AU2001293838A1 - Propionic acid derivatives with PPAR-alpha activating properties - Google Patents
Propionic acid derivatives with PPAR-alpha activating propertiesInfo
- Publication number
- AU2001293838A1 AU2001293838A1 AU2001293838A AU9383801A AU2001293838A1 AU 2001293838 A1 AU2001293838 A1 AU 2001293838A1 AU 2001293838 A AU2001293838 A AU 2001293838A AU 9383801 A AU9383801 A AU 9383801A AU 2001293838 A1 AU2001293838 A1 AU 2001293838A1
- Authority
- AU
- Australia
- Prior art keywords
- ppar
- propionic acid
- acid derivatives
- activating properties
- alpha activating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 102000023984 PPAR alpha Human genes 0.000 title 1
- 230000003213 activating effect Effects 0.000 title 1
- 229940111131 antiinflammatory and antirheumatic product propionic acid derivative Drugs 0.000 title 1
- 108091008725 peroxisome proliferator-activated receptors alpha Proteins 0.000 title 1
- 150000005599 propionic acid derivatives Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/18—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10049208.8 | 2000-10-05 | ||
| DE10049208 | 2000-10-05 | ||
| DE10124905A DE10124905A1 (en) | 2000-10-05 | 2001-05-22 | propionic acid derivatives |
| DE10124905.5 | 2001-05-22 | ||
| PCT/EP2001/011005 WO2002028821A2 (en) | 2000-10-05 | 2001-09-24 | Propionic acid derivatives with ppar-alpha activating properties |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2001293838A1 true AU2001293838A1 (en) | 2002-04-15 |
Family
ID=26007267
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001293838A Abandoned AU2001293838A1 (en) | 2000-10-05 | 2001-09-24 | Propionic acid derivatives with PPAR-alpha activating properties |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1328508A2 (en) |
| JP (1) | JP2004510757A (en) |
| CN (1) | CN1479716A (en) |
| AU (1) | AU2001293838A1 (en) |
| BG (1) | BG107684A (en) |
| BR (1) | BR0114437A (en) |
| CA (1) | CA2424540A1 (en) |
| CZ (1) | CZ2003964A3 (en) |
| EE (1) | EE200300140A (en) |
| HN (1) | HN2001000223A (en) |
| HR (1) | HRP20030346A2 (en) |
| HU (1) | HUP0302306A3 (en) |
| IL (1) | IL155125A0 (en) |
| MA (1) | MA25917A1 (en) |
| MX (1) | MXPA03002901A (en) |
| NO (1) | NO20031517L (en) |
| NZ (1) | NZ525119A (en) |
| PL (1) | PL361162A1 (en) |
| RU (1) | RU2003112968A (en) |
| SK (1) | SK4132003A3 (en) |
| UY (1) | UY26951A1 (en) |
| WO (1) | WO2002028821A2 (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10151390A1 (en) * | 2001-10-18 | 2003-05-08 | Bayer Ag | acetic acid derivatives |
| GB0214254D0 (en) * | 2002-06-20 | 2002-07-31 | Glaxo Group Ltd | Chemical compounds |
| US20040162352A1 (en) * | 2002-10-21 | 2004-08-19 | Xiaoli Chen | Treating syndrome X with substituted tetralins and indanes |
| JP2006503916A (en) * | 2002-10-21 | 2006-02-02 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Substituted tetralin and indane |
| CA2502665A1 (en) * | 2002-10-21 | 2004-05-06 | Janssen Pharmaceutica, N.V. | Substituted tetralins and indanes and their use |
| AU2003296402A1 (en) | 2003-01-06 | 2004-08-10 | Eli Lilly And Company | Thiophene derivative ppar modulators |
| CA2824106A1 (en) | 2003-08-29 | 2005-03-10 | Ono Pharmaceutical Co., Ltd. | Compound capable of binding s1p receptor and pharmaceutical use thereof |
| AR048931A1 (en) | 2004-04-21 | 2006-06-14 | Janssen Pharmaceutica Nv | PROCESS FOR THE PREPARATION OF SUBSTITUTED AND INDIAN TETRALIN DERIVATIVES AND PREPARATION OF SYNTHESIS INTERMEDIARIES |
| CN100344618C (en) | 2004-05-24 | 2007-10-24 | 北京摩力克科技有限公司 | N-benzyl acryloyl substituted tyrosine derivatives as hPPAR alpha and hPPAR gamma agonist |
| KR100699928B1 (en) | 2004-10-05 | 2007-03-26 | 재단법인서울대학교산학협력재단 | Method for preparing intermediates for the preparation of peroxysomal proliferator activated receptor alpha ligands |
| CA2591399C (en) | 2004-12-13 | 2014-05-20 | Ono Pharmaceutical Co., Ltd. | Aminocarboxylic acid derivative and medicinal use thereof |
| CN101054372B (en) * | 2006-04-11 | 2010-10-13 | 中国科学院上海药物研究所 | Pyrimidine substituted benzenepropanoic acid derivative, its preparation method and use in curing polycystic kidney disease |
| CN102300853A (en) | 2008-12-01 | 2011-12-28 | 田边三菱制药株式会社 | Carboxylic acid derivatives containing thiazole ring and their pharmaceutical use |
| JP5436941B2 (en) * | 2009-06-03 | 2014-03-05 | あすか製薬株式会社 | Lactam compound or salt thereof and PPAR activator |
| UY34200A (en) | 2011-07-21 | 2013-02-28 | Bayer Ip Gmbh | 3- (FLUOROVINIL) PIRAZOLES AND ITS USE |
| WO2016091746A1 (en) * | 2014-12-11 | 2016-06-16 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Method for acylating a cyclic peptide |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2320387A1 (en) * | 1973-04-21 | 1974-10-31 | Boehringer Mannheim Gmbh | PHENOXYALKYLCARBONIC ACID DERIVATIVES AND METHOD FOR PREPARING THE SAME |
| GB9822473D0 (en) * | 1998-10-16 | 1998-12-09 | Glaxo Group Ltd | Chemical compounds |
-
2001
- 2001-09-24 AU AU2001293838A patent/AU2001293838A1/en not_active Abandoned
- 2001-09-24 JP JP2002532408A patent/JP2004510757A/en active Pending
- 2001-09-24 NZ NZ525119A patent/NZ525119A/en unknown
- 2001-09-24 MX MXPA03002901A patent/MXPA03002901A/en unknown
- 2001-09-24 WO PCT/EP2001/011005 patent/WO2002028821A2/en not_active Ceased
- 2001-09-24 CA CA002424540A patent/CA2424540A1/en not_active Abandoned
- 2001-09-24 CN CNA018200885A patent/CN1479716A/en active Pending
- 2001-09-24 RU RU2003112968/04A patent/RU2003112968A/en not_active Application Discontinuation
- 2001-09-24 HR HR20030346A patent/HRP20030346A2/en not_active Application Discontinuation
- 2001-09-24 SK SK413-2003A patent/SK4132003A3/en not_active Application Discontinuation
- 2001-09-24 BR BR0114437-5A patent/BR0114437A/en not_active IP Right Cessation
- 2001-09-24 PL PL01361162A patent/PL361162A1/en not_active Application Discontinuation
- 2001-09-24 EP EP01974287A patent/EP1328508A2/en not_active Withdrawn
- 2001-09-24 CZ CZ2003964A patent/CZ2003964A3/en unknown
- 2001-09-24 IL IL15512501A patent/IL155125A0/en unknown
- 2001-09-24 EE EEP200300140A patent/EE200300140A/en unknown
- 2001-09-24 HU HU0302306A patent/HUP0302306A3/en unknown
- 2001-10-03 UY UY26951A patent/UY26951A1/en not_active Application Discontinuation
- 2001-10-04 HN HN2001000223A patent/HN2001000223A/en unknown
-
2003
- 2003-03-28 BG BG107684A patent/BG107684A/en unknown
- 2003-04-03 NO NO20031517A patent/NO20031517L/en not_active Application Discontinuation
- 2003-04-04 MA MA27091A patent/MA25917A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20030346A2 (en) | 2005-04-30 |
| NZ525119A (en) | 2005-04-29 |
| BR0114437A (en) | 2003-07-01 |
| MXPA03002901A (en) | 2003-10-15 |
| MA25917A1 (en) | 2003-10-01 |
| IL155125A0 (en) | 2003-10-31 |
| EE200300140A (en) | 2003-08-15 |
| NO20031517L (en) | 2003-05-28 |
| CA2424540A1 (en) | 2003-04-02 |
| BG107684A (en) | 2003-10-31 |
| PL361162A1 (en) | 2004-09-20 |
| RU2003112968A (en) | 2004-09-20 |
| HUP0302306A3 (en) | 2005-02-28 |
| CZ2003964A3 (en) | 2003-08-13 |
| NO20031517D0 (en) | 2003-04-03 |
| HN2001000223A (en) | 2001-10-25 |
| WO2002028821A3 (en) | 2002-08-15 |
| HUP0302306A2 (en) | 2003-10-28 |
| CN1479716A (en) | 2004-03-03 |
| WO2002028821A2 (en) | 2002-04-11 |
| SK4132003A3 (en) | 2004-02-03 |
| EP1328508A2 (en) | 2003-07-23 |
| JP2004510757A (en) | 2004-04-08 |
| UY26951A1 (en) | 2002-06-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |