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AU2001292092A1 - Zwitterionic polymers - Google Patents

Zwitterionic polymers

Info

Publication number
AU2001292092A1
AU2001292092A1 AU2001292092A AU9209201A AU2001292092A1 AU 2001292092 A1 AU2001292092 A1 AU 2001292092A1 AU 2001292092 A AU2001292092 A AU 2001292092A AU 9209201 A AU9209201 A AU 9209201A AU 2001292092 A1 AU2001292092 A1 AU 2001292092A1
Authority
AU
Australia
Prior art keywords
zwitterionic
polymers
water soluble
block copolymers
instance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001292092A
Inventor
Steven Peter Armes
Andrew Lennard Lewis
Emma Janice Lobb
Yinghua Ma
Sean Leo Willis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biocompatibles UK Ltd
Original Assignee
Biocompatibles Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocompatibles Ltd filed Critical Biocompatibles Ltd
Publication of AU2001292092A1 publication Critical patent/AU2001292092A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F4/00—Polymerisation catalysts
    • C08F4/40—Redox systems
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F246/00—Copolymers in which the nature of only the monomers in minority is defined
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
    • C08F293/005—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule using free radical "living" or "controlled" polymerisation, e.g. using a complexing agent
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2438/00—Living radical polymerisation
    • C08F2438/01—Atom Transfer Radical Polymerization [ATRP] or reverse ATRP

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Graft Or Block Polymers (AREA)
  • Medicinal Preparation (AREA)
  • Polyamides (AREA)
  • Polymerization Catalysts (AREA)

Abstract

Polymers may be made from zwitterionic monomers having controlled architectures and molecular weights, using living polymerisations such as group or atom transfer radical polymerisation. For instance polymers may be formed by atom transfer radical polymerisation using a copper chloride catalyst, a ligand which is water soluble, and a water soluble tertiary alkyl halide initiator to form homopolymers having controlled polydispersities of less than 1.5 and block copolymers with other hydrophilic or hydrophobic monomers. One suitable zwitterionic monomer is 2-methacryloyloxy-2'-trimethylammoniumethyl phosphate inner salt. The block copolymers may spontaneously form micelles, believed to have zwitterionic, for instance phosphorylcholine, groups at the external surface, which may be useful as drug delivery systems with improved biocompatibility.
AU2001292092A 2000-10-06 2001-10-05 Zwitterionic polymers Abandoned AU2001292092A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00308821 2000-10-06
EP00308821 2000-10-06
PCT/GB2001/004432 WO2002028929A1 (en) 2000-10-06 2001-10-05 Zwitterionic polymers

Publications (1)

Publication Number Publication Date
AU2001292092A1 true AU2001292092A1 (en) 2002-04-15

Family

ID=8173308

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001292092A Abandoned AU2001292092A1 (en) 2000-10-06 2001-10-05 Zwitterionic polymers

Country Status (8)

Country Link
US (2) US6852816B2 (en)
EP (1) EP1325046B1 (en)
JP (3) JP5049452B2 (en)
AT (1) ATE365753T1 (en)
AU (1) AU2001292092A1 (en)
DE (1) DE60129148T2 (en)
ES (1) ES2287159T3 (en)
WO (1) WO2002028929A1 (en)

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Also Published As

Publication number Publication date
ES2287159T3 (en) 2007-12-16
JP2008239997A (en) 2008-10-09
US6852816B2 (en) 2005-02-08
US20040063881A1 (en) 2004-04-01
JP5049452B2 (en) 2012-10-17
US7300990B2 (en) 2007-11-27
JP2010013651A (en) 2010-01-21
JP5386110B2 (en) 2014-01-15
EP1325046B1 (en) 2007-06-27
JP2004510851A (en) 2004-04-08
ATE365753T1 (en) 2007-07-15
DE60129148T2 (en) 2008-02-28
DE60129148D1 (en) 2007-08-09
EP1325046A1 (en) 2003-07-09
WO2002028929A1 (en) 2002-04-11
US20050159556A1 (en) 2005-07-21

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