AU2001288628A1 - Method and reagents for treatment of skin disorders by modulating the notch pathway - Google Patents
Method and reagents for treatment of skin disorders by modulating the notch pathwayInfo
- Publication number
- AU2001288628A1 AU2001288628A1 AU2001288628A AU8862801A AU2001288628A1 AU 2001288628 A1 AU2001288628 A1 AU 2001288628A1 AU 2001288628 A AU2001288628 A AU 2001288628A AU 8862801 A AU8862801 A AU 8862801A AU 2001288628 A1 AU2001288628 A1 AU 2001288628A1
- Authority
- AU
- Australia
- Prior art keywords
- modulating
- reagents
- treatment
- skin disorders
- notch pathway
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
- C12N5/0629—Keratinocytes; Whole skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
-
- G01N33/5751—
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/42—Notch; Delta; Jagged; Serrate
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Analytical Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22961400P | 2000-08-31 | 2000-08-31 | |
| US60/229,614 | 2000-08-31 | ||
| PCT/US2001/027246 WO2002018544A2 (en) | 2000-08-31 | 2001-08-31 | Method and reagents for treatment of skin disorders by modulating the notch pathway |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2001288628A1 true AU2001288628A1 (en) | 2002-03-13 |
Family
ID=22861979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001288628A Abandoned AU2001288628A1 (en) | 2000-08-31 | 2001-08-31 | Method and reagents for treatment of skin disorders by modulating the notch pathway |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US20020151487A1 (en) |
| AU (1) | AU2001288628A1 (en) |
| WO (1) | WO2002018544A2 (en) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8044259B2 (en) | 2000-08-03 | 2011-10-25 | The Regents Of The University Of Michigan | Determining the capability of a test compound to affect solid tumor stem cells |
| US6984522B2 (en) * | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
| FR2822049B1 (en) * | 2001-03-13 | 2003-08-01 | Dbv Medica 1 | PATCH INTENDED IN PARTICULAR TO DETECT THE STATE OF SENSITIZATION OF A SUBJECT TO AN ALLERGEN, METHOD OF MANUFACTURING AND USE |
| US7635488B2 (en) * | 2001-03-13 | 2009-12-22 | Dbv Technologies | Patches and uses thereof |
| US6962811B2 (en) | 2001-05-09 | 2005-11-08 | Millennium Pharmaceuticals, Inc. | 14715, a human fringe family member nucleic acids and uses therefor |
| CA2465304A1 (en) * | 2001-11-14 | 2003-05-22 | Lorantis Limited | Composition comprising inhibitors of the notch signalling pathway for the modulation of the immune system |
| JP2005526701A (en) * | 2001-11-14 | 2005-09-08 | ロランティス リミテッド | Internal medicine |
| EP1461023A4 (en) * | 2001-12-07 | 2005-08-31 | Univ Michigan | PROSPECTIVE IDENTIFICATION AND CHARACTERIZATION OF BREAST CANCER STEM CELLS |
| GB0300428D0 (en) * | 2003-01-09 | 2003-02-05 | Lorantis Ltd | Medical treatment |
| WO2004073630A2 (en) * | 2003-02-18 | 2004-09-02 | Roskamp Research Llc | Anti-angiogenic and anti-tumoral properties of beta and gamma secretase inhibitors |
| GB0307472D0 (en) * | 2003-04-01 | 2003-05-07 | Lorantis Ltd | Medical treatment |
| EP2003196A3 (en) * | 2003-06-09 | 2009-01-07 | The Regents of the University of Michigan | Compositions and methods for treating and diagnosing cancer |
| EP1671129A1 (en) * | 2003-07-21 | 2006-06-21 | Angiogenetics Sweden AB | Compounds and methods for promoting angiogenesis by using a gamma-secretase inhibitor or inhibiting the gamma-secretase pathway |
| WO2005021783A2 (en) * | 2003-08-30 | 2005-03-10 | Adrian Merlo | New use of gain and loss of notch2 function in brain tumors and the new notch2 genetic alterations of the notch2 gene per se |
| AU2005209909B8 (en) | 2004-02-03 | 2009-01-15 | The Regents Of The University Of Michigan | Compositions and methods for characterizing, regulating, diagnosing, and treating cancer |
| ES2383306T3 (en) * | 2004-02-03 | 2012-06-20 | The Regents Of The University Of Michigan | Compositions for the treatment of breast and pancreas cancer |
| WO2006047878A1 (en) * | 2004-11-03 | 2006-05-11 | British Columbia Cancer Agency Branch | Cancer therapeutics and methods for their use |
| US7794742B2 (en) * | 2005-02-08 | 2010-09-14 | University Of Washington | Devices for promoting epithelial cell differentiation and keratinization |
| US20060252073A1 (en) * | 2005-04-18 | 2006-11-09 | Regents Of The University Of Michigan | Compositions and methods for the treatment of cancer |
| ES2382814T3 (en) * | 2005-05-17 | 2012-06-13 | Merck Sharp & Dohme Ltd. | Cis-4 - [(4-chlorophenyl) sulfonyl] -4- (2,5-difluorophenyl) cyclohexanopropanoic acid for cancer treatment |
| US20070099209A1 (en) * | 2005-06-13 | 2007-05-03 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| AU2006259583A1 (en) * | 2005-06-13 | 2006-12-28 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| EP2479192A1 (en) | 2005-10-31 | 2012-07-25 | OncoMed Pharmaceuticals, Inc. | Compositions and Methods for Diagnosing and Treating Cancer |
| US7723112B2 (en) * | 2005-10-31 | 2010-05-25 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
| WO2007145840A2 (en) | 2006-06-13 | 2007-12-21 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
| EP2087006B1 (en) * | 2006-10-19 | 2016-06-08 | Genentech, Inc. | Anti-notch3 agonist antibodies and their use in the treatment of notch3-related diseases |
| WO2008136848A2 (en) | 2006-10-19 | 2008-11-13 | Genentech Inc. | Novel anti-notch3 antibodies and their use in the detection and diagnosis of disease |
| CA2670992C (en) | 2006-12-18 | 2017-11-21 | Genentech, Inc. | Antagonist anti-notch3 antibodies and their use in the prevention and treatment of notch3-related diseases |
| WO2008092002A2 (en) | 2007-01-24 | 2008-07-31 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing pancreatic cancer |
| JP5618544B2 (en) | 2007-01-24 | 2014-11-05 | オンコメッドファーマシューティカルズ インコーポレイテッド | Compositions and methods for diagnosis and treatment of cancer |
| FR2924350B1 (en) * | 2007-12-03 | 2010-08-13 | Dbv Tech | METHOD AND COMPOSITIONS FOR SKIN VACCINATION |
| FR2924349B1 (en) | 2007-12-03 | 2010-01-01 | Dbv Tech | ALLERGEN DISENSIBILITY METHOD |
| FR2926466B1 (en) * | 2008-01-23 | 2010-11-12 | Dbv Tech | METHOD FOR MANUFACTURING PATCHES BY ELECTROSPRAY |
| US9132189B2 (en) | 2008-07-08 | 2015-09-15 | Oncomed Pharmaceuticals, Inc. | Notch1 binding agents and methods of use thereof |
| NZ590127A (en) | 2008-07-08 | 2012-11-30 | Oncomed Pharm Inc | Notch1 receptor binding agents and methods of use thereof |
| BRPI0919473A2 (en) | 2008-09-26 | 2017-08-29 | Oncomed Pharm Inc | FRIZZLED BINDING AGENTS AND THEIR USES |
| US20110177042A1 (en) * | 2008-10-03 | 2011-07-21 | Meenhard Herlyn | Method for Dedifferentiating Melanocytes |
| US9752124B2 (en) | 2009-02-03 | 2017-09-05 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising the stem cells |
| NZ594271A (en) * | 2009-02-03 | 2014-02-28 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising said stem cells |
| EP2412800A1 (en) | 2010-07-29 | 2012-02-01 | Koninklijke Nederlandse Akademie van Wetenschappen | Liver organoid, uses thereof and culture method for obtaining them |
| WO2011063237A2 (en) | 2009-11-19 | 2011-05-26 | Oncomed Pharmaceuticals, Inc. | Jagged-binding agents and uses thereof |
| TWI535445B (en) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Wnt antagonists and methods of treatment and screening |
| AU2011205316B2 (en) | 2010-01-13 | 2015-05-28 | Oncomed Pharmaceuticals, Inc. | Notch1 binding agents and methods of use thereof |
| CA2794674A1 (en) | 2010-04-01 | 2011-10-06 | Oncomed Pharmaceuticals, Inc. | Frizzled-binding agents and uses thereof |
| US20130095493A1 (en) * | 2011-10-03 | 2013-04-18 | The Johns Hopkins University | Identification of the gene notch3 as a novel biomarker for human metastatic melanoma |
| JP6044950B2 (en) * | 2012-09-27 | 2016-12-14 | 株式会社マンダム | Sweat gland cell detection method |
| CN104768579A (en) | 2012-10-23 | 2015-07-08 | 昂科梅德制药有限公司 | Methods of treating neuroendocrine tumors using Wnt pathway-binding agents |
| JP6316822B2 (en) * | 2012-12-26 | 2018-04-25 | 国立大学法人京都大学 | Method for inducing pancreatic exocrine cells |
| CN105073195A (en) | 2013-02-04 | 2015-11-18 | 昂科梅德制药有限公司 | Methods of treatment with Wnt pathway inhibitors and monitoring of the treatment |
| US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
| JP6720867B2 (en) * | 2014-06-26 | 2020-07-08 | 日本ゼオン株式会社 | Method for promoting differentiation of cultured epidermal cells and agent for promoting differentiation of cultured epidermal cells |
| GB201419976D0 (en) * | 2014-11-10 | 2014-12-24 | Univ Newcastle | Biomarkers for disease progression in melanoma |
| WO2017053939A1 (en) * | 2015-09-26 | 2017-03-30 | Kung, Hsing-Jien | Method and composition for treatment of hair loss |
| GB201721615D0 (en) | 2017-12-21 | 2018-02-07 | Koninklijke Nederlandse Akademie Van Wetenschappen | Immune cell organoid co-cultures |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL101728A (en) * | 1991-05-03 | 2007-08-19 | Univ Yale | Human notch and delta, binding domains in toporythmic proteins, and methods based thereon |
| IE20030749A1 (en) * | 1991-05-03 | 2003-11-12 | Indiana University Foundation | Human notch and delta binding domains in torporythmic proteins, and methods based thereon |
| US5856441A (en) * | 1991-05-03 | 1999-01-05 | Yale University | Serrate fragments and derivatives |
| US6004924A (en) * | 1991-12-11 | 1999-12-21 | Imperial Cancer Research Technology, Ltd. | Protein sequences of serrate gene products |
| US5869282A (en) * | 1991-12-11 | 1999-02-09 | Imperial Cancer Research Technology, Ltd. | Nucleotide and protein sequences of the serrate gene and methods based thereon |
| US5786158A (en) * | 1992-04-30 | 1998-07-28 | Yale University | Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids |
| AU5168393A (en) * | 1992-09-30 | 1994-04-26 | Yale University | Therapeutic and diagnostic methods and compositions based on transducin-like enhancer of split proteins and nucleic acids |
| US5750652A (en) * | 1994-01-21 | 1998-05-12 | Yale University | Deltex proteins |
| WO1997001571A1 (en) * | 1995-06-28 | 1997-01-16 | Imperial Cancer Research Technology, Ltd. | Nucleotide and protein sequences of vertebrate delta genes and methods based thereon |
| US5780300A (en) * | 1995-09-29 | 1998-07-14 | Yale University | Manipulation of non-terminally differentiated cells using the notch pathway |
| DE69635899T2 (en) * | 1995-11-17 | 2006-11-23 | Asahi Kasei Kabushiki Kaisha | POLYPEPTIDE THAT SUPPRESSING DIFFERENTIATION |
| EP0921818A4 (en) * | 1996-05-31 | 2002-09-25 | Nat American Red Cross | THERAPEUTIC AND DIAGNOSTIC METHODS AND COMPOSITIONS OBTAINED FROM JAGGED / NOTCH PROTEINS AND NUCLEIC ACIDS |
| US6136952A (en) * | 1997-06-25 | 2000-10-24 | University Of Washington | Human jagged polypeptide, encoding nucleic acids and methods of use |
| CA2343963A1 (en) * | 1998-10-02 | 2000-04-13 | The Government Of The United States Of America As Represented By The Secretary, Dept. Of Health And Human Services, The National Institutes Of Health | Apotosis inducing agents and methods |
-
2001
- 2001-08-31 AU AU2001288628A patent/AU2001288628A1/en not_active Abandoned
- 2001-08-31 US US09/944,849 patent/US20020151487A1/en not_active Abandoned
- 2001-08-31 WO PCT/US2001/027246 patent/WO2002018544A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002018544A9 (en) | 2003-04-03 |
| WO2002018544A2 (en) | 2002-03-07 |
| WO2002018544A3 (en) | 2003-06-12 |
| US20020151487A1 (en) | 2002-10-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2001288628A1 (en) | Method and reagents for treatment of skin disorders by modulating the notch pathway | |
| WO2002086502A8 (en) | Methods for the diagnosis and treatment of bone disorders | |
| AU2001284857A1 (en) | Surgical instrumentation and method for treatment of the spine | |
| AU2001288251A1 (en) | Methods and devices for optical stimulation of neural tissues | |
| AU2001269799A1 (en) | Methods for treating various eye disorders | |
| AU2003286567A1 (en) | Methods for the treatment of skin disorders | |
| AU2001261637A1 (en) | Apparatus for treatment of spinal disorders | |
| AU3784999A (en) | Methods for treatment of pain | |
| AU2001286983A1 (en) | Method of treatment | |
| AU2001271887A1 (en) | Methods for diagnosis and treatment of psychiatric disorders | |
| AUPR074500A0 (en) | Treatment of t cell disorders | |
| AU2001240046A1 (en) | Method of treating skin conditions | |
| WO2002039997A3 (en) | Ace-2 modulating compounds and use thereof | |
| AU2003270536A1 (en) | Method of treating skin disorders | |
| AU2001290961A1 (en) | Method for topical treatment of anthralin-responsive dermatological disorders | |
| AU2002245204A1 (en) | Methods for treating blood coagulation disorders | |
| AU2002304931A1 (en) | Methods for treating disorders of the nervous and reproductive systems | |
| AU7106300A (en) | Treatment of skin disorders | |
| AU3757300A (en) | Method of treating anxiety disorders | |
| AU3899100A (en) | Treatment of hyperactivity disorders | |
| AU2002235202A1 (en) | Treatment of bone disorders by modulation of fgfr3 | |
| AU5855899A (en) | Method for identifying substances for the treatment of c-jun-mediated disorders | |
| AU2001273759A1 (en) | Essential oils and chemically related species for the treatment of increased bone resorption | |
| AU2001262177A1 (en) | Method of treatment | |
| AU1282099A (en) | Method for treatment of disorders of attention |