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AU2001290043A1 - Confocal optical scanning device - Google Patents

Confocal optical scanning device

Info

Publication number
AU2001290043A1
AU2001290043A1 AU2001290043A AU9004301A AU2001290043A1 AU 2001290043 A1 AU2001290043 A1 AU 2001290043A1 AU 2001290043 A AU2001290043 A AU 2001290043A AU 9004301 A AU9004301 A AU 9004301A AU 2001290043 A1 AU2001290043 A1 AU 2001290043A1
Authority
AU
Australia
Prior art keywords
light
confocal optical
scanning device
optical scanning
image plane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001290043A
Inventor
Vincent Lauer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0011879A external-priority patent/FR2814247A1/en
Priority claimed from FR0101138A external-priority patent/FR2819896A1/en
Priority claimed from FR0101906A external-priority patent/FR2820829A1/en
Priority claimed from FR0102254A external-priority patent/FR2821169A1/en
Priority claimed from FR0103860A external-priority patent/FR2822551A1/en
Priority claimed from FR0104841A external-priority patent/FR2823315A1/en
Priority claimed from FR0108516A external-priority patent/FR2826736A1/en
Application filed by Individual filed Critical Individual
Publication of AU2001290043A1 publication Critical patent/AU2001290043A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0056—Optical details of the image generation based on optical coherence, e.g. phase-contrast arrangements, interference arrangements
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0032—Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0036—Scanning details, e.g. scanning stages
    • G02B21/004—Scanning details, e.g. scanning stages fixed arrays, e.g. switchable aperture arrays
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0036—Scanning details, e.g. scanning stages
    • G02B21/0044—Scanning details, e.g. scanning stages moving apertures, e.g. Nipkow disks, rotating lens arrays
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0036—Scanning details, e.g. scanning stages
    • G02B21/0048—Scanning details, e.g. scanning stages scanning mirrors, e.g. rotating or galvanomirrors, MEMS mirrors
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0068—Optical details of the image generation arrangements using polarisation
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/008—Details of detection or image processing, including general computer control
    • G02B21/0084—Details of detection or image processing, including general computer control time-scale detection, e.g. strobed, ultra-fast, heterodyne detection
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B5/00—Optical elements other than lenses
    • G02B5/005—Diaphragms

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • General Engineering & Computer Science (AREA)
  • Microscoopes, Condenser (AREA)
  • Geophysics And Detection Of Objects (AREA)

Abstract

The confocal optical scanner for a microscope has an optical system to focus an illuminating beam (FX) from a light source to illuminate a pint on an object (1107). The system focuses the light from the object to a point (FEO) in a first image plane.. A rotary mirror (1104) reflects the light beam to scan the object. A spatial filter (1203) in the first image plane filters the light to obtain a beam to be detected.
AU2001290043A 2000-09-18 2001-09-18 Confocal optical scanning device Abandoned AU2001290043A1 (en)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
FR0011879 2000-09-18
FR0011879A FR2814247A1 (en) 2000-09-18 2000-09-18 Confocal optical scanner for biological microscope, has optical system to focus light from object to form beam reflected by rotary mirror for scanning
FR0101138 2001-01-23
FR0101138A FR2819896A1 (en) 2001-01-23 2001-01-23 Confocal optical scanner for biological microscope, has optical system to focus light from object to form beam reflected by rotary mirror for scanning
FR0101906 2001-02-13
FR0101906A FR2820829A1 (en) 2001-02-13 2001-02-13 Confocal optical scanner for biological microscope, has optical system to focus light from object to form beam reflected by rotary mirror for scanning
FR0102254 2001-02-20
FR0102254A FR2821169A1 (en) 2001-02-20 2001-02-20 Confocal optical scanner for biological microscope, has optical system to focus light from object to form beam reflected by rotary mirror for scanning
FR0103860 2001-03-22
FR0103860A FR2822551A1 (en) 2001-03-22 2001-03-22 Confocal optical scanner for biological microscope, has optical system to focus light from object to form beam reflected by rotary mirror for scanning
FR0104841 2001-04-10
FR0104841A FR2823315A1 (en) 2001-04-10 2001-04-10 Confocal optical scanner for biological microscope, has optical system to focus light from object to form beam reflected by rotary mirror for scanning
FR0108516A FR2826736A1 (en) 2001-06-28 2001-06-28 Confocal optical scanner for biological microscope, has optical system to focus light from object to form beam reflected by rotary mirror for scanning
FR0108516 2001-06-28
PCT/FR2001/002890 WO2002023247A1 (en) 2000-09-18 2001-09-18 Confocal optical scanning device

Publications (1)

Publication Number Publication Date
AU2001290043A1 true AU2001290043A1 (en) 2002-03-26

Family

ID=27562423

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001290043A Abandoned AU2001290043A1 (en) 2000-09-18 2001-09-18 Confocal optical scanning device

Country Status (7)

Country Link
US (1) US7391565B2 (en)
EP (2) EP1953580B1 (en)
JP (1) JP5000839B2 (en)
AT (1) ATE394697T1 (en)
AU (1) AU2001290043A1 (en)
DE (1) DE60133916D1 (en)
WO (1) WO2002023247A1 (en)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2836727B1 (en) * 2002-03-04 2006-02-24 Vincent Lauer CONFOCAL OPTICAL SCANNING DEVICE
DE10235388A1 (en) * 2002-08-02 2004-02-19 Carl Zeiss Jena Gmbh Optical arrangement with telecentric beam path has one Infinite lens, ocular, tube lens, and optical element
DK1411345T3 (en) * 2002-10-17 2007-01-02 Direvo Biotech Ag Multiparameter fluorimetric analysis in parallel with multifocal arrangement
JP2006106378A (en) * 2004-10-06 2006-04-20 Yokogawa Electric Corp Confocal microscope
EP2194485B1 (en) * 2004-11-16 2012-10-17 Illumina, Inc. Method and apparatus for reading coded microbeads
JP4755441B2 (en) * 2005-04-25 2011-08-24 株式会社日立製作所 Design support method and system
JP4887989B2 (en) * 2005-12-02 2012-02-29 ナノフォトン株式会社 Optical microscope and spectrum measuring method
GB0608923D0 (en) * 2006-05-05 2006-06-14 Visitech Internat Ltd 2-d array laser confocal scanning microscope and methods of improving image quality in such microscope
US20100167413A1 (en) * 2007-05-10 2010-07-01 Paul Lundquist Methods and systems for analyzing fluorescent materials with reduced autofluorescence
US20080277595A1 (en) * 2007-05-10 2008-11-13 Pacific Biosciences Of California, Inc. Highly multiplexed confocal detection systems and methods of using same
JP5259154B2 (en) * 2007-10-24 2013-08-07 オリンパス株式会社 Scanning laser microscope
CN101868739A (en) * 2007-11-23 2010-10-20 皇家飞利浦电子股份有限公司 Multi-focal spot generator and multi-focal multi-spot scanning microscope
JP2011504613A (en) * 2007-11-23 2011-02-10 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ Multimodal spot generator and multimodal multispot scanning microscope
EP2225598A1 (en) * 2007-12-21 2010-09-08 Koninklijke Philips Electronics N.V. Scanning microscope and method of imaging a sample.
WO2009100197A2 (en) * 2008-02-05 2009-08-13 Pocared Diagnostics Ltd. System for conducting the identification of bacteria in biological samples
NL2001464C2 (en) * 2008-04-10 2009-10-13 Amc Amsterdam Method for forming an image of an object.
JP2009288321A (en) * 2008-05-27 2009-12-10 Olympus Corp Microscope
WO2012031841A1 (en) * 2010-09-08 2012-03-15 Asml Netherlands B.V. Lithographic apparatus, euv radiation generation apparatus and device manufacturing method
CN103299231B (en) 2011-01-20 2017-07-21 通用电气医疗集团生物科学公司 Photo-scanning system
JP5907998B2 (en) * 2011-03-01 2016-04-26 ジーイー・ヘルスケア・バイオサイエンス・コーポレイション Variable orientation lighting pattern rotator
US9164247B2 (en) * 2011-07-28 2015-10-20 Source Photonics, Inc. Apparatuses for reducing the sensitivity of an optical signal to polarization and methods of making and using the same
SG2014011167A (en) * 2011-08-18 2014-09-26 Newport Corp System and method for characterizing material shrinkage using coherent anti-stokes raman scattering (cars) microscopy
KR101300733B1 (en) * 2012-01-12 2013-08-27 연세대학교 산학협력단 multi parallel confocal systeme
US10025082B2 (en) * 2012-02-23 2018-07-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Multi-focal structured illumination microscopy systems and methods
WO2013126762A1 (en) * 2012-02-23 2013-08-29 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Office Of Technology Transfer, National Institutes Of Health Multi-focal structured illumination microscopy systems and methods
DE102012102983A1 (en) * 2012-04-05 2013-10-10 Carl Zeiss Microscopy Gmbh Method and apparatus for determining a critical angle of an excitation light beam
JP2013238789A (en) * 2012-05-16 2013-11-28 Olympus Corp Observation unit and microscope system having the same
US9628676B2 (en) 2012-06-07 2017-04-18 Complete Genomics, Inc. Imaging systems with movable scan mirrors
US9488823B2 (en) * 2012-06-07 2016-11-08 Complete Genomics, Inc. Techniques for scanned illumination
DE102012216979A1 (en) * 2012-09-21 2014-04-17 Trumpf Laser Gmbh + Co. Kg Scanner device for deflecting a laser beam 2-dimensionally
JP6131448B2 (en) * 2012-12-04 2017-05-24 三星電子株式会社Ｓａｍｓｕｎｇ Ｅｌｅｃｔｒｏｎｉｃｓ Ｃｏ．，Ｌｔｄ． Confocal optical inspection apparatus and confocal optical inspection method
WO2014133481A1 (en) * 2013-02-26 2014-09-04 Hewlett-Packard Development Company, L.P. Multiview 3d telepresence
US10058246B2 (en) * 2013-03-15 2018-08-28 Neurovision Imaging, Inc. System and method for rejecting afocal light collected from an in vivo human retina
DE102013005927B4 (en) * 2013-03-28 2025-02-20 Friedrich-Schiller-Universität Jena Method for optically high-resolution raster scanning of an object and use of the method
US9720218B2 (en) * 2013-08-06 2017-08-01 Howard Hughes Medical Institute Volume imaging
EP3051276B2 (en) 2013-09-27 2026-01-21 Nikon Corporation Analysis device, microscope device, analysis method, and program
JP5999121B2 (en) 2014-02-17 2016-09-28 横河電機株式会社 Confocal light scanner
JP2015161719A (en) * 2014-02-26 2015-09-07 ソニー株式会社 Laser scanning microscope system and sampling device
US10352860B2 (en) 2014-04-24 2019-07-16 Bruker Nano, Inc. Super resolution microscopy
WO2015164843A1 (en) * 2014-04-24 2015-10-29 Vutara, Inc. Galvo scanning mirror for super-resolution microscopy
EP2963672A1 (en) * 2014-06-30 2016-01-06 FEI Company Computational scanning microscopy with improved resolution
JP6342842B2 (en) 2015-04-30 2018-06-13 オリンパス株式会社 Scanning microscope system
US10130249B2 (en) 2015-05-01 2018-11-20 Canon Kabushiki Kaisha Inspection apparatus, image processing apparatus, method of operating inspection apparatus, image processing method, and recording medium
DE102015217908A1 (en) * 2015-09-18 2017-03-23 Robert Bosch Gmbh lidar
EP3396308B1 (en) * 2015-12-25 2022-02-02 Keyence Corporation Confocal displacement meter
TWI584778B (en) * 2016-02-04 2017-06-01 慈濟學校財團法人慈濟大學 Optical measurement device and system thereof
US10222441B2 (en) 2016-04-03 2019-03-05 Q Bio, Inc. Tensor field mapping
CN108614351B (en) * 2016-12-12 2020-07-10 凝辉(天津)科技有限责任公司 Microscope with rotatable objective lens
US11650195B2 (en) 2017-02-03 2023-05-16 Q Bio, Inc. Iterative medical testing of biological samples
WO2018226836A1 (en) * 2017-06-06 2018-12-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Multi-focal structured illumination microscopy systems and methods
US11086113B2 (en) 2017-06-06 2021-08-10 The United States Of America Multi-focal structured illumination microscopy systems and methods
US10382668B2 (en) * 2017-11-14 2019-08-13 Conary Enterprise Co., Ltd. Laser collimator module on a mobile device for image measurement
CN109211854B (en) * 2018-08-10 2021-07-02 国家纳米科学中心 Multi-beam multi-photon rescanning microscopy imaging device
US11354586B2 (en) 2019-02-15 2022-06-07 Q Bio, Inc. Model parameter determination using a predictive model
US11360166B2 (en) 2019-02-15 2022-06-14 Q Bio, Inc Tensor field mapping with magnetostatic constraint
US11614509B2 (en) 2019-09-27 2023-03-28 Q Bio, Inc. Maxwell parallel imaging
US12320880B2 (en) 2019-09-27 2025-06-03 Q Bio, Inc. Maxwell parallel imaging
CA3153503C (en) 2019-09-27 2024-05-14 Q Bio, Inc. Maxwell parallel imaging
NL2026002B1 (en) * 2020-07-03 2022-03-08 Confocal Nl B V Re-scan optical systems and methods
FR3112866B1 (en) * 2020-07-22 2022-07-22 Damae Medical Systems and methods for microscopic analysis of a sample
CN112505044B (en) * 2020-11-26 2022-06-07 暨南大学 A wide-field illumination confocal microscopy imaging system and method
US11614508B1 (en) 2021-10-25 2023-03-28 Q Bio, Inc. Sparse representation of measurements
DE102021134384A1 (en) * 2021-12-22 2023-06-22 Abberior Instruments Gmbh Methods and devices for checking the lateral and axial confocality of a scanning and descanning microscope assembly
LT7019B (en) 2023-01-24 2023-08-25 Vilniaus Gedimino technikos universitetas System and method of determining the dimensions of a spatial micrometre-sized object and its surface relief

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4806004A (en) * 1987-07-10 1989-02-21 California Institute Of Technology Scanning microscopy
JPH03172815A (en) * 1989-12-01 1991-07-26 Fuji Photo Film Co Ltd Cofocus scanning type microscope
JP2994703B2 (en) * 1990-07-23 1999-12-27 興和株式会社 Ophthalmic measurement device
US5162941A (en) * 1991-07-23 1992-11-10 The Board Of Governors Of Wayne State University Confocal microscope
US5587832A (en) * 1993-10-20 1996-12-24 Biophysica Technologies, Inc. Spatially light modulated confocal microscope and method
JPH07333510A (en) * 1994-06-02 1995-12-22 Nikon Corp Laser scanning microscope device
JP3350918B2 (en) * 1996-03-26 2002-11-25 株式会社高岳製作所 Two-dimensional array confocal optical device
US6002509A (en) * 1995-10-21 1999-12-14 Leica Lasertechnik Gmbh Beam scanner for confocal microscopes
JPH09265049A (en) * 1996-03-28 1997-10-07 Dainippon Screen Mfg Co Ltd Optically reading area limiting board, module and image reader applying the same
JP3816632B2 (en) * 1997-05-14 2006-08-30 オリンパス株式会社 Scanning microscope
AU9617598A (en) * 1997-10-29 1999-05-17 Calum E. Macaulay Apparatus and methods relating to spatially light modulated microscopy
WO2000011024A2 (en) * 1998-08-21 2000-03-02 Surromed, Inc. Novel optical architectures for microvolume laser-scanning cytometers
US7209287B2 (en) * 2000-09-18 2007-04-24 Vincent Lauer Confocal optical scanning device

Also Published As

Publication number Publication date
US20070146869A1 (en) 2007-06-28
JP5000839B2 (en) 2012-08-15
DE60133916D1 (en) 2008-06-19
EP1953580B1 (en) 2014-09-17
JP2004509370A (en) 2004-03-25
EP1953580A2 (en) 2008-08-06
EP1330671A1 (en) 2003-07-30
WO2002023247A1 (en) 2002-03-21
EP1330671B1 (en) 2008-05-07
US7391565B2 (en) 2008-06-24
ATE394697T1 (en) 2008-05-15
EP1953580A3 (en) 2009-03-25

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