[go: up one dir, main page]

AU2001288628A1 - Method and reagents for treatment of skin disorders by modulating the notch pathway - Google Patents

Method and reagents for treatment of skin disorders by modulating the notch pathway

Info

Publication number
AU2001288628A1
AU2001288628A1 AU2001288628A AU8862801A AU2001288628A1 AU 2001288628 A1 AU2001288628 A1 AU 2001288628A1 AU 2001288628 A AU2001288628 A AU 2001288628A AU 8862801 A AU8862801 A AU 8862801A AU 2001288628 A1 AU2001288628 A1 AU 2001288628A1
Authority
AU
Australia
Prior art keywords
modulating
reagents
treatment
skin disorders
notch pathway
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001288628A
Inventor
Lucio Miele
Brian J. Nickoloff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Loyola University Chicago
Original Assignee
Loyola University Chicago
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Loyola University Chicago filed Critical Loyola University Chicago
Publication of AU2001288628A1 publication Critical patent/AU2001288628A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0625Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0629Keratinocytes; Whole skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0618Cells of the nervous system
    • C12N5/0621Eye cells, e.g. cornea, iris pigmented cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6834Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • G01N33/5751
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40Regulators of development
    • C12N2501/42Notch; Delta; Jagged; Serrate
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Analytical Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2001288628A 2000-08-31 2001-08-31 Method and reagents for treatment of skin disorders by modulating the notch pathway Abandoned AU2001288628A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22961400P 2000-08-31 2000-08-31
US60/229,614 2000-08-31
PCT/US2001/027246 WO2002018544A2 (en) 2000-08-31 2001-08-31 Method and reagents for treatment of skin disorders by modulating the notch pathway

Publications (1)

Publication Number Publication Date
AU2001288628A1 true AU2001288628A1 (en) 2002-03-13

Family

ID=22861979

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001288628A Abandoned AU2001288628A1 (en) 2000-08-31 2001-08-31 Method and reagents for treatment of skin disorders by modulating the notch pathway

Country Status (3)

Country Link
US (1) US20020151487A1 (en)
AU (1) AU2001288628A1 (en)
WO (1) WO2002018544A2 (en)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8044259B2 (en) 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
US6984522B2 (en) * 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
FR2822049B1 (en) * 2001-03-13 2003-08-01 Dbv Medica 1 PATCH INTENDED IN PARTICULAR TO DETECT THE STATE OF SENSITIZATION OF A SUBJECT TO AN ALLERGEN, METHOD OF MANUFACTURING AND USE
US7635488B2 (en) * 2001-03-13 2009-12-22 Dbv Technologies Patches and uses thereof
US6962811B2 (en) 2001-05-09 2005-11-08 Millennium Pharmaceuticals, Inc. 14715, a human fringe family member nucleic acids and uses therefor
CA2465304A1 (en) * 2001-11-14 2003-05-22 Lorantis Limited Composition comprising inhibitors of the notch signalling pathway for the modulation of the immune system
JP2005526701A (en) * 2001-11-14 2005-09-08 ロランティス リミテッド Internal medicine
EP1461023A4 (en) * 2001-12-07 2005-08-31 Univ Michigan PROSPECTIVE IDENTIFICATION AND CHARACTERIZATION OF BREAST CANCER STEM CELLS
GB0300428D0 (en) * 2003-01-09 2003-02-05 Lorantis Ltd Medical treatment
WO2004073630A2 (en) * 2003-02-18 2004-09-02 Roskamp Research Llc Anti-angiogenic and anti-tumoral properties of beta and gamma secretase inhibitors
GB0307472D0 (en) * 2003-04-01 2003-05-07 Lorantis Ltd Medical treatment
EP2003196A3 (en) * 2003-06-09 2009-01-07 The Regents of the University of Michigan Compositions and methods for treating and diagnosing cancer
EP1671129A1 (en) * 2003-07-21 2006-06-21 Angiogenetics Sweden AB Compounds and methods for promoting angiogenesis by using a gamma-secretase inhibitor or inhibiting the gamma-secretase pathway
WO2005021783A2 (en) * 2003-08-30 2005-03-10 Adrian Merlo New use of gain and loss of notch2 function in brain tumors and the new notch2 genetic alterations of the notch2 gene per se
AU2005209909B8 (en) 2004-02-03 2009-01-15 The Regents Of The University Of Michigan Compositions and methods for characterizing, regulating, diagnosing, and treating cancer
ES2383306T3 (en) * 2004-02-03 2012-06-20 The Regents Of The University Of Michigan Compositions for the treatment of breast and pancreas cancer
WO2006047878A1 (en) * 2004-11-03 2006-05-11 British Columbia Cancer Agency Branch Cancer therapeutics and methods for their use
US7794742B2 (en) * 2005-02-08 2010-09-14 University Of Washington Devices for promoting epithelial cell differentiation and keratinization
US20060252073A1 (en) * 2005-04-18 2006-11-09 Regents Of The University Of Michigan Compositions and methods for the treatment of cancer
ES2382814T3 (en) * 2005-05-17 2012-06-13 Merck Sharp & Dohme Ltd. Cis-4 - [(4-chlorophenyl) sulfonyl] -4- (2,5-difluorophenyl) cyclohexanopropanoic acid for cancer treatment
US20070099209A1 (en) * 2005-06-13 2007-05-03 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
AU2006259583A1 (en) * 2005-06-13 2006-12-28 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
EP2479192A1 (en) 2005-10-31 2012-07-25 OncoMed Pharmaceuticals, Inc. Compositions and Methods for Diagnosing and Treating Cancer
US7723112B2 (en) * 2005-10-31 2010-05-25 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
WO2007145840A2 (en) 2006-06-13 2007-12-21 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
EP2087006B1 (en) * 2006-10-19 2016-06-08 Genentech, Inc. Anti-notch3 agonist antibodies and their use in the treatment of notch3-related diseases
WO2008136848A2 (en) 2006-10-19 2008-11-13 Genentech Inc. Novel anti-notch3 antibodies and their use in the detection and diagnosis of disease
CA2670992C (en) 2006-12-18 2017-11-21 Genentech, Inc. Antagonist anti-notch3 antibodies and their use in the prevention and treatment of notch3-related diseases
WO2008092002A2 (en) 2007-01-24 2008-07-31 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing pancreatic cancer
JP5618544B2 (en) 2007-01-24 2014-11-05 オンコメッドファーマシューティカルズ インコーポレイテッド Compositions and methods for diagnosis and treatment of cancer
FR2924350B1 (en) * 2007-12-03 2010-08-13 Dbv Tech METHOD AND COMPOSITIONS FOR SKIN VACCINATION
FR2924349B1 (en) 2007-12-03 2010-01-01 Dbv Tech ALLERGEN DISENSIBILITY METHOD
FR2926466B1 (en) * 2008-01-23 2010-11-12 Dbv Tech METHOD FOR MANUFACTURING PATCHES BY ELECTROSPRAY
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
NZ590127A (en) 2008-07-08 2012-11-30 Oncomed Pharm Inc Notch1 receptor binding agents and methods of use thereof
BRPI0919473A2 (en) 2008-09-26 2017-08-29 Oncomed Pharm Inc FRIZZLED BINDING AGENTS AND THEIR USES
US20110177042A1 (en) * 2008-10-03 2011-07-21 Meenhard Herlyn Method for Dedifferentiating Melanocytes
US9752124B2 (en) 2009-02-03 2017-09-05 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium for epithelial stem cells and organoids comprising the stem cells
NZ594271A (en) * 2009-02-03 2014-02-28 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium for epithelial stem cells and organoids comprising said stem cells
EP2412800A1 (en) 2010-07-29 2012-02-01 Koninklijke Nederlandse Akademie van Wetenschappen Liver organoid, uses thereof and culture method for obtaining them
WO2011063237A2 (en) 2009-11-19 2011-05-26 Oncomed Pharmaceuticals, Inc. Jagged-binding agents and uses thereof
TWI535445B (en) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Wnt antagonists and methods of treatment and screening
AU2011205316B2 (en) 2010-01-13 2015-05-28 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
CA2794674A1 (en) 2010-04-01 2011-10-06 Oncomed Pharmaceuticals, Inc. Frizzled-binding agents and uses thereof
US20130095493A1 (en) * 2011-10-03 2013-04-18 The Johns Hopkins University Identification of the gene notch3 as a novel biomarker for human metastatic melanoma
JP6044950B2 (en) * 2012-09-27 2016-12-14 株式会社マンダム Sweat gland cell detection method
CN104768579A (en) 2012-10-23 2015-07-08 昂科梅德制药有限公司 Methods of treating neuroendocrine tumors using Wnt pathway-binding agents
JP6316822B2 (en) * 2012-12-26 2018-04-25 国立大学法人京都大学 Method for inducing pancreatic exocrine cells
CN105073195A (en) 2013-02-04 2015-11-18 昂科梅德制药有限公司 Methods of treatment with Wnt pathway inhibitors and monitoring of the treatment
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
JP6720867B2 (en) * 2014-06-26 2020-07-08 日本ゼオン株式会社 Method for promoting differentiation of cultured epidermal cells and agent for promoting differentiation of cultured epidermal cells
GB201419976D0 (en) * 2014-11-10 2014-12-24 Univ Newcastle Biomarkers for disease progression in melanoma
WO2017053939A1 (en) * 2015-09-26 2017-03-30 Kung, Hsing-Jien Method and composition for treatment of hair loss
GB201721615D0 (en) 2017-12-21 2018-02-07 Koninklijke Nederlandse Akademie Van Wetenschappen Immune cell organoid co-cultures

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL101728A (en) * 1991-05-03 2007-08-19 Univ Yale Human notch and delta, binding domains in toporythmic proteins, and methods based thereon
IE20030749A1 (en) * 1991-05-03 2003-11-12 Indiana University Foundation Human notch and delta binding domains in torporythmic proteins, and methods based thereon
US5856441A (en) * 1991-05-03 1999-01-05 Yale University Serrate fragments and derivatives
US6004924A (en) * 1991-12-11 1999-12-21 Imperial Cancer Research Technology, Ltd. Protein sequences of serrate gene products
US5869282A (en) * 1991-12-11 1999-02-09 Imperial Cancer Research Technology, Ltd. Nucleotide and protein sequences of the serrate gene and methods based thereon
US5786158A (en) * 1992-04-30 1998-07-28 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
AU5168393A (en) * 1992-09-30 1994-04-26 Yale University Therapeutic and diagnostic methods and compositions based on transducin-like enhancer of split proteins and nucleic acids
US5750652A (en) * 1994-01-21 1998-05-12 Yale University Deltex proteins
WO1997001571A1 (en) * 1995-06-28 1997-01-16 Imperial Cancer Research Technology, Ltd. Nucleotide and protein sequences of vertebrate delta genes and methods based thereon
US5780300A (en) * 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
DE69635899T2 (en) * 1995-11-17 2006-11-23 Asahi Kasei Kabushiki Kaisha POLYPEPTIDE THAT SUPPRESSING DIFFERENTIATION
EP0921818A4 (en) * 1996-05-31 2002-09-25 Nat American Red Cross THERAPEUTIC AND DIAGNOSTIC METHODS AND COMPOSITIONS OBTAINED FROM JAGGED / NOTCH PROTEINS AND NUCLEIC ACIDS
US6136952A (en) * 1997-06-25 2000-10-24 University Of Washington Human jagged polypeptide, encoding nucleic acids and methods of use
CA2343963A1 (en) * 1998-10-02 2000-04-13 The Government Of The United States Of America As Represented By The Secretary, Dept. Of Health And Human Services, The National Institutes Of Health Apotosis inducing agents and methods

Also Published As

Publication number Publication date
WO2002018544A9 (en) 2003-04-03
WO2002018544A2 (en) 2002-03-07
WO2002018544A3 (en) 2003-06-12
US20020151487A1 (en) 2002-10-17

Similar Documents

Publication Publication Date Title
AU2001288628A1 (en) Method and reagents for treatment of skin disorders by modulating the notch pathway
WO2002086502A8 (en) Methods for the diagnosis and treatment of bone disorders
AU2001284857A1 (en) Surgical instrumentation and method for treatment of the spine
AU2001288251A1 (en) Methods and devices for optical stimulation of neural tissues
AU2001269799A1 (en) Methods for treating various eye disorders
AU2003286567A1 (en) Methods for the treatment of skin disorders
AU2001261637A1 (en) Apparatus for treatment of spinal disorders
AU3784999A (en) Methods for treatment of pain
AU2001286983A1 (en) Method of treatment
AU2001271887A1 (en) Methods for diagnosis and treatment of psychiatric disorders
AUPR074500A0 (en) Treatment of t cell disorders
AU2001240046A1 (en) Method of treating skin conditions
WO2002039997A3 (en) Ace-2 modulating compounds and use thereof
AU2003270536A1 (en) Method of treating skin disorders
AU2001290961A1 (en) Method for topical treatment of anthralin-responsive dermatological disorders
AU2002245204A1 (en) Methods for treating blood coagulation disorders
AU2002304931A1 (en) Methods for treating disorders of the nervous and reproductive systems
AU7106300A (en) Treatment of skin disorders
AU3757300A (en) Method of treating anxiety disorders
AU3899100A (en) Treatment of hyperactivity disorders
AU2002235202A1 (en) Treatment of bone disorders by modulation of fgfr3
AU5855899A (en) Method for identifying substances for the treatment of c-jun-mediated disorders
AU2001273759A1 (en) Essential oils and chemically related species for the treatment of increased bone resorption
AU2001262177A1 (en) Method of treatment
AU1282099A (en) Method for treatment of disorders of attention