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AU2001293233A1 - Aza heterocyclic derivatives and their therapeutic use - Google Patents

Aza heterocyclic derivatives and their therapeutic use

Info

Publication number
AU2001293233A1
AU2001293233A1 AU2001293233A AU9323301A AU2001293233A1 AU 2001293233 A1 AU2001293233 A1 AU 2001293233A1 AU 2001293233 A AU2001293233 A AU 2001293233A AU 9323301 A AU9323301 A AU 9323301A AU 2001293233 A1 AU2001293233 A1 AU 2001293233A1
Authority
AU
Australia
Prior art keywords
sup
therapeutic use
heterocyclic derivatives
pharmaceutically acceptable
aza heterocyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001293233A
Inventor
Tim Machajewski
Sabina Pecci
Paul Renhowe
Cynthia Shafer
Mary-Ellen Wernette-Hammond
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of AU2001293233A1 publication Critical patent/AU2001293233A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Organic compounds having the structural formula I are provided where the variables have the values described herein and R<SUP>1 </SUP>and R<SUP>2 </SUP>join together to form a 6 membered substituted or unsubstituted ring including at least one O, N, or S atom, and Z is an O, S, NH or NR group. Pharmaceutical formulations include the organic compound or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
AU2001293233A 2000-09-01 2001-08-30 Aza heterocyclic derivatives and their therapeutic use Abandoned AU2001293233A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23182900P 2000-09-01 2000-09-01
US60/231,829 2000-09-01
PCT/US2001/041942 WO2002018383A2 (en) 2000-09-01 2001-08-30 Aza heterocyclic derivatives and their therapeutic use

Publications (1)

Publication Number Publication Date
AU2001293233A1 true AU2001293233A1 (en) 2002-03-13

Family

ID=22870779

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001293233A Abandoned AU2001293233A1 (en) 2000-09-01 2001-08-30 Aza heterocyclic derivatives and their therapeutic use

Country Status (9)

Country Link
US (4) US6756383B2 (en)
EP (1) EP1313734B1 (en)
JP (2) JP4341949B2 (en)
AT (1) ATE448226T1 (en)
AU (1) AU2001293233A1 (en)
DE (1) DE60140456D1 (en)
ES (1) ES2334641T3 (en)
PT (1) PT1313734E (en)
WO (1) WO2002018383A2 (en)

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US20040002518A1 (en) 2004-01-01
ATE448226T1 (en) 2009-11-15
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US7368459B2 (en) 2008-05-06
US20070032528A1 (en) 2007-02-08
EP1313734A2 (en) 2003-05-28
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