[go: up one dir, main page]

AU2001228759A1 - Compositions and methods for treatment of neoplastic diseases with combinations of limonoids, flavonoids and tocotrienols - Google Patents

Compositions and methods for treatment of neoplastic diseases with combinations of limonoids, flavonoids and tocotrienols

Info

Publication number
AU2001228759A1
AU2001228759A1 AU2001228759A AU2875901A AU2001228759A1 AU 2001228759 A1 AU2001228759 A1 AU 2001228759A1 AU 2001228759 A AU2001228759 A AU 2001228759A AU 2875901 A AU2875901 A AU 2875901A AU 2001228759 A1 AU2001228759 A1 AU 2001228759A1
Authority
AU
Australia
Prior art keywords
limonoids
tocotrienols
flavonoids
compositions
combinations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001228759A
Inventor
Najla Guthrie
Elzbieta Maria Kurowska
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KGK Synergize Inc
Original Assignee
KGK Synergize Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23914084&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2001228759(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by KGK Synergize Inc filed Critical KGK Synergize Inc
Publication of AU2001228759A1 publication Critical patent/AU2001228759A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2001228759A 2000-01-12 2001-01-12 Compositions and methods for treatment of neoplastic diseases with combinations of limonoids, flavonoids and tocotrienols Abandoned AU2001228759A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09481963 2000-01-12
US09/481,963 US6239114B1 (en) 1997-09-26 2000-01-12 Compositions and methods for treatment of neoplastic diseases with combinations of limonoids, flavonoids and tocotrienols
PCT/IB2001/000186 WO2001051043A2 (en) 2000-01-12 2001-01-12 Compositions and methods for treatment of neoplastic diseases with combinations of limonoids, flavonoids and tocotrienols

Publications (1)

Publication Number Publication Date
AU2001228759A1 true AU2001228759A1 (en) 2001-07-24

Family

ID=23914084

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001228759A Abandoned AU2001228759A1 (en) 2000-01-12 2001-01-12 Compositions and methods for treatment of neoplastic diseases with combinations of limonoids, flavonoids and tocotrienols

Country Status (3)

Country Link
US (1) US6239114B1 (en)
AU (1) AU2001228759A1 (en)
WO (1) WO2001051043A2 (en)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6987125B1 (en) * 1998-10-06 2006-01-17 The United States Of America As Represented By The Secretary Of Agriculture Compositions and methods of treating, reducing and preventing cardiovascular diseases and disorders with polymethoxyflavones
US7201928B1 (en) 1999-09-21 2007-04-10 Rutgers, The State University Of New Jersey Extracts of orange peel for prevention and treatment of cancer
US20030104090A1 (en) * 2000-05-05 2003-06-05 Levy Pedro E. Supplements containing annatto extracts and carotenoids and methods for using the same
GB0026018D0 (en) 2000-10-24 2000-12-13 Novartis Nutrition Ag New composition
MXPA03010080A (en) * 2001-05-02 2006-04-05 Kgk Synergize Inc Use of polymethoxylated flavones for treating insulin resistance.
CA2356438A1 (en) * 2001-09-05 2003-03-05 Andre Pichette Use of terpenes and derivatives as potentiators of antitumor agents in the treatment of cancers
US20040254357A1 (en) * 2002-12-19 2004-12-16 Zaloga Gary P. Fatty acid phenolic conjugates
US6866856B2 (en) * 2002-12-31 2005-03-15 Avon Products, Inc. Compositions and delivery methods for the treatment of wrinkles, fine lines and hyperhidrosis
US7763588B2 (en) * 2003-06-13 2010-07-27 The Salk Institute For Biological Studies Method for increasing cognitive function and neurogenesis
KR20060113651A (en) * 2003-08-08 2006-11-02 더 오하이오 스테이트 유니버시티 리서치 파운데이션 Protective and therapeutic uses of tocotrienols
JP4585201B2 (en) * 2004-01-23 2010-11-24 丸善製薬株式会社 Androgen receptor binding inhibitor, hair nourishing agent, sebum secretion inhibitor and prostate hypertrophy inhibitor
WO2005115377A1 (en) * 2004-05-26 2005-12-08 Kgk Synergize Inc Functional foods comprising flavonoids and tocotrienols and methods thereof
ATE491447T1 (en) * 2004-05-26 2011-01-15 Kgk Synergize Inc COMPOSITIONS CONTAINING FLAVONOIDS AND TOCOTRIENOLS AND USES THEREOF
AU2005247159B2 (en) * 2004-05-26 2015-07-23 Interhealth Nutraceuticals Incorporated Pharmaceutical products for treating neoplastic disease and inflammation
US7655659B2 (en) * 2004-08-19 2010-02-02 Applied Genetics Incorporated Dermatics Biomimetic of Evodia rutaecarpa fruit extract for amelioration of inflammation
WO2006045096A2 (en) * 2004-10-20 2006-04-27 Resverlogix Corp. Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases
US7252834B2 (en) * 2005-04-25 2007-08-07 Clemson University Research Foundation (Curf) Elastin stabilization of connective tissue
US7887852B2 (en) * 2005-06-03 2011-02-15 Soft Gel Technologies, Inc. Soft gel capsules containing polymethoxylated flavones and palm oil tocotrienols
US20050249803A1 (en) * 2005-06-03 2005-11-10 Udell Ronald G Soft gel capsules containing polymethoxylated flavones and palm oil tocotrienols
CN101365446B (en) 2005-07-29 2013-05-22 雷斯弗洛吉克斯公司 Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery via implantable medical devices
US20070117763A1 (en) * 2005-11-10 2007-05-24 Kgk Synergize Inc. Compositions and methods for treatment and prevention of metabolic syndrome and its associated conditions with combinations of flavonoids, liminoids and tocotrienols
WO2007135569A2 (en) * 2006-02-09 2007-11-29 Kgk Synergize Inc Methods of treating canine osteosarcoma
MY154376A (en) * 2006-02-13 2015-06-15 Malaysian Palm Oil Board Mpob A transdermal fluid
BRPI0708893A2 (en) * 2006-03-15 2011-06-28 Univ Rutgers composition, processes for increasing the ratio of hydroxylated pmfs to nonhydroxylated pmfs in a plant extract, and for preparing the plant extract, uses of a hydroxylated pmfs, and a composition, and methods for inhibiting proliferation of a cancer cell , to induce apoptosis in a cancer cell, to reduce nitrite production in a macrophage, and to inhibit activation of inos and / or cox-2 in a macrophage.
WO2008035208A2 (en) * 2006-05-19 2008-03-27 Kgk Synergize Inc The use of flavonoids for the inhibition of cellular growth
US8288369B2 (en) * 2006-06-27 2012-10-16 University Of South Florida Delta-tocotrienol treatment and prevention of pancreatic cancer
PL2118074T3 (en) 2007-02-01 2014-06-30 Resverlogix Corp Compounds for the prevention and treatment of cardiovascular diseases
MY177206A (en) * 2007-04-23 2020-09-09 Malaysian Palm Oil Board Compounds extracted from palm oil mill effluent for the treatment of cancer, compositions thereof and methods therewith
CN101322700B (en) * 2007-06-13 2010-08-25 中国科学院生物物理研究所 Application of naringenin and naringin as inhibitors of transforming growth factor-β1 signaling pathway in the preparation of medicines
US20090155337A1 (en) * 2007-11-12 2009-06-18 Endologix, Inc. Method and agent for in-situ stabilization of vascular tissue
JP2011513220A (en) * 2008-02-21 2011-04-28 ヴァトリックス・メディカル・インコーポレーテッド Treatment of aneurysms by application of connective tissue stabilizer in combination with delivery vehicle
KR101629356B1 (en) 2008-06-26 2016-06-13 리스버로직스 코퍼레이션 Methods of preparing quinazolinone derivatives
US20100119605A1 (en) * 2008-11-12 2010-05-13 Isenburg Jason C Compositions for tissue stabilization
JP5635535B2 (en) 2009-01-08 2014-12-03 レスバーロジックス コーポレイション Compounds for the prevention and treatment of cardiovascular disease
US9545117B2 (en) * 2009-02-03 2017-01-17 Tropicana Products, Inc. Microencapsulated citrus phytochemicals and application to beverages
US20100196554A1 (en) * 2009-02-03 2010-08-05 Tropicana Products, Inc. Microencapsulated citrus phytochemicals comprising citrus limonoids and application to beverages
US20100196577A1 (en) * 2009-02-03 2010-08-05 Tropicana Products, Inc. Microencapsulated citrus phytochemicals comprising citrus limonoids and application to sports drinks
US20100196549A1 (en) * 2009-02-03 2010-08-05 Tropicana Products, Inc. Microencapsulated citrus phytochemicals and application to sports drinks
WO2010106436A2 (en) 2009-03-18 2010-09-23 Resverlogix Corp. Novel anti-inflammatory agents
US20100261662A1 (en) * 2009-04-09 2010-10-14 Endologix, Inc. Utilization of mural thrombus for local drug delivery into vascular tissue
TR201818390T4 (en) 2009-04-22 2019-01-21 Resverlogix Corp NEW ANTI-INFLAMMATORY AGENTS
US20110218517A1 (en) * 2009-10-09 2011-09-08 Ogle Matthew F In vivo chemical stabilization of vulnerable plaque
US8911468B2 (en) 2011-01-31 2014-12-16 Vatrix Medical, Inc. Devices, therapeutic compositions and corresponding percutaneous treatment methods for aortic dissection
EP2709711B8 (en) 2011-05-18 2017-03-22 Vatrix Medical, Inc. Coated balloons for blood vessel stabilization
TR201909777T4 (en) 2011-11-01 2019-07-22 Resverlogix Corp ORAL RELEASE RELEASE FORMULATIONS FOR SUBSTITUTED QINAZOLINONES
CN102631446B (en) * 2012-04-20 2013-11-06 浙江省中医院 Grapefruit peel flavone extract, preparation and application thereof
US9283241B2 (en) 2012-07-10 2016-03-15 Clemson University Treatment to render implants resistant to diabetes
US20140120116A1 (en) * 2012-10-26 2014-05-01 The Chinese University Of Hong Kong Treatment of cancer using smad3 inhibitor
WO2014080290A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Cyclic amines as bromodomain inhibitors
US9765039B2 (en) 2012-11-21 2017-09-19 Zenith Epigenetics Ltd. Biaryl derivatives as bromodomain inhibitors
BR112015002626A2 (en) * 2012-11-29 2017-09-26 Yeda Res & Dev methods for tumor metastasis prevention, cancer treatment and prognosis, and identification of agents that are putative metastasis inhibitors
WO2014096965A2 (en) 2012-12-21 2014-06-26 Rvx Therapeutics Inc. Novel heterocyclic compounds as bromodomain inhibitors
US9132117B2 (en) 2013-06-17 2015-09-15 Kgk Synergize, Inc Compositions and methods for glycemic control of subjects with impaired fasting glucose
US9868715B2 (en) * 2014-04-19 2018-01-16 The Board Of Regents Of The University Of Texas Systems Apigenin analogs, compositions, and methods related thereto
US10111885B2 (en) 2015-03-13 2018-10-30 Resverlogix Corp. Compositions and therapeutic methods for the treatment of complement-associated diseases
CN105147665A (en) * 2015-09-16 2015-12-16 华南理工大学 Application of tangeretin in preparation of medicine or health-care product for preventing and treating oral cancer
KR101753560B1 (en) * 2016-03-17 2017-07-05 제주대학교 산학협력단 Composition containing naringenin and hesperetin for preventing, treating or improving pancreatic cancer
US20180228815A1 (en) * 2016-11-09 2018-08-16 The Chinese University Of Hong Kong Naringenin and asiatic acid combination treatment of cancers
CN110327313A (en) * 2019-06-21 2019-10-15 中山大学 A kind of naringenin aerosol inhalation solution preparation and preparation method thereof
CN110326622B (en) * 2019-07-23 2020-05-29 中国农业科学院棉花研究所 Composition capable of enhancing drought resistance of cotton seedlings and drought resistance method
CN113304143B (en) * 2021-05-21 2023-04-11 广州医科大学附属第一医院（广州呼吸中心） Application of hesperetin and/or derivatives thereof in preparation or application of hesperetin and/or derivatives thereof as anti-renal cancer drug sensitizer
CN113350331B (en) * 2021-05-21 2023-08-29 广州医科大学附属第一医院（广州呼吸中心） Application of hesperetin and/or derivative thereof in preparation of or application of hesperetin and/or derivative thereof in preparation of medicines for preventing and/or treating renal cell carcinoma
CN113908148B (en) * 2021-08-12 2023-02-24 上海中医药大学附属曙光医院 Application of nobiletin in preparation of anti-cholangiocarcinoma drugs

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993793A (en) 1975-06-09 1976-11-23 Thomas J. Lipton, Inc. Soft ice cream
US4368213A (en) 1981-06-23 1983-01-11 The Procter & Gamble Company Emulsion concentrate for palatable polyester beverage
US4603142A (en) 1984-06-01 1986-07-29 Wisconsin Alumni Research Foundation Cholesterol lowering method of use
JP2724333B2 (en) * 1988-09-16 1998-03-09 豊玉香料株式会社 Tumor preventive
US5217992A (en) 1989-10-04 1993-06-08 Bristol-Myers Squibb Company Tocotrienols in the treatment of hypercholesterolemia, hyperlipidemia and thromboembolic disorders
JPH0554883A (en) 1991-04-25 1993-03-05 Furukawa Battery Co Ltd:The Manufacture of hydrogen storage electrode for alkaline storage battery
JPH07504887A (en) * 1991-11-22 1995-06-01 リポジェニックス，インコーポレイテッド Tocotrienols and tocotrienol-like compounds and methods of using them
US5545398A (en) * 1993-01-13 1996-08-13 Perricone; Nicholos V. Method and compositions for topical application to the skin of tocotrienol for prevention and/or treatment of skin damage
US5336685A (en) * 1993-04-12 1994-08-09 Sloan-Kettering Institute For Cancer Research Use of flavonoids to treat multidrug resistant cancer cells
JPH07135922A (en) 1993-11-18 1995-05-30 Akira Ishii Production of cream and cake
CA2134138C (en) 1994-01-24 1998-06-16 William E. Haast Lyophilized health food products and methods of making same
DE4444238A1 (en) * 1994-12-13 1996-06-20 Beiersdorf Ag Cosmetic or dermatological drug combinations of cinnamic acid derivatives and flavone glycosides
IT1271301B (en) * 1994-12-20 1997-05-27 Indena Spa NATURAL AND SYNTHETIC CALCONES AND THEIR ESTERS WITH ANTI-PROLIFERATIVE ACTIVITY IN CANCER OF THE UTERUS, OVARIAN AND BREAST AND FORMULATIONS CONTAINING THEM
JPH08283154A (en) 1995-04-12 1996-10-29 Nippon Shinyaku Co Ltd Lipid metabolism improver
IT1274549B (en) * 1995-05-23 1997-07-17 Indena Spa USE OF FLAVANOLIGNANI FOR THE PREPARATION OF MEDICATIONS FOR ANTI-PROLIFERATIVE ACTIVITY IN CANCER OF THE UTERUS, OVARIAN AND BREAST
US5955269A (en) * 1996-06-20 1999-09-21 Rutgers, The State University Of New Jersey Methods of screening foods for nutraceuticals
KR100213895B1 (en) * 1996-10-14 1999-08-02 박원훈 A composition for preventing and treating cardiovascular diseases comprising citrus peel extract, hesperidin or naringin isolated therefrom
WO1998038993A1 (en) 1997-03-04 1998-09-11 Wisconsin Alumni Research Foundation Method of suppressing tumor growth with combinations of isoprenoids and statins
US6251400B1 (en) * 1997-09-26 2001-06-26 Kgk Synergize Inc Compositions and methods of treatment of neoplastic diseases and hypercholesterolemia with citrus limonoids and flavonoids and tocotrienols
JP3333777B2 (en) * 1997-10-28 2002-10-15 コリア インスティテュート オブ サイエンス アンド テクノロジー Acyl COA-cholesterol-O-acyl transferase inhibitor, inhibitor of macrophage-lipid complex accumulation on arterial wall, and citrus peel extract as prophylactic or therapeutic agent for liver disease

Also Published As

Publication number Publication date
WO2001051043A2 (en) 2001-07-19
US6239114B1 (en) 2001-05-29
WO2001051043A3 (en) 2002-05-30

Similar Documents

Publication Publication Date Title
AU2001228759A1 (en) Compositions and methods for treatment of neoplastic diseases with combinations of limonoids, flavonoids and tocotrienols
AU2001267412A1 (en) Ring fixator
AU2001245437A1 (en) Lightweight methods and compositions for well treating
AU2001261752A1 (en) Compositions and methods for treating otic, ophthalmic and nasal infections
AU2002223827A1 (en) Well treatment
AU2001289684A1 (en) Glass-ceramics, process for their preparation and use
AU2002340999A1 (en) Phenylsulfonyl-1,3-dihydro-2h-indole-2-one derivatives, their preparation and their therapeutic use
AU2001222215A1 (en) Lumbago treating girdle
MXPA03003741A (en) Methods and compositions for the treatment of diseases of the eye.
AU2001288972A1 (en) Antipsychotic sulfonamide-heterocycles, and methods of use thereof
AU2001237939A1 (en) Methods for treating glaucoma
ZA200205098B (en) Dihydrobenzopyrans, dihydrobenzothiopyrans, and tetrahydroquinolines for the treatment of cox-2-mediated disorders.
HUP0302065A3 (en) Chromanone derivatives, production and use thereof
AU2002233407A1 (en) 2-arylimino-2,3-dihydrothiazole derivatives, methods for preparing them and therapeutic use thereof
AU2000254308A1 (en) Pyrazolopyrimidinone derivatives, process for their preparation and their use
AU2001234616A1 (en) Vaccine composition, process and methods
AU2001261748A1 (en) Antibiotic compositions for treatment of the eye, ear and nose
AU2002221760A1 (en) Vaccine for treating allergy
AU2002229870A1 (en) Mikanolide derivatives, their preparation and therapeutic uses
AUPR957001A0 (en) Isoflavone conjugates, derivatives thereof and therapeutic methods involving same
AU2001281465A1 (en) Treatment of rosacea
AUPR520701A0 (en) Herbal composition for the treatment of drug addiction
AU2002227952A1 (en) Klainetin and derivatives thereof, method for their production and the use of the same
AU2001253560A1 (en) Methods of treatment
AU2002365643A1 (en) Substituted aryl-cycloalkanes, and use thereof as anticancer agents