AU2002210403A1 - Pregnancy-associated plasma protein-a2 (papp-a2) - Google Patents
Pregnancy-associated plasma protein-a2 (papp-a2)Info
- Publication number
- AU2002210403A1 AU2002210403A1 AU2002210403A AU1040302A AU2002210403A1 AU 2002210403 A1 AU2002210403 A1 AU 2002210403A1 AU 2002210403 A AU2002210403 A AU 2002210403A AU 1040302 A AU1040302 A AU 1040302A AU 2002210403 A1 AU2002210403 A1 AU 2002210403A1
- Authority
- AU
- Australia
- Prior art keywords
- papp
- pregnancy
- plasma protein
- associated plasma
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 101000610209 Homo sapiens Pappalysin-2 Proteins 0.000 title 1
- 102100040154 Pappalysin-2 Human genes 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4715—Pregnancy proteins, e.g. placenta proteins, alpha-feto-protein, pregnancy specific beta glycoprotein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C07K2319/41—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a Myc-tag
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96486—Metalloendopeptidases (3.4.24)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24184000P | 2000-10-20 | 2000-10-20 | |
| DKPA200001571 | 2000-10-20 | ||
| DKPA200001571 | 2000-10-20 | ||
| US60/241,840 | 2000-10-20 | ||
| PCT/DK2001/000695 WO2002032953A2 (fr) | 2000-10-20 | 2001-10-19 | Proteine plasmatique a2 associee a la grossesse (papp-a2) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2002210403A1 true AU2002210403A1 (en) | 2002-04-29 |
Family
ID=44063430
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2002210403A Abandoned AU2002210403A1 (en) | 2000-10-20 | 2001-10-19 | Pregnancy-associated plasma protein-a2 (papp-a2) |
Country Status (6)
| Country | Link |
|---|---|
| US (6) | US7083940B2 (fr) |
| EP (2) | EP2339020B1 (fr) |
| JP (3) | JP4460829B2 (fr) |
| AU (1) | AU2002210403A1 (fr) |
| CA (2) | CA2464121C (fr) |
| WO (1) | WO2002032953A2 (fr) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2339020B1 (fr) | 2000-10-20 | 2017-03-08 | Como Biotech APS | Méthode de Diagnostique basée sur Proteine plasmatique A associée a la grossesse (PAPP-A). |
| AT500321B1 (de) * | 2003-12-30 | 2006-02-15 | Red Bull Gmbh | Verfahren zur diagnose des down-syndroms |
| JP4903585B2 (ja) * | 2004-01-28 | 2012-03-28 | ツルン ユリオピスト | 急性冠症候群用に改善された診断方法 |
| US20050277147A1 (en) * | 2004-06-11 | 2005-12-15 | Ameet Patki | Identifying chromosomal abnormalities in cells obtained from follicular fluid |
| US20060205651A1 (en) * | 2005-02-25 | 2006-09-14 | Royal College Of Surgeons In Ireland | Method of treating cancer |
| WO2006097051A1 (fr) * | 2005-03-18 | 2006-09-21 | The Chinese University Of Hong Kong | Marqueurs pour diagnostic et surveillance prenataux |
| EP2245052B1 (fr) * | 2008-01-25 | 2017-05-24 | Aarhus Universitet | Inhibition de l'exosite sélectif de l'activité de papp-a contre igfbp-4 |
| GB0910751D0 (en) * | 2009-06-23 | 2009-08-05 | Procure Therapeutics Ltd | Prostate cancer vaccine |
| SG185080A1 (en) * | 2010-04-28 | 2012-12-28 | Watlow Electric Mfg | Flow through heater |
| WO2011144999A1 (fr) * | 2010-05-17 | 2011-11-24 | Sandra Reznik | Protéine plasmatique a2 (papp-a2) comme marqueur de détection d'un risque d'anomalies chromosomiques |
| WO2013053359A1 (fr) * | 2011-10-14 | 2013-04-18 | Aarhus Universitet | Utilisation diagnostique et pronostique de complexes de prombp |
| US10670610B2 (en) | 2012-06-15 | 2020-06-02 | Wayne State University | Biomarker test for prediction or early detection of preeclampsia and/or HELLP syndrome |
| US20140141456A1 (en) * | 2012-08-30 | 2014-05-22 | Ansh Labs, LLC | Papp-a2 as a marker for monitoring, predicting and diagnosing preeclampsia |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| US10543259B2 (en) * | 2015-03-02 | 2020-01-28 | Children's Hospital Medical Center | Methods and compositions for the identification and treatment of individuals having or likely to develop short stature |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| CN110194801B (zh) * | 2018-02-26 | 2022-06-14 | 张灏 | 一种融合蛋白和多克隆抗体及其应用 |
| US11988674B2 (en) | 2018-08-07 | 2024-05-21 | University Of South Carolina | Methods for measuring gene expression levels to identify viable oocytes |
| EP4070113A4 (fr) | 2019-12-04 | 2023-12-20 | Biora Therapeutics, Inc. | Évaluation de la prééclampsie à l'aide de dosages du facteur de croissance placentaire libre et dissocié |
| AR131055A1 (es) | 2022-11-15 | 2025-02-12 | Calico Life Sciences Llc | Anticuerpos anti-papp-a y métodos de uso de estos |
| WO2025106597A2 (fr) * | 2023-11-13 | 2025-05-22 | Calico Life Sciences Llc | Compositions et procédés pour modulateurs à base de peptides de papp-a |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI83662C (fi) * | 1980-07-17 | 1991-08-12 | Scripps Clinic Res | Diagnostik antikropp och foerfarande foer dess framstaellning. |
| US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
| NZ207394A (en) | 1983-03-08 | 1987-03-06 | Commw Serum Lab Commission | Detecting or determining sequence of amino acids |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US6780613B1 (en) | 1988-10-28 | 2004-08-24 | Genentech, Inc. | Growth hormone variants |
| GB9614615D0 (en) | 1996-07-11 | 1996-09-04 | Isis Innovation | Diagnosis of pre-eclampsia |
| US6432628B1 (en) * | 1997-08-26 | 2002-08-13 | Thomas Jefferson University | Caspase-14, an apoptotic protease, nucleic acids encoding and methods of use |
| DE60034779T2 (de) * | 1999-03-15 | 2008-01-17 | Mayo Foundation For Medical Education And Research, Rochester | Insulinartiger-wachstumsfaktorbindungsprotein-4-protease |
| US6436703B1 (en) * | 2000-03-31 | 2002-08-20 | Hyseq, Inc. | Nucleic acids and polypeptides |
| US6656700B2 (en) * | 2000-05-26 | 2003-12-02 | Amersham Plc | Isoforms of human pregnancy-associated protein-E |
| WO2001095855A2 (fr) * | 2000-06-16 | 2001-12-20 | Harald Tschesche | Proteine plasmatique e associee a la grossesse (papp-e) |
| EP2339020B1 (fr) | 2000-10-20 | 2017-03-08 | Como Biotech APS | Méthode de Diagnostique basée sur Proteine plasmatique A associée a la grossesse (PAPP-A). |
| US6500630B2 (en) * | 2001-01-12 | 2002-12-31 | Mayo Foundation For Medical Education And Research | Marker for inflammatory conditions |
| CA2612389A1 (fr) * | 2005-06-17 | 2006-12-28 | Genizon Biosciences, Inc. | Carte genique genemap des genes humains associes a la longevite |
| US20080071151A1 (en) * | 2006-06-30 | 2008-03-20 | Sogin David C | Method and Apparatus for Diagnosing Pre-eclampsia |
| WO2009094665A1 (fr) * | 2008-01-25 | 2009-07-30 | Perkinelmer Health Sciences, Inc. | Procédés de détermination du risque de complications prénatales |
-
2001
- 2001-10-19 EP EP10183761.5A patent/EP2339020B1/fr not_active Expired - Lifetime
- 2001-10-19 WO PCT/DK2001/000695 patent/WO2002032953A2/fr not_active Ceased
- 2001-10-19 EP EP01978230.9A patent/EP1346061B1/fr not_active Expired - Lifetime
- 2001-10-19 AU AU2002210403A patent/AU2002210403A1/en not_active Abandoned
- 2001-10-19 CA CA2464121A patent/CA2464121C/fr not_active Expired - Lifetime
- 2001-10-19 JP JP2002536334A patent/JP4460829B2/ja not_active Expired - Fee Related
- 2001-10-19 CA CA2818654A patent/CA2818654A1/fr not_active Abandoned
- 2001-10-22 US US09/983,025 patent/US7083940B2/en not_active Expired - Lifetime
-
2006
- 2006-06-13 US US11/451,495 patent/US20070141669A1/en not_active Abandoned
-
2009
- 2009-12-22 JP JP2009291514A patent/JP5072950B2/ja not_active Expired - Fee Related
-
2010
- 2010-10-28 US US12/914,312 patent/US20110091920A1/en not_active Abandoned
-
2012
- 2012-06-29 JP JP2012147230A patent/JP2012229235A/ja active Pending
- 2012-09-24 US US13/625,088 patent/US9005949B2/en not_active Expired - Fee Related
- 2012-09-24 US US13/625,261 patent/US20130095482A1/en not_active Abandoned
-
2014
- 2014-08-22 US US14/466,055 patent/US10392610B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010222341A (ja) | 2010-10-07 |
| US20130095569A1 (en) | 2013-04-18 |
| WO2002032953A3 (fr) | 2003-01-09 |
| US20150132770A1 (en) | 2015-05-14 |
| EP1346061B1 (fr) | 2014-12-17 |
| US20030124529A1 (en) | 2003-07-03 |
| JP2004511253A (ja) | 2004-04-15 |
| JP5072950B2 (ja) | 2012-11-14 |
| CA2464121C (fr) | 2013-08-13 |
| US10392610B2 (en) | 2019-08-27 |
| JP2012229235A (ja) | 2012-11-22 |
| EP1346061A2 (fr) | 2003-09-24 |
| CA2818654A1 (fr) | 2002-04-25 |
| US7083940B2 (en) | 2006-08-01 |
| JP4460829B2 (ja) | 2010-05-12 |
| US20130095482A1 (en) | 2013-04-18 |
| EP2339020A1 (fr) | 2011-06-29 |
| EP2339020B1 (fr) | 2017-03-08 |
| US9005949B2 (en) | 2015-04-14 |
| US20110091920A1 (en) | 2011-04-21 |
| CA2464121A1 (fr) | 2002-04-25 |
| US20070141669A1 (en) | 2007-06-21 |
| WO2002032953A2 (fr) | 2002-04-25 |
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