AU2001288460A1 - Compositions for treating sexual dysfunction, containing an no-donor and an antioxidant - Google Patents
Compositions for treating sexual dysfunction, containing an no-donor and an antioxidantInfo
- Publication number
- AU2001288460A1 AU2001288460A1 AU2001288460A AU8846001A AU2001288460A1 AU 2001288460 A1 AU2001288460 A1 AU 2001288460A1 AU 2001288460 A AU2001288460 A AU 2001288460A AU 8846001 A AU8846001 A AU 8846001A AU 2001288460 A1 AU2001288460 A1 AU 2001288460A1
- Authority
- AU
- Australia
- Prior art keywords
- antioxidant
- donor
- compositions
- sexual dysfunction
- treating sexual
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000003963 antioxidant agent Substances 0.000 title abstract 3
- 230000003078 antioxidant effect Effects 0.000 title abstract 3
- 201000001880 Sexual dysfunction Diseases 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 231100000872 sexual dysfunction Toxicity 0.000 title abstract 2
- 210000004392 genitalia Anatomy 0.000 abstract 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 abstract 1
- 229930064664 L-arginine Natural products 0.000 abstract 1
- 235000014852 L-arginine Nutrition 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000002840 nitric oxide donor Substances 0.000 abstract 1
- CMFNMSMUKZHDEY-UHFFFAOYSA-N peroxynitrous acid Chemical compound OON=O CMFNMSMUKZHDEY-UHFFFAOYSA-N 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Gynecology & Obstetrics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Methods for treating sexual dysfunction are disclosed. The methods generally comprise the administration of an NO donor and an antioxidant; the active ingredients can be administered topically to the genitals of the patient. The methods allow for localized NO delivery through topical application of the present compounds, while minimizing, if not preventing, damage associated with peroxynitrite formation. Compositions comprising L-arginine, or a derivative thereof and an antioxidant in a pharmaceutical carrier suitable for application to the genitals is also disclosed.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/653,794 | 2000-09-01 | ||
| US09/653,794 US7128930B1 (en) | 2000-09-01 | 2000-09-01 | Compositions and methods for treating sexual dysfunction |
| PCT/US2001/026817 WO2002019999A2 (en) | 2000-09-01 | 2001-08-29 | Compositions for treating sexual dysfunction, containing an no-donor and an antioxidant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2001288460A1 true AU2001288460A1 (en) | 2002-03-22 |
Family
ID=24622335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001288460A Abandoned AU2001288460A1 (en) | 2000-09-01 | 2001-08-29 | Compositions for treating sexual dysfunction, containing an no-donor and an antioxidant |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7128930B1 (en) |
| EP (1) | EP1317309B1 (en) |
| JP (1) | JP2004511443A (en) |
| AT (1) | ATE299740T1 (en) |
| AU (1) | AU2001288460A1 (en) |
| CA (1) | CA2419404C (en) |
| DE (1) | DE60112102T2 (en) |
| ES (1) | ES2242768T3 (en) |
| MX (1) | MXPA03001798A (en) |
| WO (1) | WO2002019999A2 (en) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL1022860C2 (en) * | 2003-03-06 | 2004-09-07 | Concepto Worldwide Ltd | Device for stimulating the female sexual organ, packaging and dosing device. |
| ATE418976T1 (en) * | 2005-08-04 | 2009-01-15 | Extarma Ag | LIQUID COMPOSITION CONTAINING ARGININE AND ALPHA-LIPOIC ACID TO IMPROVE SEXUAL FUNCTION |
| US20090197892A1 (en) * | 2007-08-21 | 2009-08-06 | Nawaz Ahmad | Anhydrous compositions useful for attaining enhanced sexual wellness |
| WO2011130608A1 (en) * | 2010-04-15 | 2011-10-20 | Life Science Enhancement Corporation | Methods and compositions for enhancing female sexual arousal and treating female sexual dysfunction |
| JP2013049670A (en) * | 2011-08-04 | 2013-03-14 | Fancl Corp | Ascorbic acid preparation |
| US9314423B2 (en) | 2013-03-13 | 2016-04-19 | Transdermal Biotechnology, Inc. | Hair treatment systems and methods using peptides and other compositions |
| US9295647B2 (en) | 2013-03-13 | 2016-03-29 | Transdermal Biotechnology, Inc. | Systems and methods for delivery of peptides |
| US9295637B2 (en) | 2013-03-13 | 2016-03-29 | Transdermal Biotechnology, Inc. | Compositions and methods for affecting mood states |
| US9687520B2 (en) | 2013-03-13 | 2017-06-27 | Transdermal Biotechnology, Inc. | Memory or learning improvement using peptide and other compositions |
| US9750787B2 (en) | 2013-03-13 | 2017-09-05 | Transdermal Biotechnology, Inc. | Memory or learning improvement using peptide and other compositions |
| US9320706B2 (en) | 2013-03-13 | 2016-04-26 | Transdermal Biotechnology, Inc. | Immune modulation using peptides and other compositions |
| US9339457B2 (en) | 2013-03-13 | 2016-05-17 | Transdermal Biotechnology, Inc. | Cardiovascular disease treatment and prevention |
| US9393265B2 (en) | 2013-03-13 | 2016-07-19 | Transdermal Biotechnology, Inc. | Wound healing using topical systems and methods |
| US20140271937A1 (en) | 2013-03-13 | 2014-09-18 | Transdermal Biotechnology, Inc. | Brain and neural treatments comprising peptides and other compositions |
| US9393264B2 (en) | 2013-03-13 | 2016-07-19 | Transdermal Biotechnology, Inc. | Immune modulation using peptides and other compositions |
| US9241899B2 (en) * | 2013-03-13 | 2016-01-26 | Transdermal Biotechnology, Inc. | Topical systems and methods for treating sexual dysfunction |
| US9724419B2 (en) | 2013-03-13 | 2017-08-08 | Transdermal Biotechnology, Inc. | Peptide systems and methods for metabolic conditions |
| US9314433B2 (en) | 2013-03-13 | 2016-04-19 | Transdermal Biotechnology, Inc. | Methods and systems for treating or preventing cancer |
| US9320758B2 (en) | 2013-03-13 | 2016-04-26 | Transdermal Biotechnology, Inc. | Brain and neural treatments comprising peptides and other compositions |
| US20140271938A1 (en) | 2013-03-13 | 2014-09-18 | Transdermal Biotechnology, Inc. | Systems and methods for delivery of peptides |
| US9849160B2 (en) | 2013-03-13 | 2017-12-26 | Transdermal Biotechnology, Inc. | Methods and systems for treating or preventing cancer |
| US9314422B2 (en) | 2013-03-13 | 2016-04-19 | Transdermal Biotechnology, Inc. | Peptide systems and methods for metabolic conditions |
| US9387159B2 (en) | 2013-03-13 | 2016-07-12 | Transdermal Biotechnology, Inc. | Treatment of skin, including aging skin, to improve appearance |
| US20140271731A1 (en) | 2013-03-13 | 2014-09-18 | Transdermal Biotechnology, Inc. | Cardiovascular disease treatment and prevention |
| US9314417B2 (en) | 2013-03-13 | 2016-04-19 | Transdermal Biotechnology, Inc. | Treatment of skin, including aging skin, to improve appearance |
| US9295636B2 (en) | 2013-03-13 | 2016-03-29 | Transdermal Biotechnology, Inc. | Wound healing using topical systems and methods |
| DE102013018565A1 (en) | 2013-10-28 | 2015-04-30 | Gmbu E.V., Fachsektion Dresden | Personal care products and their use |
| ITMI20132049A1 (en) | 2013-12-09 | 2015-06-10 | Multichem S A S Di Gabriele Segall A | COMPOSITIONS AND METHODS FOR THE STIMULATION OF THE FEMALE AND MALE SEXUAL RESPONSE |
| WO2018094377A1 (en) * | 2016-11-21 | 2018-05-24 | REV Pharmaceuticals LLC | Sexual health enhancement composition |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5242391A (en) | 1990-04-25 | 1993-09-07 | Alza Corporation | Urethral insert for treatment of erectile dysfunction |
| GB9214247D0 (en) | 1992-07-04 | 1992-08-19 | Stephan Peter M | Composition for use as a food or food supplement |
| JP3204510B2 (en) | 1993-04-05 | 2001-09-04 | コンペティティブ テクノロジーズ,インク. | Diagnosis and treatment of erectile dysfunction |
| US5439938A (en) | 1993-04-07 | 1995-08-08 | The Johns Hopkins University | Treatments for male sexual dysfunction |
| ES2091724B1 (en) | 1995-04-07 | 1997-06-01 | Ropero Wermenlinger Luis | NEW POTENTIATING LOTION OF SEXUAL CAPACITY IN MAN, PROCEDURE FOR ITS PREPARATION AND ITS APPLICATIONS. |
| US5595753A (en) * | 1995-04-14 | 1997-01-21 | President And Fellows Of Harvard College | Topical formulations and methods for treating hemorrhoidal pain and sphincter and smooth muscle spasm in the gastrointestinal tract |
| US5645839A (en) * | 1995-06-07 | 1997-07-08 | Trustees Of Boston University | Combined use of angiotensin inhibitors and nitric oxide stimulators to treat fibrosis |
| US6207713B1 (en) * | 1997-09-17 | 2001-03-27 | Eric T. Fossel | Topical and oral delivery of arginine to cause beneficial effects |
| US6071272A (en) | 1997-10-28 | 2000-06-06 | Hoffman; Alan S. | Method for treating erectile dysfunctionality |
| US6180133B1 (en) * | 1997-11-25 | 2001-01-30 | Watson Pharmaceuticals, Inc. | Antioxidant composition for topical/transdermal prevention and treatment of wrinkles |
| AU3221599A (en) | 1998-04-03 | 1999-10-25 | Daily Wellness Company, The | Compositions comprising l-arginine, ginseng and gingko biloba for enhancing blood circulation |
| US6031002A (en) * | 1998-05-01 | 2000-02-29 | Michael Ebert | Method for enhancing female sexual response and a composition therefor |
| AU4699299A (en) | 1998-06-26 | 2000-01-17 | Nutracorp Scientific, Inc. | Promoting nitric oxide and cyclic gmp activity |
| US6007824A (en) * | 1998-07-09 | 1999-12-28 | Duckett; Melvin J. | Natural composition and method for the treatment of sexual dysfunction |
| US6476037B1 (en) * | 2000-03-23 | 2002-11-05 | The Regents Of The University Of California | L-arginine and phosphodiesterase (PDE) inhibitor synergism |
| RU2163805C1 (en) | 2000-03-29 | 2001-03-10 | Закрытое Акционерное Общество Научно-Производственный Центр "Борщаговский Химико-Фармацевтический Завод" | Agent for treatment of men with sexual dysfunction |
-
2000
- 2000-09-01 US US09/653,794 patent/US7128930B1/en not_active Expired - Fee Related
-
2001
- 2001-08-29 MX MXPA03001798A patent/MXPA03001798A/en active IP Right Grant
- 2001-08-29 EP EP01968197A patent/EP1317309B1/en not_active Expired - Lifetime
- 2001-08-29 JP JP2002524484A patent/JP2004511443A/en not_active Withdrawn
- 2001-08-29 CA CA2419404A patent/CA2419404C/en not_active Expired - Fee Related
- 2001-08-29 ES ES01968197T patent/ES2242768T3/en not_active Expired - Lifetime
- 2001-08-29 WO PCT/US2001/026817 patent/WO2002019999A2/en not_active Ceased
- 2001-08-29 AT AT01968197T patent/ATE299740T1/en not_active IP Right Cessation
- 2001-08-29 AU AU2001288460A patent/AU2001288460A1/en not_active Abandoned
- 2001-08-29 DE DE60112102T patent/DE60112102T2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002019999A3 (en) | 2003-03-27 |
| ES2242768T3 (en) | 2005-11-16 |
| EP1317309A2 (en) | 2003-06-11 |
| DE60112102T2 (en) | 2006-05-24 |
| WO2002019999A2 (en) | 2002-03-14 |
| CA2419404A1 (en) | 2002-03-14 |
| US7128930B1 (en) | 2006-10-31 |
| CA2419404C (en) | 2012-10-16 |
| DE60112102D1 (en) | 2005-08-25 |
| EP1317309B1 (en) | 2005-07-20 |
| JP2004511443A (en) | 2004-04-15 |
| MXPA03001798A (en) | 2004-11-01 |
| ATE299740T1 (en) | 2005-08-15 |
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