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AU2001233576A1 - A novel recombinant staphylokinase derivant and its preparation method and application thereof - Google Patents

A novel recombinant staphylokinase derivant and its preparation method and application thereof

Info

Publication number
AU2001233576A1
AU2001233576A1 AU2001233576A AU3357601A AU2001233576A1 AU 2001233576 A1 AU2001233576 A1 AU 2001233576A1 AU 2001233576 A AU2001233576 A AU 2001233576A AU 3357601 A AU3357601 A AU 3357601A AU 2001233576 A1 AU2001233576 A1 AU 2001233576A1
Authority
AU
Australia
Prior art keywords
derivant
preparation
application
novel recombinant
recombinant staphylokinase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001233576A
Inventor
Gang Song
Houyan Song
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fudan University
Original Assignee
Fudan University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fudan University filed Critical Fudan University
Publication of AU2001233576A1 publication Critical patent/AU2001233576A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
AU2001233576A 2000-01-28 2001-01-23 A novel recombinant staphylokinase derivant and its preparation method and application thereof Abandoned AU2001233576A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNB001116274A CN100342007C (en) 2000-01-28 2000-01-28 Recombination gluconokinase and its preparing process
CN00111627 2000-01-28
PCT/CN2001/000102 WO2001055359A1 (en) 2000-01-28 2001-01-23 A novel recombinant staphylokinase derivant and its preparation method and application thereof

Publications (1)

Publication Number Publication Date
AU2001233576A1 true AU2001233576A1 (en) 2001-08-07

Family

ID=4581536

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001233576A Abandoned AU2001233576A1 (en) 2000-01-28 2001-01-23 A novel recombinant staphylokinase derivant and its preparation method and application thereof

Country Status (5)

Country Link
US (2) US7407789B2 (en)
CN (1) CN100342007C (en)
AU (1) AU2001233576A1 (en)
RU (1) RU2283863C2 (en)
WO (1) WO2001055359A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100342007C (en) * 2000-01-28 2007-10-10 复旦大学 Recombination gluconokinase and its preparing process
CN100400656C (en) * 2004-10-22 2008-07-09 中国人民解放军军事医学科学院微生物流行病研究所 A novel RGD staphylokinase bifunctional molecule, its preparation method and application
US7498410B2 (en) * 2005-07-18 2009-03-03 Humab Solutions, Inc. Bifunctional variants of recombinant tissue-type plasminogen activator with platelet aggregation inhibitory activity
CN100445390C (en) * 2005-10-14 2008-12-24 中国人民解放军军事医学科学院基础医学研究所 A highly active, low antigenic staphylokinase derivative and its preparation method
CN100445389C (en) * 2005-10-14 2008-12-24 中国人民解放军军事医学科学院基础医学研究所 A kind of low antigenicity recombinant staphylokinase mutant and its preparation method
CN101139578B (en) * 2007-08-24 2010-09-15 河北师范大学 Bifunctional staphylokinase mutant with anti-platelet aggregation and fibrinolytic activity, application and preparation method thereof
RU2422457C2 (en) * 2009-04-21 2011-06-27 Эспосито Трейдинг Лтд Method of purifying recombinant staphylokinase protein
WO2010122175A1 (en) * 2009-04-24 2010-10-28 Dsm Ip Assets B.V. Improved pig liver esterases
RU2422153C1 (en) * 2010-03-26 2011-06-27 Эспосито Трейдинг Лтд RECOMBINANT PLASMID DNA CONTAINING SEQUENCE OF MATURE STAPHYLOKINASE STAPHYLOCOCCUS AUREUS WITH REPLACEMENT OF CODONS K74, E75 AND R77 WITH TRIPLETS CODING Ala, STRAINS OF ESCHERICHIA COLI MZ09 AND METHOD OF OBTAINING RECOMBINANT PROTEIN, CONTAINING SEQUENCE OF MATURE STAPHYLOKINASE GENE WITH REPLACEMENT OF CODONS K74, E75 AND R77 WITH Ala-CODING TRIPLETS
CN102199585B (en) * 2011-04-13 2012-08-22 中国科学院过程工程研究所 Preparation method of recombinant staphylokinase dimer and site-specific modificaton of polyethylene glycol
CN117643621B (en) * 2023-10-27 2024-07-02 江苏省人民医院（南京医科大学第一附属医院） Thrombolytic drug PLT-r-SAK and preparation method thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE158613T1 (en) * 1990-12-17 1997-10-15 Yakult Honsha Kk THROMBOLYTIC PEPTIDE, ITS PRODUCTION AND THROMBOLIC AGENT
CN1035192C (en) * 1994-04-04 1997-06-18 上海医科大学 Preparing method for recomposing staphylokinase
JPH08289790A (en) * 1995-01-06 1996-11-05 Leuven Res & Dev Vzw Novel staphylokinase derivative
US6383483B1 (en) * 1995-01-06 2002-05-07 Désiré José Collen Staphylokinase derivatives with cysteine substitutions
CN1109508A (en) * 1995-01-23 1995-10-04 成都世新药物技术开发中心 Full DNA sequence of recombinative glucokinase
CN1196391A (en) * 1997-04-16 1998-10-21 中国人民解放军军事医学科学院基础医学研究所 Novel staphylokinase and its production method
ATE294865T1 (en) * 1998-02-04 2005-05-15 Thromb X N V IDENTIFICATION, PRODUCTION AND USE OF STAPHYLOKINASE DERIVATIVES WITH REDUCED IMMUNOGENICITY AND/OR REDUCED CLEARANCE
CN1064406C (en) * 1998-05-11 2001-04-11 中国人民解放军军事医学科学院微生物流行病研究所 Method for producing glucokinase by gene engrg. technique
CN100342007C (en) * 2000-01-28 2007-10-10 复旦大学 Recombination gluconokinase and its preparing process

Also Published As

Publication number Publication date
US20090087421A1 (en) 2009-04-02
RU2283863C2 (en) 2006-09-20
US7407789B2 (en) 2008-08-05
US20050202000A1 (en) 2005-09-15
CN1264736A (en) 2000-08-30
RU2002123058A (en) 2004-01-27
CN100342007C (en) 2007-10-10
WO2001055359A1 (en) 2001-08-02

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