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AU2002218166A1 - Collections of repeat proteins comprising repeat modules - Google Patents

Collections of repeat proteins comprising repeat modules

Info

Publication number
AU2002218166A1
AU2002218166A1 AU2002218166A AU1816602A AU2002218166A1 AU 2002218166 A1 AU2002218166 A1 AU 2002218166A1 AU 2002218166 A AU2002218166 A AU 2002218166A AU 1816602 A AU1816602 A AU 1816602A AU 2002218166 A1 AU2002218166 A1 AU 2002218166A1
Authority
AU
Australia
Prior art keywords
repeat
collections
proteins
modules
repeat proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002218166A
Inventor
Hans Kaspar Binz
Patrick Forrer
Andreas Pluckthun
Michael Tobias Stumpp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zurich Universitaet Institut fuer Medizinische Virologie
Original Assignee
Zurich Universitaet Institut fuer Medizinische Virologie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zurich Universitaet Institut fuer Medizinische Virologie filed Critical Zurich Universitaet Institut fuer Medizinische Virologie
Publication of AU2002218166A1 publication Critical patent/AU2002218166A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1044—Preparation or screening of libraries displayed on scaffold proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to collections of repeat proteins comprising repeat modules which are derived from one or more repeat units of a family of naturally occurring repeat proteins, to collections of nucleic acid molecules encoding said repeat proteins, to methods for the construction and application of such collections and to individual members of such collections.
AU2002218166A 2000-09-08 2001-09-10 Collections of repeat proteins comprising repeat modules Abandoned AU2002218166A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00119670.8 2000-09-08
EP00119670 2000-09-08
PCT/EP2001/010454 WO2002020565A2 (en) 2000-09-08 2001-09-10 Collections of repeat proteins comprising repeat modules

Publications (1)

Publication Number Publication Date
AU2002218166A1 true AU2002218166A1 (en) 2002-03-22

Family

ID=8169793

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002218166A Abandoned AU2002218166A1 (en) 2000-09-08 2001-09-10 Collections of repeat proteins comprising repeat modules

Country Status (10)

Country Link
US (4) US7417130B2 (en)
EP (2) EP2149604A1 (en)
JP (3) JP5291279B2 (en)
AT (1) ATE448301T1 (en)
AU (1) AU2002218166A1 (en)
CA (1) CA2421447C (en)
DE (1) DE60140474D1 (en)
DK (1) DK1332209T3 (en)
ES (1) ES2335861T3 (en)
WO (1) WO2002020565A2 (en)

Families Citing this family (447)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
AU2004323200B2 (en) * 2003-12-11 2008-12-04 Clonex Development, Inc. Cell lines for use in increasing protein yield from a cell culture
US7875465B2 (en) 2005-05-31 2011-01-25 Canon Kabushiki Kaisha Target substance capturing molecule
JP5322653B2 (en) 2005-11-28 2013-10-23 ザイモジェネティクス， インコーポレイテッド IL-21 antagonist
AR059448A1 (en) * 2006-02-13 2008-04-09 Divergence Inc UNION VEGETABLE CHEMICAL POLIPEPTIDES FOR UNIVERSAL MOLECULAR RECOGNITION
AU2013201171B2 (en) * 2006-02-13 2016-01-21 Monsanto Technology Llc Plant chimeric binding polypeptides for universal molecular recognition
AU2015203464B2 (en) * 2006-02-13 2017-08-10 Monsanto Technology Llc Plant chimeric binding polypeptides for universal molecular recognition
WO2007098611A1 (en) 2006-03-03 2007-09-07 Queen's University At Kingston Compositions for treatment of cancer
AU2007246144B2 (en) 2006-04-28 2012-12-06 Delenex Therapeutics Ag Antibodies binding to the extracellular domain of the Receptor Tyrosine Kinase ALK
US20110182904A1 (en) 2006-09-05 2011-07-28 Deborah Zimmerman Antibodies to bone morphogenic proteins and receptors therefor and methods for their use
PT2066351E (en) 2006-10-02 2015-11-30 Squibb & Sons Llc Human antibodies that bind cxcr4 and uses thereof
JP5207222B2 (en) * 2006-11-17 2013-06-12 独立行政法人農業生物資源研究所 Protein production method using repetitive sequence such as leucine rich repeat (LRR) sequence
WO2008066752A2 (en) 2006-11-22 2008-06-05 Adnexus, A Bristol-Myers Squibb R & D Company Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including igf-ir
KR20150067395A (en) 2006-12-01 2015-06-17 메다렉스, 엘.엘.시. Human antibodies that bind cd22 and uses thereof
CL2007003622A1 (en) 2006-12-13 2009-08-07 Medarex Inc Human anti-cd19 monoclonal antibody; composition comprising it; and tumor cell growth inhibition method.
JP2010513306A (en) 2006-12-14 2010-04-30 メダレックス インコーポレーティッド Human antibodies that bind to CD70 and uses thereof
EP3202786A3 (en) 2007-03-12 2017-10-11 ESBATech, an Alcon Biomedical Research Unit LLC Sequence based engineering and optimization of single chain antibodies
WO2008127680A2 (en) * 2007-04-11 2008-10-23 The Jackson Laboratory Diagnosis and treatment of diseases caused by misfolded proteins
CA2687395C (en) 2007-05-03 2017-07-11 Medizinische Universitat Innsbruck Complement factor h-derived short consensus repeat-antibody constructs
AU2008262384B9 (en) 2007-06-05 2014-11-27 Yale University Inhibitors of receptor tyrosine kinases and methods of use thereof
JP5506670B2 (en) 2007-06-25 2014-05-28 エスバテック − ア ノバルティス カンパニー エルエルシー Engineering and optimization based on the sequence of single chain antibodies
CA2689941C (en) 2007-06-25 2019-10-29 Esbatech Ag Methods of modifying antibodies, and modified antibodies with improved functional properties
CA2700391A1 (en) * 2007-09-24 2009-04-02 University Of Zuerich Designed armadillo repeat proteins
US20110008345A1 (en) 2007-11-30 2011-01-13 Claire Ashman Antigen-binding constructs
RU2504552C2 (en) 2007-12-07 2014-01-20 Займодженетикс, Инк. Monoclonal antibodies against il-21 of human being
EP2242846A1 (en) * 2008-02-13 2010-10-27 DSM IP Assets B.V. Process for the production of a peptide
JP2011517314A (en) 2008-02-14 2011-06-02 ブリストル−マイヤーズ スクイブ カンパニー Targeted therapeutics based on engineered proteins that bind to EGFR
EP2103936A1 (en) * 2008-03-19 2009-09-23 Institut Pasteur Reagentless fluorescent biosensors comprising a designed ankyrin repeat module and methods of their design and use
WO2009115919A2 (en) * 2008-03-19 2009-09-24 Institut Pasteur Reagentless fluorescent biosensors comprising a designed ankyrin repeat protein module, rational design methods to create reagentless fluorescent biosensors and methods of their use
EP2708559B1 (en) 2008-04-11 2018-03-28 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
AR071634A1 (en) 2008-05-06 2010-06-30 Glaxo Group Ltd NANOPARTICLES FOR ENCAPSULATION OF BIOLOGICALLY ACTIVE AGENTS
JP2011520961A (en) 2008-05-22 2011-07-21 ブリストル−マイヤーズ スクイブ カンパニー Scaffold domain protein based on multivalent fibronectin
PL3241843T3 (en) 2008-06-25 2021-12-27 Novartis Ag Solubility optimization of immunobinders
CN102177438A (en) 2008-07-25 2011-09-07 理查德·W·瓦格纳 protein screening method
EP2326351B1 (en) 2008-08-19 2017-12-27 Nektar Therapeutics Conjugates of small-interfering nucleic acids
BRPI0921469B1 (en) * 2008-11-03 2022-01-18 Molecular Partners Ag BINDING PROTEINS THAT INHIBIT INTERACTION WITH THE VEGF-A RECEPTOR, PHARMACEUTICAL COMPOSITION
TW201029662A (en) 2008-12-19 2010-08-16 Glaxo Group Ltd Novel antigen binding proteins
AU2010207552A1 (en) 2009-01-21 2011-09-01 Oxford Biotherapeutics Ltd. PTA089 protein
US20110305692A1 (en) 2009-02-24 2011-12-15 Glaxo Group Limited Antigen-binding contructs
JP5764071B2 (en) 2009-02-24 2015-08-12 エスバテック − ア ノバルティスカンパニー エルエルシー Methods for identifying immunobinders of cell surface antigens
JP2012518400A (en) 2009-02-24 2012-08-16 グラクソ グループ リミテッド Multivalent and / or multispecific RANKL binding constructs
US20110305693A1 (en) 2009-02-24 2011-12-15 Glaxo Group Limited Anitigen-binding constructs
PL2403878T3 (en) 2009-03-05 2017-12-29 E. R. Squibb & Sons, L.L.C. Fully human antibodies specific to cadm1
EP2421898B1 (en) 2009-04-20 2016-03-16 Oxford BioTherapeutics Ltd Antibodies specific to cadherin-17
IE20090514A1 (en) 2009-07-06 2011-02-16 Opsona Therapeutics Ltd Humanised antibodies and uses therof
EP2459053A2 (en) 2009-07-28 2012-06-06 F. Hoffmann-La Roche AG Non-invasive in vivo optical imaging method
US20120231004A1 (en) 2009-10-13 2012-09-13 Oxford Biotherapeutic Ltd. Antibodies
US20120282177A1 (en) 2009-11-02 2012-11-08 Christian Rohlff ROR1 as Therapeutic and Diagnostic Target
EP2496944A2 (en) 2009-11-05 2012-09-12 Novartis AG Biomarkers predictive of progression of fibrosis
TW201120210A (en) 2009-11-05 2011-06-16 Hoffmann La Roche Glycosylated repeat-motif-molecule conjugates
US20110150885A1 (en) 2009-12-11 2011-06-23 Atyr Pharma, Inc. Aminoacyl trna synthetases for modulating hematopoiesis
US9150653B2 (en) 2010-01-28 2015-10-06 Glaxo Group Limited CD127 binding proteins
CN102770767A (en) 2010-02-10 2012-11-07 诺瓦提斯公司 Methods and compounds for muscle growth
US10745467B2 (en) 2010-03-26 2020-08-18 The Trustees Of Dartmouth College VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders
CN103119054B (en) 2010-03-26 2017-01-18 达特茅斯大学理事会 VISTA regulatory T cell mediator protein, VISTA binding agent and use thereof
US20150231215A1 (en) 2012-06-22 2015-08-20 Randolph J. Noelle VISTA Antagonist and Methods of Use
TWI667257B (en) 2010-03-30 2019-08-01 中外製藥股份有限公司 Antibodies with modified affinity to fcrn that promote antigen clearance
WO2011139714A2 (en) 2010-04-26 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-trna synthetase
CN103096911B (en) 2010-04-27 2018-05-29 Atyr 医药公司 Treatment relevant with the protein fragments of Isoleucyl-tRNA synthetase, diagnosis and the innovation of antibody compositions are found
AU2011248489B2 (en) 2010-04-28 2016-10-06 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl tRNA synthetases
EP2563383B1 (en) 2010-04-29 2017-03-01 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl trna synthetases
JP6008838B2 (en) 2010-04-29 2016-10-19 エータイアー ファーマ， インコーポレイテッド Innovative discovery of therapeutic, diagnostic and antibody compositions related to protein fragments of asparaginyl tRNA synthetase
AR081361A1 (en) 2010-04-30 2012-08-29 Molecular Partners Ag MODIFIED UNION PROTEINS THAT INHIBIT THE RECEPTOR INTERACTION OF THE VASCULAR ENDOTELIAL GROWTH FACTOR FROM GLICOPROTEIN TO VEGF-A
AU2011248355B2 (en) 2010-05-03 2017-01-19 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Arginyl-tRNA synthetases
AU2011248230B2 (en) 2010-05-03 2016-10-06 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-tRNA synthetases
EP2566495B1 (en) 2010-05-03 2017-03-01 aTyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-trna synthetases
JP6008844B2 (en) 2010-05-04 2016-10-19 エータイアー ファーマ， インコーポレイテッド Innovative discovery of therapeutic, diagnostic and antibody compositions related to protein fragments of the p38 MULTI-tRNA synthetase complex
WO2011138462A1 (en) 2010-05-07 2011-11-10 F. Hoffmann-La Roche Ag Diagnostic method for the detection of cells ex vivo
ES2816898T3 (en) 2010-05-13 2021-04-06 Sarepta Therapeutics Inc Compounds that modulate the signaling activity of interleukins 17 and 23
CN103200953B (en) 2010-05-14 2017-02-15 Atyr 医药公司 Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-trna synthetases
AU2011258106B2 (en) 2010-05-27 2017-02-23 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-tRNA synthetases
UY33421A (en) 2010-06-03 2011-12-30 Glaxo Wellcome House HUMANIZED ANTIGEN UNION PROTEINS
PT2591006T (en) 2010-07-09 2019-07-29 Bioverativ Therapeutics Inc Processable single chain molecules and polypeptides made using same
CN103118695B (en) 2010-07-12 2016-08-03 Atyr医药公司 Discovery of therapeutic, diagnostic and antibody compositions related to protein fragments of glycyl-tRNA synthetase
SG10201508118WA (en) 2010-09-30 2015-11-27 Agency Science Tech & Res Methods and reagents for detection and treatment of esophageal metaplasia
AR083495A1 (en) 2010-10-22 2013-02-27 Esbatech Alcon Biomed Res Unit STABLE AND SOLUBLE ANTIBODIES
US20130273055A1 (en) 2010-11-16 2013-10-17 Eric Borges Agents and methods for treating diseases that correlate with bcma expression
HRP20180421T1 (en) 2010-11-17 2018-04-20 Chugai Seiyaku Kabushiki Kaisha Multi-specific antigen-binding molecule having alternative function to function of blood coagulation factor viii
EP3211009A1 (en) 2010-11-23 2017-08-30 Glaxo Group Limited Antigen binding proteins to oncostatin m (osm)
AU2011333738A1 (en) 2010-11-24 2013-07-11 Glaxo Group Limited Multispecific antigen binding proteins targeting HGF
US9284361B2 (en) 2010-11-26 2016-03-15 Molecular Partners Ag Designed repeat proteins binding to serum albumin
TWI654204B (en) 2010-11-30 2019-03-21 中外製藥股份有限公司 Antibody with calcium-dependent antigen binding ability
JP6043629B2 (en) 2011-01-07 2016-12-14 中外製薬株式会社 Methods for improving antibody physical properties
US9499592B2 (en) * 2011-01-26 2016-11-22 President And Fellows Of Harvard College Transcription activator-like effectors
WO2012128868A1 (en) 2011-02-15 2012-09-27 Immunogen, Inc. Cytotoxic benzodiazepine derivatives
WO2012115241A1 (en) 2011-02-25 2012-08-30 中外製薬株式会社 Fcγriib-specific fc antibody
EP3825325A3 (en) 2011-03-30 2021-10-13 Chugai Seiyaku Kabushiki Kaisha Retention of antigen-binding molecules in blood plasma and method for modifying immunogenicity
AU2012241373B2 (en) 2011-04-15 2016-06-09 Compugen Ltd. Polypeptides and polynucleotides, and uses thereof for treatment of immune related disorders and cancer
EA201391607A1 (en) * 2011-04-29 2014-04-30 Янссен Байотек, Инк. BINDING IL4 / IL13 PROTEINS WITH REPEATERS AND THEIR APPLICATION
SG10201500953YA (en) 2011-05-06 2015-04-29 Nvip Pty Ltd Anti-nerve growth factor antibodies and methods of preparing and using the same
ES2905682T3 (en) 2011-05-06 2022-04-11 Zoetis Services Llc Anti-nerve growth factor antibodies and methods of preparation and use thereof
GB201114858D0 (en) 2011-08-29 2011-10-12 Nvip Pty Ltd Anti-nerve growth factor antibodies and methods of using the same
JP6181043B2 (en) 2011-05-06 2017-08-16 ネックスヴェット オーストラリア プロプライエタリー リミテッド Anti-nerve growth factor antibodies and methods of preparing and using the same
AU2012264890C1 (en) 2011-05-27 2016-03-10 Glaxo Group Limited BCMA (CD269/TNFRSF17) -binding proteins
PL2717898T3 (en) 2011-06-10 2019-06-28 Bioverativ Therapeutics Inc. Pro-coagulant compounds and methods of use thereof
MX343580B (en) 2011-06-13 2016-11-10 Csl Ltd Antibodies against g-csfr and uses thereof.
BR112013032928A2 (en) 2011-06-21 2017-01-24 Immunogen Inc "peptide-binding maytansinoid derivatives and conjugates thereof, pharmaceutical composition comprising and use thereof"
UA114478C2 (en) 2011-06-28 2017-06-26 Берлін-Хемі Аг ANTIBODY THAT SPECIFICALLY Binds to BST1
HUE033713T2 (en) 2011-06-28 2017-12-28 Oxford Biotherapeutics Ltd Therapeutic and diagnostic purpose
MX340498B (en) 2011-06-30 2016-07-11 Chugai Pharmaceutical Co Ltd HETERODIMERIZED POLYPEPTIDE.
KR20200096692A (en) 2011-09-30 2020-08-12 추가이 세이야쿠 가부시키가이샤 Antigen-binding molecule for promoting elimination of antigens
AU2012313594C1 (en) 2011-09-30 2018-05-10 Chugai Seiyaku Kabushiki Kaisha Ion concentration-dependent binding molecule library
CN104093424A (en) 2011-09-30 2014-10-08 中外制药株式会社 Antigen-binding molecules that induce an immune response against a target antigen
TW201817744A (en) 2011-09-30 2018-05-16 日商中外製藥股份有限公司 Therapeutic antigen-binding molecule having an FcRn binding domain that promotes antigen clearance
WO2013047748A1 (en) 2011-09-30 2013-04-04 中外製薬株式会社 Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities
US20150299313A1 (en) 2011-10-05 2015-10-22 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule for promoting clearance from plasma of antigen comprising suger chain receptor-binding domain
WO2013059886A1 (en) 2011-10-28 2013-05-02 Patrys Limited Pat-lm1 epitopes and methods for using same
WO2013074840A1 (en) 2011-11-15 2013-05-23 Allergan, Inc. Treatment of dry age related macular degeneration
CN113416256A (en) 2011-11-30 2021-09-21 中外制药株式会社 Drug comprising transporter (carrier) that enters into cell to form immune complex
EP2612916A1 (en) 2012-01-09 2013-07-10 Universität Zürich Cellular high throughput encapsulation for screening or selection
HUE039033T2 (en) 2012-01-10 2018-12-28 Biogen Ma Inc Enhancement of transport of therapeutic molecules across the blood brain barrier
JP6226752B2 (en) 2012-02-09 2017-11-08 中外製薬株式会社 Modified Fc region of antibody
SG11201404850SA (en) 2012-02-13 2014-09-26 Agency Science Tech & Res IL-1β NEUTRALIZING HUMAN MONOCLONAL ANTIBODIES
EP3311847A1 (en) 2012-02-16 2018-04-25 Atyr Pharma, Inc. Histidyl-trna synthetases for treating autoimmune and inflammatory diseases
US20150037251A1 (en) 2012-02-17 2015-02-05 Universitat Bern Mammalian homologues of flower, their use in cancer diagnostics, prevention and treatment
JP6138108B2 (en) 2012-02-24 2017-05-31 中外製薬株式会社 Antigen-binding molecule that promotes disappearance of antigen via FcγRIIB
GB2502127A (en) 2012-05-17 2013-11-20 Kymab Ltd Multivalent antibodies and in vivo methods for their production
ES2753135T3 (en) 2012-05-07 2020-04-07 Allergan Inc Treatment method of AMD in patients resistant to anti-VEGF therapy
WO2013175276A1 (en) 2012-05-23 2013-11-28 Argen-X B.V Il-6 binding molecules
EP3892638A1 (en) 2012-05-30 2021-10-13 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule for eliminating aggregated antigens
CN104487457B (en) 2012-05-30 2018-01-26 中外制药株式会社 target tissue specific antigen binding molecule
WO2013187495A1 (en) 2012-06-14 2013-12-19 中外製薬株式会社 ANTIGEN-BINDING MOLECULE CONTAINING MODIFIED Fc REGION
US9890215B2 (en) 2012-06-22 2018-02-13 King's College London Vista modulators for diagnosis and treatment of cancer
BR112014032276A2 (en) 2012-06-22 2017-11-28 King S College London vista-ig constructs and the use of vista-ig for the treatment of autoimmune, allergic and inflammatory disorders
EP2867360B1 (en) * 2012-06-28 2019-05-08 Molecular Partners AG Designed ankyrin repeat proteins binding to platelet-derived growth factor
AR091774A1 (en) 2012-07-16 2015-02-25 Dow Agrosciences Llc PROCESS FOR THE DESIGN OF REPEATED, LONG, DIVERGENT DNA SEQUENCES OF OPTIMIZED CODONS
EP2692731A1 (en) * 2012-07-31 2014-02-05 Paul-Ehrlich-Institut Bundesamt für Sera und Impfstoffe Recombinant Adeno-Associated virus (AAV) vector particles displaying high-affinity ligands for cell-type specific gene delivery
GB201213652D0 (en) 2012-08-01 2012-09-12 Oxford Biotherapeutics Ltd Therapeutic and diagnostic target
WO2014031566A1 (en) 2012-08-22 2014-02-27 Immunogen, Inc. Cytotoxic benzodiazepine derivatives
JP6774164B2 (en) 2012-08-24 2020-10-21 中外製薬株式会社 Mouse FcγRII specific Fc antibody
RU2729831C2 (en) 2012-08-24 2020-08-12 Чугаи Сейяку Кабусики Кайся Versions of fcγriib-specific fc-region
EP3552628A1 (en) 2012-09-07 2019-10-16 The Trustees Of Dartmouth College Vista modulators for diagnosis and treatment of cancer
EP2902787B1 (en) 2012-09-28 2018-03-28 Chugai Seiyaku Kabushiki Kaisha Method for evaluating blood coagulation reaction
JP2015532306A (en) 2012-10-15 2015-11-09 チューリッヒ大学 Bispecific HER2 ligand for cancer therapy
EP2719706A1 (en) 2012-10-15 2014-04-16 Universität Zürich Bispecific HER2 ligands for cancer therapy
PE20150956A1 (en) 2012-11-08 2015-06-20 Hoffmann La Roche HER3 FORK BINDING HER3 ANTIGEN BINDING PROTEINS
EP2738180A1 (en) 2012-11-30 2014-06-04 Molecular Partners AG Binding proteins comprising at least two binding domains against HER2.
CN104995303A (en) 2012-12-18 2015-10-21 诺华股份有限公司 Compositions and methods that utilize a peptide tag that binds to hyaluronan
JP6433297B2 (en) 2012-12-27 2018-12-05 中外製薬株式会社 Heterodimerized polypeptide
DK2953972T3 (en) 2013-02-05 2020-10-12 Engmab Sarl PROCEDURE FOR SELECTING ANTIBODIES AGAINST BCMA
EP2762496A1 (en) 2013-02-05 2014-08-06 EngMab AG Method for the selection of antibodies against BCMA
GB201302447D0 (en) 2013-02-12 2013-03-27 Oxford Biotherapeutics Ltd Therapeutic and diagnostic target
BR112015017800A2 (en) 2013-02-26 2017-11-21 Roche Glycart Ag t-cell activating bispecific antigen binding molecules, polynucleotide, polypeptide, vector, host cell, method of making the t-cell activating bispecific antigen binding molecule, pharmaceutical composition and use of the t-cell activating bispecific antigen binding molecule
US9901647B2 (en) 2013-02-28 2018-02-27 Immunogen, Inc. Conjugates comprising cell-binding agents and cytotoxic agents
DK2962100T3 (en) 2013-02-28 2021-11-01 Caprion Proteomics Inc TUBERCULOSEBIOMARKEARS AND USES THEREOF
US9999680B2 (en) 2013-02-28 2018-06-19 Immunogen, Inc. Conjugates comprising cell-binding agents and maytansinoids as cytotoxic agents
WO2014144549A1 (en) 2013-03-15 2014-09-18 Biogen Idec Ma Inc. Factor ix polypeptide formulations
KR20210130260A (en) 2013-04-02 2021-10-29 추가이 세이야쿠 가부시키가이샤 Fc region variant
GB201308363D0 (en) 2013-05-09 2013-06-19 Bagshawe Kenneth D Tumour therapy
WO2014194030A2 (en) 2013-05-31 2014-12-04 Immunogen, Inc. Conjugates comprising cell-binding agents and cytotoxic agents
CN105209483B (en) * 2013-05-31 2021-07-27 分子组合公司 A designer ankyrin repeat protein that binds to hepatocyte growth factor
US10208125B2 (en) 2013-07-15 2019-02-19 University of Pittsburgh—of the Commonwealth System of Higher Education Anti-mucin 1 binding agents and uses thereof
KR102236367B1 (en) 2013-07-26 2021-04-05 삼성전자주식회사 Bispecific chimeric proteins with DARPins
JP6584012B2 (en) 2013-10-06 2019-10-02 アメリカ合衆国 Modified Pseudomonas exotoxin A
KR20160070164A (en) 2013-11-05 2016-06-17 알러간, 인코포레이티드 Method of treating conditions of the eye with an anti-vegf darpin
WO2015070014A1 (en) 2013-11-08 2015-05-14 Biogen Idec Ma Inc. Procoagulant fusion compound
BR112016012094A2 (en) 2013-12-04 2017-09-26 Chugai Pharmaceutical Co Ltd antigen binding molecules, whose antigen binding activity varies according to the concentration of compounds and libraries of said molecules
WO2015089585A1 (en) 2013-12-18 2015-06-25 Csl Limited Method of treating wounds
EP3087098B1 (en) 2013-12-24 2020-04-08 Janssen Pharmaceutica NV Anti-vista antibodies and fragments
US11014987B2 (en) 2013-12-24 2021-05-25 Janssen Pharmaceutics Nv Anti-vista antibodies and fragments, uses thereof, and methods of identifying same
KR20150092637A (en) 2014-02-05 2015-08-13 삼성전자주식회사 p16 protein variant and composition for preventing or treating a cancer containing the same
KR20150092638A (en) 2014-02-05 2015-08-13 삼성전자주식회사 p15 protein variant and composition for preventing or treating a cancer containing the same
KR20150097304A (en) 2014-02-18 2015-08-26 삼성전자주식회사 Anti-EGFR/Anti-HER2 Bispecific Antibodies With Anti-EGFR DARPins
JP6997619B2 (en) 2014-06-11 2022-01-17 キャシー・エイ・グリーン Use of VISTA agonists and VISTA antagonists for suppression or enhancement of humoral immunity
TWI831106B (en) 2014-06-20 2024-02-01 日商中外製藥股份有限公司 Pharmaceutical compositions for the prevention and/or treatment of diseases that develop and/or progress due to reduced or deficient activity of coagulation factor VIII and/or activated coagulation factor VIII
EP3160991A2 (en) 2014-06-25 2017-05-03 Novartis AG Compositions and methods for long acting proteins
WO2015198243A2 (en) 2014-06-25 2015-12-30 Novartis Ag Compositions and methods for long acting proteins
CA2957250A1 (en) 2014-08-15 2016-02-18 Adynxx, Inc. Oligonucleotide decoys for the treatment of pain
US9381256B2 (en) 2014-09-03 2016-07-05 Immunogen, Inc. Cytotoxic benzodiazepine derivatives
KR102632830B1 (en) 2014-09-03 2024-02-02 이뮤노젠 아이엔씨 Cytotoxic benzodiazepine derivatives
AU2015324924B2 (en) 2014-10-01 2021-07-01 Medimmune, Llc Method of conjugating a polypeptide
WO2016059602A2 (en) 2014-10-16 2016-04-21 Glaxo Group Limited Methods of treating cancer and related compositions
SI3224275T1 (en) 2014-11-14 2020-07-31 F. Hoffmann-La Roche Ag Antigen binding molecules comprising a tnf family ligand trimer
AU2015357463B2 (en) 2014-12-05 2021-10-07 Immunext, Inc. Identification of VSIG8 as the putative vista receptor and its use thereof to produce vista/VSIG8 modulators
CA2963760A1 (en) 2014-12-19 2016-06-23 Yoshinao Ruike Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use
SG11201705064XA (en) 2014-12-24 2017-07-28 Neximmune Inc Nanoparticle compositions and methods for immunotherapy
MX2017008978A (en) 2015-02-05 2017-10-25 Chugai Pharmaceutical Co Ltd Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, il-8-binding antibodies, and uses therof.
EP3277711B9 (en) 2015-04-02 2023-08-16 Molecular Partners AG Designed ankyrin repeat domains with binding specificity for serum albumin
AU2016248786B2 (en) 2015-04-14 2022-01-20 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition for prevention and/or treatment of atopic dermatitis containing lL-31 antagonist as active ingredient
CN107454906B (en) 2015-04-17 2022-05-27 豪夫迈·罗氏有限公司 Combination therapy using coagulation factors and multispecific antibodies
US10682391B2 (en) 2015-06-04 2020-06-16 Ospedale San Raffaele Srl Inhibitors of IGFBP3 binding to TMEM219 for treatment of intestinal diseases
EA033821B1 (en) 2015-06-04 2019-11-29 Ospedale San Raffaele Srl Use of inhibitor of igfbp3/tmem219 axis for treating diabetes
KR101713944B1 (en) 2015-06-19 2017-03-09 한국과학기술원 Novel polypeptide binding with human vascular endothelial growth factor and Uses Thereof
EP3313882B1 (en) 2015-06-24 2020-03-11 Janssen Pharmaceutica NV Anti-vista antibodies and fragments
LT3331910T (en) 2015-08-03 2020-03-25 Engmab Sarl Monoclonal antibodies against human b cell maturation antigen (bcma)
TW202446797A (en) 2015-09-18 2024-12-01 日商中外製藥股份有限公司 Il-8-binding antibodies and uses thereof
AR106188A1 (en) 2015-10-01 2017-12-20 Hoffmann La Roche ANTI-CD19 HUMANIZED HUMAN ANTIBODIES AND METHODS OF USE
MX2018003820A (en) 2015-10-02 2018-12-10 F Hoffmann ­La Roche Ag Bispecific antibodies specific for a costimulatory tnf receptor.
US10287352B2 (en) 2015-10-02 2019-05-14 Hoffman-La Roche Inc. Bispecific antibodies specific for PD1 and TIM3
CR20180171A (en) 2015-10-07 2018-05-03 Hoffmann La Roche BIESPECTIFIC ANTIBODIES WITH TETRAVALENCE FOR A FNT CO-STIMULATOR RECEIVER
EP3371311B1 (en) 2015-11-06 2021-07-21 Orionis Biosciences BV Bi-functional chimeric proteins and uses thereof
US20180339024A1 (en) 2015-11-19 2018-11-29 Asclepix Therapeutics, Llc Peptides with anti-angiogenic, anti-lymphangiogenic, and anti-edemic properties and nanoparticle formulations
CN108368167B (en) 2015-11-27 2023-09-05 杰特有限公司 CD131 binding proteins and uses thereof
WO2017096236A1 (en) * 2015-12-02 2017-06-08 Fred Hutchinson Cancer Research Center Circular tandem repeat proteins
JP6142069B1 (en) 2015-12-18 2017-06-07 中外製薬株式会社 Anti-myostatin antibody, polypeptide comprising mutant Fc region, and method of use
WO2017134302A2 (en) 2016-02-05 2017-08-10 Orionis Biosciences Nv Targeted therapeutic agents and uses thereof
EP3413910A1 (en) 2016-02-12 2018-12-19 Janssen Pharmaceutica NV Anti-vista (b7h5) antibodies
EP3426278B1 (en) 2016-03-07 2024-01-03 Vib Vzw Cd20 binding single domain antibodies
EP3231813A1 (en) 2016-03-29 2017-10-18 F. Hoffmann-La Roche AG Trimeric costimulatory tnf family ligand-containing antigen binding molecules
AU2017250294B2 (en) 2016-04-15 2022-07-21 Immunext Inc. Anti-human VISTA antibodies and use thereof
EP3243836A1 (en) 2016-05-11 2017-11-15 F. Hoffmann-La Roche AG C-terminally fused tnf family ligand trimer-containing antigen binding molecules
EP3455254B1 (en) 2016-05-11 2021-07-07 F. Hoffmann-La Roche AG Antigen binding molecules comprising a tnf family ligand trimer and a tenascin binding moiety
US11753463B2 (en) 2016-05-13 2023-09-12 Orionis Biosciences BV Therapeutic targeting of non-cellular structures
US11236141B2 (en) 2016-05-13 2022-02-01 Orionis Biosciences BV Targeted mutant interferon-beta and uses thereof
EP3243832A1 (en) 2016-05-13 2017-11-15 F. Hoffmann-La Roche AG Antigen binding molecules comprising a tnf family ligand trimer and pd1 binding moiety
TWI611811B (en) 2016-06-17 2018-01-21 中外製藥股份有限公司 Anti-myostatin antibody and method of use
WO2018011405A1 (en) 2016-07-15 2018-01-18 Universität Zürich Il-13ralpha1 antibodies for use in treatment of atopic inflammation, sepsis and neutropenia
IL265144B2 (en) 2016-09-06 2024-10-01 Chugai Pharmaceutical Co Ltd Methods for using a bispecific antibody that recognizes coagulation factor IX and/or activated coagulation factor IX and coagulation factor X and/or activated coagulation factor X
US11453726B2 (en) 2016-09-15 2022-09-27 Quadrucept Bio Limited Multimers, tetramers and octamers
AU2017331329B2 (en) 2016-09-22 2020-10-29 Molecular Partners Ag Recombinant binding proteins and their use
US20190248920A1 (en) 2016-09-23 2019-08-15 Csl Limited Coagulation factor binding proteins and uses thereof
SG10202103032QA (en) 2016-10-04 2021-05-28 Asclepix Therapeutics Inc Compounds and methods for activating tie2 signaling
EP3529264B1 (en) 2016-10-24 2022-03-09 Orionis Biosciences BV Targeted mutant interferon-gamma and uses thereof
KR102687833B1 (en) 2016-11-02 2024-07-24 브리스톨-마이어스 스큅 컴퍼니 Combination use of dual specific antibodies and immunological drugs against BCMA and CD3 for the treatment of multiple myeloma
KR102221364B1 (en) 2016-11-21 2021-03-04 쿠레아브 게엠베하 Anti-GP73 　 Antibody 　 and 　 Immunoconjugate
IL266860B2 (en) 2016-11-28 2024-09-01 Chugai Pharmaceutical Co Ltd A polypeptide bearing a chemical group and containing an antigen-binding complex
IL266827B2 (en) 2016-11-28 2025-04-01 Chugai Pharmaceutical Co Ltd Ligand-binding molecule having adjustable ligand-binding activity, fusion protein thereof with a ligand, pharmaceutical compositions comprising them, and method of producing them
CA3039430A1 (en) 2016-12-19 2018-06-28 F. Hoffmann-La Roche Ag Combination therapy with targeted 4-1bb (cd137) agonists
EP3559034B1 (en) 2016-12-20 2020-12-02 H. Hoffnabb-La Roche Ag Combination therapy of anti-cd20/anti-cd3 bispecific antibodies and 4-1bb (cd137) agonists
BR112019013189A2 (en) 2017-01-03 2019-12-10 Hoffmann La Roche bispecific antigen binding molecules, polynucleotide, host cell, bispecific antigen binding molecule production method, pharmaceutical composition, use, methods for inhibiting tumor cell growth in an individual and for treating cancer or an infectious disease
CN110546160A (en) 2017-02-06 2019-12-06 奥里尼斯生物科学公司 Targeted chimeric proteins and their uses
EP3576765B1 (en) 2017-02-06 2025-07-16 Orionis Biosciences, Inc. Targeted engineered interferon and uses thereof
WO2018146074A1 (en) 2017-02-07 2018-08-16 Vib Vzw Immune-cell targeted bispecific chimeric proteins and uses thereof
IL313912A (en) 2017-02-28 2024-08-01 Immunogen Inc History of methanosinoids with peptide linkers and their conjugates
EP3601346A1 (en) 2017-03-29 2020-02-05 H. Hoffnabb-La Roche Ag Bispecific antigen binding molecule for a costimulatory tnf receptor
WO2018178074A1 (en) 2017-03-29 2018-10-04 F. Hoffmann-La Roche Ag Trimeric antigen binding molecules specific for a costimulatory tnf receptor
EP3601345A1 (en) 2017-03-29 2020-02-05 H. Hoffnabb-La Roche Ag Bispecific antigen binding molecule for a costimulatory tnf receptor
EP3603670A4 (en) 2017-03-31 2021-03-10 Public University Corporation Nara Medical University MEDICINAL COMPOSITION FOR USE FOR PREVENTING AND / OR TREATING ANOMALY OF BLOOD COAGULATION FACTOR IX, INCLUDING A MULTISPECIFIC ANTIGEN BINDING MOLECULE REPLACING THE FUNCTION OF BLOOD COAGULATION FACTOR VIII
TWI704158B (en) 2017-04-04 2020-09-11 瑞士商赫孚孟拉羅股份公司 Novel bispecific antigen binding molecules capable of specific binding to cd40 and to fap
CN116375876A (en) 2017-04-05 2023-07-04 豪夫迈·罗氏有限公司 Bispecific antibody specifically binding to PD1 and LAG3
TW201839001A (en) 2017-04-20 2018-11-01 美商伊繆諾金公司 Cytotoxic benzodiazepine derivatives and conjugates thereof
AR111963A1 (en) 2017-05-26 2019-09-04 Univ California METHOD AND MOLECULES
WO2019028427A1 (en) 2017-08-03 2019-02-07 Asclepix Therapeutics, Llc. Methods for identifying and preparing pharmaceutical agents for activating tie2 receptor
PT3681911T (en) 2017-09-11 2024-12-18 Univ Monash Binding proteins to the human thrombin receptor, par4
TW202423960A (en) 2017-09-29 2024-06-16 日商中外製藥股份有限公司 Multispecific antigen-binding molecule having blood coagulation factor VIII (FVIII) cofactor function-substituting activity, and pharmaceutical formulation containing said molecule as active ingredient
WO2019075056A1 (en) 2017-10-10 2019-04-18 The Johns Hopkins University Biodegradable biomimetic particles
EP3697812A4 (en) 2017-10-18 2021-09-22 CSL Limited HUMAN SERIAL ALBUMIN VARIANTS AND THEIR USES
WO2019086497A2 (en) 2017-11-01 2019-05-09 F. Hoffmann-La Roche Ag Combination therapy with targeted ox40 agonists
EP3703746A1 (en) 2017-11-01 2020-09-09 F. Hoffmann-La Roche AG Novel tnf family ligand trimer-containing antigen binding molecules
MY205342A (en) 2017-11-01 2024-10-16 Hoffmann La Roche Bispecific 2+1 contorsbodies
MX2020005220A (en) 2017-11-28 2020-08-24 Chugai Pharmaceutical Co Ltd Polypeptide including antigen-binding domain and carrying section.
TWI880235B (en) 2017-11-28 2025-04-11 日商中外製藥股份有限公司 Ligand-binding molecules capable of regulating ligand binding activity
WO2019104385A1 (en) 2017-11-29 2019-06-06 Csl Limited Method of treating or preventing ischemia-reperfusion injury
EP3502140A1 (en) 2017-12-21 2019-06-26 F. Hoffmann-La Roche AG Combination therapy of tumor targeted icos agonists with t-cell bispecific molecules
WO2019133652A1 (en) 2017-12-28 2019-07-04 Immunogen, Inc. Benzodiazepine derivatives
BR112020013663A2 (en) 2018-01-05 2020-12-01 Ac Immune Sa binding molecules to tdp-43 incorrectly folded
WO2019148089A1 (en) 2018-01-26 2019-08-01 Orionis Biosciences Inc. Xcr1 binding agents and uses thereof
EP3746480A1 (en) 2018-01-31 2020-12-09 F. Hoffmann-La Roche AG Bispecific antibodies comprising an antigen-binding site binding to lag3
JP2021511782A (en) 2018-01-31 2021-05-13 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Stabilized immunoglobulin domain
CN112074267B (en) 2018-02-05 2024-06-28 奥里尼斯生物科学公司股份有限公司 Fibroblast binding agent and use thereof
CA3091646A1 (en) 2018-02-14 2019-08-22 Abba Therapeutics Ag Anti-human pd-l2 antibodies
US11655293B2 (en) 2018-02-22 2023-05-23 Universitat Zurich Ligands to GM-CSF or GM-CSF-receptor for use in leukemia in a patient having undergone allo-HCT
EP3623382A1 (en) 2018-09-14 2020-03-18 Universität Zürich Ligands to gm-csf or gm-csf-receptor for use in leukemia in a patient having undergone allo-hct
CA3092002A1 (en) 2018-03-13 2019-09-19 F. Hoffmann-La Roche Ag Therapeutic combination of 4-1 bb agonists with anti-cd20 antibodies
TWI841551B (en) 2018-03-13 2024-05-11 瑞士商赫孚孟拉羅股份公司 Combination therapy with targeted 4-1bb (cd137) agonists
GB201804092D0 (en) * 2018-03-14 2018-04-25 Imperial Innovations Ltd Methods and compositions
EP3768833A1 (en) 2018-03-22 2021-01-27 Charité - Universitätsmedizin Berlin Crispr associated protein reactive t cell immunity
WO2019178645A1 (en) 2018-03-23 2019-09-26 Csl Limited Method of treating asthma
MX2020010732A (en) 2018-04-13 2020-11-09 Hoffmann La Roche Her2-targeting antigen binding molecules comprising 4-1bbl.
WO2019204643A2 (en) * 2018-04-18 2019-10-24 Altius Institute For Biomedical Sciences Animal pathogen-derived polypeptides and uses thereof for genetic engineering
IL317554A (en) 2018-06-01 2025-02-01 Novartis Ag Binding molecules against bcma and uses thereof
EP3807401A1 (en) 2018-06-15 2021-04-21 Universität Bern LIGANDS TO LIGHT OR ITS RECEPTOR LTßR FOR USE IN HAEMATOLOGIC MALIGNANCIES
EP3812399A4 (en) 2018-06-20 2022-03-23 Chugai Seiyaku Kabushiki Kaisha METHOD FOR ACTIVATING THE IMMUNE RESPONSE OF A TARGET CELL AND ASSOCIATED COMPOSITION
US12264181B2 (en) 2018-06-27 2025-04-01 Altius Institute For Biomedical Sciences Nucleic acid binding domains and methods of use thereof
CN112424228B (en) 2018-07-04 2024-08-09 豪夫迈·罗氏有限公司 Novel bispecific agonistic 4-1BB antigen binding molecules
KR102259473B1 (en) 2018-08-10 2021-06-02 추가이 세이야쿠 가부시키가이샤 Anti-CD137 antigen binding molecules and uses thereof
US11242396B2 (en) 2018-10-01 2022-02-08 Hoffmann-La Roche Inc. Bispecific antigen binding molecules comprising anti-FAP clone 212
WO2020070035A1 (en) 2018-10-01 2020-04-09 F. Hoffmann-La Roche Ag Bispecific antigen binding molecules with trivalent binding to cd40
EP3632929A1 (en) 2018-10-02 2020-04-08 Ospedale San Raffaele S.r.l. Antibodies and uses thereof
AU2019358419A1 (en) 2018-10-08 2021-04-15 Universität Zürich HER2-binding tetrameric polypeptides
WO2020089437A1 (en) 2018-10-31 2020-05-07 Engmab Sàrl Combination therapy
EP3890773A4 (en) 2018-11-08 2022-11-09 Orionis Biosciences, Inc. MODULATION OF DENDRITIC CELL LINES
WO2020104627A1 (en) 2018-11-21 2020-05-28 Universität Zürich Photochemically induced conjugation of radiometals to small molecules, peptides and nanoparticles in a simultaneous one-pot reaction
WO2020127628A1 (en) 2018-12-21 2020-06-25 F. Hoffmann-La Roche Ag Tumor-targeted superagonistic cd28 antigen binding molecules
AU2019410073B2 (en) 2018-12-21 2024-08-01 F. Hoffmann-La Roche Ag Tumor-targeted agonistic CD28 antigen binding molecules
EP3677911A3 (en) 2019-01-03 2020-07-29 Universität Basel Use of non-agonist ligands for suppression of metastasis
EP3908274A1 (en) 2019-01-11 2021-11-17 Universitätsspital Basel Sglt-2 inhibitors or il-1r antagonists for reduction of hypoglycaemia after bariatric surgery
JP2022520632A (en) 2019-02-15 2022-03-31 インテグラル・モレキュラー・インコーポレイテッド Antibodies containing a common light chain and their use
JP7570338B2 (en) 2019-02-15 2024-10-21 インテグラル・モレキュラー・インコーポレイテッド Claudin 6 antibodies and uses thereof
JP7562148B2 (en) 2019-02-27 2024-10-07 国立大学法人 東京医科歯科大学 Fusion protein of antigen-binding protein and fluorescent protein or fluorescently labeled tag protein
GB201903233D0 (en) 2019-03-08 2019-04-24 Oxford Genetics Ltd Method of selecting for antibodies
KR20210137128A (en) 2019-03-08 2021-11-17 옥스포드 제네틱스 리미티드 Methods for selecting antibodies
WO2020189748A1 (en) 2019-03-19 2020-09-24 中外製薬株式会社 Antigen-binding molecule containing antigen-binding domain of which binding activity to antigen is changed depending on mta, and library for obtaining said antigen-binding domain
GB201903767D0 (en) 2019-03-19 2019-05-01 Quadrucept Bio Ltd Multimers, tetramers & octamers
KR20220022112A (en) 2019-03-21 2022-02-24 이뮤노젠 아이엔씨 Methods of Preparing Cell-Binding Agent-Drug Conjugates
EP3947395A1 (en) 2019-03-29 2022-02-09 ImmunoGen, Inc. Cytotoxic bis-benzodiazepine derivatives and conjugates thereof with cell-binding agents for inhibiting abnormal cell growth or for treating proliferative diseases
IL286630B2 (en) 2019-04-02 2025-05-01 Chugai Pharmaceutical Co Ltd Method of introducing target-specific foreign gene
WO2020207771A1 (en) 2019-04-10 2020-10-15 Universität Zürich A method for determining the likelihood of a patient being responsive to cancer immunotherapy
JP7301155B2 (en) 2019-04-12 2023-06-30 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Bispecific antigen-binding molecules containing lipocalin muteins
JP7689373B2 (en) 2019-04-18 2025-06-06 エイシー イミューン ソシエテ アノニム Novel molecules for therapy and diagnosis
EP3958977B1 (en) 2019-04-26 2023-09-13 ImmunoGen, Inc. Camptothecin derivatives
US20220396631A1 (en) 2019-05-21 2022-12-15 Lu HUANG Trispecific binding molecules against bcma and uses thereof
CN121293351A (en) 2019-05-21 2026-01-09 诺华股份有限公司 CD19 binding molecules and uses thereof
EP3972993A1 (en) 2019-05-21 2022-03-30 Novartis AG Variant cd58 domains and uses thereof
CA3137882A1 (en) 2019-05-23 2020-11-26 Tamara SEREDENINA Anti-tdp-43 binding molecules and uses thereof
WO2020245746A1 (en) 2019-06-04 2020-12-10 Molecular Partners Ag Multispecific proteins
WO2020245173A1 (en) 2019-06-04 2020-12-10 Molecular Partners Ag Recombinant fap binding proteins and their use
CA3139041A1 (en) 2019-06-04 2020-12-10 Christian REICHEN Recombinant 4-1bb binding proteins and their use
SG11202112927UA (en) 2019-06-04 2021-12-30 Molecular Partners Ag Designed ankyrin repeat domain with improved stability
BR112021023735A2 (en) 2019-06-05 2022-01-04 Chugai Pharmaceutical Co Ltd Antibody cleavage site binding molecule
JP7716979B2 (en) 2019-06-05 2025-08-01 中外製薬株式会社 Protease substrates and polypeptides containing protease cleavage sequences
JP7516368B2 (en) 2019-06-07 2024-07-16 中外製薬株式会社 Information processing system, information processing method, program, and method for producing antigen-binding molecule or protein
JP2022537337A (en) 2019-06-18 2022-08-25 マックス－プランク－ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ Site-specific, kinetically inert conjugation of labels and/or carriers to target molecules such as His-tagged proteins via metal complex reagents
EP3990477A1 (en) 2019-06-26 2022-05-04 F. Hoffmann-La Roche AG Fusion of an antibody binding cea and 4-1bbl
JP7354306B2 (en) 2019-06-27 2023-10-02 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Novel ICOS antibodies and tumor-targeting antigen-binding molecules containing them
US20220332845A1 (en) 2019-09-05 2022-10-20 Genome Biologics Ug Inhibition of mthfd1l for use in hypertrophic heart disease and heart failure
KR20220100611A (en) 2019-11-15 2022-07-15 엔테라 에스.알.엘. TMEM219 antibody and therapeutic use thereof
AU2020385631A1 (en) 2019-11-20 2022-06-02 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Archaeal peptide recombinase – a novel peptide ligating enzyme
BR112022006590A2 (en) 2019-11-20 2022-06-28 Chugai Pharmaceutical Co Ltd PREPARATION CONTAINING ANTIBODIES
US20230039165A1 (en) 2019-11-21 2023-02-09 Enthera S.R.L. Igfbp3 antibodies and therapeutic uses thereof
CN115666594A (en) 2019-11-29 2023-01-31 苏州诺沃泰医药科技有限公司 Application of CART cells in the preparation of drugs for treating cancer
CN114929730A (en) 2019-12-11 2022-08-19 分子合作伙伴股份公司 Recombinant peptide-MHC complex binding proteins and their production and use
EP4073093A2 (en) 2019-12-11 2022-10-19 Molecular Partners AG Recombinant peptide-mhc complex binding proteins and their generation and use
WO2021122813A1 (en) 2019-12-16 2021-06-24 Universität Basel Angiogenesis promoting agents for prevention of metastatic cancer
TWI895351B (en) 2020-02-12 2025-09-01 日商中外製藥股份有限公司 Anti-CD137 antigen binding molecules for the treatment of cancer
EP3868396A1 (en) 2020-02-20 2021-08-25 Enthera S.R.L. Inhibitors and uses thereof
WO2021176008A1 (en) 2020-03-04 2021-09-10 Cornell University Agents targeting baf155 or brg1 for use in treatment of advanced prostate cancer
WO2021190980A1 (en) 2020-03-22 2021-09-30 Quadrucept Bio Limited Multimers for viral strain evolution
EP4126241A1 (en) 2020-03-27 2023-02-08 Novartis AG Bispecific combination therapy for treating proliferative diseases and autoimmune disorders
GB202004514D0 (en) 2020-03-27 2020-05-13 Inst De Medicina Molecular Joaeo Lobo Antunes Treatment of Immunosuppressive Cancer
AR121706A1 (en) 2020-04-01 2022-06-29 Hoffmann La Roche OX40 AND FAP-TARGETED BSPECIFIC ANTIGEN-BINDING MOLECULES
EP4132578A1 (en) 2020-04-06 2023-02-15 Universität Zürich Artc1 ligands for cancer treatment
IL297940A (en) 2020-05-06 2023-01-01 Molecular Partners Ag New ankyrin repeat binding proteins and their uses
KR20230022176A (en) 2020-05-14 2023-02-14 몰리큘라 파트너스 아게 multispecific protein
US20240279309A1 (en) 2020-05-14 2024-08-22 Molecular Partners Ag Recombinant cd40 binding proteins and their use
PH12022553153A1 (en) 2020-05-19 2024-02-26 Boehringer Ingelheim Int Binding molecules for the treatment of cancer
WO2021239844A1 (en) 2020-05-27 2021-12-02 Universitätsspital Basel Sglt-2 inhibitors or il-1r antagonists for reduction of hypoglycaemia in prediabetes
WO2021239999A1 (en) 2020-05-28 2021-12-02 Universität Zürich Il-12 pd-l1 ligand fusion protein
TW202216769A (en) 2020-06-23 2022-05-01 瑞士商赫孚孟拉羅股份公司 Agonistic cd28 antigen binding molecules targeting her2
CN115916830A (en) 2020-06-25 2023-04-04 豪夫迈·罗氏有限公司 Anti-CD3/anti-CD28 bispecific antigen-binding molecules
AU2021317974A1 (en) 2020-07-31 2023-03-16 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical Composition comprising Cell Expressing Chimeric Receptor
WO2022029306A1 (en) 2020-08-07 2022-02-10 F. Hoffmann-La Roche Ag Method for producing protein compositions
WO2022034228A1 (en) 2020-08-14 2022-02-17 Ac Immune Sa Humanized anti-tdp-43 binding molecules and uses thereof
EP4199964A1 (en) 2020-08-18 2023-06-28 Universität Zürich A cd25-biased anti-il-2 antibody
EP3957649A1 (en) 2020-08-18 2022-02-23 Athebio AG Improved n-terminal capping modules of ankyrin repeat domains
EP4204448A2 (en) 2020-08-27 2023-07-05 cureab GmbH Anti-golph2 antibodies for macrophage and dendritic cell differentiation
KR102269716B1 (en) 2020-09-01 2021-06-28 추가이 세이야쿠 가부시키가이샤 A pharmaceutical composition for the prevention and/or treatment of dialysis pruritus comprising an IL-31 antagonist as an active ingredient
US20220235137A1 (en) 2020-10-14 2022-07-28 Viridian Therapeutics, Inc. Compositions and methods for treatment of thyroid eye disease
AU2021361108A1 (en) 2020-10-15 2023-05-25 F. Hoffmann-La Roche Ag Non-covalent protein-hyaluronan conjugates for long-acting ocular delivery
WO2022079297A1 (en) 2020-10-16 2022-04-21 Ac Immune Sa Antibodies binding to alpha-synuclein for therapy and diagnosis
CN112230587B (en) * 2020-10-29 2021-08-10 中国民用航空总局第二研究所 Instrument landing system same-frequency different-call operation monitoring system and method
IL302412A (en) 2020-11-06 2023-06-01 Novartis Ag Anti-cd19 agent and b cell targeting agent combination therapy for treating b cell malignancies
IL302569A (en) 2020-11-06 2023-07-01 Novartis Ag CD19 binding molecules and their uses
JP2023549316A (en) 2020-11-16 2023-11-24 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Combination therapy with CD40 agonists targeting FAP
US20240018265A1 (en) 2020-12-11 2024-01-18 Friedrich Miescher Institute For Biomedical Research Hdac6 binding proteins and their anti-viral use
JP2023554351A (en) 2020-12-16 2023-12-27 モレキュラー パートナーズ アクチェンゲゼルシャフト Novel extended-release prodrugs
AU2021403658A1 (en) 2020-12-16 2023-06-29 Molecular Partners Ag Recombinant cd3 binding proteins and their use
KR20230117406A (en) 2021-01-06 2023-08-08 에프. 호프만-라 로슈 아게 Combination therapy using PD1-LAG3 bispecific antibody and CD20 T cell bispecific antibody
EP4288455A1 (en) 2021-02-03 2023-12-13 Mozart Therapeutics, Inc. Binding agents and methods of using the same
US20240310378A1 (en) 2021-02-11 2024-09-19 Universität Zürich Use of markers found on lymph node metastatic samples for the prognosis of breast cancer
WO2022184659A1 (en) 2021-03-01 2022-09-09 Quadrucept Bio Limited Antibody domains & multimers
MX2023010543A (en) 2021-03-09 2023-10-13 Molecular Partners Ag Novel darpin based multi-specific t-cell engagers.
AU2022232216A1 (en) 2021-03-09 2023-10-05 Molecular Partners Ag Protease cleavable prodrugs
EP4304729A1 (en) 2021-03-09 2024-01-17 Molecular Partners AG Novel darpin based cd123 engagers
WO2022190010A1 (en) 2021-03-09 2022-09-15 Molecular Partners Ag Novel darpin based cd33 engagers
WO2022219185A1 (en) 2021-04-16 2022-10-20 Athebio Ag N-terminal capping modules of ankyrin repeat domains
EP4342984A4 (en) 2021-05-19 2025-04-23 Chugai Seiyaku Kabushiki Kaisha Method for predicting the in vivo pharmaceutical kinetics of a molecule
WO2022243261A1 (en) 2021-05-19 2022-11-24 F. Hoffmann-La Roche Ag Agonistic cd40 antigen binding molecules targeting cea
AR126009A1 (en) 2021-06-02 2023-08-30 Hoffmann La Roche CD28 ANTIGEN-BINDING AGONIST MOLECULES THAT TARGET EPCAM
JP2024525381A (en) 2021-07-02 2024-07-12 ジェネンテック， インコーポレイテッド Methods and Compositions for Treating Cancer
KR20240045260A (en) 2021-08-05 2024-04-05 이뮤노스 테라퓨틱스 아게 Combination therapeutics containing HLA fusion proteins
KR20240045259A (en) 2021-08-05 2024-04-05 이뮤노스 테라퓨틱스 아게 Pharmaceutical composition comprising HLA fusion protein
EP4384219A4 (en) 2021-08-10 2025-06-18 Viridian Therapeutics, Inc. COMPOSITIONS, DOSES AND METHODS FOR THE TREATMENT OF THYROID EYE DISEASE
WO2023021006A1 (en) 2021-08-16 2023-02-23 Universität Zürich Il-1 targeting agents for treatment of pitiyriasis rubra pilaris
EP4137508A1 (en) 2021-08-17 2023-02-22 Athebio AG Variants of ankyrin repeat domains
WO2023021050A1 (en) 2021-08-17 2023-02-23 Athebio Ag Variants of ankyrin repeat domains
IL311043A (en) 2021-08-30 2024-04-01 Lassen Therapeutics 1 Inc Anti-IL---11RA antibodies
WO2023036849A1 (en) 2021-09-07 2023-03-16 ETH Zürich Identifying and predicting future coronavirus variants
EP4163380A1 (en) 2021-10-08 2023-04-12 ETH Zurich Device and method for manipulation of extracellular vesicles
WO2023076876A1 (en) 2021-10-26 2023-05-04 Mozart Therapeutics, Inc. Modulation of immune responses to viral vectors
AR127692A1 (en) 2021-11-16 2024-02-21 Ac Immune Sa ANTI-ASC ANTIBODIES FOR USE IN ANTI-INFLAMMATORY TREATMENTS
WO2023110942A1 (en) 2021-12-14 2023-06-22 Charité-Universitätsmedizin Berlin Prevention of impaired fracture healing
WO2023110983A1 (en) 2021-12-14 2023-06-22 Molecular Partners Ag Designed repeat domains with dual binding specificity and their use
CR20240246A (en) 2021-12-20 2024-07-19 Hoffmann La Roche AGONIST ANTI-LTBR ANTIBODIES AND BISPECIFIC ANTIBODIES THAT INCLUDE THEM
US20250382633A1 (en) 2021-12-21 2025-12-18 Universität Zürich Adenoviral vectors
AU2023221539A1 (en) 2022-02-16 2024-08-22 Ac Immune Sa Humanized anti-tdp-43 binding molecules and uses thereof
EP4499846A1 (en) 2022-03-25 2025-02-05 Universität Zürich Adenoviral mediated targeting of activated immune cells
WO2023186756A1 (en) 2022-03-28 2023-10-05 F. Hoffmann-La Roche Ag Interferon gamma variants and antigen binding molecules comprising these
JPWO2023195515A1 (en) * 2022-04-06 2023-10-12
CN119156401A (en) 2022-04-08 2024-12-17 Ac免疫有限公司 Anti-TDP-43 binding molecules
EP4260907A1 (en) 2022-04-11 2023-10-18 Universität Zürich Agents for treatment of endometriosis and other benign gynecological neoplasms
JP2025517657A (en) 2022-05-10 2025-06-10 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル Syncytin-1 fusion proteins and their use for cargo delivery to target cells - Patents.com
WO2024002914A1 (en) 2022-06-27 2024-01-04 Charité-Universitätsmedizin Berlin Prediction of, and composition to improve, tendon healing
JP2025523630A (en) 2022-07-04 2025-07-23 ブイアイビー ブイゼットダブリュ Blood-cerebrospinal fluid barrier crossing antibodies
WO2024028278A1 (en) 2022-08-01 2024-02-08 Molecular Partners Ag Charge modified designed repeat domains and their use
WO2024030956A2 (en) 2022-08-03 2024-02-08 Mozart Therapeutics, Inc. Cd39-specific binding agents and methods of using the same
WO2023194628A2 (en) 2022-08-16 2023-10-12 Athebio Ag Variants of ankyrin repeat domains
WO2024037743A1 (en) 2022-08-16 2024-02-22 Athebio Ag Variants of ankyrin repeat domains
WO2024038307A1 (en) 2022-08-19 2024-02-22 Novartis Ag Dosing regimens for sars-cov-2 binding molecules
WO2024044770A1 (en) 2022-08-26 2024-02-29 Core Biotherapeutics, Inc. Oligonucleotides for the treatment of breast cancer
WO2024047114A1 (en) 2022-08-31 2024-03-07 Universität Zürich Adenoviral-based in situ delivery of bispecific t cell engagers
AU2023342646A1 (en) 2022-09-15 2025-02-20 Avidicure Ip B.V. Multispecific antigen binding proteins for stimulating nk cells and use thereof
CA3267921A1 (en) 2022-10-06 2024-04-11 Bicara Therapeutics Inc. Multispecific proteins and related methods
WO2024074706A1 (en) 2022-10-07 2024-04-11 Universität Zürich Paracrine adenoviral delivery of biomolecules
CN120152989A (en) 2022-11-03 2025-06-13 豪夫迈·罗氏有限公司 Combination therapy of anti-CD19/anti-CD28 bispecific antibodies
GB202216503D0 (en) 2022-11-05 2022-12-21 Quadrucept Bio Ltd Non-human vertebrates & cells
IL319951A (en) 2022-11-30 2025-05-01 Integral Molecular Inc Antibodies directed to claudin 6, including bispecific formats thereof
EP4638473A1 (en) 2022-12-19 2025-10-29 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Means and methods to target endogenous condensates
CN120858108A (en) 2023-01-06 2025-10-28 拉森医疗公司 Anti-IL-18BP antibody
WO2024148240A1 (en) 2023-01-06 2024-07-11 Lassen Therapeutics 1, Inc. ANTI-IL-11Rα ANTIBODIES FOR TREATING THYROID EYE DISEASE
EP4646433A1 (en) 2023-01-06 2025-11-12 Lassen Therapeutics, Inc. Anti-il-18bp antibodies
WO2024165671A1 (en) 2023-02-08 2024-08-15 Immunos Therapeutics Ag FUSION PROTEINS OF ß2 MICROGLOBULIN, HLA HEAVY CHAIN POLYPEPTIDES, AND INHIBITOR OF CD47-SIRPA
WO2024179981A1 (en) 2023-02-27 2024-09-06 Molecular Partners Ag Darpins for use in reducing renal accumulation of drugs
WO2024184494A1 (en) 2023-03-08 2024-09-12 Ac Immune Sa Anti-tdp-43 binding molecules and uses thereof
EP4428159A1 (en) 2023-03-10 2024-09-11 Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST S.r.l. Melanoma targeting human antibodies and therapeutic uses thereof
EP4428158A1 (en) 2023-03-10 2024-09-11 Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST S.r.l. Lung cancer targeting human antibodies and therapeutic uses thereof
EP4680635A1 (en) 2023-03-13 2026-01-21 F. Hoffmann-La Roche AG Combination therapy employing a pd1-lag3 bispecific antibody and an hla-g t cell bispecific antibody
AU2024243709A1 (en) 2023-04-03 2025-11-06 Katholieke Universiteit Leuven Blood-brain barrier crossing antibodies
WO2024243423A1 (en) 2023-05-24 2024-11-28 Mozart Therapeutics, Inc. Cd8-specific binding proteins and methods of using the same
WO2024246086A1 (en) 2023-06-01 2024-12-05 F. Hoffmann-La Roche Ag Immunostimulatory antigen binding molecules that specifically bind to bcma
TW202504918A (en) 2023-06-01 2025-02-01 瑞士商赫孚孟拉羅股份公司 Bispecific antibodies targeting bcma and cd28
WO2024251695A1 (en) 2023-06-06 2024-12-12 Molecular Partners Ag Recombinant cd47 binding proteins and their use
WO2024251628A1 (en) 2023-06-06 2024-12-12 Molecular Partners Ag Recombinant cd16a binding proteins and their use
AU2024286934A1 (en) 2023-06-06 2025-12-18 Molecular Partners Ag Recombinant cd2 binding proteins and their use
WO2024261027A1 (en) 2023-06-19 2024-12-26 Vector Biopharma Ag Il-7-retargeting of adenoviruses for cell specific infection
WO2024261013A1 (en) 2023-06-21 2024-12-26 F. Hoffmann-La Roche Ag Combination therapy with fap-targeted lymphotoxin beta receptor agonists
WO2025008519A1 (en) 2023-07-05 2025-01-09 Universität Bern Il-1ra blockers for treatment and prevention of sepsis
AU2024290964A1 (en) 2023-07-05 2026-01-08 CSL Innovation Pty Ltd Methods of treating or preventing a complication of sickle cell disease
WO2025014774A1 (en) 2023-07-07 2025-01-16 Viridian Therapeutics, Inc. Methods of treating active and chronic thyroid eye disease
WO2025024334A1 (en) 2023-07-21 2025-01-30 Marrow Therapeutics, Inc. Hematopoietic cell targeting conjugates and related methods
WO2025021293A1 (en) 2023-07-25 2025-01-30 Universität Zürich Disruption of rbr1 expression in plant cells
WO2025061682A1 (en) 2023-09-21 2025-03-27 Universität Zürich Adenoviral targeting of dendritic cells
WO2025072791A2 (en) 2023-09-29 2025-04-03 Aktis Oncology, Inc. Miniproteins, conjugates & uses thereof
EP4537907A1 (en) 2023-10-10 2025-04-16 Enthera S.r.l. Cd248 inhibitors and uses thereof
WO2025093683A1 (en) 2023-11-03 2025-05-08 Neuvasq Biotechnologies Sa Wnt7 signaling agonists
WO2025136985A1 (en) 2023-12-17 2025-06-26 Viridian Therapeutics, Inc. Compositions, doses, and methods for treatment of thyroid eye disease
WO2025137687A2 (en) * 2023-12-22 2025-06-26 Conagen Inc. Production of peptides using tandem repetitive recombination strategy
WO2025146491A1 (en) 2024-01-05 2025-07-10 Molecular Partners Ag Designed repeat domains with dual binding specificity for cd117 and cd47-binding agent
WO2025146487A1 (en) 2024-01-05 2025-07-10 Molecular Partners Ag Multispecific binding proteins
WO2025146490A1 (en) 2024-01-05 2025-07-10 Molecular Partners Ag Recombinant cd117 binding proteins and their use
WO2025151502A1 (en) 2024-01-09 2025-07-17 Viridian Therapeutics, Inc. Modified antibodies
WO2025151492A1 (en) 2024-01-09 2025-07-17 Viridian Therapeutics, Inc. Compositions and methods for treatment of thyroid eye disease
WO2025151496A1 (en) 2024-01-09 2025-07-17 Viridian Therapeutics, Inc. Compositions and methods for treatment of thyroid eye disease
WO2025149633A1 (en) 2024-01-12 2025-07-17 Laigo Bio B.V. Bispecific antigen binding proteins
US20250375499A1 (en) 2024-01-26 2025-12-11 Flagship Pioneering Innovations Vii, Llc Immunoreceptor inhibitory proteins and related methods
WO2025163083A1 (en) 2024-01-31 2025-08-07 Molecular Partners Ag Recobminant dll3 binding proteins and their use
WO2025163144A1 (en) 2024-01-31 2025-08-07 Molecular Partners Ag Recombinant mesothelin binding proteins and their use
WO2025181039A1 (en) 2024-03-01 2025-09-04 Molecular Partners Ag Therapeutic combinations comprising a multi-specific t cell engager
WO2025191133A1 (en) 2024-03-15 2025-09-18 Avidicure Ip B.V. Il-21 muteins, fusion proteins comprising the same and uses thereof
WO2025191136A1 (en) 2024-03-15 2025-09-18 Avidicure Ip B.V. Muteins of 4-1bb ligand extracellular domain, fusion proteins comprising the same and uses thereof
WO2025191144A1 (en) 2024-03-15 2025-09-18 Avidicure Ip B.V. Conjugates of egfr-specific antigen binding proteins and cytokines
WO2025202503A1 (en) 2024-03-28 2025-10-02 Universität Zürich Extracellular vesicles carrying cancer specific splice variants
WO2025222129A2 (en) 2024-04-19 2025-10-23 Mozart Therapeutics, Inc. Engineered cytokines and targeted cytokine delivery
US20250353881A1 (en) 2024-05-16 2025-11-20 Flagship Pioneering Innovations Vii, Llc Immunoreceptor inhibitory proteins and related methods
WO2025245111A1 (en) 2024-05-22 2025-11-27 Flagship Pioneering Innovations Vii, Llc Immunoreceptor targeting proteins and related methods
WO2026013218A1 (en) 2024-07-10 2026-01-15 Ac Immune Sa Anti-tdp-43 vectors, binding molecules and uses thereof
WO2026013280A1 (en) 2024-07-11 2026-01-15 Johann Wolfgang Goethe-Universität Frankfurt am Main Designed ankyrin repeat proteins binding p53, and uses thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU612340B2 (en) * 1986-11-04 1991-07-11 Protein Polymers Technologies, Inc. Construction of synthetic dna and its use in large polypeptide synthesis
DE68927933T2 (en) 1988-09-02 1997-08-14 Dyax Corp PRODUCTION AND SELECTION OF RECOMBINANT PROTEINS WITH DIFFERENT BINDING POINTS
WO1991005058A1 (en) 1989-10-05 1991-04-18 Glenn Kawasaki Cell-free synthesis and isolation of novel genes and polypeptides
US5270170A (en) 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
US5348867A (en) 1991-11-15 1994-09-20 George Georgiou Expression of proteins on bacterial surface
JP2702285B2 (en) 1992-08-21 1998-01-21 バイオジェン，インコーポレイテッド TAT-derived transport polypeptide
EP2022856B1 (en) * 1994-08-20 2011-09-14 Gendaq Limited Improvements in or relating to binding proteins for recognition of DNA
DE19631106A1 (en) 1996-08-01 1998-02-05 Heinz Peter Brandstetter Stator plate or stator element
US5932440A (en) 1996-08-16 1999-08-03 Life Technologies, Inc. Mammalian ribonuclease inhibitors and use thereof
CA2196496A1 (en) 1997-01-31 1998-07-31 Stephen William Watson Michnick Protein fragment complementation assay for the detection of protein-protein interactions
ATE321849T1 (en) 1997-04-23 2006-04-15 Univ Zuerich METHOD FOR DETECTING NUCLEIC ACID MOLECULES CODING FOR (POLY)PEPTIDES WHICH INTERACT WITH TARGET MOLECULES
US5827692A (en) * 1997-04-24 1998-10-27 Heska Corporation Dirofilaria and Brugia ankyrin proteins, nucleic acid molecules, and uses thereof
AU750229B2 (en) * 1997-07-18 2002-07-11 Yale University Structure of the ankyrin binding domain of a alpha-Na,K-ATPase
US6416950B1 (en) 1998-12-02 2002-07-09 Phylos, Inc. DNA-protein fusions and uses thereof
EP1137941B2 (en) 1998-12-10 2013-09-11 Bristol-Myers Squibb Company Protein scaffolds for antibody mimics and other binding proteins
US20020042094A1 (en) * 1999-12-15 2002-04-11 Venezia Domenick R. RING finger protein zapop2
EP1266004A2 (en) 2000-02-17 2002-12-18 Millennium Pharmaceuticals, Inc. Molecules of the pyrin domain protein family and uses thereof
US20020035739A1 (en) * 2000-05-05 2002-03-21 Michael Lassner Evolution of plant disease response plant pathways to enable the development of based biological sensors and to develop novel disease resistance strategies
WO2002002739A2 (en) * 2000-06-29 2002-01-10 University Of Florida Ubiquitin ligase

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US20120142611A1 (en) 2012-06-07
US8110653B2 (en) 2012-02-07
US20150275201A1 (en) 2015-10-01
DK1332209T3 (en) 2010-03-29
US20090082274A1 (en) 2009-03-26
CA2421447A1 (en) 2002-03-14
EP1332209A2 (en) 2003-08-06
JP2004508033A (en) 2004-03-18
ATE448301T1 (en) 2009-11-15
EP1332209B1 (en) 2009-11-11
JP5291279B2 (en) 2013-09-18
JP2013179942A (en) 2013-09-12
ES2335861T3 (en) 2010-04-06
US20040132028A1 (en) 2004-07-08
JP2016053031A (en) 2016-04-14
WO2002020565A3 (en) 2002-11-07
US9006389B2 (en) 2015-04-14
EP2149604A1 (en) 2010-02-03
WO2002020565A2 (en) 2002-03-14
CA2421447C (en) 2012-05-08
US9657287B2 (en) 2017-05-23
US7417130B2 (en) 2008-08-26

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