods 0.000 description 1
HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 description 1
229910001000 nickel titanium Inorganic materials 0.000 description 1
235000015097 nutrients Nutrition 0.000 description 1
238000002355 open surgical procedure Methods 0.000 description 1
210000000963 osteoblast Anatomy 0.000 description 1
230000001599 osteoclastic effect Effects 0.000 description 1
230000035515 penetration Effects 0.000 description 1
VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000013600 plasmid vector Substances 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
229920000098 polyolefin Polymers 0.000 description 1
229920001155 polypropylene Polymers 0.000 description 1
229920000915 polyvinyl chloride Polymers 0.000 description 1
239000004800 polyvinyl chloride Substances 0.000 description 1
230000008439 repair process Effects 0.000 description 1
239000004576 sand Substances 0.000 description 1
231100000241 scar Toxicity 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
239000012679 serum free medium Substances 0.000 description 1
239000012781 shape memory material Substances 0.000 description 1
210000004872 soft tissue Anatomy 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
238000011105 stabilization Methods 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
210000000130 stem cell Anatomy 0.000 description 1
229920001059 synthetic polymer Polymers 0.000 description 1
230000008467 tissue growth Effects 0.000 description 1
208000037816 tissue injury Diseases 0.000 description 1
229910052719 titanium Inorganic materials 0.000 description 1
239000010936 titanium Substances 0.000 description 1
239000013598 vector Substances 0.000 description 1
239000013603 viral vector Substances 0.000 description 1
239000011800 void material Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
- A61F2/446—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages having a circular or elliptical cross-section substantially parallel to the axis of the spine, e.g. cylinders or frustocones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools for implanting artificial joints
- A61F2/4601—Special tools for implanting artificial joints for introducing bone substitute, for implanting bone graft implants or for compacting them in the bone cavity
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/442—Intervertebral or spinal discs, e.g. resilient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/30199—Three-dimensional shapes
- A61F2002/30224—Three-dimensional shapes cylindrical
- A61F2002/30235—Three-dimensional shapes cylindrical tubular, e.g. sleeves
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30593—Special structural features of bone or joint prostheses not otherwise provided for hollow
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
- A61F2002/30677—Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0069—Three-dimensional shapes cylindrical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/64—Animal cells

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Orthopedic Medicine & Surgery (AREA)
Transplantation (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Oral & Maxillofacial Surgery (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Dermatology (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Neurology (AREA)
Physical Education & Sports Medicine (AREA)
Molecular Biology (AREA)
Neurosurgery (AREA)
Pharmacology & Pharmacy (AREA)
Materials For Medical Uses (AREA)
Surgical Instruments (AREA)
Infusion, Injection, And Reservoir Apparatuses (AREA)

AU2002220069A 2000-10-24 2001-10-24 Methods and instruments for treating pseudoarthrosis Ceased AU2002220069B2 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US24295000P	2000-10-24	2000-10-24
US60/242,950		2000-10-24
PCT/US2001/045479 WO2002034113A2 (fr)	2000-10-24	2001-10-24	Procedes et instruments destines au traitement de pseudarthrose

Publications (2)

Publication Number	Publication Date
AU2002220069A1 AU2002220069A1 (en)	2002-07-11
AU2002220069B2 true AU2002220069B2 (en)	2005-12-15

Family

ID=22916758

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AU2002220069A Ceased AU2002220069B2 (en)	2000-10-24	2001-10-24	Methods and instruments for treating pseudoarthrosis
AU2006902A Pending AU2006902A (en)	2000-10-24	2001-10-24	Methods and instruments for treating pseudoarthrosis

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AU2006902A Pending AU2006902A (en)	2000-10-24	2001-10-24	Methods and instruments for treating pseudoarthrosis

Country Status (5)

Country	Link
EP (1)	EP1335771A4 (fr)
JP (1)	JP2004512078A (fr)
AU (2)	AU2002220069B2 (fr)
CA (1)	CA2426402A1 (fr)
WO (1)	WO2002034113A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20020114795A1 (en)	2000-12-22	2002-08-22	Thorne Kevin J.	Composition and process for bone growth and repair
US8002775B2 (en)	2001-10-24	2011-08-23	Warsaw Orthopedic, Inc.	Methods and instruments for treating pseudoarthrosis
AU2003234493A1 (en) *	2002-05-06	2003-11-11	Genentech, Inc.	Use of vegf for treating bone defects
FR2860422A1 (fr) *	2003-10-02	2005-04-08	Emmanuel Berque	Dispositif d'application de substances adherentes biocompatible a clapet interne
WO2006102417A2 (fr) *	2005-03-22	2006-09-28	Warsaw Orthopedic, Inc.	Mecanismes d'osteoinduction a l'aide d'une proteine de mineralisation lim-1 (lmp-1)
US7850656B2 (en)	2005-04-29	2010-12-14	Warsaw Orthopedic, Inc.	Devices and methods for delivering medical agents
US8083722B2 (en)	2005-04-29	2011-12-27	Warsaw Orthopedic, Inc	Instrumentation for injection of therapeutic fluid into joints
WO2010040076A2 (fr) *	2008-10-02	2010-04-08	Trans1, Inc.	Procédé et appareil destinés à l’insertion de greffe osseuse
WO2011111301A1 (fr) *	2010-03-09	2011-09-15	国立大学法人神戸大学	Implant d'apophyse inter-épineux
IT201900003947A1 (it) *	2019-03-19	2020-09-19	Mt Ortho S R L	Granulo in materiale metallico biocompatibile per vertebroplastica.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4013080A (en) *	1974-10-03	1977-03-22	Froning Edward C	Cannula connector and direction indicator means for injection system
WO2000049978A1 (fr) *	1999-02-22	2000-08-31	Guagliano Peter A	Procede de traitement de disque intervertebral

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS58155867A (ja) *	1982-03-12	1983-09-16	テルモ株式会社	穿刺針および穿刺針付医療用容器
US6241734B1 (en) *	1998-08-14	2001-06-05	Kyphon, Inc.	Systems and methods for placing materials into bone
JP3424049B2 (ja) *	1994-03-09	2003-07-07	山之内製薬株式会社	骨形成用移植体
GB9407135D0 (en) *	1994-04-11	1994-06-01	Aberdeen University And Plasma	Treatment of osteoporosis
JP3125579B2 (ja) *	1994-05-24	2001-01-22	三菱マテリアル株式会社	生体用セメント充填装置
US5584839A (en) *	1994-12-12	1996-12-17	Gieringer; Robert E.	Intraarticular drill guide and arthroscopic methods
US5676976A (en) *	1995-05-19	1997-10-14	Etex Corporation	Synthesis of reactive amorphous calcium phosphates
US6039762A (en) *	1995-06-07	2000-03-21	Sdgi Holdings, Inc.	Reinforced bone graft substitutes
US5779708A (en) *	1996-08-15	1998-07-14	Cyberdent, Inc.	Intraosseous drug delivery device and method
AU742748B2 (en) *	1996-10-16	2002-01-10	Etex Corporation	Method of preparing a poorly crystalline calcium phosphate and methods of its use
IL128261A0 (en) *	1999-01-27	1999-11-30	Disc O Tech Medical Tech Ltd	Expandable element
JP4302877B2 (ja) *	1997-07-30	2009-07-29	エモリー・ユニバーシテイ	新規な骨鉱化蛋白質、ｄｎａ、ベクター及び発現系
JPH11313674A (ja) *	1998-04-30	1999-11-16	Hoechst Marion Roussel Kk	ヒトｂｍｐ−４プロモーターおよびこれを用いた骨関連物質の探索法

2001
- 2001-10-24 WO PCT/US2001/045479 patent/WO2002034113A2/fr not_active Ceased
- 2001-10-24 AU AU2002220069A patent/AU2002220069B2/en not_active Ceased
- 2001-10-24 EP EP01988541A patent/EP1335771A4/fr not_active Withdrawn
- 2001-10-24 JP JP2002537173A patent/JP2004512078A/ja active Pending
- 2001-10-24 AU AU2006902A patent/AU2006902A/xx active Pending
- 2001-10-24 CA CA002426402A patent/CA2426402A1/fr not_active Abandoned

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4013080A (en) *	1974-10-03	1977-03-22	Froning Edward C	Cannula connector and direction indicator means for injection system
WO2000049978A1 (fr) *	1999-02-22	2000-08-31	Guagliano Peter A	Procede de traitement de disque intervertebral

Also Published As

Publication number	Publication date
CA2426402A1 (fr)	2002-05-02
WO2002034113A2 (fr)	2002-05-02
AU2006902A (en)	2002-05-06
EP1335771A4 (fr)	2006-06-07
WO2002034113A3 (fr)	2002-10-24
JP2004512078A (ja)	2004-04-22
EP1335771A2 (fr)	2003-08-20

Publication	Publication Date	Title
US8002775B2 (en)	2011-08-23	Methods and instruments for treating pseudoarthrosis
US11969354B2 (en)	2024-04-30	Medical implant for fixation and integration with hard tissue
CA2269342C (fr)	2006-09-12	Ecarteurs vertebraux
JP4159255B2 (ja)	2008-10-01	脊柱固定用移植部材
US5989289A (en)	1999-11-23	Bone grafts
US7329259B2 (en)	2008-02-12	Articulating spinal implant
US7608077B2 (en)	2009-10-27	Method and apparatus for spinal distraction and fusion
US7727263B2 (en)	2010-06-01	Articulating spinal implant
US20090171394A1 (en)	2009-07-02	Devices And Methods For The Treatment Of Facet Joint Disease
US20050165483A1 (en)	2005-07-28	Bone grafts
JP2002534211A5 (fr)	2008-11-27
AU2002220069B2 (en)	2005-12-15	Methods and instruments for treating pseudoarthrosis
AU2002220069A1 (en)	2002-07-11	Methods and instruments for treating pseudoarthrosis
EP3203941B1 (fr)	2020-09-09	Améliorations apportées à un échafaudage osseux
US20120310348A1 (en)	2012-12-06	Bone grafts
AU773116B2 (en)	2004-05-20	Spinal spacer
CA2547680A1 (fr)	1998-04-30	Ecarteurs vertebraux

Legal Events

Date	Code	Title	Description
2006-04-13	FGA	Letters patent sealed or granted (standard patent)
2007-02-15	PC	Assignment registered	Owner name: WARSAW ORTHOPEDIC, INC. Free format text: FORMER OWNER WAS: SDGI HOLDINGS, INC.
2008-05-22	MK14	Patent ceased section 143(a) (annual fees not paid) or expired

Date

Code

Title

Description

2006-04-13

FGA

Letters patent sealed or granted (standard patent)

2007-02-15

Assignment registered

Owner name: WARSAW ORTHOPEDIC, INC.

Free format text: FORMER OWNER WAS: SDGI HOLDINGS, INC.

2008-05-22

MK14

Patent ceased section 143(a) (annual fees not paid) or expired